Article
Chemistry, Analytical
Sumita Subedi, Lok Nath Neupane, Hyeongseok Yu, Keun-Hyeung Lee
Summary: A highly selective ratiometric fluorescent chemodosimeter was synthesized for the detection of Hg2+, which showed remarkable detection properties including high selectivity and sensitivity, large fluorescent signal changes, and well-operation in aqueous solutions. The displacement reaction between phenylboronic acid and Hg2+ ions provided a covalent adduct of mercury ion, leading to significant fluorescent signal changes when aggregated in aqueous solution. With a low detection limit of 15.2 nM, nanomolar concentrations of Hg2+ could be successfully detected, providing a ratiometric fluorescent detection method for quantifying low levels of Hg2+ in groundwater and tap water samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Yuan-Jun Tong, Lu-Dan Yu, Nan Li, Qi Fu, Ke Xu, Jiajun Wei, Yu-Xin Ye, Jianqiao Xu, Fang Zhu, Janusz Pawliszyn, Gangfeng Ouyang
Summary: A new strategy for designing a multipurpose ratiometric probe is presented in this study, which can detect the presence of mercury and fluoride ions simultaneously, establishing a successful on-site water monitoring method.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Wen-Juan Gong, Hua-Rui Nan, Hong-Bo Peng, You-Qun Wang, Zhi-Min Dong, Zhi-Bin Zhang, Xiao-Hong Cao, Yun-Hai Liu
Summary: In this study, a new ratiometric fluorescent sensor was developed by encapsulating blue-fluorescent carbon dots (B-CDs) with SiO2, coupling gold nanoclusters (GSH-AuNCs) to the surface, and anchoring a layer of Ag+. The presence of UO22+ resulted in fluorescence quenching of the ratiometric fluorescent probe in aqueous solutions, attributed to photoinduced electron transfer (PET) between B-CDs@SiO2@GSH-AuNCs/Ag+ and UO22+. With excellent selectivity, the ratiometric fluorescent probes detected UO22+ at 37 nmol/L and showed promising potential for convenient monitoring of UO22+ levels in real-world water samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Spectroscopy
Qian Zhang, Haichang Ding, Xiaohang Xu, Huaxin Wang, Gang Liu, Shouzhi Pu
Summary: In this study, a novel fluorescent probe 1 based on rhodamine and anthracene groups was designed and synthesized for the selective, sensitive, and ratiometric detection of Hg2+ using the FRET mechanism. The probe exhibited a fast response time and a visible color change, and it was successfully used for cell imaging of Hg2+ detection. The mechanism of Hg2+ detection by probe 1 was verified through various experimental techniques.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Fanfan Yu, Hui Xiang, Shiyu He, Gan Zhao, Zheng Cao, Lina Yang, Honglin Liu
Summary: The study successfully fabricated a nanocomplex based on gold nanoclusters with promising applications in bioimaging and biosensing. It demonstrates good ratiometric fluorescence sensing capability and biological imaging ability, along with high stability and excellent biocompatibility.
Article
Chemistry, Analytical
Wenlong Sheng, Yamin Yu, Na Gao, Meng Jin, Lizhen Wang, Ning Li, Can Li, Huili Zhang, Yun Zhang, Kechun Liu
Summary: A novel fluorescent probe CP-Hg with high sensitivity and selectivity was successfully synthesized for the detection of mercury ions. The probe can react with mercury ions with a distinct color change and has been proven to have low toxicity, showing successful applications in detecting mercury in water samples, macrophages and zebrafish model.
