Article
Critical Care Medicine
Neha A. Sathe, Eric D. Morrell, Pavan K. Bhatraju, Michael B. Fessler, Renee D. Stapleton, Mark M. Wurfel, Carmen Mikacenic
Summary: This study aimed to determine whether hyperinflammatory and hypoinflammatory ARDS subtypes display differences in bronchoalveolar lavage (BALF) biomarker profiles, and to describe the relationship between these subtypes and novel phenotypes derived from BALF biomarkers. The research, a secondary analysis of a clinical trial, involved 88 mechanically ventilated adults with ARDS. The results showed that hyperinflammatory and hypoinflammatory subtypes were associated with differences in BALF biomarkers, and that the BALF-derived subtypes were associated with the clinical severity of pulmonary disease.
CRITICAL CARE MEDICINE
(2023)
Article
Biology
Chien-Ming Chu, Chia-Jung Chung, Chih-Yu Huang, Chung-Chieh Yu, Chao-Hung Wang, Li-Fu Li, Huang-Pin Wu
Summary: This study investigated the trends of HLA-DR and cytokine expressions in alveolar monocytes of pneumonia-related ARDS patients. The results showed that survivors had serial increases in HLA-DR expression and decreases in IL-10 expression, highlighting their importance in the immune responses and potential therapeutic targets.
Review
Medicine, Research & Experimental
Najmaldin Saki, Mohammadreza Javan, Bahareh Moghimian-Boroujeni, Richard Eric Kast
Summary: Acute respiratory distress syndrome (ARDS) is a medical condition characterized by widespread inflammation in the lungs, leading to loss of gas exchange function. Cytokines and immune cells play a crucial role in the development and progression of ARDS. Understanding the relevant mechanisms can aid in the diagnosis and treatment of this disease.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jie Sun, Xiaokun Zhang, Liliang Ma, Yong Yang, Xia Li
Summary: This study examines the therapeutic efficacy of rhGM-CSF in patients with extrapulmonary-induced ARDS. The results show that rhGM-CSF treatment improves lung function and reduces blood inflammation. However, it does not significantly affect the incidence of ventilator-associated pneumonia or 28-day mortality in ARDS patients.
Article
Medicine, General & Internal
Xiaoyan Gai, Xiaoyan Sun, Xiang Zhu, Qingtao Zhou, Yongchang Sun
Summary: In this case report, a 19-year-old female patient developed acute respiratory failure and diffuse pulmonary opacities after liposuction and fat grafting. Bronchoalveolar lavage confirmed the diagnosis of fat embolism syndrome. The patient was successfully treated with noninvasive mechanical ventilation and glucocorticoids. Early recognition and appropriate treatment are crucial for improving the outcome of pulmonary fat embolism, and awareness of this rare adverse event is important due to the increasing popularity of liposuction and fat grafting surgeries.
FRONTIERS IN MEDICINE
(2023)
Article
Plant Sciences
Peter P. Sordillo, Andrea Allaire, Annie Bouchard, Dan Salvail, Sebastien M. Labbe
Summary: SPPCT-800 was effective in reducing manifestations of ARDS. SPPCT-800 should be further investigated as therapy for ARDS, especially in longer duration or higher cumulative dose studies.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Cell Biology
Philipp K. Buehler, Annelies S. Zinkernagel, Daniel A. Hofmaenner, Pedro David Wendel Garcia, Claudio T. Acevedo, Alejandro Gomez-Mejia, Srikanth Mairpady Shambat, Federica Andreoni, Martina A. Maibach, Jan Bartussek, Matthias P. Hilty, Pascal M. Frey, Reto A. Schuepbach, Silvio D. Brugger
Summary: Superinfections are common among COVID-19 patients with acute respiratory distress syndrome, leading to lower survival rates, longer intensive care treatment, and reduced ventilator-free days despite the use of empirical antibiotic therapy.
