Article
Biochemical Research Methods
Jia An, Meizhu Chen, Guoyi Liu, Yongqin Hu, Rubing Chen, Ying Lyu, Sanjiv Sharma, Yufei Liu
Summary: In this study, CsPbBr3 perovskite quantum dots were successfully encapsulated in poly(styrene/acrylamide) microspheres, creating PDPS composites with stable photoluminescence and water solubility. These composites were used to construct a real-time pH monitoring platform that showed a good linear relationship within the pH range of 4-12 and was further extended for urea and urease detection. The detection limits for urea and urease were found to be 1.67 μM and 2.1 mU/mL, respectively, demonstrating the expanding applications of perovskite materials.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Reena K. Sajwan, Purnima Sharma, G. B. V. S. Lakshmi, Pratima R. Solanki
Summary: A fluorescence Turn-On based strategy using MPA-CdSe QDs was utilized for urea determination, with a detection range from 1 to 120 mM and a lower detection limit of 1 mM. The pH sensitivity of MPA-CdSe QDs was key in detecting urea through the enzymatic reaction with urease and the release of ammonia.
Article
Chemistry, Analytical
Baha Ondes, Fatma Akpinar, Murat Uygun, Mihrican Muti, Deniz Aktas Uygun
Summary: A highly stable urea biosensor was prepared by immobilizing urease enzyme onto nanoparticles, showing a detection limit of 0.77 mu M and a linear concentration range of 0.01 mM-500 mM. The biosensor system exhibited high repeatability and retained a certain level of activity after long-term storage. Interference from common interferents was found to be negligible, and the biosensor was proven suitable for detecting urea in artificial human serum.
MICROCHEMICAL JOURNAL
(2021)
Article
Polymer Science
Wafaa Metwly, Eman Fadl, Moataz Soliman, Shaker Ebrahim, Sally A. Sabra
Summary: ZnS quantum dots (QDs) capped with glutathione (GSH) were synthesized and characterized. The GSH-capped ZnS QDs showed potential as optical probes for non-enzymatic and enzymatic detection of urea, with improved sensitivity and applicability achieved through enzyme conjugation.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2023)
Article
Chemistry, Analytical
Svetlana A. Mescheryakova, Ivan S. Matlakhov, Pavel D. Strokin, Daniil D. Drozd, Irina Yu. Goryacheva, Olga A. Goryacheva
Summary: Doxorubicin (DOX) is a commonly used anti-tumor drug in chemotherapy, but it has high cardio-, neuro- and cytotoxicity. Therefore, continuous monitoring of DOX concentrations in biofluids and tissues is important. This study demonstrates the capabilities of analytical nanosensors based on the quenching of fluorescence of alloyed CdZnSeS/ZnS quantum dots (QDs) for operative DOX detection. Optimized turn-off fluorescence nanosensors were developed for direct DOX determination in undiluted human plasma.
Article
Spectroscopy
Jia An, Yongqin Hu, Da Yang, Yaqin Han, Jiajing Zhang, Yufei Liu
Summary: In this study, carbon quantum dots (CDs) were successfully synthesized and combined with silicon (SiO2) spheres to form composite materials. The composites exhibited a significantly higher fluorescence intensity than pure CDs and a simplified purification process. Furthermore, the composites were utilized to develop a sensing platform for ultrasensitive detection of urea and urease, with promising applications in biological analysis and real sample detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Urosa Latief, Shafi Ul Islam, Zeeshan Khan, Mohd. Shahid Khan
Summary: Manganese and europium doped zinc sulphide quantum dots were prepared via direct aqueous route, showing tunable emission and enhanced photoluminescence. These doped quantum dots also exhibited excellent sensing performance for detecting Cu2+ in water samples. Furthermore, their potential applications in white LEDs were demonstrated through CIE Chromaticity diagram.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Engineering, Environmental
Salhah D. Al-Qahtani, Hanan K. Alzahrani, Omer A. Azher, Zeid O. Owidah, Matokah Abualnaja, Turki M. Habeebullah, Nashwa M. El-Metwaly
Summary: A high-sensitivity viscose fabric was developed for colorimetric recognition of urea in fluids using co-encapsulated calcium alginate nanoparticles. Extracted anthocyanin from red-cabbage and urease enzyme were studied for their role in the fabrication of a biosensor on fabrics. The colorimetric changes of the fabric were monitored with increasing urea concentration, showing a shift in absorbance spectra and color variations.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Spectroscopy
Like Yang, Jia Ge, Demiao Ma, Jinlu Tang, Hongqi Wang, Zhaohui Li
Summary: In this study, a unique fluorescence biosensor based on MoS(2 )quantum dots was developed for methotrexate assay. The fluorescence of MoS(2 )QDs was quenched by methotrexate due to the inner filter effect (IFE). The IFE-based method showed a linear relationship between MoS(2 )QDs fluorescence intensity and methotrexate concentration in the range of 0.05-1 μM.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Engineering, Electrical & Electronic
Miao Sun, Shuangshuang Zhang, Jiajia Wang, Zhenhong Jia, Xiaoyi Lv, Xiaohui Huang
Summary: The angle spectrum method was used to further improve the sensitivity of porous silicon-assembled microcavity biosensors, successfully detecting different concentrations of target DNA with a detection limit of 13.25 pM. This method offers advantages such as being spectrometer free and cost-effective.
