Article
Public, Environmental & Occupational Health
Ruizi Shi, Fang Wang, Wanying Xu, Li Fu
Summary: This study assessed the impact of night flights on sleep disorders among aging airline pilots and found that the duration of night flights and age have a combined effect on sleep disorders. The results showed an interaction between night flight duration and age on sleep disorders, and night flight duration, body mass index, hyperuricemia, and regular exercise were associated with sleep disorders in different age groups.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Fatema Al-Rashed, Sardar Sindhu, Ashraf Al Madhoun, Abdulwahab Alghaith, Rafaat Azinn, Fand Al-Mulla, Rasheed Ahmad
Summary: The study revealed that in Kuwait, both sleep quality and duration were inadequate among the population, with a significant association between sleep quality and obesity independent of age and sex. Sleep duration was found to correlate with various metabolic factors, such as blood pressure and insulin resistance, indicating a potential indirect contribution of sleep deprivation and disturbance to the development of obesity and metabolic syndromes like type 2 diabetes.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Oncology
Mohammed Al Maqbali
Summary: Sleep disturbance is common among Arabic women post-treatment for breast cancer, with poor sleepers more likely to have comorbidities and receive multiple treatments. Poor sleep was associated with lower quality of life in cancer patients, highlighting the importance of addressing sleep disturbances in clinical settings and developing interventions for management.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Public, Environmental & Occupational Health
S. Sathvik, L. Krishnaraj, Muhammad Irfan
Summary: Approximately 21% of workers in developing and developed countries are shift workers. This study assessed the impact of different shift schedules on shift workers and found that rotational shift workers had the shortest total sleep time and a significant number of them were affected by sleep disorders.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Charlotte Kreutz, Jana Mueller, Martina E. Schmidt, Karen Steindorf
Summary: Sleep problems were common in breast cancer patients starting neoadjuvant chemotherapy, and subjective and objective assessments showed significant differences in various parameters. PSQI and ActiGraph measurements had limited agreement, suggesting a combination of both methods might be most promising.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Chelsea G. Ratcliff, Stephanie G. Zepeda, Martica H. Hall, Emily A. Tullos, Shaelyn Fowler, Alejandro Chaoul, Amy Spelman, Banu Arun, Lorenzo Cohen
Summary: Disturbed sleep is common among breast cancer survivors, with risk factors including race/ethnicity, low income, and BMI. Sleep disturbance may have long-term effects on multiple aspects of QOL for women undergoing treatment for breast cancer, informing strategies to identify patients at greatest risk.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Clinical Neurology
Weiye Wang, Haozhe Meng, Yiwa Liu, Wei Yin, Zetong Li, Mengting Wan, Linbing Zou, Dongfeng Zhang
Summary: This case-control study showed that poor sleep quality and short or long sleep duration in early pregnancy were associated with gestational diabetes mellitus (GDM), with an interaction effect between short sleep duration and poor sleep quality on GDM.
SLEEP AND BREATHING
(2022)
Article
Neurosciences
Michelle Rissling, Lianqi Liu, Shawn D. Youngstedt, Vera Trofimenko, Loki Natarajan, Ariel B. Neikrug, Neelum Jeste, Barbara A. Parker, Sonia Ancoli-Israel
Summary: This study examined the effects of daily increased morning light exposure on sleep and circadian patterns in women undergoing chemotherapy for breast cancer. The results suggested that the group exposed to bright white light had longer night-time sleep, less sleep disturbances, and more daytime activity compared to the group exposed to dim red light. However, there were uncertainties regarding sleep quality and daytime dysfunction.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Guangfei Li, Yu Chen, Shefali Chaudhary, Clara S. Li, Dongmei Hao, Lin Yang, Chiang-Shan R. Li
Summary: This study examines the relationship between hypothalamic resting state functional connectivity (rsFC), sleep dysfunction, cognitive performance, and subjective mood states. The results show that sleep dysfunction is associated with negative emotions and altered hypothalamic-insula rsFC, particularly in men.
Article
Oncology
Zuoyun Wang, Yan Wang, Jing Huang, Jietian Xu, Fangzhen Chen, Zidan Zhu, Lingling Gao, Jie Qin, Binbin Liu, Chunmin Liang
Summary: Sleep-wake disturbance is prevalent in patients with liver cancer, especially in those with non-HBV cirrhosis. Poor sleep quality is associated with immune factors.
