Article
Clinical Neurology
Minjoon Cho, Kl-Han You, Jin Sup Yeom, Hyoungmin Kim, Kwang Bok Lee, Jae Hwan Cho, Jae Jun Yang, Jae Hyup Lee
Summary: This study evaluated the mid-term efficacy and safety of E.BMP-2/HA in lumbar posterolateral fusion. The results showed that E.BMP-2/HA had superior fusion quality compared to AIBG and both groups showed improvement in pain scores and quality of life. There were no significant differences in safety between the two groups.
EUROPEAN SPINE JOURNAL
(2023)
Article
Orthopedics
Toshitaka Yoshii, Motonori Hashimoto, Satoru Egawa, Takashi Hirai, Hiroyuki Inose, Atsushi Okawa
Summary: The study demonstrated that the use of hydroxyapatite/collagen composite with bone marrow aspirate as a substitute for autologous bone graft in intervertebral spinal fusion resulted in a high complete fusion rate in patients, comparable to traditional local bone grafts.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Orthopedics
Dong-Gune Chang, Jong-Beom Park, Yangjun Han
Summary: The study aimed to assess surgical outcomes of two types of DBM/local autograft composites in PLF. Fusion rates for both types of composites were not significantly different at 12 and 24 months postoperatively. Diabetes, smoking, and obesity negatively affected fusion rates, while clinical symptoms improved after surgery.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Orthopedics
Andreas K. Andresen, Line A. Wickstrom, Randi B. Holm, Leah Y. Carreon, Mikkel Osterheden Andersen
Summary: This study compared the outcomes of spinal fusion with and without instrumentation in elderly patients with degenerative spondylolisthesis. The results showed that there was no difference in patient-reported outcomes between the two groups, but the group with instrumentation had a significantly higher fusion success rate.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Clinical Neurology
Hani Chanbour, Anthony M. Steinle, Alan R. Tang, Raymond J. Gardocki, Amir M. Abtahi, Byron F. Stephens, Scott L. Zuckerman
Summary: This study compared transforaminal lumbar interbody fusion (TLIF) and posterolateral fusion (PLF) alone in terms of discharge disposition, return to work, and patient-reported outcomes. The results showed no significant differences between TLIF and PLF alone in discharge disposition, return to work, and pain scores.
Article
Medicine, General & Internal
Zhenyu Wu, Bo Zhou, Liang Chen, Xiaofeng Wang, Mohamed E. A. Abdelrahim, Cheng Wei
Summary: According to the meta-analysis results, bone morphogenetic protein-2 has higher fusion rates, shorter surgery time, and less blood loss compared to autologous iliac crest bone graft in posterolateral fusion of the lumbar spine. However, no significant difference was found in non-union rates, hospitalization days, and adverse events between the two methods.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Clinical Neurology
Hee Jung Son, Sung Hoon Choi, Myoung Keun Lee, Chang-Nam Kang
Summary: This study aimed to evaluate the efficacy and safety of different sources of bone morphogenetic protein-2 in lumbar fusion surgery, and the results showed that 1mg of E.BMP-2 is a safe and effective osteoinductive material.
Article
Orthopedics
Jianbin Guan, Tao Liu, Xing Yu, Ningning Feng, Guozheng Jiang, Wenhao Li, He Zhao, Yongdong Yang
Summary: The study investigated the feasibility of using the Isobar TTL system and posterolateral fusion for treating mild and moderate lumbar degenerative disease. The results showed that this approach was effective and could provide a safe alternative to traditional surgical methods.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Biotechnology & Applied Microbiology
Jeffrey L. Van Eps, Joseph S. Fernandez-Moure, Fernando J. Cabrera, Francesca Taraballi, Francesca Paradiso, Silvia Minardi, Xin Wang, Bayan Aghdasi, Ennio Tasciotti, Bradley K. Weiner
Summary: The human bony skeleton undergoes constant remodeling with a turnover of up to 10% bone volume annually. The study evaluated the regenerative ability of a nanostructured MHA/Coll scaffold augmented by autologous PRP in a model of spinal fusion. Both groups showed significantly more new bone formation compared to controls, with Group 2 exhibiting enhanced bone production and successful fusion rates. This study demonstrates the potential of using nanostructured MHA/Coll scaffold and autologous PRP in achieving successful clinical fusion.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Orthopedics
James D. Crowley, Rema A. Oliver, Michael J. Dan, Daniel J. Wills, John W. Rawlinson, Rebekah A. Crasto, James M. O'Connor, Gregory J. Mitchell, Christopher J. Tan, William R. Walsh
Summary: The study describes the preoperative procedures and surgical techniques used in single level PLF in a NZW rabbit model, emphasizing the importance of understanding rabbit lumbar anatomy and perioperative care. The majority of rabbits had seven lumbar vertebrae, and fusion rates at 12 weeks using iliac crest autograft were 76.9% and 70.0%, assessed by manual palpation and radiographic assessment.
