Article
Chemistry, Multidisciplinary
Toshiharu Ishizaki, Hideaki Karasaki, Yuto Kage, Misaki Kamioka, Yitong Wang, Shigeki Mori, Naoto Ishikawa, Takamitsu Fukuda, Hiroyuki Furuta, Soji Shimizu
Summary: In this study, a novel pyrrolopyrrole azadipyrrin with Janus duality was successfully synthesized, enabling the formation of one-dimensional arrays in solution and in the solid state. The supramolecular assembly of the zinc complex in solution was investigated based on the isodesmic model, while the cobalt complex exhibited unique magnetic relaxation behavior in the solid state.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Jie Hu, Linkun Cai, Huihui Wang, Kun Chen, Panchao Yin
Summary: Hybrid nanocomposites of uranyl peroxide nanocages are assembled from the ionic interaction between anionic uranyl peroxide nanocage clusters and cationic surfactants. The materials exhibit enriched microphase-separated structures and show different Li+ conducting mechanisms across the critical temperature. The design of the nanocomposites offers approaches to fabricate solid-state electrolytes with high ion conductivities and promising mechanical strengths.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Inorganic & Nuclear
Liladhar B. Kumbhare, Anu Prathap M. Udayan, Hardik Singla, Shilpa N. Sawant, Priyanka Ruz, Amey Wadawale, Jitendra Bahadur
Summary: A series of 2-(3,5-dimethylpyrazol-1-yl)phenyl substituted selenoether complexes of palladium were synthesized and their molecular structures and aggregation were analyzed. These complexes were converted to capping free palladium selenide nanoparticles and evaluated for electrocatalytic activity in alkaline medium.
DALTON TRANSACTIONS
(2023)
Review
Chemistry, Multidisciplinary
Sahil Ahlawat, Kaustubh R. Mote, Nils-Alexander Lakomek, Vipin Agarwal
Summary: In the past two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has evolved from investigating small molecules and industrial polymers to decrypting complex biological systems. This transformation is due to improvements in hardware design, sample preparation, and sensitivity. This review discusses state-of-the-art ssNMR methods and recent developments in signal filtering, proton methodologies, and data acquisition speed in fast magic-angle spinning (MAS) systems.
Article
Chemistry, Organic
Houchen Wang, Mingyue Chen, Yuanyuan Zhu, Yu Li, Han Zhang, Tiesheng Shi
Summary: In this study, a functional molecule with a specific monomeric conformer was synthesized and stable aggregates were prepared by temperature control. The polymerization mechanism was proposed, providing insights into the complexity of supramolecular polymerizations and offering a new approach for the synthesis of other building blocks.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Biochemistry & Molecular Biology
Patrick C. A. van der Wel
Summary: Solid-state NMR spectroscopy provides valuable high-resolution structural information primarily focused on inter-atomic distance measurements. This review examines the utility of measuring angular constraints as a complement to distance-based structure determination, focusing on the judicious recoupling of multiple anisotropic ssNMR parameters.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biophysics
Shuai Cao, Le Zhou, Chang Liu, Huacheng Zhang, Yuxin Zhao, Yanli Zhao
Summary: The ingenious design and synthesis of novel macrocycles brought renewed vigor to supramolecular chemistry in the past decade. Pillarene and pillararene-based functional materials have seen rapid growth in electrochemical studies due to their unique structures and physiochemical properties. Challenges and future developments in this field have been discussed, providing a solid foundation for further bioelectrochemical applications of pillararene systems.