ANALYTICAL METHODS
(2021)
Review
Chemistry, Inorganic & Nuclear
Xiaojing Nan, Yuchen Huyan, Hongjuan Li, Shiguo Sun, Yongqian Xu
Summary: Transition metal ions play crucial roles in medicine, life sciences, and environmental science, but some like mercury, copper, and iron ions pose serious health and environmental risks due to biomagnification. Monitoring metal ion levels in organisms and the environment is urgent, and reaction-based fluorescent probes offer higher sensitivity and selectivity than traditional methods. Research on these probes for Hg2+, Cu2+, and Fe2+/Fe2+ detection has advanced in the past decade, with potential for interdisciplinary development in the future.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Dan Chang, Zhonghua Zhao, Wenyan Li, Hu Shi, Yongxing Yang, Lihong Shi, Shaomin Shuang
Summary: A novel ratiometric fluorescent probe was designed to distinguish glutathione (GSH) from structurally similar substances, providing a potential for rapid detection and imaging in physiological and pathological processes, with high application potential.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Chemistry, Analytical
Keqin Yang, Li Hou, Zhifang Li, Tianran Lin, Jianniao Tian, Shulin Zhao
Summary: A ratiometric fluorescent nanoprobe for detecting peroxynitrite was successfully constructed, showing selective accumulation in mitochondria and linear detection in the range of 0-6.0 µM. This nanoprobe enables ratiometric fluorescence imaging of endogenous peroxynitrite in cell mitochondria.
Article
Spectroscopy
Bingpeng Guo, Tianjiao Shen, Yifan Liu, Jing Jing, Changxiang Shao, Xiaoling Zhang
Summary: Esterase is primarily distributed in the endoplasmic reticulum (ER) and often overexpressed in cancer cells. To solve the limitations of existing probes, an ER-specific ratiometric fluorescent probe (ER-EST) is designed for detecting esterase in living cells. The ER-EST shows a ratiometric and red-shifted emission from 435 to 560 nm after hydrolysis by esterase, and it has a low detection limit and good biocompatibility.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Spectroscopy
Jie Zhao, Jiawei Zhang, Baojun Hu, Chunyu Gao, Zan Li, Zhiwei Sun, Jinmao You
Summary: A new ratiometric fluorescent probe (APS-NA) was designed and synthesized for the detection of mercury ions in the environment and multiple biological samples. The probe shows a large Stokes shift, high selectivity, high sensitivity and naked eye visualization.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Shan Wang, Bingya Wang, Lei Zhu, Ji-Ting Hou, Kang-Kang Yu
Summary: The ratiometric fluorescent probe presented in this study offers excellent photostability and chemostability for monitoring pH changes in living cells. Quantifying the down-regulation of intracellular pH during autophagy induced by various stimuli can provide valuable guidance for constructing autophagy models to study related pathological processes.
CHEMICAL COMMUNICATIONS
(2021)
Article
Engineering, Environmental
Pramod Kumar Mehta, Jongyong Jeon, Ki Ryu, See-Hyoung Park, Keun-Hyeung Lee
Summary: Ratiometric fluorescent peptidyl probe was synthesized and used for quantifying Pb(II) in aquatic environment and live cells. The probe displayed high selectivity and sensitivity towards Pb(II), with cell-permeability and rapid response. The study revealed that the probe formed a complex with Pb(II) and formed red-emissive nanoparticles and fibrils.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Analytical
An-Min Song, Yuan-Jun Tong, Ru-Ping Liang, Jian-Ding Qiu
Summary: The novel ThT@luminol-Eu-GMP CPNPs were synthesized for sensitive detection of ALP and arsenate, with boosted fluorescent performance of ThT achieved through a dual-path design involving molecular rotation restriction and FRET effect.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Dongmei Wang, Jiajia He, Junyong Sun
Summary: The thiolysis of NBD-A enables specific detection of H2S and real-time imaging in living organisms. The NBD@PFO probes, constructed with ratiometric mode and two-photon excitation, show high selectivity, fast response, and are successfully applied for monitoring H2S concentration in living cells and zebrafish. This work demonstrates the potential of polymer nanoparticles to enhance the imaging capability of an organic small molecular probe.
