Article
Chemistry, Multidisciplinary
Teresa Rodrigues, Federica Curti, Yann R. Leroux, Alexandre Barras, Quentin Pagneux, Henri Happy, Christoph Kleber, Rabah Boukherroub, Roger Hasler, Stefano Volpi, Maria Careri, Roberto Corradini, Sabine Szunerits, Wolfgang Knoll
Summary: DNA-based aptamers are commonly used as bioreceptors due to their adjustable affinity and specificity. However, the use of peptide nucleic acids (PNAs) as aptamers has been challenging because of the lack of selection methods and difficulty in mimicking established DNA-based receptors. In this study, a high-affinity PNA aptamer for cardiac Troponin I (cTnI) was immobilized on a graphene-based FET transducer and compared to a DNA-based aptamer. Both receptors showed similar dissociation constants and comparable detection limits. The PNA aptamer demonstrated stability and consistency in complex biological matrices.
Article
Biophysics
Yiqing Wang, Tao Liu, Min Yang, Chuanjian Wu, Wei Zhang, Zhenyu Chu, Wanqin Jin
Summary: The handheld device designed in this study based on dual-gate ISFET showed high sensitivity, wide linear range, and low detection limit for cTnI detection in serum, providing reliable results and potential applications for early screening and diagnosis of AMI.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Electrochemistry
Rahul Prajesh, Vinay Goyal, Saloni Kakkar, Jyayasi Sharma, M. A. Alam, Ranjan Kumar Maurya, Vijayender Bhalla, Ajay Agarwal
Summary: A highly sensitive and robust polysilicon Field Effect transistor (SiFET) has been developed for the detection of Cardiac Troponin I (cTnI), a gold standard biomarker of myocardial infarction. The device utilizes a thin film of gold layer as a gate terminal biofunctionalized with specific cTnI binding DNA receptor aptamer. Experimental results showed significant response for cTnI concentration as low as 0.1 ng ml(-1) for label free detection.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Engineering, Electrical & Electronic
Mengke Xu, Min Guan, Ning Cui, Chenfeng Zhao, Yang Zhang, Yiping Zeng, Sufang Li
Summary: Different structures of EG-HEMT were designed for cTnI detection, with 50y structure showing the highest biological regulation ability and a broader detection range. The biological regulation ability increases with increasing y value, but the growth rate decreases. 30y EG-HEMT performs best in clinical sample detection of cTnI concentration.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Physical
Cao-An Vu, Yi-Ting Su, Jui-Shen Wang, Chia-Yu Chang, Wen-Pin Hu, Chun-Jen Huang, Hardy Wai-Hong Chan, Wen-Yih Chen
Summary: This study compares different surface modification methods for silica-based biosensor fabrication and evaluates their performance in quantifying cardiac troponin I (cTnI) at ultralow concentrations and small increment resolution in human serum. The results show that only the silane-PEG-modified samples provide a superior surface for probe immobilization and high antifouling capability for the PEG-SiNWFET biosensors to accurately quantify cTnI at ultralow levels in human serum.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Analytical
Chubing Lin, Lijun Li, Jun Feng, Yan Zhang, Xin Lin, Heyuanxi Guo, Rui Li
Summary: A sensitive label-based SERS strategy was developed for the quantitative determination of cTnI in human serum. The strategy utilized magnetic bimetallic nanoparticles as the substrate, specific aptamer for target protein capture, and the Bradford method for signal enhancement. The Raman signal intensity showed a linear relationship with cTnI concentration, and the LOD was estimated to be 5.50 pg.mL(-1).
Article
Chemistry, Analytical
Mingxing Liu, Rongrong Jiang, Meie Zheng, Mengjiao Li, Qingjie Yu, Hongda Zhu, Huiling Guo, Hongmei Sun
Summary: A sensitive unlabeled ratiometric biosensor was developed for the detection of cTnI. The biosensor was established using a glassy carbon electrode coated with graphene oxide and bonded with N, Zn co-doped graphene quantum dots (N, Zn-GQDs). The ratiometric biosensor showed a good response to cTnI, with a detection limit of 4.59 pg L-1 in the concentration range of 10-106 pg L-1. The method was evaluated for cTnI detection in human serum and showed consistent results compared to the standard ELISA method.
