Crude extract ofRheum palmatumL. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells

TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5

(2015) Jun-jie Chen et al.   Oncotarget

Crude extract of Rheum palmatum L induced cell death in LS1034 human colon cancer cells acts through the caspase-dependent and -independent pathways

(2013) Yi-Shih Ma et al.   ENVIRONMENTAL TOXICOLOGY

Apigenin-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria

(2013) Sreemanti Das et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Apoptosis is Induced in Cancer Cells via the Mitochondrial Pathway by the Novel Xylocydine-Derived Compound JRS-15

(2013) Chao Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apoptotic and inflammatory signaling via Fas and tumor necrosis factor receptor I contribute to the development of chest trauma-induced septic acute lung injury

(2013) Sebastian Weckbach et al.   Journal of Trauma and Acute Care Surgery

The Inhibitory Effect of Rheum palmatum Against Coxsackievirus B3in Vitro and in Vivo

(2012) Hai-Rong Xiong et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Carnosic acid modulates Akt/IKK/NF-κB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells

(2012) Susanta Kar et al.   APOPTOSIS

Naringenin prevents high glucose-induced mitochondria-mediated apoptosis involving AIF, Endo-G and caspases

(2012) Radhika Kapoor et al.   APOPTOSIS

Butein Induces Apoptosis in Human Uveal Melanoma Cells Through Mitochondrial Apoptosis Pathway

(2012) Zhihua Cui et al.   CURRENT EYE RESEARCH

The crude extract ofCorni Fructusinduces apoptotic cell death through reactive oxygen species-modulated pathways in U-2 OS human osteosarcoma cells

(2012) Ching-Lung Liao et al.   ENVIRONMENTAL TOXICOLOGY

AKT signalling and mitochondrial pathways are involved in mushroom polysaccharide-induced apoptosis and G1 or S phase arrest in human hepatoma cells

(2012) Fengju OuYang et al.   FOOD CHEMISTRY

Ethyl Gallate Induces Apoptosis of HL-60 Cells by Promoting the Expression of Caspases-8, -9, -3, Apoptosis-Inducing Factor and Endonuclease G

(2012) Woong-Hyun Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

1-Benzyl-2-Phenylbenzimidazole (BPB), a Benzimidazole Derivative, Induces Cell Apoptosis in Human Chondrosarcoma through Intrinsic and Extrinsic Pathways

(2012) Ju-Fang Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Swainsonine promotes apoptosis in human oesophageal squamous cell carcinoma cells in vitro and in vivo through activation of mitochondrial pathway

(2012) Zhaocai Li et al.   JOURNAL OF BIOSCIENCES

CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells

(2011) Jang-Chang Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antioxidant and Anti-inflammatory Activities of Selected Medicinal Plants Containing Phenolic and Flavonoid Compounds

(2011) Lin Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Investigation of the “dose–time–response” relationships of rhubarb on carbon tetrachloride-induced liver injury in rats

(2011) Xiao-yan Xing et al.   JOURNAL OF ETHNOPHARMACOLOGY

Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway

(2011) Yu-Jen Chiu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic

(2011) Chang-Lin Wu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Hepatotoxicity or Hepatoprotection? Pattern Recognition for the Paradoxical Effect of the Chinese Herb Rheum palmatum L. in Treating Rat Liver Injury

(2011) Jia-bo Wang et al.   PLoS One

Toxic effects caused by rhubarb (Rheum palmatum L.) are reversed on immature and aged rats

(2010) Jia-bo Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells

(2010) Wen-Wen Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway

(2009) Meng-Liang Lin et al.   CANCER LETTERS

Anti-proliferative effects of estrogen receptor-modulating compounds isolated from Rheum palmatum

(2008) Se Chan Kang et al.   ARCHIVES OF PHARMACAL RESEARCH

Osteosarcoma Development and Stem Cell Differentiation

(2008) Ni Tang et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Phenols from the Roots ofRheum palmatumAttenuate Chemotaxis in Rat Hepatic Stellate Cells

(2008) Yun-Lian Lin et al.   PLANTA MEDICA