Article
Medicine, General & Internal
Sebastian Weiss, Alexander Korthaus, Nora Baumann, Jin Yamamura, Alexander S. Spiro, Andreas M. Luebke, Karl-Heinz Frosch, Carsten Schlickewei, Matthias Priemel
Summary: Soft-tissue sarcomas are often misinterpreted as benign lesions in MRI reports. While most reports correctly identify the mass as abnormal, there are frequent deviations from the recommended MRI report elements. Significantly, a high percentage of reports mention signs of malignancy, but there is often a mismatch between suspected and final diagnosis.
Review
Oncology
Khabab Osman, Shakir Hussain, Frederick Downes, Harshadkumar Dhirajlal Rajgor, Vaiyapuri Sumathi, Rajesh Botchu, Scott Evans
Summary: Non-diagnostic biopsies are occasionally encountered in the investigation of soft tissue sarcoma. A retrospective review of these biopsies was performed to establish the incidence, predictive factors, and effectiveness of multi-disciplinary team (MDT) decisions. The study found that an MDT approach utilizing radiological and clinical information leads to high diagnostic rates and prevents unnecessary repeat biopsies.
Article
Oncology
Maria Danieli, Francesco Barretta, Marco Fiore, Stefano Radaelli, Claudia Sangalli, Marta Barisella, Silvia Stacchiotti, Elena Palassini, Rosalba Miceli, Dario Callegaro, Paolo Giovanni Casali, Alessandro Gronchi
Summary: The study investigated the outcomes of patients who underwent reexcision for ESTSTS compared with those primarily resected, and found that the presence of microscopic residual disease (MR) in the reexcision specimen is associated with a higher risk of local relapse (LR) but not with overall survival (OS) or distant metastasis (DM).
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Sang Kyum Kim, Jee Hung Kim, Seung Hyun Kim, Young Han Lee, Jung Woo Han, Wooyeol Baek, Ha Young Woo, Min Kyung Jeon, Hyo Song Kim
Summary: Based on the evaluation of PD-L1 expression in tumor tissues from advanced STS patients treated with pazopanib, it was found that PD-L1 expression can help predict the clinical outcome of pazopanib therapy, with PD-L1 positive tumors showing poorer response to treatment.
Article
Biochemistry & Molecular Biology
Adriano Pasqui, Anna Boddi, Domenico Andrea Campanacci, Guido Scoccianti, Andrea Bernini, Daniela Grasso, Elisabetta Gambale, Federico Scolari, Ilaria Palchetti, Annarita Palomba, Sara Fancelli, Enrico Caliman, Lorenzo Antonuzzo, Serena Pillozzi
Summary: In this study, we observed a severe deregulation of the nucleotide excision repair (NER) pathway in soft tissue sarcoma (STS) patients and described the effect of SNP rs1047768 in the ERCC5 structure for the first time. These findings revealed the correlation between specific genotypes of ERCC genes and the proficiency of the NER pathway in STS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Annemarie S. Melis, Melissa Vos, Melinda S. Schuurman, Thijs van Dalen, Winan J. van Houdt, Jos A. van der Hage, Yvonne M. Schrage, Lukas B. Been, Johannes B. Bonenkamp, Marc H. A. Bemelmans, Dirk J. Grunhagen, Cornelis Verhoef, Vincent K. Y. Ho
Summary: This study investigated the occurrence of unplanned excisions in soft tissue sarcomas (STS) and identified the associated patient, tumor, and treatment characteristics. The results showed that unplanned excisions accounted for 18.2% of first operations for STS, with a quarter of them occurring outside hospitals. Younger patients were more likely to undergo unplanned excisions, and these tumors were generally smaller and superficially located, with preoperative imaging often being omitted. Unplanned excisions were more likely to result in positive margins, requiring re-excision.
Article
Oncology
Benoit Allignet, Paul Pou, Floriane Izarn, Isabelle Ray-Coquard, Jean-Yves Blay, Armelle Dufresne, Mehdi Brahmi, Amine Bouhamama, Pierre Meeus, Gualter Vaz, Francois Gouin, Alexandra Meurgey, Marie Karanian, Coralie Moncharmont, Waisse Waissi, Marie-Pierre Sunyach
Summary: The objective of this study was to evaluate the efficacy and safety of adjuvant radiotherapy in patients with soft-tissue sarcoma re-excised after unplanned tumor resection. The results showed that adjuvant radiotherapy was associated with reduced local failure and longer local recurrence-free survival. Age and tumor grade were independent predictors of the effectiveness of adjuvant radiotherapy. Overall, adjuvant radiotherapy was safe and beneficial for patients with soft-tissue sarcoma re-excised after unplanned tumor resection.