BIOSENSORS & BIOELECTRONICS
(2021)
Editorial Material
Cell Biology
Paulina Strzyz
Summary: Ma et al. demonstrate the crucial role of CCT2 in the clearance of solid protein aggregates.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Engineering, Biomedical
Sean H. Kelly, Emmanuel E. Opolot, Yaoying Wu, Benjamin Cossette, Ajay K. Varadhan, Joel H. Collier
Summary: The SIMPL tablet vaccine, which can be administered sublingually, shows promising results in raising antibody responses against various epitopes, including a model epitope from ovalbumin and a clinically relevant epitope from Mycobacterium tuberculosis. The heat-stable feature of this vaccine is particularly advantageous for global distribution and equity in vaccine coverage.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Chandrakanta Guchhait, Vembanan Suriyaa, Nihar Sahu, Sovik Dey Sarkar, Bimalendu Adhikari
Summary: Ferrocene has potential applications in various fields such as ligand design, catalysis, analytical chemistry, biological chemistry, medicinal chemistry, and materials chemistry. It can be used as a building block in supramolecular chemistry, forming stable host-guest complexes with different macrocyclic host molecules. The unique properties of ferrocene make it suitable for the development of smart molecular receptors, metal-organic assemblies, supramolecular polymers, gels, and metal nanoparticle assemblies.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Arisa Jinno, Yuna Ogasawara, Tomoko Hashimoto, Masaki Mitsumoto, Tso-Fu Mark Chang, Masato Sone, Hiromichi Kurosu
Summary: In this study, PET textiles were metallized with Pt via sc-CO2 catalyzation using Pd(hfac)2 as the catalyst source. NMR spectroscopy was used to elucidate the effects of the treatments on PET's structural changes and molecular mobility. The results showed that Pd could exist near the C--O carbon and the catalyzation reduced the molecular mobility of PET. Additionally, the X-ray diffraction studies demonstrated that sc-CO2 catalyzation increased PET's crystallinity.
JOURNAL OF SUPERCRITICAL FLUIDS
(2023)
Article
Chemistry, Multidisciplinary
Shan-Shan Jia, Wen-Shi Xu, Yong Chen, Yu Liu
Summary: This study utilized an effective strategy to improve the stability and conductivity of conductive polymers by constructing different supramolecular assemblies. Five different supramolecular macrocycles were used, and the electrochemical performance of the assembly electrodes was significantly improved.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Linda Cerofolini, Kristian Vasa, Elisa Bianconi, Maria Salobehaj, Giulia Cappelli, Alice Bonciani, Giulia Licciardi, Anna Perez-Rafols, Luis Padilla-Cortes, Sabrina Antonacci, Domenico Rizzo, Enrico Ravera, Caterina Viglianisi, Vito Calderone, Giacomo Parigi, Claudio Luchinat, Antonio Macchiarulo, Stefano Menichetti, Marco Fragai
Summary: Several protein-drug conjugates are currently used in cancer therapy, relying on covalently attached cytotoxic organic compounds or non-covalent interactions. Human transthyretin (TTR) has been identified as a potential carrier protein for cytotoxic drug delivery. This study demonstrates the importance of integrating multiple biophysical and structural techniques, such as microscale thermophoresis, X-ray crystallography, and NMR. Solid-state NMR is particularly valuable in revealing ligand binding effects and their impact on macromolecular complex stability.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
ShengQi Xiang, Cecilia Pinto, Marc Baldus
Summary: Membrane proteins play important biological roles by forming complexes in cell membranes. This study focuses on understanding the role of the lipoprotein BamC in the assembly of the beta-barrel assembly machinery (BAM) complex in lipid bilayers. By developing a selective preparation scheme and using proton-detected solid-state NMR methods, the researchers were able to investigate the structure and dynamics of BamC embedded in the entire BAM complex in lipid bilayers. This approach provides insights into the formation and functioning of membrane protein complexes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Biomedical
Nicole L. Votaw, Lauren Collier, Elizabeth J. Curvino, Yaoying Wu, Chelsea N. Fries, Madison T. Ojeda, Joel H. Collier
Summary: This study introduced a self-assembling randomized polypeptide nanomaterial capable of inducing strong Type 2/TH2/IL-4 immune responses, with potential applications ranging from vaccination to tissue repair. The modified peptides showed improved antigen presenting cell uptake, strong B-cell and T-cell epitopes, increased IL-4 production by T cells, extended nanofiber residence time, minimal swelling in footpad injections, and decreased overall T cell expansion compared to unmodified nanofibers, suggesting a TH2 T-cell response with minimal inflammation.