Review
Clinical Neurology
Teresa Paolucci, Francesco Agostini, Elena Mussomeli, Sara Cazzolla, Marco Conti, Francescapia Sarno, Andrea Bernetti, Marco Paoloni, Massimiliano Mangone
Summary: This scoping review focuses on the treatment opportunities in neurorehabilitation for patients with chronic stroke sequelae. The review finds that, despite the chronicity of the disease, rehabilitation treatment can lead to significant improvement in motor function and quality of life.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Rong Chen, Nicholas B. Dadario, Brennan Cook, Lichun Sun, Xiaolong Wang, Yujie Li, Xiaorong Hu, Xia Zhang, Michael E. Sughrue
Summary: An improved understanding of the brain's neuroplastic potential has led to advancements in neuromodulatory treatments for acute stroke patients. However, there is still limited knowledge about individual differences in treatment response and recovery. This study used personalized connectivity analyses to identify unique recovery trajectories in response to repetitive transcranial magnetic stimulation (rTMS) treatment. The results demonstrated the feasibility of using individualized connectivity analyses to differentiate phenotypes and better understand patient recovery with neuromodulatory treatment.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Sheng Li, Gerard E. Francisco, W. Zev Rymer
Summary: The relationship between poststroke spasticity and motor recovery can be confusing. True motor recovery involves neural recovery and repair in the acute and subacute stages, while functional recovery is mainly mediated by compensatory mechanisms. Spasticity interferes with true motor recovery but does not affect functional recovery in the acute and subacute stages, although appropriate management can lead to improvement in motor function during the chronic stage of stroke.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Multidisciplinary Sciences
Noor Sajid, Emma Holmes, Thomas M. Hope, Zafeirios Fountas, Cathy J. Price, Karl J. Friston
Summary: Functional recovery after brain damage varies depending on factors such as lesion site and extent. Recovery can occur by engaging residual components or utilizing intact neural structures, with different types of lesions having different effects.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Marie-Claire Smith, Benjamin J. Scrivener, Cathy M. Stinear
Summary: This observational study investigated whether lower limb motor-evoked potentials 1 week post-stroke can predict recovery of independent walking at 3 and 6 months post-stroke. The results showed that the presence of lower limb motor-evoked potentials can predict independent walking at 3 and 6 months post-stroke, but clinical factors are more important.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Emilia Conti, Alessandro Scaglione, Giuseppe de Vito, Francesco Calugi, Maria Pasquini, Tommaso Pizzorusso, Silvestro Micera, Anna Letizia Allegra Mascaro, Francesco Saverio Pavone
Summary: The study reveals that the extension and localization of new motor representations are specific to the treatment, with most treatments promoting segregation of motor representation to the peri-infarct region. Interestingly, only the combined therapy promotes both the recovery of forelimb functionality and the rescue of spatio-temporal features of motor-related activity.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Article
Neurosciences
Jianghong Fu, Shugeng Chen, Xiaokang Shu, Yifang Lin, Zewu Jiang, Dongshuai Wei, Jiajia Gao, Jie Jia
Summary: This study proposed a functional-oriented, portable BCI equipment for hand motor recovery after stroke. The BCI group showed significantly better progress in rehabilitation outcomes compared to the control group. The results suggest that BCI training can effectively promote hand recovery after a stroke, making it a promising approach for clinical practice.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Nursing
Kendy Gui Fang Chan, Ying Jiang, Wen Ting Choo, Hadassah Joann Ramachandran, Yanjuan Lin, Wenru Wang
Summary: This systematic review and meta-analysis aimed to evaluate the effectiveness of exergaming on balance, lower limb functional mobility, and functional independence in individuals with chronic stroke. Results showed that exergaming has favorable effects on these aspects, but most studies lacked sufficient description of bias prevention measures.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Neurosciences
Congcong Huo, Gongcheng Xu, Hui Xie, Haihong Zhao, Xuemin Zhang, Wenhao Li, Simin Zhang, Jianfei Huo, Huiyuan Li, Aiping Sun, Zengyong Li
Summary: This study aimed to investigate the effects of rTMS combined with bilateral arm training (BAT) on brain functional reorganization in patients with chronic stroke using functional near-infrared spectroscopy (fNIRS). The results showed that the rTMS-BAT paradigm had additional effects on task-dependent brain functional reorganization, and the engagement of the ipsilesional motor area in the functional network was associated with the motor impairment severity of stroke patients. fNIRS-based assessments may provide information about the neural mechanisms underlying combination interventions for stroke rehabilitation.