CELL REPORTS MEDICINE
(2021)
Article
Allergy
Andreas Ronit, Ronan Mg Berg, Jakob T. Bay, Anna K. Haugaard, Magnus G. Ahlstrom, Kristoffer S. Burgdorf, Henrik Ullum, Sara B. Rorvig, Klaus Tjelle, Nicolai B. Foss, Thomas Benfield, Hanne Vibeke Marquart, Ronni R. Plovsing
Summary: In critically ill patients with COVID-19 ARDS, there is a distinct immunological profile in the lungs, characterized by a dominance of immature neutrophils, lymphopenia of CD4 and CD8 T cells, and higher fractions of regulatory T cells and TH17 cells. The lung exhibits a heavily hyperinflammatory environment with upregulation of activation markers on CD4 and CD8 T cells and macrophages, along with high levels of various cytokines such as IL-1RA, IL-6, IL-8, IP-10, and MCP-1.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Guillaume Franchineau, Juliette Chommeloux, Marc Pineton de Chambrun, Guillaume Lebreton, Nicolas Brechot, Guillaume Hekimian, Simon Bourcier, Loic Le Guennec, Charles-Edouard Luyt, Alain Combes, Matthieu Schmidt
Summary: This study aims to investigate the impact of bronchoalveolar lavage on regional ventilation in mechanically ventilated patients with acute respiratory distress syndrome, using electrical impedance tomography. It also aims to identify morphologic patterns according to respiratory failure severity.
CRITICAL CARE MEDICINE
(2022)
Article
Oncology
Susanne Ghandili, Philipp H. von Kroge, Marcel Simon, Frank O. Henes, Holger Rohde, Armin Hoffmann, Nick Benjamin Lindeman, Carsten Bokemeyer, Walter Fiedler, Franziska Modemann
Summary: Infections pose a major threat to leukemia patients, even with broad-spectrum anti-infective treatment. Approximately half of all patients with acute leukemia still have detectable pathogens in bronchoalveolar samples. However, these detections do not frequently lead to changes in treatment.
Article
Medicine, General & Internal
Yeong-Nan Cheng, Wei-Chih Huang, Chen-Yu Wang, Pin-Kuei Fu
Summary: This study compared the microbiota profiles of endotracheal aspirate (EA) and bronchoalveolar lavage (BAL) samples in ICU patients with severe pneumonia, and found that the microbial diversity, composition, and community correlations were similar between the two methods. Furthermore, the BAL samples did not provide more information than EA in microbiota analysis. Therefore, EA is suggested to be more useful than BAL for microbiome identification in mechanically ventilated patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Virology
Ahmed El-Nawawy, Manal A. M. Antonios, Marwa A. Meheissen, Marwan M. Fahim
Summary: This study aimed to assess viral agents causing severe pneumonia among mechanically ventilated pediatric patients, and found that viral infection rate was high at 73.4%, with rhinovirus and RSV being the most common. The mortality rate for viral-associated severe pneumonia reached 56.36%, with a threefold increase in mortality odds in the presence of comorbid conditions and a tenfold increase with congenital heart disease.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Respiratory System
William Bain, Haopu Yang, Faraaz Ali Shah, Tomeka Suber, Callie Drohan, Nameer Al-Yousif, Rebecca S. DeSensi, Nicole Bensen, Caitlin Schaefer, Brian R. Rosborough, Ashwin Somasundaram, Creg J. Workman, Caleb Lampenfeld, Anthony R. Cillo, Carly Cardello, Feng Shan, Tullia C. Bruno, Dario A. A. Vignali, Prabir Ray, Anuradha Ray, Yingze Zhang, Janet S. Lee, Barbara Methe, Bryan J. McVerry, Alison Morris, Georgios D. Kitsios
Summary: COVID-19 ARDS and ARDS from other etiologies have differences in demographic, physiologic parameters, and clinical outcomes, such as IL-6 levels and minute ventilation. Despite some similarities, COVID-19 ARDS shows longer duration of mechanical ventilation compared to other ARDS patients.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Immunology
Chien-Chih Lai, Yi-Syuan Sun, Fang-Chi Lin, Chih-Yu Yang, Chang-Youh Tsai