Editorial Material
Chemistry, Physical
Jin Ma, Xi Xiao, Lijie Luo, Jiaming Liu, Yuanqiang Hao, Peisheng Zhang, Rongjin Zeng, Shu Chen
Summary: This paper reported the synthesis and application of polymelamine (pMel) in deep eutectic solvents (DES) for dopamine sensing. The first attempt to electrosynthesize pMel in a DES system was a valuable contribution, but there are some missing points that may lead to errors in the analysis of cyclic voltammetry and make it difficult to synthesize pMel under the described conditions.
Article
Nanoscience & Nanotechnology
Jia Tang, Yong Tian, Zhong Lin, Chonghua Zhang, Peisheng Zhang, Rongjin Zeng, Si Wu, Xudong Chen, Jian Chen
Summary: In this study, novel photoswitchable multistate fluorescent supramolecular polymers (PMFSPs) were prepared via host-guest interactions under a facile ultrasonication strategy. By adjusting the stimulation wavelength and utilizing photoinduced fluorescence resonance energy transfer (FRET), the supramolecular polymers can undergo reversible tristate fluorescence switching among none, red, and green. Due to the high contrast, rapid photoresponsiveness and prominent photoreversibility of the prepared PMFSPs, they have great potential in advanced anti-counterfeiting and multilevel information encryption.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemical Research Methods
Xiang Li, Zhong Lin, Yong Tian, Chonghua Zhang, Peisheng Zhang, Rongjin Zeng, Lei Qiao, Jian Chen
Summary: In this study, a novel negative photochromic spiropyran derivative, MAHD-SP, was designed with stable ring-opened state and notable orange fluorescence. The fluorescence of MAHD-SP was quenched by the Michael addition reaction of SO2 derivative. A ratiometric fluorescent polymeric nanoprobe (RFPN) was constructed using MAHD-SP, a fluorescent conjugated polymer PFO, and a polymeric surfactant PEO113-b-PS49. The RFPN exhibited high sensitivity and selectivity for the ratiometric detection of SO2 derivatives in aqueous solutions, and could visualize SO2 derivative generation in living cells.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Polymer Science
Yong Tian, Yuqi Li, Xiang Li, Zhong Lin, Chonghua Zhang, Qiyun Kuang, Peisheng Zhang, Rongjin Zeng, Jian Chen
Summary: In this study, thermostable photoswitchable red fluorescent polymer nanoparticles (TPFPNs) were developed through a facile miniemulsion polymerization. TPFPNs exhibited adjustable FRET efficiency, outstanding thermal stability, prominent long-term stability, superior photoreversibility, as well as high contrast of on/off fluorescence. Moreover, TPFPNs were successfully used for photo-rewritable patterning and reversible fluorescence bioimaging in Zebrafish.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Applied
Tiancheng Wu, Yong Tian, Jingmei Wu, Xiang Li, Ping Wang, Peisheng Zhang, Jiaxi Cui, Jian Chen, Xudong Chen
Summary: Nowadays, high security of information encryption technology, especially those time-dependent encrypting, are increasingly important, but remains a great challenge. Herein, we developed a novel time-dependent information encryption technology, which based on a series of photochromic spirooxazine-contained polymers with different rigidity. The color of these polymers can be reversibly switched between blue and colorless via irradiation of UV light and storage in dark. The decoloration rate of these polymers can be modulated by changing the rigidity of the polymers. By taking full advantage of this property, two self-erased time-dependent information encryption strategies were established. After UV irradiation, the encoded information was self-erased with time in dark. During this process, fake or correct information was generated. The correct information was only identified at a pre-designed period of time. This time-dependent property implies new prospect for information encryption with a high level of security.
