Article
Environmental Sciences
M. Mani, S. Pavithra, K. Mohanraj, S. Kumaresan, Saqer S. Alotaibi, Mostafa M. Eraqi, Arumugam Dhanesh Gandhi, Ranganathan Babujanarthanam, M. Maaza, K. Kaviyarasu
Summary: In this study, silver nanoparticles were successfully synthesized using a green approach based on Basella alba leaf extract. Various techniques such as FTIR, XRD, TEM, DLS, Zeta potential, and UV were utilized to analyze the structure and properties, revealing superior antioxidant and antibacterial activities of the green-synthesized silver nanoparticles.
ENVIRONMENTAL RESEARCH
(2021)
Article
Chemistry, Analytical
Qiang Shi, Ting Wang, Ying Zheng, Qian Guo, Bing Wang, Sujuan Zhu
Summary: A highly sensitive colorimetric sensor based on the aggregation of gold nanoparticles (Au NPs) and a smartphone camera as detector is developed for the determination of cyromazine. By optimizing the reaction parameters, a linear relationship between the absorbance ratio at 666 nm and 520 nm and the cyromazine concentration is established. The method provides a simple and portable strategy for the determination of cyromazine with lower detection limits compared to previous studies.
ANALYTICAL LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Vishal Dhavle, Mehul R. Kateshiya, Tae-Jung Park, Suresh Kumar Kailasa
Summary: The colorimetric assay using GSH-Lac-Ag NPs prepared by functionalizing the surface allows rapid and sensitive detection of thiram in real samples, showing high selectivity and suitability for on-site testing.
JOURNAL OF ELECTRONIC MATERIALS
(2021)
Article
Chemistry, Analytical
Denghao Wang, Changbao Gong, Huimin Zhao
Summary: A highly sensitive colorimetric sensor based on Au NPs@NC@MnO2 was developed for the detection of Cr (VI) in water. The sensor exhibited excellent selectivity and detection performance, and was successfully applied to real samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Physical
Wenrui Zhang, Junlin Ma, Fanxing Meng, Yu Jiang, Liuxue Shen, Tongrui Sun, Yanan Qin, Nan Zhu, Minwei Zhang
Summary: The successfully synthesized core-shell Prussian blue nanomaterials with high electrochemical activity, water solubility, and stability were used to construct wearable sensors using screen printing technology for the detection of biomarkers with high sensitivities. The combination of microfluidic technology is expected to enable large-scale health management monitoring and clinical applications.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Analytical
Tahereh Rohani Bastami, Mansour Bayat, Roberto Paolesse
Summary: In this study, a novel and facile colorimetric assay based on Au@AgNPs as a chemosensor for the naked-eye detection of morphine was developed. The aggregation of Au@AgNPs upon exposure to morphine resulted in a visible color change from light-yellow to brown. The method showed excellent stability, selectivity, prompt detection, and cost-effectiveness.
Article
Spectroscopy
Yuzhu Zhai, Yijing Li, Xiaoke Huang, Juying Hou, Houshen Li, Shiyun Ai
Summary: A colorimetric and ratiometric fluorescent dual-mode assay based on UiO-66-NH2@Au was constructed for sensitive and specific detection of Hg2+. The assay utilized the peroxidase-like activity of UiO-66-NH2@Au stimulated by the addition of Hg2+, leading to changes in colorimetric and fluorescent signals. The assay demonstrated linear correlation with Hg2+ concentration and was successfully applied to the determination of Hg2+ in tap water and river water.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Applied
Qin Zhang, Luying He, Karuppasamy Kohila Rani, Deyin Wu, Jiaojiao Han, Yanhong Chen, Wenjin Su
Summary: The rapid colorimetric detection of neomycin sulfate was achieved using polyvinyl pyrrolidone-coated gold nanoparticles (Au@PVP NPs) solution. The method showed excellent performance with high sensitivity, low cost, and satisfaction recovery in a wide linear range for neomycin sulfate determination.
