Journal
SENSORS
Volume 17, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/s17122760
Keywords
flexural plate-wave; tetrahydrocannabinol; circular-type interdigital transducer; reflective grating structure; low insertion loss; field-programmable gate array; readout system
Funding
- Ministry of Science and Technology [MOST 105-2622-E-006-018-CC2, MOST 105-2218-E-110-006, MOST 105-2221-E-110-080, MOST 104-2622-E-006-040-CC2]
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This paper presents a highly sensitive flexural plate-wave (FPW)-based microsystem for rapid detection of tetrahydrocannabinol (THC) in human urine. First, a circular-type interdigital transducer (IDT) was integrated with a circular-type silicon-grooved reflective grating structure (RGS) to reduce insertion loss. Then, with lower insertion loss (-38.758 dB), the FPW device was used to develop a novel THC biosensor, and the results reveal that this FPW-THC biosensor has low detection limit (1.5625 ng/mL) and high mass-sensitivity (126.67 cm(2)/g). Finally, this biosensor was integrated with field-programmable gate array (FPGA) board and discrete components for prototyping a FPW readout system, whose maximum error was 12.378 kHz to ensure that the linearity of detection up to R-square is equal to 0.9992.
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