Article
Nutrition & Dietetics
Changwei Cao, Zhichao Xiao, Huiquan Tong, Yuntao Liu, Yinglong Wu, Changrong Ge
Summary: The study found that orally administered chicken bone collagen peptides have significant effects in alleviating skin aging by improving the composition and structure of aging skin, enhancing skin antioxidant levels, and inhibiting inflammation. The mechanism of action involves reducing skin oxidation, activating the TGF-beta/Smad signaling pathway for collagen synthesis, inhibiting collagen degradation, and suppressing skin inflammation. It was also discovered that lysosomes activation may play an important role in the anti-aging effects of orally administered collagen peptides.
Review
Food Science & Technology
Xiaocao Zhao, Xuejiao Zhang, Dengyong Liu
Summary: Bioactive peptides, particularly collagen peptides, have great potential in skin anti-aging due to their diverse biological activities and high security. These peptides can provide skin protection effects by affecting various physiological pathways of the skin, thereby improving skin health.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Biochemistry & Molecular Biology
Alla Zorina, Vadim Zorin, Dmitry Kudlay, Pavel Kopnin
Summary: Skin aging is a multi-factorial process that involves impairment of skin structures and functions, particularly in the dermal extracellular matrix (ECM), leading to disrupted functioning of dermal fibroblasts (DFs). The integrity of the collagen matrix (CM) is crucial for proper adhesion and mechanical tension in DFs, allowing them to maintain collagen homeostasis. Impaired CM integrity disrupts mechanotransduction and impairs DF functioning, contributing to the progression of aging processes in skin tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Su Jin Lee, Ji Eun Kim, Yun Ju Choi, Jeong Eun Gong, So Hae Park, Bounleuane Douangdeuane, Onevilay Souliya, Ju Min Park, Hee Seob Lee, Bae-Hwan Kim, Dae Youn Hwang
Summary: The methanol extracts of Dipterocarpus tuberculatus Roxb. (MED) showed therapeutic effects against UV-induced photoaging by enhancing antioxidant activity, anti-apoptotic effects, ECM modulation, skin appearances, and anti-inflammatory response in both NHDF cells and nude mice. The identified active components in MED, along with the recovered levels of NO concentration, SOD activity, and Nrf2 expression, contributed to the observed anti-photoaging effects. Furthermore, MED treatment suppressed COX-2-induced iNOS mediated pathway, inflammatory cytokine expression, and inflammasome activation in UV-radiated NHDF cells.
Article
Engineering, Biomedical
Hongqian Lv, Nan Gao, Qixin Zhou, Yan Wang, Guixia Ling, Peng Zhang
Summary: This study develops rapidly dissolving microneedles (DMNs) using hydrolyzed collagen (HC) as the main raw material, which can deliver collagen to the skin in a simple and minimally invasive way. The DMNs dissolve completely in the skin within 15 min and release drug within approximately 8 h, without causing toxicity or irritation. The drug-loaded DMNs overcome the drawbacks of traditional methods, enabling efficient and safe treatment. The successful preparation and research of HC DMNs have innovative and practical significance in the field of transdermal drug delivery.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Geriatrics & Gerontology
Sela Marin, Ines Godet, Lolita S. Nidadavolu, Jing Tian, Laura E. Dickinson, Jeremy D. Walston, Daniele M. Gilkes, Peter M. Abadir
Summary: Collagen is crucial for the firmness and elasticity of the skin, but its production decreases as we age. In this study, we found that valsartan had the highest penetration in human skin among eight angiotensin receptor blockers (ARBs). Treating skin cells with valsartan and sacubitril increased collagen production significantly, suggesting a potential application of this drug combination for aging skin.
EXPERIMENTAL GERONTOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Taihao Quan
Summary: As the most extensive and abundant tissue in the human body, the skin undergoes gradual atrophy during the aging process, causing disruptions to its structure and functionality. Recent molecular discoveries related to skin aging emphasize the importance of preventive approaches, such as the use of topical retinoids, which show promise in enhancing skin texture and thickness.