Article
Chemistry, Applied
Maggie P. Wear, Audra A. Hargett, John E. Kelly, Scott A. McConnell, Conor J. Crawford, Daron I. Freedberg, Ruth E. Stark, Arturo Casadevall
Summary: The physicochemical properties of Cryptococcus neoformans exopolysaccharide (EPS) are significantly affected by lyophilization. Lyophilization leads to the attenuation of the EPS signals in solution 1H Nuclear Magnetic Resonance (NMR) and the broadening of the resonances. Observation through 1H solid-state Nuclear Magnetic Resonance (ssNMR), dynamic light scattering, and transmission electron microscopy suggests that lyophilized and resuspended EPS becomes disordered and contains larger dense aggregates. Additionally, lyophilized EPS shows weaker binding to monoclonal antibodies (mAbs) compared to native EPS.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Analytical
Zhenjing Zhuang, Chunyan Zhang, Zhengdi Yu, Wenyuan Liu, Yajun Zhong, Jingyun Zhang, Zhihui Xu
Summary: Au/CuO nanocomposites prepared by solution-phase synthesis demonstrated efficient hydroquinone (HQ)-oxidase activity and good specificity. The nanocomposites exhibited a strong color reaction with HQ, allowing for quantitative measurement via colorimetric analysis. The sensor was successfully applied to the determination of HQ in real water samples.
Article
Chemistry, Analytical
Caixuan Sun, Hongyan Liu, Junkai Shao, Guofeng Pan, Xueli Yang, Mengjie Wang, Junyi Dong, Mengya Zhu, Yuhang Qi
Summary: In this study, Zn2SnO4/SnO2/ZnO nanosheets decorated with Au nanoparticles were synthesized using hydrothermal and impregnation techniques for the rapid and accurate detection of triethylamine gas. The synthesized materials were characterized and showed hexagonal nanosheets with specific dimensions. The gas sensors based on the synthesized materials exhibited enhanced sensing performance, including higher response, improved stability, selectivity, and low detection limits.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Qiwen Bao, Gang Li, Zhengchun Yang, Jun Liu, Hanjie Wang, Gaoju Pang, Qianjin Guo, Jun Wei, Wenbo Cheng, Ling Lin
Summary: To combat the highly transmissible avian influenza A virus subtype H1N1, a biosensor was developed for rapid and sensitive electrochemical immunoassay. By employing antibody-virus binding, an active molecule-antibody-adapter structure was created on an Au NP substrate electrode, providing a specific surface area and good electrochemical activity for selective amplification detection of H1N1 virus. The results showed that the BSA/H1N1 Ab/Glu/Cys/Au NPs/CP electrode achieved a sensitivity of 92.1 muA (pg/mL)(-1) cm(2), LOD of 0.25 pg/ml, linear ranges of 0.25-5 pg/mL, and linearity of (R-2 = 0.9846). A convenient H1N1 antibody-based electrochemical electrode for molecular detection of the H1N1 virus will be highly valuable in epidemic prevention and raw poultry protection.
Article
Materials Science, Multidisciplinary
Umar Nishan, Ujala Sabba, Abdur Rahim, Muhammad Asad, Mohibullah Shah, Anwar Iqbal, Jibran Iqbal, Nawshad Muhammad
Summary: Dopamine, a neurotransmitter, plays a key role in pathological disorders. Ionic liquid tuned titanium dioxide nanoparticles were used in colorimetric detection of dopamine, showing good sensitivity and selectivity.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Chemistry, Analytical
Muhammad Asad, Nawshad Muhammad, Naeem Khan, Mohibullah Shah, Muslim Khan, Mansoor Khan, Amir Badshah, Zahina Latif, Umar Nishan
Summary: This study reports the drug-mediated synthesis of silver nanoparticles (AgNPs) and their functionalization with an ionic liquid (IL) for acetone determination. The synthesized nanoparticles were characterized and showed excellent performance as a sensor for acetone detection in diabetic patient's urine samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Analytical
Wei Xu, Jianwen Fei, Wei Yang, Yani Zheng, Yin Dai, Marwan Sakran, Jun Zhang, Wanying Zhu, Junli Hong, Xuemin Zhou
Summary: A novel nanocomposite Fe3O4@MoS2-Au NPs was constructed and a colorimetric/electrochemical dual-mode sensor was successfully prepared for H2O2 detection. The sensor showed a wide linear range, low detection limits, and can be used for detecting H2O2 in normal human serum, with promising application prospects.