Review
Clinical Neurology
Jessica M. Cassidy, Jasper Mark, Steven C. Cramer
Summary: Stroke is a major cause of disability, and predicting post-stroke recovery is challenging. Neuroimaging-based biomarkers, particularly those measuring structural and functional connectivity of the brain, have shown potential in predicting motor recovery after stroke. This review explores the use of functional neural network connectivity measurements obtained from various imaging techniques in describing and predicting post-stroke behavioral status and recovery. The authors argue for the importance of implementing a causal inference framework in stroke research to move from association to causation.
Review
Neurosciences
S. Conti, C. Spalletti, M. Pasquini, N. Giordano, N. Barsotti, M. Mainardi, S. Lai, A. Giorgi, M. Pasqualetti, S. Micera, M. Caleo
Summary: Despite limited efficacy of robotic rehabilitation technologies for post-stroke motor recovery, combining robotic rehabilitation with chemogenetic stimulation of serotonin release shows promise in enhancing post-stroke motor performance. This combined approach results in substantial functional gains in mice that persist beyond treatment period and is associated with a reduction in GABAergic neurotransmission in perilesional areas. The immediate translational potential of this combined approach is demonstrated by the administration of a clinically approved drug, Buspirone, targeting the serotonin 1A receptor to significantly improve motor recovery after stroke.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Rehabilitation
Kent P. Simmonds, Zhehui Luo, Mathew Reeves
Summary: The study showed significant racial/ethnic disparities in poststroke function, with Black and Hispanic patients having lower FIM scores compared to White patients. These disparities varied by stroke subtype, with the most prominent differences observed between Black and White patients. Age was a major confounding factor for Black-White disparities, especially for patients with hemorrhagic stroke.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Loris Pignolo, Paolo Tonin, Pierluigi Nicotera, Giacinto Bagetta, Damiana Scuteri
Summary: This study aims to assess the impact of robot-assisted neurorehabilitation on the prevention of poststroke pain. A total of 118 stroke patients will be enrolled and randomly allocated to receive either ARAMIS or conventional rehabilitation. The study will evaluate the efficacy of the treatments and their effect on the quality of life of stroke survivors.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Emily R. Olafson, Keith W. Jamison, Elizabeth M. Sweeney, Hesheng Liu, Danhong Wang, Joel E. Bruss, Aaron D. Boes, Amy Kuceyeski
Summary: Motor recovery after ischemic stroke is dependent on the brain's ability to compensate for damaged tissue through functional reorganization. Research has shown that regions in the cerebellar/subcortical networks undergo the most frequent functional reorganization, and that areas with more disruption due to stroke experience more remapping over time. Additionally, greater motor impairment at baseline correlates with more extensive early subacute functional reorganization, leading to better motor recovery at 6 months.
Review
Clinical Neurology
Ji-Hun Yoo, Benjamin Chong, Peter Alan Barber, Cathy Stinear, Alan Wang
Summary: This review examines the methodologies currently used in motor outcome prediction studies using atlas-based voxel neuroimaging features. The study found that there are various limitations in the current methods, such as a lack of detailed reporting on image acquisition and a lack of consensus on the use of a single sensorimotor atlas for prediction. Therefore, there is a need for further validation and improvement in neuroimaging feature development for motor outcome prediction.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Rehabilitation
Ayhan Askin, Emel Atar, Aliye Tosun, Umit Demirdal, Ozlem Koca
DISABILITY AND REHABILITATION
(2020)
Article
Computer Science, Cybernetics
Cagdas Esiyok, Ayhan Askin, Aliye Tosun, Sahin Albayrak
UNIVERSAL ACCESS IN THE INFORMATION SOCIETY
(2020)
Article
Rehabilitation
Ayhan Askin, Emel Atar, Ilker Sengul, Aliye Tosun, Umit Demirdal, Ferhan Elmali
DISABILITY AND REHABILITATION
(2020)
Article
Rehabilitation
Ibrahim Bilir, Ayhan Askin, Ilker Sengul, Aliye Tosun
Summary: High-frequency repetitive transcranial magnetic stimulation to the left dorsolateral prefrontal cortex did not show any significant beneficial effect on pain, stiffness, fatigue, quality of life, mood, and cognitive state over sham stimulation.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Computer Science, Cybernetics
Cagdas Esiyok, Ayhan Askin, Aliye Tosun, Sahin Albayrak
Summary: The study proposed two novel interaction techniques, HeadCam and HeadGyro, based on a software switch approach to recognize head movements through a standard camera or gyroscope sensor, translating them into virtual switch presses. While HeadGyro showed slightly higher performance in objective evaluation metrics, HeadCam received better ratings in subjective evaluation. All participants agreed that these proposed interaction techniques are promising solutions for computer access tasks.