Summary: Analysis of bronchoalveolar lavage fluid (BALF) reveals high prevalence rates of PJP and CMV infections in SLE patients with pneumonia and respiratory failure. Thrombocytopenia, bacteremia, and PJP are identified as risk factors for increased 30-day mortality in SLE patients.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Immunology
Yukun He, Jia Li, Wenyi Yu, Yali Zheng, Donghong Yang, Yu Xu, Lili Zhao, Xinqian Ma, Pihua Gong, Zhancheng Gao
Summary: The study found that the lower respiratory tract microbiome characteristics in patients with post-HSCT pneumonia are different from those with CAP and healthy controls, which may be associated with the patient's outcome. High abundance of Actinobacteria and low abundance of Bacteroidetes were observed in post-HSCT pneumonia samples. Pathogenic bacteria such as Pseudomonas, Acinetobacter, Burkholderia, and Mycobacterium were prominent in the pneumonia group after HSCT.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Ching-Yang Wu, Chia-Lin Lee, Ching-Feng Wu, Jui-Ying Fu, Cheng-Ta Yang, Chi-Tsung Wen, Yun-Hen Liu, Hui-Ping Liu, Jason Chia-Hsun Hsieh
Review
Oncology
Ping-Chih Hsu, Cheng-Ta Yang, David M. Jablons, Liang You
Article
Chemistry, Medicinal
Ping-Chih Hsu, Chun-Yao Huang, Chin-Chou Wang, Scott Chih-Hsi Kuo, Chia-Hsun Chu, Pi-Hung Tung, Allen Chung-Cheng Huang, Chih-Liang Wang, Li-Chung Chiu, Yueh-Fu Fang, Cheng-Ta Yang
Article
Oncology
Wen-Chi Hsu, Pei-Ching Huang, Kuang-Tse Pan, Wen-Yu Chuang, Ching-Yang Wu, Ho-Fai Wong, Cheng-Ta Yang, Yung-Liang Wan
Summary: Benign lesions, atypical adenomatous hyperplasia, and malignancies such as adenocarcinoma in situ, minimally invasive adenocarcinoma, and invasive adenocarcinoma may present as pure ground-glass nodules on chest CT images. The prognosis of patients with invasive adenocarcinoma is worse than others. The presence of an air cavity is a significant predictor of invasive adenocarcinoma in pure ground-glass nodules.
Review
Immunology
Li-Chung Chiu, Shu-Min Lin, Yu-Lun Lo, Scott Chih-Hsi Kuo, Cheng-Ta Yang, Ping-Chih Hsu
Summary: Early-stage NSCLC patients face high risks of recurrence and death even after surgery, with limited improvements from traditional treatments like chemotherapy and radiation. Immunotherapies, including immune checkpoint inhibitors and cancer vaccination, have shown potential in improving survival rates and are being actively researched in clinical trials.
Article
Microbiology
Chung-Guei Huang, Avijit Dutta, Ching-Tai Huang, Pi-Yueh Chang, Mei-Jen Hsiao, Yu-Chia Hsieh, Shu-Min Lin, Shin-Ru Shih, Kuo-Chien Tsao, Cheng-Ta Yang
Summary: During the initial outbreak in Taiwan, some COVID-19 patients experienced delayed virus clearance, possibly due to the presence of excessive but compromised antibodies in the early stage. These patients had higher levels of serum antibodies, which might affect the effectiveness of virus clearance.
Article
Oncology
John Wen-Cheng Chang, Chen-Yang Huang, Yueh-Fu Fang, Ching-Fu Chang, Cheng-Ta Yang, Chih-Hsi Scott Kuo, Ping-Chih Hsu, Chiao-En Wu
Summary: A novel nomogram was created in this study to help physicians suggest the optimal treatment for EGFRm+ NSCLC patients. The nomogram was based on pretreatment factors and stratified patients into five different risk groups for progression-free survival (PFS) and overall survival (OS). This risk stratification can provide additional information for clinicians and patients in determining the optimal therapeutic options.
Article
Oncology
Chiao-En Wu, Ching-Fu Chang, Chen-Yang Huang, Cheng-Ta Yang, Chih-Hsi Scott Kuo, Ping-Chih Hsu, John Wen-Cheng Chang
Summary: This study reviewed the clinical outcomes and safety of EGFR-TKI treatment in lung adenocarcinoma patients with poor performance status and identified independent prognostic factors. The results showed that patients treated with 40 mg afatinib had better survival outcomes and dose adjustment was an independent prognostic factor for both progression-free survival and overall survival. This study provided evidence and prognostic factors for the use of EGFR-TKIs in patients with poor performance status.