Review
Clinical Neurology
John Rathbone, Matthew Rackham, David Nielsen, So Mang Lee, Wayne Hing, Sukhman Riar, Matthew Scott-Young
Summary: This study compared stand-alone anterior lumbar interbody fusion (ALIF) with posterior fusion techniques in patients with spondylolisthesis and degenerative disc disease. The results showed that ALIF had shorter operative time and less blood loss compared to the posterior fusion techniques, and also a shorter hospital stay compared to transforaminal lumbar interbody fusion (TLIF). However, the patient-reported outcome measures were not conclusive in determining the superiority between the different techniques.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Ananth Eleswarapu, F. Andrew Rowan, Hai Le, Joseph B. Wick, Rolando F. Roberto, Yashar Javidan, Eric O. Klineberg
Summary: A retrospective cohort study compared demineralized bone matrix (DBM) with recombinant human bone morphogenetic protein-2 (rhBMP-2) as adjuncts for instrumented lumbar spine fusion. The study found similar fusion rates between the two groups, but the DBM group showed better clinical outcomes while the rhBMP-2 group had higher rates of radiographic complications and costs.
GLOBAL SPINE JOURNAL
(2021)
Review
Clinical Neurology
Francois Dantas, Fernando Luiz Rolemberg Dantas, Ricardo Vieira Botelho
Summary: This study compared the effects of PLF and IBF on degenerative spondylolisthesis. The results showed that IBF had better improvements in fusion rate and sacral slope, but there were no significant differences in clinical outcomes between the two groups.
Review
Clinical Neurology
Elsayed Said, Mohamed E. Abdel-Wanis, Mohamed Ameen, Ali A. Sayed, Khaled H. Mosallam, Ahmed M. Ahmed, Hamdy Tammam
Summary: The meta-analysis revealed that patients undergoing PLIF had a significantly higher fusion rate compared to PLF. However, there were no statistically significant differences in clinical outcomes, complication rates, revision rates, operation time, or blood loss between the two fusion methods.
GLOBAL SPINE JOURNAL
(2022)
Article
Clinical Neurology
Vishwajeet Singh, Marcelo Oppermann, Nathan Evaniew, Alex Soroceanu, Fred Nicholls, W. Bradley Jacobs, Ken Thomas, Ganesh Swamy
Summary: This study investigated the clinical and radiographic fusion rates with lateral interbody approach and rhBMP-2 in multiple-level lumbar fusion in the ASD population. The results showed that over 90% of patients achieved successful fusion, with only a small number experiencing radiographic pseudoarthrosis and symptomatic pseudoarthrosis.
GLOBAL SPINE JOURNAL
(2022)
Article
Clinical Neurology
Kyung-Soo Suk, Kathryn Anne Jimenez, Je Hyung Jo, Hak-Sun Kim, Hwan-Mo Lee, Seong-Hwan Moon, Byung Ho Lee
Summary: This study found that in anterior cervical discectomy and fusion (ACDF) surgery, a longer fusion length, lower postoperative T1 slope, and anterior plate-screws technique increase the risk of cervical spacer failure. Pedicle screws provide the best biomechanical stability among the three fixation methods.
GLOBAL SPINE JOURNAL
(2023)
Article
Clinical Neurology
Sang Yun Seok, Dong-Ho Lee, Hyung Rae Lee, Sehan Park, Jae Hwan Cho, Chang Ju Hwang, Choon Sung Lee
Summary: This retrospective study found that the incidence of semispinalis cervicis injury during cervical laminoplasty is related to the size of the C2 inter-spinous angle. Preserving the C2 semispinalis cervicis insertion is more likely when the C2 inter-spinous angle is above 60 degrees, resulting in better clinical outcomes.
GLOBAL SPINE JOURNAL
(2023)
Article
Clinical Neurology
Dong-Ho Lee, Hyeong-Joo Lee, Jae Hwan Cho, Chang Ju Hwang, Jae Jun Yang, Choon Sung Lee, Sehan Park
Summary: Bone regrowth commonly occurs after posterior cervical foraminotomy. It occurs in all directions, but medial facet growth contributes more to foraminal restenosis. Greater widening of foramen during surgery is a risk factor for postoperative foraminal restenosis.
GLOBAL SPINE JOURNAL
(2023)
Article
Clinical Neurology
Minjoon Cho, Kl-Han You, Jin Sup Yeom, Hyoungmin Kim, Kwang Bok Lee, Jae Hwan Cho, Jae Jun Yang, Jae Hyup Lee
Summary: This study evaluated the mid-term efficacy and safety of E.BMP-2/HA in lumbar posterolateral fusion. The results showed that E.BMP-2/HA had superior fusion quality compared to AIBG and both groups showed improvement in pain scores and quality of life. There were no significant differences in safety between the two groups.
