Article
Biochemistry & Molecular Biology
Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, Xin Zhang, Kumar Vishven Naveen, Myeong-Hyeon Wang
Summary: Drug-resistant microorganisms can be overcome by using combinational drug delivery systems based on biopolymer chitosan (CS) and metal nanoparticles. Therefore, PEGylated zinc oxide nanoparticles (P-ZnO NPs) decorated chitosan-based nanoparticles (CS NPs) were prepared to deliver ampicillin (AMP) for improved antibacterial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Applied
Kimberly M. Trevino, Caitlyn R. Wagner, Eric K. Tamura, Joel Garcia, Angelique Y. Louie
Summary: Small molecules with specific electronic and structural features are being used for metal-sensing applications in various fields. Copper sensing has gained increasing interest in the past decade due to its biological importance and potential contamination in water and fuels. This review focuses on small molecule copper(II) sensors that exhibit color changes in solution. The article presents the molecular structures, sensing mechanisms, and performance of these sensors in different environmental, agricultural, and biological samples. The challenges and future prospects of using fluorophore/chromophore-ligand chemistry for fluorometric and colorimetric assays of copper(II) are also discussed.
Article
Engineering, Environmental
Sushil Kumar Shukla, Sneha Pandey, Swastika Saha, Hare Ram Singh, Pradeep Kumar Mishra, Sunil Kumar, Santosh Kumar Jha
Summary: Copper nanoparticles impregnated biocomposites were prepared and used as an efficient adsorbent for dye decolorization, showing high performance under optimum conditions and in simulated industrial textile effluents. The decolorization process of crystal violet was consistent with pseudo-second-order kinetics and best fitted with the Freundlich adsorption isotherm. Discussions were made on the nature and potential processes involved in interactions between the dye and the nano-bioadsorbents during decoloration.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Polymer Science
Ahmed E. Abdelhamid, Eman H. Ahmed, Hanem M. Awad, Magdy M. H. Ayoub
Summary: A new system consisting of chitosan nanoparticles encapsulated pre-synthesized selenium nanoparticles in the presence of 5-fluorouracil was successfully prepared for cancer treatment. The selenium nanoparticles were synthesized using ascorbic acid as a reducing agent under mild conditions. The chitosan nanoparticles were prepared using the ionic gelation technique. The encapsulated nanocomposites showed potent cytotoxic activities against various cancer cell lines with enhanced anticancer activity compared to single drugs or neat selenium nanoparticles.
Article
Chemistry, Multidisciplinary
Mengfei Jin, Shangyong Li, Yanhong Wu, Dandan Li, Yantao Han
Summary: The study successfully delivered anti-inflammatory drugs to the inflamed sites of ulcerative colitis through RES-PCAC-NPs, showing promising results in significantly improving the inflammatory markers in DSS-induced mice, demonstrating the potential in the treatment of UC.
Review
Polymer Science
Mahwash Mukhtar, Eszter Fenyes, Csilla Bartos, Mahira Zeeshan, Rita Ambrus
Summary: Chitosan, a natural biopolymer, is commonly used in drug delivery due to its biodegradability and biocompatibility. Its derivatives have been synthesized to enhance mucoadhesion and solubility, while nano and micro particles of chitosan have been reported to improve drug bioavailability. Chitosan has also shown promise in active targeted drug and gene delivery, thanks to its tunable surface modifications.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Molongnenla Jamir, C. Borgohain, J. P. Borah
Summary: This study investigated the substitution of copper with CoFe2O4 nanoparticles and the coating of chitosan to enhance their efficiency for hyperthermia treatment. The results showed the emergence of well-crystalline structures and the presence of chitosan coating on the nanoparticle surface. The nanoparticles exhibited magnetic characteristics that varied with Cu+2 doping concentration, and the self-heating characteristics indicated a decrease in specific absorption rate as concentration increases. Notably, the chitosan coating at x = 0.37 nanoparticles showed the best performance for magnetic hyperthermia therapy.
PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES
(2023)
Article
Polymer Science
Rita Das Mahapatra, Ara Jo, Kusuma Betha Cahaya Imani, Jin-Woong Chung, Jinhwan Yoon
Summary: This study developed a pH-sensitive ampicillin-loaded double-network hydrogel for local delivery of antibiotics against Gram-positive bacteria. The hydrogel exhibited excellent biocompatibility and antimicrobial activity, making it suitable for in situ delivery of antibiotics in post-operative patients.