Review
Medicine, General & Internal
Ye Luo, Guofeng Yu, Yuanfei Liu, Chengjun Zhuge, Yinge Zhu
Summary: This study aimed to estimate the prevalence of poor sleep quality after stroke through a systematic review and meta-analysis. The findings showed that poor sleep quality is common in patients with stroke, with a prevalence rate of 53%. Therefore, effective measures should be taken to improve the sleep quality of stroke patients.
Review
Clinical Neurology
Gholami Fatemeh, Moradi Sajjad, Rasaei Niloufar, Soveid Neda, Setayesh Leila, Mirzaei Khadijeh
Summary: Exogenous melatonin treatment has a positive impact on sleep quality in adults, especially among those with respiratory diseases, metabolic disorders, and primary sleep disorders. Subgroup analysis based on health status revealed significant effects of melatonin intervention in these specific groups.
JOURNAL OF NEUROLOGY
(2022)
Article
Psychology, Multidisciplinary
Cheng Guo
Summary: It is important to assess sleep quality among nonclinical adolescents for the surveillance of their psychological and physical health. This study examined the validity and reliability of the Chinese version of the Pittsburgh Sleep Quality Index (PSQI) in a sample of Chinese students. The results showed moderate internal consistency of the PSQI and supported its three-dimensional model and measurement invariance across gender and age. The correlations between PSQI scores and measures of positive life aspects and mental illness and distress provided evidence for criterion validity. A cutoff point of 6.5 was identified as optimal for diagnosing sleep disturbance using the PSQI.
CURRENT PSYCHOLOGY
(2023)
Article
Medicine, General & Internal
Xia Zhong, Fuyue Gou, Huachen Jiao, Dongsheng Zhao, Jing Teng
Summary: This study investigates the association between night sleep latency and hypertension in the Chinese population. The findings show that longer night sleep latency is positively correlated with hypertension, as well as other sleep factors.
Article
Clinical Neurology
Anna Bara Unnarsdottir, Arna Hauksdottir, Thor Aspelund, Vigdis Gunnarsdottir, Gunnar Tomasson, Johanna Jakobsdottir, Unnur Anna Valdimarsdottir, Edda Bjork Thordardottir
Summary: This large-scale population-based study aimed to assess the prevalence of severe sleep problems and associated factors among women in Subarctic regions. The study found that severe sleep problems were more common during winter and among young and late-midlife women, single women, women with children, and those facing socio-economic challenges. Additionally, obesity, suboptimal health behaviors, excessive screen time, and mental health problems were associated with severe sleep problems.
Article
Gastroenterology & Hepatology
Mikhail Efanov, Diana Salimgereeva, Ruslan Alikhanov, Andrew G. R. Wu, David Geller, Federica Cipriani, Davit L. Aghayan, Asmund Avdem Fretland, Jasper Sijberden, Andrea Belli, Marco V. Marino, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Prieto, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Constantino Fondevila, Fernando Rotellar, Gi-Hong Choi, Ricardo Robless Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Eric Lai, Charing C. Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, Paulo Herman, Fabrizio Di Benedetto, T. Peter Kingham, Rong Liu, Tran Cong Duy Long, Alessandro Ferrero, Giovanni Battista Levi Sandri, Daniel Cherqui, Olivier Scatton, Go Wakabayashi, Roberto I. Troisi, Tan-To Cheung, Atsushi Sugioka, Ho-Seong Han, Mohammad Abu Hilal, Olivier Soubrane, David Fuks, Luca Aldrighetti, Bjorn Edwin, Brian K. P. Goh
Summary: This study compares the outcomes of laparoscopic liver resection of segments 7 and 8 and finds that atypical resection of segment 7 is more difficult than segment 8, while segmentectomy 8 is more difficult than segmentectomy 7.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Yun-Le Linn, Andrew G. Wu, Ho-Seong Han, Rong Liu, Kuo-Hsin Chen, David Fuks, Olivier Soubrane, Daniel Cherqui, David Geller, Tan-To Cheung, Bjorn Edwin, Luca Aldrighetti, Mohammad Abu Hilal, Roberto Troisi, Go Wakabayashi, Brian K. P. Goh
Summary: This study reviewed the literature on difficulty scoring systems (DSS) for minimally invasive liver resection (MILR) and found that existing DSS are effective in predicting the difficulty of the surgery.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Surgery
Epameinondas Dogeas, David A. A. Geller, Samer Tohme, Jennifer Steel, Winifred Lo, Brittany Morocco, Amit Tevar, Michele Molinari, Christopher Hughes, Abhinav Humar
Summary: This study compared textbook outcomes (TO) of open live donor right hepatectomy (RH) versus open right hepatic lobectomy for cancer in a single Western center and identified clinical factors associated with failure to achieve a TO. The results showed that the TO rate after RH for live donor purposes was 92.2% and for RH for cancer cases was 53.7%.