Review
Food Science & Technology
David Fonseca Hernandez, Eugenia Lugo Cervantes, Diego A. Luna-Vital, Luis Mojica
Summary: Food contains bioactive compounds with diverse biological activities, used in the cosmetic industry for nutricosmetic and cosmeceutical products aimed at reducing skin aging and inflammation. Phytochemicals from fruits, vegetables, herbs, and plants are being utilized for their anti-aging potential. These compounds have antioxidant and biological properties that modulate molecular markers involved in the aging process.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Chemistry, Medicinal
Ebtesam A. Mohamad, Aya A. Aly, Aya A. Khalaf, Mona Ahmed, Reham M. Kamel, Sherouk M. Abdelnaby, Yasmine H. Abdelzaher, Marize G. Sedrak, Shaker A. Mousa
Summary: Punicalagin extracted from pomegranate shows promising antioxidant properties in protecting human skin from aging, reducing cell growth arrest, activating collagen production, lowering harmful substance levels, maintaining collagen levels, and increasing TERT concentration in skin cells.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Barbara Jacczak, Blazej Rubis, Ewa Toton
Summary: The stability of telomeres is crucial for cell function, and research on telomere biology and telomerase activity has been of great interest in various medical and scientific fields. Maintaining optimal telomere length and telomerase activity is an important step in anti-aging strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Tengfei Liu, Lifang Zou, Xiaowen Ji, Guiran Xiao
Summary: This study prepared low molecular weight chicken skin collagen peptides (CCP) and novel CCP-chelated zinc (CCP-Zn) to improve the utilization value of chicken by-products. The bioavailability of CCP-Zn was found to be higher than ZnSO4 and it effectively suppressed tumor growth, invasion, and migration in a Drosophila malignant tumor model. Mechanistic studies revealed that CCP-Zn inhibits tumor progression by reducing autophagy in tumor cells and the microenvironment.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Patricia Galvez-Martin, Cristina Soto-Fernandez, Jessica Romero-Rueda, Jesus Cabanas, Anna Torrent, Gloria Castells, Daniel Martinez-Puig
Summary: The objective of this study was to extract, characterise and evaluate the potential of a hyaluronic acid (HA) matrix ingredient for anti-aging. The results showed that the HA matrix had regenerative, moisturising, anti-aging and antioxidant effects on skin cells, as well as potential oral and topical applications for skin care products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Hye-Sun Lim, Seung Hoon Lee, Huiyun Seo, Hwi-Ho Lee, Kyeongno Yoon, Yong-ung Kim, Moon-Ki Park, Jin Ho Chung, Yong-Seok Lee, Dong Hun Lee, Gunhyuk Park
Summary: UV rays are an important environmental factor that affects the homeostasis of the skin, adrenal glands, and brain. Psychological stress during early UVB irradiation inhibits collagen production, leading to skin aging. Increased levels of corticosterone during UV irradiation are caused by enhanced CYP11B1/2 levels. Inhibiting CYP11B1/2 with osilodrostat preserves skin collagen and suppresses skin aging.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Agriculture, Multidisciplinary
Jieyu Zeng, Miaoqing An, Wenni Tian, Kun Wang, Bing Du, Pan Li
Summary: Sacha inchi albumin improves skin moisture, collagen level, and antioxidant enzyme activities while reducing inflammation. It also modulates the expression of collagen and metalloproteinases, activates the TGF-beta/Smad pathway, and alters the composition of gut microbiota.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Nutrition & Dietetics
Visarut Buranasudja, Chawanphat Muangnoi, Kittipong Sanookpan, Hasseri Halim, Boonchoo Sritularak, Pornchai Rojsitthisak
Summary: The study found that eriodictyol can protect human dermal fibroblasts from the harmful effects of hydrogen peroxide by directly neutralizing reactive oxygen species, enhancing detoxifying enzyme activities, and regulating the expression of Nrf2 signaling system.