UNIVERSAL ACCESS IN THE INFORMATION SOCIETY
(2021)
Article
Rheumatology
Emel Atar, Ayhan Askin
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2020)
Article
Neurosciences
Ayhan Askin, Ilker Sengul, Aliye Tosun
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2020)
Article
Rehabilitation
Ali Dogan, Ilker Sengul, Ayhan Askin, Aliye Tosun
Summary: The study found that patients with patellofemoral pain syndrome had lower vastus medialis obliquus fiber angle compared to healthy individuals, but there was no significant change in the angle with knee flexion.
Article
Psychology, Developmental
Emel Atar, Erdal Dilekci, Tugba Ozsoy Unubol, Nermin Gunduz, Murat Atar, Ayhan Askin
Summary: This study translated and validated the Turkish version of the Caregiver Difficulties Scale (CDS), demonstrating its validity and reliability in Turkish informal family caregivers of children with cerebral palsy (CP).
CHILD CARE HEALTH AND DEVELOPMENT
(2022)
Article
Neurosciences
Ilker Sengul, Ayhan Askin, Aliye Tosun
Summary: This study investigated the effect of muscle selection for BoNT-A treatment on spasticity in post-stroke patients with elbow flexor muscle over-activity. The results indicated that targeting brachialis for BoNT-A injection may be more effective in reducing the severity of spasticity in stroke patients with a spontaneous spastic posture of elbow flexion and forearm pronation.
SOMATOSENSORY AND MOTOR RESEARCH
(2022)
Article
Rehabilitation
Korhan Baris Bayram, Ilker Sengul, Ayhan Askin, Aliye Tosun
Summary: This study investigated the inter-rater reliability of the Australian Spasticity Assessment Scale (ASAS) in adult stroke patients with spasticity. The results showed that the inter-rater reliability of the ASAS differed depending on the spastic muscle group assessed and the statistical method used. Weighted kappa values indicated good to very good agreement for the ASAS in assessing muscle spasticity.
INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
(2022)
Article
Clinical Neurology
Ilker Sengul, Ayhan Askin, Aylin Altun, Aliye Tosun
Summary: The effect of a single-session repetitive transcranial magnetic stimulation (rTMS) of the contralesional dorsal premotor cortex on poststroke upper-limb spasticity was investigated. The study included inhibitory rTMS group (n=12), excitatory rTMS group (n=12), and sham stimulation group (n=13). The primary outcome measure was the Modified Ashworth Scale (MAS) and the secondary outcome measure was the F/M amplitude ratio. The results showed that only the excitatory rTMS group had a significant change in MAS score over time.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Aylin Altun, Ayhan Askin, Ilker Sengul, Nazrin Aghazada, Yagmur Aydin
Summary: This study investigates the reliability, sufficiency, and accuracy of YouTube videos about CRPS. The majority of the videos have partially sufficient data and include intermediate-high quality content. Videos with higher content quality have higher viewing rates, interaction indexes, and better reliability and accuracy scores. High-quality and reliable videos are needed to reduce misinformation about CRPS.
KOREAN JOURNAL OF PAIN
(2022)
Article
Medicine, General & Internal
Ayhan Askin, Ibrahim Bilir, Ilker Sengul, Aylin Altun, Aliye Tosun
CUKUROVA MEDICAL JOURNAL
(2020)
Article
Neurosciences
Elif Umay Altas, Ayhan Askin, Lutfullah Besiroglu, Aliye Tosun
SOMATOSENSORY AND MOTOR RESEARCH
(2019)
