Article
Chemistry, Analytical
Zhixia Yao, Hanmeng Liu, Yaosheng Liu, Yongxing Diao, Guangxing Hu, Qifang Zhang, Zhuang Li
Summary: A novel fluorometric strategy using PVP-Cu NCs as fluorescent probe is proposed for detecting curcumin, with good sensitivity and selectivity, successfully applied for real sample analysis.
Article
Engineering, Environmental
Kangli He, Sa Dong, Jinghan Yang, Qiuyun Shi, Lingjun Guan, Li Sun, Zhiyang Chen, Jianguo Feng
Summary: In this study, a bilayer metal-organic framework UiO-66@Cu was synthesized and a fluorescence off/on strategy was constructed for the detection of ACE. The method showed low detection limit and wide linear range under optimal conditions, and exhibited good sensitivity, selectivity, and reproducibility, providing a new approach for the direct detection of ACE.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Chemistry, Analytical
Yawen Wu, Xiaolong Chen, Xiaogang Luo, Mei Yang, Changjun Hou, Danqun Huo
Summary: In this study, a bimetallic organic framework Cu/UiO-66 was synthesized and utilized to develop a sensitive and accurate method for CEA detection, showing promising applications in clinical diagnosis.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Physical
Kunfeng Zhong, Changchun Hao, Hengyu Liu, Haiyan Yang, Runguang Sun
Summary: In this study, BSA-Au NCs and BSA-Cu NCs were synthesized and mixed to develop a ratiometric fluorescent sensor for Hg2+ and Cu2+ ions detection. The fluorescence of BSA-Au NCs was quenched significantly by only Hg2+ and Cu2+ ions among 15 common metal ions tested. The nanohybrid probe showed excellent linear relationships and low detection limits for both Cu2+ and Hg2+ ions, with visible fluorescence color changes at higher concentrations.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Biology
Jingliang Zhang, Chenyu Zhang, Xiaoling Chen, Bingwei Wang, Weining Ma, Yang Yang, Ruimao Zheng, Zhuo Huang
Summary: Temporal lobe epilepsy (TLE) is a common and intractable neurological disorder, with dysfunctional PKA signaling playing a role in its development. A study found that reduced autophosphorylation of the PKA-RIIβ subunit is associated with decreased PKA activity and altered neuronal excitability, suggesting it as a potential therapeutic target for TLE.
COMMUNICATIONS BIOLOGY
(2021)
Article
Chemistry, Analytical
Yulong Ju, Yiwen Yang, Qiukai Tang, Mengqi Wang, Yanbo Zeng, Zulei Zhang, Yunyun Zhai, Hailong Wang, Lei Li
Summary: This study developed a label-free fluorescence aptasensor for the accurate and sensitive detection of alpha-fetoprotein (AFP) in the diagnosis and treatment of liver cancer. The sensor exhibited high sensitivity, high specificity, and the ability to directly detect AFP in actual serum samples.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Hao Yu, Qiang Zhao
Summary: In this study, a rapid and sensitive detection method for the heavy metal cadmium ions (Cd2+) using an aptamer-based fluorescence anisotropy (FA) sensor was demonstrated. The sensor showed high affinity, sensitivity, simplicity, and high throughput, and allowed direct detection without the need for labeling Cd2+. The method was successfully applied in the detection of Cd2+ in real water samples, showing potential for broad application.
Article
Chemistry, Analytical
Kexin Sun, Junlong Li
Summary: CEA is a widely used tumor marker, especially for gastrointestinal cancers like colorectal malignancy. The current methods for CEA detection are limited by high costs and long waiting times. By altering the secondary structure of fluorescent modified DNA, a new method for CEA detection was established, providing a simple, fast, and cheap sensing platform for biomarkers detection. This method shows great potential in tumor screening among populations and may have prospective effects on tumor treatment.