MICROCHEMICAL JOURNAL
(2022)
Review
Chemistry, Analytical
Rajat Singh, Preeti Thakur, Atul Thakur, Harish Kumar, Prince Chawla, Jigneshkumar V. Rohit, Ravinder Kaushik, Naveen Kumar
Summary: The study summarized the recent applications of surface-modified nanoparticles for the detection of residual pesticides, which are rapid, cost-effective, and suitable for on-site detection. The sensitivity and selectivity of the detection methods have been greatly improved through functionalization and modification of nanoparticles.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2021)
Article
Materials Science, Biomaterials
Seung Hoon Baek, Jihyeok Roh, Chan Yeong Park, Min Woo Kim, Rongjia Shi, Suresh Kumar Kailasa, Tae Jung Park
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Food Science & Technology
Seung Hoon Baek, Chan Yeong Park, Thang Phan Nguyen, Min Woo Kim, Jong Pil Park, Changsun Choi, Soo Young Kim, Suresh Kumar Kailasa, Tae Jung Park
Article
Materials Science, Biomaterials
Mittal L. Desai, Sanjay Jha, Hirakendu Basu, Sudeshna Saha, Rakesh Kumar Singhal, Suresh Kumar Kailasa
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Chemistry, Analytical
Shraddha Borse, Z. V. P. Murthy, Tae-Jung Park, Suresh Kumar Kailasa
Summary: A facile one-step green route was introduced for the synthesis of pepsin protected ultra-small blue fluorescent copper nanoclusters for the detection of flutamide and chloramphenicol drugs. The prepared pepsin-CuNCs showed specific fluorescence quenching when in contact with the target drugs, providing a simple analytical protocol for their identification. The method offers detection limits of 61.82 and 188.32 nM for flutamide and chloramphenicol, respectively, in pharmaceutical compositions, biofluids, and water samples.
MICROCHEMICAL JOURNAL
(2021)
Review
Chemistry, Analytical
Suresh Kumar Kailasa, Janardhan Reddy Koduru, Tae Jung Park, Rakesh Kumar Singhal, Hui-Fen Wu
Summary: SDME is recognized as a simple miniaturized sample preparation tool for the isolation and preconcentration of various analytes from complex sample matrices. The use of nanoparticles in SDME enables rapid analysis of trace-level target analytes. Introduction of new extracting solvent systems like ionic liquids, deep eutectic solvents, and SUPRAS improves the selectivity and sensitivity of various analytical techniques towards analytes.
TRENDS IN ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Electrical & Electronic
Vishal Dhavle, Mehul R. Kateshiya, Tae-Jung Park, Suresh Kumar Kailasa
Summary: The colorimetric assay using GSH-Lac-Ag NPs prepared by functionalizing the surface allows rapid and sensitive detection of thiram in real samples, showing high selectivity and suitability for on-site testing.