Article
Biochemistry & Molecular Biology
Jianxiong Xu, Hongyi Zhang, Ziyu Guo, Chaoyang Zhang, Haihu Tan, Guo Gong, Maolin Yu, Lijian Xu
Summary: The article introduces a fully physical crosslinked conductive BSA-MA-PPy/P(AM-co-AA)/Fe3+ hydrogel with excellent mechanical strength, fast self-recovery performance, and good conductivity. It can be used as a strain sensor to monitor joint motion and as a soft electrode in an electrocardiogram device for wireless heart-rate monitoring.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Xiang Li, Hong Wang, Jian Chen, Yong Tian, Chongchen Xiang, Wanqiang Liu, Zhihua Zhou, Jiaxi Cui, Xudong Chen
Summary: Photoswitchable fluorescent polymers (PFPs) are promising systems for applications such as photowritable pattern, optical anti-counterfeiting, and information encryption. However, the use of harmful UV light as stimulus often leads to photobleaching and poor reversibility. To address this issue, visible-light-driven PFPs are developed by copolymerization of a novel negative photochromic spiropyran monomer and methyl acrylate. These copolymers exhibit bright red fluorescence, which can be reversibly turned off by visible light irradiation. The system demonstrates fast photo-responsibility, prominent photo-reversibility and photostability, simple preparation process, and processability. Applications in photorewritable patterns, optical anti-counterfeiting, and information encryption are demonstrated.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Polymer Science
Jingjing Du, Yutong Zhang, Yilin Huang, Qiao Zhang, Wenzhi Wang, Maolin Yu, Lijian Xu, Jianxiong Xu
Summary: In this research, chitosan-based hydrogels with integrated functionalities were easily prepared by solution polymerization. The hydrogel exhibited tough mechanical properties and moderate tissue adhesion due to the dual cross-linking between quaternized carboxymethyl chitosan and acrylamide/sodium p-styrene sulfonate. Furthermore, the hydrogel showed satisfactory biocompatibility, hemocompatibility, and excellent antibacterial ability, and it accelerated epidermal regeneration and wound closure in a rat model for bacterial infection incision.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Polymer Science
Maolin Yu, Yuhan Gao, Ao Ying, Lili Li, Guohua Xie, Shaolong Gong, Xiang Gao, Tao Wang, Chuluo Yang
Summary: In this study, we designed and synthesized a TSCT-based alternating TADF copolymer consisting of non-conjugated poly(maleimide-alt-styrene) as the backbone, acridine as the electron donor, and triazine as the electron acceptor. The solution-processed OLED using the alternating TADF copolymer as the emitter achieved a maximum external quantum efficiency of 20.9%, which was 2.8 times higher than that of the corresponding random copolymer. This highlights the superiority of alternating copolymerization in constructing TSCT-based TADF copolymers.
Article
Chemistry, Multidisciplinary
Haitao Deng, Hong Wang, Yong Tian, Zhong Lin, Jiaxi Cui, Jian Chen
Summary: Photoswitchable supramolecular fluorescent polymers (PSFPs) were prepared by integrating photochromic molecules into a hydrophobic polymer matrix with fluorine elastomer, exhibiting adaptive fluorescence switching between none, green, and red under different light irradiation. PSFPs exhibited excellent photoswitchable properties, outstanding stretchability, hydrophobicity, antifouling, self-healing ability, and simplified preparation process, making them suitable for underwater data encryption and anti-counterfeiting labels applications.
MATERIALS HORIZONS
(2023)
Article
Materials Science, Multidisciplinary
Hong Wang, Jia Tang, Haitao Deng, Yong Tian, Zhong Lin, Jiaxi Cui, Jian Chen
Summary: In this study, photoswitchable fluorescent supramolecular polymers (PFSPs) were prepared through two independent host-guest interactions and successfully applied in information encryption and anti-counterfeiting systems. These polymers demonstrate excellent fluorescence properties, fast photo-responsiveness, and prominent photo-reversibility.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Haitao Deng, Hong Wang, Yong Tian, Zhong Lin, Jiaxi Cui, Jian Chen
Summary: Photoswitchable supramolecular fluorescent polymers (PSFPs) were prepared that can adaptively change their fluorescence between none, green and red by the irradiation of different light. PSFPs exhibited excellent photoswitchable properties and other desired physical properties. They were successfully applied in underwater data encryption and anti-counterfeiting labels.
MATERIALS HORIZONS
(2023)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)