IEEE PHOTONICS JOURNAL
(2021)
Article
Engineering, Environmental
Shikha Jain, Neeraj Dilbaghi, Nitin Kumar Singhal, Ajeet Kaushik, Ki-Hyun Kim, Sandeep Kumar
Summary: Accumulation of heavy metal ions in the ecosystem is a major concern for their negative effects on animals, humans, and aquatic habitats. A rapid and portable sensing system is crucial for detecting and managing such pollutants. A fluorescence-based biosensor has been developed for the selective and sensitive detection of Pb2+ ions using a DNAzyme system that responds only to the presence of lead (II) ions (Pb2+). This novel biosensing approach offers insights into the rapid and sensitive detection of major pollutants for food and environmental safety.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Cara E. Bradsher, Cayla D. Ontko, Alexandra C. Koziel, James R. McBride, Sandra J. Rosenthal
Summary: This research has found that ferroelectric behavior can be achieved in nanoparticles through ion exchange, with fluorescence retention achieved through CdS shelling before ion exchange, containing defects in the CdS shell rather than the fluorescent CdSe cores. The ferroelectric response remains constant with an increase in the number of CdS monolayers, while fluorescence retention also increases, reaching 99% at 8 monolayers, allowing for the addition of ferroelectric applications to the growing list of quantum dot applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Food Science & Technology
Zeyu Xu, Yizhong Wang, Jiaran Zhang, Ce Shi, Xinting Yang
Summary: The detection of trace amounts of Cu2+ in water using MPA-InP/ZnS QDs probes shows excellent sensitivity and selectivity, with a low limit of detection of 0.22 nM. The proposed fluorescence-quenching mechanism is applied successfully to real water samples and drink samples.
Article
Chemistry, Analytical
Xiaowan Li, Jiankun Qin, Yingcheng Hu
Summary: Here, a switch-on hydrogel biosensor based on self-assembled Mn-doped ZnS quantum dots (QDs) in cellulose nanofibrils (CNFs) has been developed for rapid and selective sensing of glutathione (GSH) in serum sample. The biosensor integrates Mn:ZnS QDs with high quantum yield, stability and photostability into CNFs hydrogel networks in a single step. The fluorescence of Mn:ZnS QDs@CNHs is quenched by Hg2+, but the addition of GSH to the system leads to the recovery of fluorescence.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Applied
Faezeh Rahimi, Hamideh Roshanfekr, Hossein Peyman
Summary: An ultrasensitive aptasensor based on carbon quantum dots/octahedral Cu2O nano composite and AFB1 aptamer was developed, showing fast detection and accuracy of AFB1 concentrations under optimized experimental conditions. The sensor exhibited considerable repeatability, reproducibility, accuracy, and robustness, with sufficient selectivity, stability, and reliability for future practical assays.
