Review
Chemistry, Analytical
Mahmoud A. Hefnawy, Sahar A. Fadlallah, Rabab M. El-Sherif, Shymaa S. Medany
Summary: Cholesterol is a crucial component in animal bodies, necessary for hormone production and creating vitamin D. High blood cholesterol levels increase the risk of heart disease, making clinical diagnosis of cholesterol concentration vital for human healthcare. Electrochemical sensors offer high accuracy for detecting cholesterol in biological fluids and this review compares enzymatic and non-enzymatic techniques for electrochemical sensing. The article discusses recent progress in electrochemical determination of cholesterol using various materials, such as metal composites, carbonaceous materials, ionic liquid crystals, and polymers, as well as different sensing methods.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Electrochemistry
Junhao Chen, Azadeh Nilghaz, Xinyu Chen, Shan Liu, Junfei Tian
Summary: This study presents a novel strategy for fabricating a third-generation glucose sensor on a screen-printed carbon electrode (SPCE). The direct electron transfer (DET) between glucose oxidase (GOx) and SPCE was achieved by immobilizing GOx in poly (3,4-ethylenedioxythiophene) (PEDOT) functionalized electrodes. This strategy eliminates the need for a mediated agent and shows high electrochemical responses of glucose in human blood plasma.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Haocheng Yin, Chao Tan, Shabnam Siddiqui, Prabhu U. Arumugam
Summary: We have successfully fabricated and characterized concentric gold nanoring electrodes (Au NREs) using a microfabrication technique. The Au NREs were patterned on a silicon micropillar tip with an insulating layer, resulting in excellent cylindricality and intact concentric Au NREs. The electrochemical behavior of the Au NREs was studied and their applicability to electrochemical sensing was demonstrated through redox cycling. This micro-nanofabrication approach shows great promise for creating and expanding 3D NRE arrays for various electroanalytical applications.
Article
Chemistry, Analytical
Kentaro Ito, Kumi Y. Inoue, Takahiro Ito-Sasaki, Miho Ikegawa, Shinichiro Takano, Kosuke Ino, Hitoshi Shiku
Summary: In this study, we developed an electrochemical endotoxin sensor using an interdigitated array electrode (IDAE) device. The IDAE device showed high redox cycling efficiency and signal amplification rate. The sensor successfully detected p-aminophenol (pAP) released from Boc-Leu-Gly-Arg-p-aminophenol (LGR-pAP) as a product of an endotoxin-induced LAL reaction. The sensor could detect as low as 0.7 and 1.0 endotoxin unit/L after the LAL reaction for 1 h and 45 min, respectively, and these values were within the cut-off range for ultrapure dialysis fluid. Therefore, the highly sensitive endotoxin sensor is useful for ensuring medical safety.
Article
Chemistry, Analytical
Sevki Furkan Kucukayar, Veli Simsek, Mustafa Oguzhan Caglayan, Zafer Ustundag, Samet Sahin
Summary: In this study, carbonaceous materials were synthesized from typha tassel (TT) and pussy willow (PW) as biomass sources for enzymatic electrode modification. Different immobilization strategies using the carbonized TT (CTT) and PW (CPW) together with glucose oxidase (GOx), ferrocene (Fc), and Chitosan (Chit) were investigated. The results showed that Chit could preserve the activity of GOx, and when Fc was co-immobilized with GOx, better performance was achieved. The prepared electrodes demonstrated promising results for glucose biosensing. This study provides a comprehensive investigation of different immobilization strategies of GOx on carbonaceous electrodes and explores the potential use of biomass materials in bioelectronics approaches.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Physical
Sergey Yu. Luchkin, Maria A. Kirsanova, Dmitry A. Aksyonov, Svetlana A. Lipovskikh, Victoria A. Nikitina, Artem M. Abakumov, Keith J. Stevenson
Summary: Li-rich layered metal oxides have been extensively studied as potential positive electrode materials for Li-ion batteries. This research investigates the cycling-driven electrochemical activation process in Li-rich materials, which leads to an increase in reversible capacity. The activation process involves oxidation and reduction reactions, with the rate being influenced by the cycling rate.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Electrochemistry
Tali Dotan, Michael Nazarenko, Yuval Atiya, Yosi Shacham-Diamand
Summary: We conducted a study on the transport effects of a microfluidic sensor-chip, where electrochemical sensing is enhanced by redox cycling using an interdigitated electrode array (IDA). We developed a comprehensive three-dimensional simulation model and a simple one-dimensional model to analyze the transition velocity between the two dominant regimes. The results show that one regime is limited by redox cycling diffusion (a unique feature of IDAs), while the other regime is limited by convection and has significant flow effects. The transition velocity between the two regimes is found to be vflow = 0.335 L[mu m] + 0.04, which matches the prediction of the one-dimensional model that vflow is proportional to 1/L.