Article
Biochemistry & Molecular Biology
Tae-Hwan Hyun, Won-Ju Cho
Summary: This article presents the development of a high-performance potasium-selective biosensor platform based on an amorphous indium gallium zinc oxide thin-film transistor. The sensor exhibits high sensitivity and selectivity for potassium detection, making it applicable for high-performance potassium detection.æ
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Teresa Rodrigues, Vladyslav Mishyn, Yann R. Leroux, Laura Butruille, Eloise Woitrain, Alexandre Barras, Patrik Aspermair, Henri Happy, Christoph Kleber, Rabah Boukherroub, David Montaigne, Wolfgang Knoll, Sabine Szunerits
Summary: Cardiovascular diseases result in millions of deaths globally, and early identification and prevention can significantly reduce the mortality rate. This study demonstrates the exceptional properties of an aptamer modified graphene-based FET for specific sensing of cardiac troponin I in different bodily fluids. The sensor allows real-time detection of cardiac troponin I within the clinically important range, enabling differentiation between individuals with different risks for myocardial infarction. The results show promise for the development of a point-of-care device for troponin I sensing in clinical settings.
Article
Biochemistry & Molecular Biology
Vien Thi Tran, Heongkyu Ju
Summary: This study demonstrates the quantitative assay of cardiac Troponin I using the fluorescence-based SPCE technology, achieving ultrahigh sensitivity and significantly enhanced signal-to-noise ratio. The SPCE greatly improves the fluorescence signal while suppressing photo-bleaching, making it a promising technology for early diagnosis of cTnI in blood samples.
Letter
Medicine, General & Internal
Felix Hennig, Christoph Knosalla
Summary: Devereaux et al. have contributed to the characterization of appropriate thresholds for defining myocardial damage after cardiac surgery, particularly in relation to the use of different cardioplegic solutions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Engineering, Electrical & Electronic
Chia-Hsu Hsieh, Chih-Hsien Huang, Jia-Huei Lin, Ling-Shan Yu, I-Yu Huang
Summary: In this study, we developed a three-dimensional microsensor based on an extended gate field-effect transistor (EGFET) using microelectromechanical systems (MEMS) technology for the detection of cardiac troponin (cTnI). The microsensor exhibited high sensitivity and linearity in the tested concentration ranges. Bridge-type source read-out, temperature correction, and temperature compensation circuits were also successfully designed to minimize the influence of temperature on the sensing signals.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2023)
Article
Spectroscopy
Shahenda S. Ahmed, Ahmed O. Youssef, Ekram H. Mohamed, Mohamed S. Attia
Summary: A novel, easy and selective spectrofluorimetric technique using the optical sensor Eu3+-BINAM complex was successfully applied for sensitive determination of High Sensitivity Cardiac Troponin (TNHS I) in serum samples of patients with malignant tumors. The technique is based on luminescence intensity quenching of the Eu3+-BINAM complex upon introduction of different concentrations of TNHS I. The synthesis and characterization of the optical sensor were performed, and the sensor was found to offer excitation at 394 nm in acetonitrile at pH 7.5. The concentration of TNHS I in serum samples was proportional to the luminescence intensity quenching of the Eu3+-BINAM complex, most notably at lambda(em) = 618 nm. The technique proved its applicability, simplicity, and low interference, making it effective for quantifying TNHS I in human serum samples.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Tae-Hwan Hyun, Won-Ju Cho
Summary: In this study, a high-performance dopamine-sensitive biosensor platform based on a dual-gate FET on a silicon-on-insulator substrate was proposed, which overcame the limitations of conventional approaches and increased the sensitivity of dopamine sensors. The biosensor platform consisted of a dual-gate FET transducer unit and a dopamine-sensitive extended gate sensing unit. The capacitive coupling between the top- and bottom-gate of the transducer unit allowed for self-amplification of dopamine sensitivity, resulting in an increased sensitivity of 373.98 mV/log[DA] from concentrations 10 fM to 1 mu M. Therefore, the proposed FET-based dopamine sensor is expected to be widely applied as a highly sensitive and reliable biosensor platform, enabling fast and accurate detection of dopamine levels in various applications such as medical diagnosis and drug development.
Article
Chemistry, Analytical
Hao Ji, Zhenhua Wang, Shun Wang, Chao Wang, Kai Zhang, Yu Zhang, Lin Han
Summary: In this study, a high-performance InSe-FET biosensor is developed for the detection of the CA125 biomarker in clinical samples. The biosensor is integrated with a homemade microfluidic channel, which provides good electrical stability during the liquid channel process. It is capable of quantitatively detecting the CA125 biomarker in breast cancer within the range of 0.01-1000 U/mL, with a detection time of 20 minutes. This work provides a universal detection tool for protein biomarker sensing and shows promising application in early screenings of major diseases.