JOURNAL OF ELECTRONIC MATERIALS
(2021)
Article
Chemistry, Physical
Soujanya Akavaram, Mittal L. Desai, Tae-Jung Park, Z. V. P. Murthy, Suresh Kumar Kailsa
Summary: In this study, gold-silver bimetallic nanoclusters were synthesized using trypsin as a ligand, showing high fluorescence intensity and potential applications in detecting multiple pollutants. The trypsin-decorated Au-Ag NCs were successfully used as probes for fluorescence turn-off for quinalphos and turn-on for Cd2+ and Zn2+ ions, with detection limits at nanomolar concentration. This work provides a new analytical strategy for detecting pollutants and has been validated in food and environmental samples.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Analytical
Jigna R. Bhamore, Anam Rana Gul, Suresh Kumar Kailasa, Kyoung-Woong Kim, Jin Soo Lee, Heewon Park, Tae Jung Park
Summary: A facile, selective, and sensitive optical method based on guanidine thiocyanate (GT)-functionalized gold nanoparticles (AuNPs) has been developed for the quantification of Cd2+ in environmental water samples. The method utilizes the surface plasmon resonance properties of AuNPs to selectively detect Cd2+ by forming a stable complex with GT. The interaction between Cd2+ and GT-AuNPs results in aggregation of the nanoparticles, causing a detectable color change visible to the naked eye and by UV-vis spectroscopy.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Environmental Sciences
Subhadeep Ghosh, Anam Rana Gul, Chan Yeong Park, Min Woo Kim, Ping Xu, Seung Hoon Baek, Jigna R. Bhamore, Suresh Kumar Kailasa, Tae Jung Park
Summary: A convenient one-pot synthetic route for the fabrication of carbon dots TEF-CDs from Tagetes erecta flower was developed, showing high selectivity towards chlorpyrifos and quinalphos as fluorescent probes. The synthesized CDs exhibited strong blue fluorescence, a high quantum yield, and were mainly composed of C, O, and N. Furthermore, the TEF-CDs-based fluorescent nanoprobe showed effective accuracy in estimating chlorpyrifos and quinalphos in rice and fruit samples with rapid detection time.
Article
Chemistry, Analytical
Subhadeep Ghosh, Anam Rana Gul, Chan Yeong Park, Ping Xu, Seung Hoon Baek, Jigna R. Bhamore, Min Woo Kim, Min Lee, Suresh Kumar Kailasa, Tae Jung Park
Summary: This study successfully synthesized carbon dots with high quantum yield and excitation-dependent emission spectra from Calotropis procera leaves through hydrothermal carbonization. The CDs exhibited robust fluorescence performance without requiring surface modifications and showed good fluorescence intensity under different pH conditions.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Organic
Amit B. Patel, Jignesh Rohit
Summary: 1,3,4-thiadiazole and piperazine substituted quinazoline derivatives were synthesized and tested for their antimycobacterial activity in vitro. The bromo, trifluoromethyl, and hydroxy substituted analogs showed strong efficacy in the range of 3.12-6.25 μg/mL.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Review
Chemistry, Analytical
Vaibhavkumar N. Mehta, Nirav Ghinaiya, Jigneshkumar Rohit, Rakesh Kumar Singhal, Hirakendu Basu, Suresh Kumar Kailasa
Summary: Metal nanoparticles have shown significant potential in enhancing the sensitivity of UV -Visible spectrometry and can be used for miniaturized colorimetric assay of various molecules. The interaction between metal nanoparticles and trace level pesticides can induce aggregation and cause noticeable color changes. This review summarizes the role of ligand chemistry on metal nanoparticles for colorimetric detection of pesticides and discusses the challenges and future perspectives.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Humairah Tabasum, Basharat A. Bhat, Bashir A. Sheikh, Vaibhavkumar N. Mehta, Jigneshkumar V. Rohit
Summary: This article discusses the current issue of antimicrobial resistance, introduces the application of plant-derived nanoparticles in the medical field, and summarizes aspects such as synthesis, medical applicability, challenges, and potential solutions.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Chemistry, Analytical
Suresh Kumar Kailasa, Vaibhavkumar N. Mehta, Janardhan Reddy Koduru, Hirakendu Basu, Rakesh Kumar Singhal, Z. V. P. Murthy, Tae-Jung Park
Summary: This article discusses the use of molecular biology tools and nanotechnology-based analytical tools in the diagnosis of COVID-19, focusing on the rapid screening and accurate detection of 2019-nCoV. These tools play a crucial role in minimizing local transmission and preventing an epidemic.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