Article
Psychology, Developmental
Adriane M. Soehner, Rebecca A. Hayes, Peter L. Franzen, Tina R. Goldstein, Brant P. Hasler, Daniel J. Buysse, Greg J. Siegle, Ronald E. Dahl, Erika E. Forbes, Cecile D. Ladouceur, Dana L. McMakin, Neal D. Ryan, Jennifer S. Silk, Maria Jalbrzikowski
Summary: This study aimed to investigate whether interindividual differences in naturalistic sleep patterns are correlated with deviations from typical brain aging. The results showed that later sleep timing was associated with more advanced brain aging, but sleep duration, continuity, and regularity were not significantly associated with brain age gap. Gender and age did not moderate the relationship between sleep and brain age gap. Additionally, depression severity was not associated with brain age gap or sleep in this psychiatrically healthy sample.
JOURNAL OF ADOLESCENT HEALTH
(2023)
Article
Gastroenterology & Hepatology
Giada Aizza, Nadia Russolillo, Alessandro Ferrero, Nicholas L. Syn, Federica Cipriani, Davit Aghayan, Marco Marino, Riccardo Memeo, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Marco Vivarelli, Fabrizio Di Benedetto, Sung-Hoon Choi, Jae Hoon Lee, James O. Park, Mikel Gastaca, Constantino Fondevila, Mikhail Efanov, Fernando Rotellar, Gi-Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Chung Ngai Tang, Charing C. Chong, Mathieu D'Hondt, Chee Chien Yong, Andrea Ruzzenente, Paolo Herman, T. Peter Kingham, Olivier Scatton, Rong Liu, Giovanni Battista Levi Sandri, Olivier Soubrane, Alejandro Mejia, Santiago Lopez-Ben, Kazateru Monden, Go Wakabayashi, Daniel Cherqui, Roberto Troisi, Mengqiu Yin, Felice Giuliante, David Geller, Atsushi Sugioka, Bjorn Edwin, Tan-To Cheung, Tran Cong Duy Long, Mohammad Abu Hilal, David Fuks, Kuo-Hsin Chen, Luca Aldrighetti, Ho-Seong Han, Brian K. P. Goh
Summary: This study aimed to investigate the relationship between tumor size and the difficulty of laparoscopic left lateral sectionectomy (L-LLS). Three optimal tumor size cutoffs (40-, 70-, and 100-mm) were identified. As tumor size increased, there was a stepwise increase in the rates of open conversion, operative time, blood loss, intraoperative blood transfusion, Pringle maneuver use, major morbidity, and 30-day readmission.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Surgery
Victor Lopez-Lopez, Jaime Arthur Pirola Krurger, Christopher Kuemmerli, Samer Tohme, Concepcion Gomez-Gavara, Maria Iniesta, Asuncion Lopez-Conesa, Epameinondas Dogeas, Mar Dalmau, Roberto Brusadin, Ignacio Sanchez-Esquer, David A. Geller, Paulo Herman, Ricardo Robles-Campos
Summary: This study compared the short-term and long-term outcomes of hand-assisted laparoscopic (HALS)/Hybrid and pure laparoscopic (PLS) resection for colorectal cancer liver metastasis. The results showed no differences in long-term oncologic outcomes between the two techniques. However, the PLS group had longer operative time, higher rates of intraoperative ablation, positive resection margins, and longer time to control bleeding. HALS/Hybrid may have a shorter learning curve and better hemorrhage control.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Guido P. Fiorentini, Yasmin Essaji, David A. Geller, David A. Iannitti, Erin H. Baker, Susanne G. Warner, Iswanto Sucandy, Pablo E. Serrano, Edwin Onkendi, William S. Helton, Adnan Alseidi, Sean P. Cleary
Summary: The aim of this study was to determine the benchmark performance of MILLS throughout the AMILES database. Results showed that among 1665 minimally invasive liver resections, 49% of MILLS cases met all textbook outcomes. Benchmark performance metrics for MILLS included conversion rate, blood loss, OR time, transfusion rate, complication rate, and length of stay.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
Winifred M. M. Lo, Samer T. T. Tohme, David A. A. Geller
Summary: Minimally invasive surgery, including laparoscopic and robotic approaches, is a safe and effective option for treating liver metastases from colorectal cancer. Laparoscopic liver resection (LLR) is associated with shorter hospital stays and similar post-operative complications compared to open techniques. LLR allows for early initiation of chemotherapy and simultaneous resection of colorectal and liver tumors can be safe in selected patients. Robotic liver resection (RLR) has comparable safety and may improve resection rates. It is important to carefully select patients and ensure surgeon experience when considering minimally invasive liver surgery for colorectal liver metastases.