Article
Spectroscopy
Xuhua Zhao, Xiaochun Dai, Suya Zhao, Xiaohua Cui, Tao Gong, Zhiling Song, Hongmin Meng, Xiaobing Zhang, Baofeng Yu
Summary: Aptamers, as short single-stranded RNA or DNA molecules that can recognize targets with high affinity and specificity, have unique advantages such as easy chemical synthesis, high stability, low molecular weight, and lack of immunogenicity. Utilizing aptamers in fluorescent sensors provides exciting opportunities for sensitive detection and quantification of analytes, particularly in the field of cancer biomarker detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Inorganic & Nuclear
Kang-Kang Feng, Ji-Song Wu, Yan-Ping Li, Yong-An Tan, Xin-Zhang
Summary: Benzimidazole and its derivatives have attracted attention due to their good biocompatibility and excellent optical properties. In this study, two benzimidazole coordination polymers were successfully synthesized, exhibiting rare in-situ methylene transformation and fluorescence properties. Theoretical calculations showed high consistency with experimental results, providing a new strategy for constructing materials with C=C bond and photo-luminescence effect.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biophysics
Xiaoqin Liu, Ting Wang, Yuwei Wu, Yifu Tan, Ting Jiang, Ke Li, Beibei Lou, Liwei Chen, Yanfei Liu, Zhenbao Liu
Summary: This article summarizes fluorescence detection methods based on aptamers for intracellular molecular detection. By combining different nanostructures, these biosensors can enter living cells for analysis and enable in situ monitoring. The principles, limit of detection, advantages, and disadvantages of different platforms for intracellular molecular fluorescence response are reviewed, and the current challenges and future developments are discussed.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Applied
Yi Huang, Shiming Chen, Wei Huang, Xiaoting Zhuang, Jiahao Zeng, Mingcong Rong, Li Niu
Summary: By combining Au NCs-CDs nanocomposite-based test paper and PVA film with a smartphone, sensitive and specific visual monitoring of sulfide can be achieved, with the advantages of simplicity, convenience, and accuracy.
Article
Materials Science, Multidisciplinary
Rana Bagheri, Fathallah Karimzadeh, Ahmad Kermanpur, Mahshid Kharaziha
Summary: A simple and novel method for immobilization of AS1411 aptamer on Cu nanoparticles electrode was presented and validated by experiments. The study found that choosing 0.03 M Cu concentration, 10 μM aptamer concentration, and 20 minutes incubation time achieved the optimized performance, which was confirmed by quartz crystal microbalance.
Article
Chemistry, Analytical
Pengfei Ma, Hualin Guo, Hua Ye, Yin Zhang, Zhouping Wang
Summary: In this study, the binding mechanism of a 19-base ZEN aptamer (Z19) with ZEN was systematically studied. The binding driving forces, key bases, conformational changes, and thermodynamic information were discovered. Based on this, a novel fluorescence polarization aptasensor was constructed using the rapid properties of fluorescence polarization and target recycling induced by Exo III. The aptasensor showed excellent analytical performance with a linear range of 0.01-100 ng/mL and a limit of detection as low as 0.004 ng/mL.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Applied
Qin Ouyang, Li Wang, Waqas Ahmad, Yawen Rong, Huanhuan Li, Yuqian Hu, Quansheng Chen
Summary: A sensitive biosensor based on luminescent resonance energy transfer (LRET) was developed for detecting carbendazim (CBZ) pesticide residues. The biosensor showed high sensitivity and specificity for quantifying CBZ within a range of 0.1-5000 ng.mL(-)(1). Validation of the biosensor's precision and accuracy was carried out using an HPLC method with no significant differences observed.
Article
Biodiversity Conservation
Xu Wang, Chao Wang, M. Francesca Cotrufo, Lifei Sun, Ping Jiang, Ziping Liu, Edith Bai
GLOBAL CHANGE BIOLOGY
(2020)
Article
Optics
Yajun Wang, Jae Sang Hyun, Song Zhang, Bin Luo, Ziping Liu, Chufan Jiang, Bo Tao
OPTICS AND LASER TECHNOLOGY
(2020)
Article
Soil Science
Xun Duan, Xiaofei Yu, Zhe Li, Qiguang Wang, Ziping Liu, Yuanchun Zou
SOIL BIOLOGY & BIOCHEMISTRY
(2020)
Article
Environmental Sciences
Yige Wang, Chunhong Zhao, Ziping Liu, Decai Gao
Summary: This study analyzed the trends of AIDS epidemic in different provincial administrative units in mainland China from 2005 to 2017 using Markov chain matrix and geospatial clustering. Results showed higher AIDS prevalence in southeastern China but a decreasing trend overall. Economic development was closely related to the rate of AIDS incidence, with potential influencing factors including economy, traffic and transportation, medical care, and education.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Engineering, Biomedical
Ziping Liu, Joyce C. Mhlanga, Richard Laforest, Paul-Robert Derenoncourt, Barry A. Siegel, Abhinav K. Jha
Summary: Tumor segmentation in oncological PET faces challenges due to partial-volume effects and tissue-fraction effects. The proposed Bayesian approach for tumor volume estimation outperforms conventional methods, demonstrating accurate and reliable tumor segmentation results across different clinical-scanner configurations.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Abhinav K. Jha, Kyle J. Myers, Nancy A. Obuchowski, Ziping Liu, Md Ashequr Rahman, Babak Saboury, Arman Rahmim, Barry A. Siegel
Article
Radiology, Nuclear Medicine & Medical Imaging
Ziping Liu, Hae Sol Moon, Zekun Li, Richard Laforest, Joel S. Perlmutter, Scott A. Norris, Abhinav K. Jha
Summary: This study proposes and evaluates a fully automated segmentation method based on tissue-fraction estimation for segmenting the caudate, putamen, and GP from DaT-SPECT images. The results demonstrate that the method accurately segments these regions and provides reliable quantification.