Review
Chemistry, Analytical
Palaniyandi Velusamy, Chia-Hung Su, Palaniappan Ramasamy, Viswanathan Arun, Narayanan Rajnish, Pachaiappan Raman, Vaseeharan Baskaralingam, Sakkarapalayam Murugesan Senthil Kumar, Subash C. B. Gopinath
Summary: Biomarkers are biological molecules associated with physiological changes of the body, aiding in the detection and prediction of disease onset. Breath analysis, as a noninvasive, rapid, and inexpensive method, has become a research focus in early detection of health issues.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xuekai Zhao, Subash C. B. Gopinath, Weichao Zhao
Summary: An immunosensor based on a multiwalled carbon nanotube-modified surface was developed in this study to quantify the CRP level in blood. By constructing specific anti-CRP on the multiwalled carbon nanotube surface, the sensor exhibited a dose-dependent linear pattern in the range of 200 to 3000 pM and was able to identify CRP in biological samples.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hu Hui, Subash C. B. Gopinath, Zool H. Ismail, Yeng Chen, K. Pandian, Palaniyandi Velusamy
Summary: Myocardial infarction (MI) is a life-threatening condition that can cause cardiac arrest and organ damage. Current diagnostic techniques are not sensitive enough for early detection, but blood biomarker-based diagnosis, specifically the measurement of cardiac troponin I (cTnI), provides a potential solution. In this study, a sensor based on interdigitated electrodes was developed and used to detect cTnI. The use of aptamer-conjugated gold nanoparticles and detection antibodies in a sandwich pattern significantly improved the sensitivity of the detection. The developed sensor showed promising results for diagnosing MI.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Green & Sustainable Science & Technology
Muhammad Nur Aiman Uda, Subash C. B. Gopinath, Uda Hashim, Muhammad Nur Afnan Uda, Tijjani Adam, Nor Azizah Parmin, Sreeramanan Subramaniam, Suresh V. Chinni, Veeranjaneya Reddy Lebaka, Ramachawolran Gobinath
Summary: Rice is increasingly exposed to inorganic arsenic, affecting half of the world population as rice consumers. This study investigated the effects of silica and graphene nanomaterials treatment on varied arsenic levels, and found that silica nanoparticles showed the highest inhibition on arsenic accumulation. Arsenic adversely affected plant growth and even caused death at high concentrations, but silica nanoparticles demonstrated potential in reducing consumer health risks.
Review
Biotechnology & Applied Microbiology
Theivasanthi Thirugnanasambandan, Subash C. B. Gopinath
Summary: The storage of food grains against fungal infection is a major challenge for farmers, but nanotechnology offers a solution by replacing synthetic fungicides with inorganic nanoparticles such as silver and zinc oxide, as well as green synthesized nanoparticles. Plant extracts and essential oils show effective antifungal properties, and nanoparticles can be impregnated in packaging materials for safe food storage. This overview discusses the nanomaterials-mediated protection of food materials from mycotoxin contamination and its impact on the environment.
Article
Health Care Sciences & Services
Dayang Nooreffazleen Yahya, Rhanye Mac Guad, Yuan-Seng Wu, Siew Hua Gan, Subash C. B. Gopinath, Hasif Adli Zakariah, Rusdi Abdul Rashid, Maw Shin Sim
Summary: The rs4755404 gene polymorphism of SLC1A2 is significantly associated with METH-induced psychosis, especially for individuals with the GG homozygous genotype.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Green & Sustainable Science & Technology
Wan Yuen Tan, Subash C. B. Gopinath, Periasamy Anbu, Ahmad Radi Wan Yaakub, Sreeramanan Subramaniam, Yeng Chen, Sreenivasan Sasidharan
Summary: With the development of bionanotechnology, the field of nanobiocatalysts has grown rapidly and transformed various nanomaterials into novel nanocarriers for enzyme immobilization. Nanotubes, nanofibers, nanopores, nanoparticles, and nanocomposites have been successfully used as nanocarriers. The combination of enzymes and nanocarriers through different immobilization techniques has attracted attention due to their exceptional catalytic performance, stability, and reusability. The review discusses enzyme immobilization on nanocarriers and highlights the techniques, properties, preparations, and applications of nanoimmobilized enzymes.
Review
Biotechnology & Applied Microbiology
Hussaini Adam, Subash C. B. Gopinath, M. K. Md Arshad, Tijjani Adam, N. A. Parmin, Irzaman Husein, Uda Hashim
Summary: In severe cases, Parkinson's disease causes uncontrolled movements known as motor symptoms such as dystonia, rigidity, bradykinesia, and tremors. Parkinson's disease also causes non-motor symptoms such as insomnia, constipation, depression and hysteria. Disruption of neural networks in the substantia nigra pars compacta is a major cause of motor symptoms in Parkinson's disease, highlighting the need for better methods of detection. Improved diagnosis and treatment of Parkinson's disease can help avoid some of its devastating symptoms.