Article
Obstetrics & Gynecology
Roxanna M. Twedt, Daniel J. Buysse, Peter L. Franzen, Megan E. Hamm, Francesca L. Facco
Summary: A sleep education program specific to pregnancy for patients with gestational diabetes mellitus was developed and tested. The study showed the feasibility of this intervention in typical care but did not demonstrate any improvement in sleep knowledge or glycemic control during pregnancy.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Clinical Neurology
Brant P. Hasler, Meredith L. Wallace, Jessica L. Graves, Rachel Witt, Kathryn Guo, Daniel J. Buysse, Greg J. Siegle, Duncan B. Clark
Summary: Later circadian timing during adolescence is associated with worse sleep, more severe depression, and greater alcohol involvement. The COVID-19 pandemic provided an opportunity to examine whether adolescents with later circadian timing showed improvements in sleep, depression, and alcohol use. Results showed that individuals with later circadian timing reported less sleep and experienced greater increases in alcohol use during the pandemic.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Oncology
Jurgis Alvikas, Winifred Lo, Samer Tohme, David A. Geller
Summary: Surgically removing part of the liver is an essential method of treating liver cancers, particularly hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM). Laparoscopic liver resection (LLR) has been developed as a minimally invasive technique, offering better short-term outcomes compared to open liver resection (OLR). LLR patients have fewer complications, reduced blood loss, and shorter hospital stays, while maintaining similar long-term survival as OLR. The article also discusses patient selection for LLR and the emerging robotic-assisted liver resection technique.
Article
Health Care Sciences & Services
Kate Loveys, Michael Antoni, Liesje Donkin, Mark Sagar, Elizabeth Broadbent
Summary: This study compared the feasibility and acceptability of virtual humans, teletherapy, and self-guided e-manuals in delivering stress management interventions. Results showed that all three technologies were feasible and acceptable for delivering one module of cognitive behavioral stress management to distressed adult women. The technologies had unique strengths and limitations that may depend on individual characteristics and specific circumstances.
JMIR FORMATIVE RESEARCH
(2023)
Article
Psychology, Clinical
Ruth G. St Fleur, Sara M. St George, Daniel J. Feaster, Tae Kyoung Lee, Michael H. Antoni
Summary: The study examined the effects of cognitive behavioral therapy (CBT)-based group interventions on the quality of life (QoL) in breast cancer patients. It found that the intervention improved emotional and functional QoL by increasing benefit finding. This effect was particularly significant among patients with low optimism levels before surgery.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Oncology
Xicai Li, Jingquan Huang, Qiulin Wu, Qiang Du, Yingyu Wang, Yubin Huang, Xiaoyong Cai, David A. Geller, Yihe Yan
Summary: This study reveals the relationship between CHK1 expression and the tumor microenvironment in hepatocellular carcinoma (HCC). High CHK1 expression is associated with advanced tumor stage and poor prognosis. CHK1 inhibition and cisplatin induce DNA damage and apoptosis in HCC cells. CHK1 directly interacts with IRF1 to regulate MICA expression, which is correlated with NK cell and CD8+T cell infiltration in HCC.
Article
Obstetrics & Gynecology
Marquis S. Hawkins, Rachel K. Conlon, Shannon Donofry, Daniel J. Buysse, Elizabeth M. Venditti, Yu Cheng, Michele D. Levine
Summary: This study found that sleep can modify the relationship between physical activity change from the 2nd to 3rd trimester and excessive gestational weight gain. Increasing physical activity while maintaining good sleep quality, sleep efficiency, and daytime function is key to reducing excessive gestational weight gain.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.