Article
Immunology
Chin-Chou Wang, Li-Chung Chiu, Jia-Shiuan Ju, Yu-Ching Lin, Yueh-Fu Fang, Cheng-Ta Yang, Ping-Chih Hsu
Summary: The study found that consolidation durvalumab is effective and safe for post-CCRT unresectable stage III NSCLC in clinical practice, but EGFR mutation is an unfavorable factor for consolidation durvalumab therapy. Therefore, it is necessary to search for a better consolidation therapy for patients with EGFR mutations.
Article
Cell Biology
Shu-Er Chow, Yaa-Jyuhn J. Meir, Jhy-Ming Li, Ping-Chih Hsu, Cheng-Ta Yang
Summary: This study investigates the dynamic changes in nuclear p120 catenin localization during cell cycle progression, revealing its role in the formation of the chromosome periphery and its interaction with lumican. Furthermore, it validates the protective role of p120 catenin in maintaining chromosome integrity.
CELL DEATH & DISEASE
(2022)
Article
Oncology
How-Wen Ko, Chi-Tsun Chiu, Chih-Liang Wang, Tsung-Ying Yang, Chien-Ying Liu, Chih-Teng Yu, Li-Chuan Tseng, Chih-Hsi Scott Kuo, Chin-Chou Wang, Muh-Hwa Yang, Cheng-Ta Yang
Summary: This study demonstrated the beneficial effect of denosumab treatment on the overall survival of NSCLC patients with bone metastasis and EGFR mutations. Denosumab also prolonged the SRE-free survival in patients without initial skeletal-related events and improved the overall survival of those with initial or pre-existing events.
Article
Biotechnology & Applied Microbiology
Satoru Miura, Hyun Ae Jung, Shin Yup Lee, Seung Hyeun Lee, Min Ki Lee, Yong Chul Lee, Maximilian J. Hochmair, Cheng-Ta Yang, Angela Marten, James Chih-Hsin Yang, Sanjay Popat
Summary: Sequential afatinib/osimertinib treatment showed promising activity in Asian patients with EGFR mutation-positive NSCLC, especially those with Del19-positive disease. This treatment was effective in real-world patients, including those with T790M-mediated acquired resistance and poor ECOG PS or brain metastases.
ONCOTARGETS AND THERAPY
(2022)
Article
Oncology
Yan-Jei Tang, John Wen-Cheng Chang, Ching-Fu Chang, Chen-Yang Huang, Cheng-Ta Yang, Chih-Hsi Scott Kuo, Yueh-Fu Fang, Ping-Chih Hsu, Chiao-En Wu
Summary: This study confirmed the greater efficacy of later-line osimertinib for NSCLC with acquired T790M mutation than for NSCLC without acquired T790M mutation. Detection of the T790M mutation after frontline treatment is crucial for prolonging the survival of NSCLC patients. Osimertinib may be considered an option for NSCLC with unknown T790M mutations.
Article
Medicine, General & Internal
Ping-Chih Hsu, Tai-Di Chen, Tsung-Yu Tsai, Cheng-Ta Yang
Summary: Anti-PD-1/PD-L1 immune checkpoint inhibitors combined with bevacizumab and platinum-based chemotherapy have shown promising efficacy in treating metastatic non-squamous cell lung cancer. However, drug-induced nephrotoxicity is a rare but serious adverse effect that requires careful evaluation and management.
CLINICS AND PRACTICE
(2023)
Article
Medicine, General & Internal
Li-Chung Chiu, Ping-Chih Hsu, Tzung-Hai Yen, Scott Chih-Hsi Kuo, Yueh-Fu Fang, Yu-Lun Lo, Shu-Min Lin, Cheng-Ta Yang, Chung-Shu Lee
Summary: The study found a significant association between blood cadmium levels and oxygen desaturation during the 6MWT in COPD patients, with the high-blood cadmium group exhibiting significantly higher levels of desaturation than the low-blood cadmium group.
MEDICINA-LITHUANIA
(2021)