Article
Biochemistry & Molecular Biology
William G. J. Kerrison, Alexander T. J. Lee, Khin Thway, Robin L. Jones, Paul H. Huang
Summary: Immunotherapy in soft tissue sarcoma has become a popular and promising therapeutic strategy, with immune checkpoint inhibitors showing effectiveness in certain subtypes. Combination therapies have also shown enhanced response rates.
Article
Medicine, General & Internal
Yusuke Aoki, Yasunori Tome, Hiromichi Oshiro, Ryo Katsuki, Tomoko Tamaki, Naoki Wada, Kennosuke Karube, Kotaro Nishida
Summary: The present study aimed to investigate the clinical outcomes of elderly soft tissue sarcoma patients who did not receive neoadjuvant or adjuvant chemotherapy. The study found that tumor resections with adequate margins may contribute to the patients' survival ratio, regardless of histological grade. There was no significant relationship between histological grades and local recurrences or distant metastases.
Article
Agriculture, Dairy & Animal Science
Riccardo Finotello, Kate Whybrow, Giulia Scarin, Lorenzo Ressel
Summary: Tumour-associated macrophages (TAMs) are identified and counted in canine soft tissue sarcomas (STSs), showing a positive correlation between TAM numbers and histologic grade. TAMs are more abundant in higher grade STSs, leading to a potential risk of misdiagnosis as histiocytic sarcoma by pathologists.
Article
Oncology
Yao Liang, Tian-Hui Guo, Bu-Shu Xu, Dong-Chun Hong, Hai-Bo Qiu, Zhi-Wei Zhou, Xing Zhang
Summary: UPE in STS patients has distinct characteristics, and although the high incidence of residual tumor in the UPE group leads to an unfavorable clinical course, patients who undergo an additional wide R0 resection after UPE have similar oncological survival compared to those in the PE group.
FRONTIERS IN ONCOLOGY
(2021)
Article
Orthopedics
Shai S. Shemesh, Erika L. Garbrecht, Tal Frenkel Rutenberg, Sheila A. Conway, Andrew E. Rosenberg, Juan Pretell-Mazzini
Summary: The study found that the accuracy of intra-operative pathologic assessment in unplanned excisions was similar to planned excisions, but there was a higher risk of the need for repeat assessments and subsequent resection in the unplanned excision group.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Oncology
Toshiyuki Takemori, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue
Summary: The purpose of this study was to clarify the clinical outcomes and prognostic factors in patients with STS who underwent unplanned excision (UE). The results showed that there was no significant difference in overall survival, local recurrence-free survival, or disease-free survival between the UE and planned excision (PE) groups. However, metastasis-free survival was significantly better in the UE group. Older age and larger primary tumor were associated with poorer disease-free survival in the UE group.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Oncology
Helene Weigl, Peter Hohenberger, Alexander Marx, Nikolaos Vassos, Jens Jakob, Christian Galata
Summary: The study investigated the accuracy, safety, and histologic results of ultrasound guided core needle biopsy in patients with soft tissue lesions. The findings suggest that ultrasound guided core needle biopsy is a safe and effective procedure with high diagnostic accuracy when performed in a dedicated outpatient setting for sarcoma patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Brandon K. K. Fields, Natalie L. Demirjian, Darryl H. Hwang, Bino A. Varghese, Steven Y. Cen, Xiaomeng Lei, Bhushan Desai, Vinay Duddalwar, George R. Matcuk
Summary: The study successfully differentiated between benign and malignant soft tissue tumors using MRI radiomics metrics and machine learning. Adaboost and Random Forest machine learning approaches performed similarly well in distinguishing between benign and malignant lesions. Even when restricted to T2FS and STIR sequences, the machine learning models maintained comparable performance, showing promise in clinical application scenarios.
EUROPEAN RADIOLOGY
(2021)