EUROPEAN SPINE JOURNAL
(2023)
Article
Medicine, General & Internal
Dong-Chan Eun, Yong-Ho Lee, Jin-Oh Park, Kyung-Soo Suk, Hak-Sun Kim, Seong-Hwan Moon, Si-Young Park, Byung-Ho Lee, Sang-Jun Park, Ji-Won Kwon, Sub-Ri Park
Summary: In this retrospective study, the clinical and radiological outcomes of patients with multilevel lumbar stenosis who underwent BESS and microscopic ULBD were compared. The results showed that the BESS group had better clinical outcomes, with significant improvements in back and leg pain scores and medication use. Radiological outcomes were also superior in the BESS group. The short-term follow-up period demonstrated the efficacy of multilevel decompression with the BESS technique.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Orthopedics
Sehan Park, Dong-Ho Lee, Choon Sung Lee, Chang-Ju Hwang, Jae Jun Yang, Jae Hwan Cho
Summary: Occasionally, ossification of the posterior longitudinal ligament (OPLL) causes cord compression, resulting in cervical myelopathy. The surgical strategy for OPLL differs from other causes of cervical spondylotic myelopathy, and both anterior and posterior approaches have their own benefits and drawbacks. Anterior decompression and fusion (ADF) can improve neurological recovery, restore lordosis, and prevent OPLL mass progression.
ASIAN SPINE JOURNAL
(2023)
Article
Orthopedics
Sam Yeol Chang, Jae Hun Kim, Sujung Mok, Bong-Soon Chang, Choon-Ki Lee, Hyoungmin Kim
Summary: This retrospective case series aimed to determine whether direct vertebral rotation with a high-density construct can reduce fusion segments without increasing adverse outcomes in selective thoracic fusion for adolescent idiopathic scoliosis. The study found that direct vertebral rotation with a high-density construct can indeed decrease fusion segments without increasing adverse outcomes.
ASIAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Jae Hwan Cho, Darryl Lau, Kimberly Ashayeri, Vedat Deviren, Christopher P. Ames
Summary: This retrospective comparative study aimed to assess the relationship between fusion mass bone density on CT and the development of rod fractures (RFs) and proximal junctional kyphosis (PJK) in adult spinal deformity patients. It was found that patients with PJK had lower fusion mass density at the upper instrumented vertebra (UIV), while patients with RFs and pseudarthrosis had higher bone density near the osteotomy site. The density of posterior fusion mass on CT may be helpful in assessing the risk for PJK and understanding the causes of RFs.
Article
Clinical Neurology
Sang Yun Seok, Dong-Ho Lee, Hyung Rae Lee, Jae Hwan Cho, Chang Ju Hwang, Choon Sung Lee, Seong Meen Yoon
Summary: Posterior ring hypoplasia of the atlas (C1) is a rare condition, usually asymptomatic and found incidentally. However, it can be accompanied by instability or space-occupying lesions, requiring surgery if symptomatic cord compression occurs. A novel and safer posterior arch decompression technique involving mobilization and posterior translation of the posterior arch as whole is presented here.
WORLD NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Yong-Ho Lee, Mahmoud Abdou, Ji-Won Kwon, Kyung-Soo Suk, Seong-Hwan Moon, You-Gun Won, Tae-Jin Lee, Byung-Ho Lee
Summary: C5 palsy is a common complication of cervical myeloradiculopathy surgery. This study investigated different techniques for foraminal decompression and found that the incidence of C5 palsy was significantly lower in groups using posterior foraminotomy with pedicle screws compared to groups using uncovertebrectomy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Choon Sung Lee, Chang-Ju Hwang, Dong-Ho Lee, Jae Hwan Cho, Sehan Park
Summary: This retrospective cohort study aimed to investigate the risk factors of intraoperative neurophysiological monitoring (IONM) alert in adolescent idiopathic scoliosis (AIS) deformity correction surgery and describe the outcomes of patients who underwent staged correction surgery due to IONM alert. The study found that patients in the IONM alert group had significantly higher preoperative Cobb angle, operative time, estimated blood loss, and number of levels fused compared to the non-alert group. Eight patients (0.8%) underwent staged operation due to IONM alert, with a correction rate of 64.9%±15.1% and no permanent neurologic deficits.
GLOBAL SPINE JOURNAL
(2023)
Article
Orthopedics
Jae Hwan Cho, Chang Ju Hwang, Dong-Ho Lee, Choon Sung Lee
Summary: This study investigated the effects of the lordotic angle of cages on sagittal alignment in patients undergoing lumbar interbody fusion. The results showed that there was no improvement in sagittal alignment, even with the use of larger lordotic angles and more anterior positioning of the cages, especially at the L5-S1 level.
ASIAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Hyung Rae Lee, Jae Hwan Cho, Dong-Ho Lee, Sang Yun Seok, Chang Ju Hwang, Choon Sung Lee
Summary: This study aimed to identify the risk factors for the aggravation of sagittal balance after L5-S1 PLIF. Patients were divided into two groups based on postoperative changes in the segmental angle. The study found that large preoperative values of lumbosacral angle, segmental angle, and flexion lumbosacral angle were independent risk factors for the aggravation of sagittal balance.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Dong-Ho Lee, Sung Tan Cho, Sehan Park, Chang Ju Hwang, Jae Hwan Cho, Jin Hwan Kim
Summary: This retrospective cohort study evaluated the incidence of complications after vertebral body sliding osteotomy (VBSO) and compared them with anterior cervical corpectomy and fusion (ACCF). The most common complications after VBSO were dysphagia and significant subsidence. VBSO had lower rates of reoperation and subsidence compared to ACCF.