Article
Engineering, Biomedical
Ziping Liu, Scott Wolfe, Zitong Yu, Richard Laforest, Joyce C. Mhlanga, Tyler J. Fraum, Malak Itani, Farrokh Dehdashti, Barry A. Siegel, Abhinav K. Jha
Summary: Synthetic images generated by simulation studies play a crucial role in developing and evaluating imaging systems. However, for clinically relevant development and evaluation, it is important to ensure the clinical realism and similarity in distribution between real and synthetic images. This paper investigates two approaches, including ideal-observer study and expert-human-observer study, to quantitatively evaluate the clinical realism of synthetic images.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Proceedings Paper
Optics
Kaushik Dutta, Ziping Liu, Richard Laforest, Abhinav Jha, Kooresh Shoghi
Summary: This study aims to develop a deep-learning based framework to generate high-count PET images from low-count PET images using Residual U-Net and Dilated U-Net architectures. The experimental results show that both DL methods outperform existing non-DL denoising techniques in terms of SSIM, PSNR, and NRMSE, and perform better in quantitative tasks as well.
MEDICAL IMAGING 2022: PHYSICS OF MEDICAL IMAGING
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Ziping Liu, Zekun Li, Joyce C. Mhlanga, Barry A. Siegel, Abhinav K. Jha
Summary: This study proposes a technique for evaluating quantitative imaging methods without a gold standard, by accurately ranking different methods based on simulated correlated noise. Experimental results showed that the technique reliably estimated the noise-to-slope ratio and correctly identified the most precise method in 83% of the trials. The results motivate further validation of this technique with realistic simulation studies and patient data.
MEDICAL IMAGING 2022: IMAGE PERCEPTION, OBSERVER PERFORMANCE, AND TECHNOLOGY ASSESSMENT
(2022)
Proceedings Paper
Nuclear Science & Technology
Liu Ziping, Ji Yu, Zhang Han, Sun Jun
Summary: This study established a three-dimensional heat conduction model considering the impact of inner heat source on dispersion fuel spheres, and found that existing models tend to overestimate the effective thermal conductivity and subsequently underestimate the average temperature. The distribution of inner heat source was revealed to affect the effective thermal conductivity, while the values of inner heat source did not impact the effective thermal conductivity.
PROCEEDINGS OF 2021 28TH INTERNATIONAL CONFERENCE ON NUCLEAR ENGINEERING (ICONE28), VOL 2
(2021)
Proceedings Paper
Optics
Ziping Liu, Richard Laforest, Joyce Mhlanga, Tyler J. Fraum, Malak Itani, Farrokh Dehdashti, Barry A. Siegel, Abhinav Kumar Jha
Summary: This study developed a stochastic and physics-based method to generate realistic oncological 2-D PET images for objective evaluation. The method was able to capture observed variabilities in tumor properties and generate clinically relevant tumor types. Results from a human-observer study with trained readers showed promising results and support the application of this method to PET imaging.
MEDICAL IMAGING 2021: IMAGE PERCEPTION, OBSERVER PERFORMANCE, AND TECHNOLOGY ASSESSMENT
(2021)
Article
Spectroscopy
Hao Tian-yi, Han Yang, Liu Zi-ping, Li Zi-ying, Zhao Yun-sheng, Niu Hao-fang, Yao Hai-yan
SPECTROSCOPY AND SPECTRAL ANALYSIS
(2020)
Proceedings Paper
Engineering, Industrial
Ziping Liu
2020 IEEE 7TH INTERNATIONAL CONFERENCE ON INDUSTRIAL ENGINEERING AND APPLICATIONS (ICIEA 2020)
(2020)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Hae Sol Moon, Ziping Liu, Maria Ponisio, Richard Laforest, Abhinav Jha
JOURNAL OF NUCLEAR MEDICINE
(2020)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