Review
Microbiology
Suaidah Ramli, Yuan Seng Wu, Kalaivani Batumalaie, Rhanye Mac Guad, Ker Woon Choy, Ashok Kumar, Subash C. B. Gopinath, Md. Moklesur Rahman Sarker, Vetriselvan Subramaniyan, Mahendran Sekar, Neeraj Kumar Fuloria, Shivkanya Fuloria, Suresh V. Chinni, Gobinath Ramachawolran
Summary: This review focuses on the therapeutic efficacy and molecular mechanisms of Withania somnifera (WS) extracts and their phytochemicals against SARS-CoV-2 infection. It also discusses the use of molecular docking in developing potential inhibitors from WS to target the virus and host cell receptors. Additionally, the review explores the use of nanoformulations or nanocarriers in enhancing WS delivery for improved bioavailability and treatment efficacy.
Article
Infectious Diseases
Valiappan Ranjutha, Yeng Chen, Lamya Ahmed Al-Keridis, Mitesh Patel, Nawaf Alshammari, Mohd Adnan, Sumaira Sahreen, Subash C. B. Gopinath, Sreenivasan Sasidharan
Summary: Polyalthia longifolia is a medicinal plant used in traditional medicine for skin diseases. This study confirms the synergistic antimicrobial activity of Polyalthia longifolia methanol leaf extract (MEPL) and ceftriaxone against methicillin-resistant Staphylococcus aureus (MRSA) bacteria. The combination of MEPL and ceftriaxone significantly reduces the minimum inhibitory concentration of ceftriaxone and inhibits the expression of the resistant mecA gene in MRSA.
Review
Multidisciplinary Sciences
A. L. Olatomiwa, Tijjani Adam, C. O. Edet, A. A. Adewale, Abdullah Chik, Mohammed Mohammed, Subash C. B. Gopinath, U. Hashim
Summary: This review provides a comprehensive overview of articles on the electronic and optical properties of graphene using density functional theory and machine learning approaches. It summarizes the thermodynamic stability parameters of various doped graphene systems and discusses the strengths and uncertainties of the used models and potentials. Future studies should explore the thermal properties, heterostructure modeling, superconducting behavior, and optimization of DFT models to enhance the potential of graphene.
Article
Green & Sustainable Science & Technology
Roslaili Abdul Aziz, Mok Yiwen, Mawaddah Saleh, Mohd Nazry Salleh, Subash C. B. Gopinath, Sunny Goh Eng Giap, Suresh V. Chinni, Ramachawolran Gobinath
Summary: This study evaluated the accumulation of trace elements, such as copper, zinc, and lead, in paddy fields and soil, and analyzed their transfer to rice plants. The findings show that the accumulation of heavy metals in soil varies depending on the location and the order of accumulation differs for different metals. The study also found that soil properties and metal abundance can influence the growth characteristics of rice plants.
Article
Food Science & Technology
Raja Hasnida Raja Hashim, Ahmad Anas Nagoor Gunny, Sam Sung Ting, Subash C. B. Gopinath, Yeong Yin Fong, Sunil Pareek, Muaz Mohd Zaini Makhtar, Hafiza Shukor
Summary: This study investigated the effect of Coleus aromaticus essential oil (CAEO) on an active film made of polylactic acid, chitosan, and cellulose nanocrystal for fruit packaging. The addition of CAEO improved the mechanical properties and antioxidant activity of the film, and exhibited inhibitory effects against pathogenic fungus. The results suggest that the PLA/Cs/CNC/CAEO films can enhance microbial safety and prolong the shelf life of fruits, potentially replacing petroleum-based plastics for fruit packaging applications.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Multidisciplinary Sciences
Mohammed Mohammed, Jawad K. Oleiwi, Anwar Ja 'afar Mohamad Jawad, Aeshah M. Mohammed, Azlin F. Osman, Rozyanty Rahman, Tijjani Adam, Bashir O. Betar, Subash C. B. Gopinath, Omar S. Dahham
Summary: This study aimed to enhance the flexural properties of unsaturated polyester/kenaf fiber nanocomposites by using zinc oxide nanoparticles for surface treatment. The findings showed that the addition of ZnONPs significantly improved the performance of the composites, with 2% being the optimal loading, and surface treatment with ZnONPs resulted in kenaf fibers with improved flexural properties.
Article
Engineering, Biomedical
S. Iswarya, T. Theivasanthi, Subash C. B. Gopinath
Summary: Sodium alginate/hydroxyapatite/nanocellulose (SA/HA/NC) nanocomposite films were prepared for bone tissue engineering using a simple solution casting method. The structure and properties of the composite films were studied by XRD, SEM, EDAX, and FTIR analysis. The results showed that the inclusion of different concentrations of NC improved the tensile strength of the biopolymer film. These bionanocomposite films have the potential to be used as biomaterials in bone tissue engineering.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