Article
Chemistry, Analytical
Chakavak Esmaeili, Lee Yook Heng, Chew Poh Chiang, Zulkafli A. Rashid, Eka Safitri, Radha Swathe Priya Malon Marugan
SENSORS AND ACTUATORS B-CHEMICAL
(2017)
Article
Multidisciplinary Sciences
Noor Zuhartini Md Muslim, Musa Ahmad, Lee Yook Heng, Bahruddin Saad
Article
Chemistry, Analytical
Nik Nurhanan Nik Mansor, Tan Toh Leong, Eka Safitri, Dedi Futra, Nurul Saadah Ahmad, Dian Nasriana Nasuruddin, Azlin Itnin, Ida Zarina Zaini, Khaizurin Tajul Arifin, Lee Yook Heng, Nurul Izzaty Hassan
Article
Multidisciplinary Sciences
Eda Yuhana Ariffin, Nik Nurhanan Nik Mansor, Eka Safitri, Lee Yook Heng, Nurul Izzaty Hassan
Article
Polymer Science
Eka Safitri, Hani Humaira, Murniana Murniana, Nazaruddin Nazaruddin, Muhammad Iqhrammullah, Nor Diyana Md Sani, Chakavak Esmaeili, Susilawati Susilawati, Muhammad Mahathir, Salsabilla Latansa Nazaruddin
Summary: The optical pH sensor, constructed using a pectin-chitosan polyelectrolyte complex and extracted anthocyanin, has shown high sensitivity, good reproducibility, and stability in response, enabling its use within five days. It has been successfully used to measure saliva pH across different age groups, showing no significant difference compared to a potentiometric method.
Article
Materials Science, Multidisciplinary
Eka Safitri, Zatul Omaira, Nazaruddin Nazaruddin, Irfan Mustafa, Sitti Saleha, Rinaldi Idroes, Binawati Ginting, Muhammad Iqhrammullah, Sagir Alva, Maria Paristiowati
Summary: In this study, a new optical pH sensor based on a polyelectrolyte membrane was developed for rapid and accurate measurement of fish freshness. Through trial-and-error investigation and optimization, a sensor with good reproducibility and stable response was successfully fabricated. The sensor was capable of measuring pH changes on fish skin at different temperatures.
Article
Chemistry, Analytical
Eka Safitri, Lee Yook Heng, Musa Ahmad, Ling Ling Tan, Nazaruddin Nazaruddin, Khairi Suhud, Chew Poh Chiang, Muhammad Iqhrammullah
Summary: A new electrochemical DNA biosensor based on mercaptopropionic acid-capped ZnS quantum dots has been developed, which improved the bioanalytical assay of target biomolecules by enhancing the electron transfer.
Article
Chemistry, Analytical
Uswatun Hasanah, Nor Diyana Md Sani, Lee Yook Heng, Rinaldi Idroes, Eka Safitri
Article
Chemistry, Analytical
Uswatun Hasanah, Mita Setyowati, Rustam Efendi, Muslem Muslem, Nor Diyana Md Sani, Eka Safitri, Lee Yook Heng, Rinaldi Idroes
Proceedings Paper
Chemistry, Applied
Bambang Kuswandi, Alni Riskyna, Musa Ahmad
RECENT ADVANCEMENT ON APPLIED PHYSICS, INDUSTRIAL CHEMISTRY AND CHEMICAL TECHNOLOGY
(2018)
Proceedings Paper
Chemistry, Applied
Mariam Abubaker, Che Wan Zanariah Che Wan Ngah, Musa Ahmad, Bambang Kuswandi
RECENT ADVANCEMENT ON APPLIED PHYSICS, INDUSTRIAL CHEMISTRY AND CHEMICAL TECHNOLOGY
(2018)
Article
Pharmacology & Pharmacy
Abdul Kadir Azidah, Abdul Kadir Arifah, A. H. Roslida, Abdul Manan Mat Jais, Julia Omar, Abdul Nawfar Sadagatullah, Azlina Ishak, Norhayati Mohd. Noor, Ahmad Tarmizi Musa
ORIENTAL PHARMACY AND EXPERIMENTAL MEDICINE
(2017)
Article
Crystallography
Khairi Suhud, Siti Aishah Hasbullah, Musa Ahmad, Lee Yook Heng, Mohammad B. Kassim
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2017)
Article
Chemistry, Analytical
Faiz Bukhari Mohd Suah, Musa Ahmad
ANALYTICA CHIMICA ACTA
(2017)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