Article
Chemistry, Applied
Lihua Li, Xinyu Sun, Hui Zhang, Mengna Dong, Jiao Wang, Shuang Zhao, Minghui Shang, Xin Wang, Hui Zhangsun, Li Wang
Summary: This study successfully prepared protein-polysaccharide nanoparticles as an effective nano-delivery system for nutrients, encapsulating and delivering two types of nutrient models with good stability and biocompatibility.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Lingmin Meng, Shanyou Li, Changxu Wanyan
Summary: This study successfully prepared a novel chitosan-based metal nanocomposite, which showed promising antimicrobial activity and promoted wound healing.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Dalila Miele, Xin Xia, Laura Catenacci, Milena Sorrenti, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, John J. Rossi, Maria Cristina Bonferoni
Summary: Oligonucleotide therapeutics such as miRNAs and siRNAs are developed to modulate gene expression, but face issues of instability and easy degradation. Viral and non-viral vectors are used for efficient delivery, with non-viral vectors like polymeric nanocarriers providing safer and more effective means of delivery.
Article
Biochemistry & Molecular Biology
G. Revathi, S. Elavarasi, K. Saravanan, M. Ashokkumar, Chukwuebuka Egbuna
Summary: Diabetes is a complex disease with adverse effects, and current medications have noticeable side effects. Medicinal plants may provide an alternative source of anti-diabetic drugs. A combination of multiple herbs has higher therapeutic potential, but absorption issues hinder its effectiveness. Encapsulation of the polyherbal drug with chitosan nanoparticles offers a solution due to its biocompatibility and targeted drug delivery characteristics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Mostafa Saeedi, Omid Vahidi, Mohammad Reza Moghbeli, Sepideh Ahmadi, Mohsen Asadnia, Omid Akhavan, Farzad Seidi, Mohammad Rabiee, Mohammad Reza Saeb, Thomas J. Webster, Rajender S. Varma, Esmaeel Sharifi, Ali Zarrabi, Navid Rabiee
Summary: This article reviews the importance of chitosan in drug delivery applications, discussing different types and functionalities of cross-linkers and fabrication methods for chitosan hydrogels. It also explores recent advances in advanced chitosan hydrogels for oral drug delivery, transdermal drug delivery, and cancer therapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Food Science & Technology
Ozi Adi Saputra, Wahyu Nur Safitriono, Dyah Ellyawati Kusumaningtyas Maharani, Amalia Febiana, Fajar Rakhman Wibowo
Summary: This study aims to overcome the limitations of curcumin by formulating a nano-emulsion called curcumin emulsion (CE) and encapsulating it within chitosan-assembled mesoporous silica nanoparticles (Chi@SiO2@CE). The CE exhibited strong antioxidant activity compared to curcumin alone, and the Chi@SiO2@CE showed pH-controlled release behavior, indicating potential as a pH-responsive drug delivery material.
Article
Chemistry, Multidisciplinary
Wei Sun, Bikash Karmakar, Hala A. Ibrahium, Nasser S. Awwad, Attalla F. El-kott
Summary: This study successfully synthesized nontoxic and stable copper nanoparticles using chitosan/starch hydrogel, which showed significant anti-thyroid carcinoma effects and strong antioxidant activity.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sarabjit Kaur, Avani Bhararia, Krishna K. Sharna, Sherry Mittal, Rahul Jain, Nishima Wangoo, Rohit K. Sharma
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Sherry Mittal, Sarabjit Kaur, Anuradha Swami, Indresh K. Maurya, Rahul Jain, Nishima Wangoo, Rohit K. Sharma
Article
Chemistry, Multidisciplinary
Sherry Mittal, Indresh K. Maurya, Sarabjit Kaur, Anuradha Swami, Rahul Jain, Nishima Wangoo, Rohit K. Sharma
Article
Engineering, Environmental
Sarabjit Kaur, Priya Manhas, Anuradha Swami, Ranjana Bhandari, Krishna K. Sharma, Rahul Jain, Ravinder Kumar, Satish K. Pandey, Anurag Kuhad, Rohit K. Sharma, Nishima Wangoo
CHEMICAL ENGINEERING JOURNAL
(2018)
Article
Nanoscience & Nanotechnology
Nishima Wangoo, Sarabjit Kaur, Manish Bajaj, D. V. S. Jain, Rohit K. Sharma
Article
Materials Science, Biomaterials
Nishima Wangoo, Anuradha Swami, Sarabjit Kaur, Kavita Bansal, Rohit K. Sharma
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)