ELECTROCHIMICA ACTA
(2023)
Article
Electrochemistry
Navaneeth Punnakkal, Jeethu Raveendran, Suneesh Punathil Vasu, Bipin G. Nair, T. G. Satheesh Babu
Summary: The electrochemical detection of cholesterol was carried out using pencil lead electrode in acetonitrile and acetone solution with lithium perchlorate. The PLE exhibited a wide linear detection range and high sensitivity, with high specificity to cholesterol in the presence of interfering biomolecules. Calibration plots for real samples showed a highly linear response in both serum and skin cholesterol samples.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Tatjana Safarik, Aleksandar Karajic, Stephane Reculusa, Philip N. Bartlett, Nicolas Mano, Alexander Kuhn
Summary: This study reports the electrochemical elaboration and characterization of a 3D coaxial macroporous twin-electrode, which is obtained by a low-cost bottom-up approach using nanoengineered highly organized porous material. The resulting electrode architecture allows for signal amplification in electroanalytical measurements and has potential applications in various (bio)electroanalytical fields.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Stanislav Trashin, Francisco Morales-Yanez, Saranya Thiruvottriyur Shanmugam, Linda Paredis, Erik N. Carrion, Idalia Sariego, Serge Muyldermans, Katja Polman, Sergiu M. Gorun, Karolien De Wael
Summary: A new method for detecting the antigen marker of human toxocariasis is proposed, utilizing a rapid sandwich immunoassay sensor that achieves high sensitivity to pg/mL levels through a redox cycle involving photocatalytic oxidation and electrochemical reduction steps.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xiang He, Michael S. Eberhart, Alex B. F. Martinson, David M. Tiede, Karen L. Mulfort
Summary: The study found that surface functionalization of metal oxides with a Ru(II)poly(pyridyl) complex can create hybrid assemblies with optimized electrochemical performance for water remediation. This approach effectively suppresses the formation of hydroxyl radicals and inhibits the competing side reaction of water splitting.
Article
Chemistry, Analytical
Oana Elena Carp, Mariana Pinteala, Adina Arvinte
Summary: This study explores the use of the Liebermann-Burchard reaction for quantitative electrochemical analysis of cholesterol. By optimizing factors such as applied potential and acidic volume, a method with high sensitivity, low detection limit, and good linearity was developed. The method showed minimal interference from bioactive substances such as glucose, uric acid, ascorbic acid, KCl, and NaCl. Ultimately, the optimized method was successfully applied to the determination of cholesterol content in real blood samples.
Article
Chemistry, Applied
Satyajit Das, Partha Pratim Sahu
Summary: A novel interdigitated capacitive sensor was introduced for the detection and debittering of limonin. The sensor showed high sensitivity and fast response time, allowing for both quantification and measurement of the debittering effect of citrus juice. The results of the sensor were validated and it proved to be a distinctive and promising device for on-site and rapid quantification and reduction of limonin content in citrus juices without toxicity.
Review
Chemistry, Multidisciplinary
Nianjun Yang, Siyu Yu, Wenjun Zhang, Hui-Ming Cheng, Patrice Simon, Xin Jiang
Summary: This study introduces a method to improve the energy density of electrochemical capacitors (ECs) by using confined soluble redox electrolytes and porous electrodes. The method utilizes the diffusion-controlled faradaic processes of confined redox electrolytes at the surface of a porous electrode, combining the high power densities of ECs and high energy densities of batteries. Significant progress has been made in this field, and strategies to improve performance are highlighted.
ADVANCED MATERIALS
(2022)
Review
Biochemical Research Methods
Yoo Seok Lee, Rokas Gerulskis, Shelley D. Minteer
Summary: This review summarizes non-enzymatic and enzymatic electrochemical approaches for cofactor regeneration and discusses recent developments to solve major issues. Issues discussed include enzyme mutual inactivation, electron transfer rates, catalyst sustainability, product selectivity, and simplifying product purification. Recently reported remedies include heterogeneous metal catalysts and redox-polymer immobilized enzymatic systems.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Yeong Min Kwon, Hee-Jun Kim, Bora Ye, Hong-Dae Kim, Yun Sik Lee, Heungjoo Shin, Jeong Min Baik
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Chemistry, Analytical
Jongmin Lee, Soosung Kim, Heungjoo Shin
Summary: This study develops a highly sensitive electrochemical heavy metal sensor based on hierarchical porous carbon electrodes, which can detect Cd(II) and Pb(II) at low concentrations. The hierarchical porous structure and sub-micrometer edges of the nanoporous carbon electrodes contribute to the enhanced performance of the sensor.
Article
Engineering, Electrical & Electronic
Subin Choi, Chan Sam Park, Hee Young Chae, Byungjoo Oh, Jongmin Lee, Yeong Min Kwon, Jeong Min Baik, Heungjoo Shin, Jae Joon Kim
Summary: This study introduces a wide-dynamic-range multi-sensor readout interface for portable environmental monitoring systems, optimizing current and resistance detection performance through two-step self-optimization. The ROIC prototype, fabricated in a 180-nm CMOS process, achieves high dynamic range and signal-to-noise ratio, successfully supporting wireless air quality and water pollution monitoring.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
(2021)
Article
Chemistry, Analytical
Taejung Kim, Seungwook Lee, Wootaek Cho, Yeong-Min Kwon, Jeong-Min Baik, Heungjoo Shin
Summary: The suspended network of longitudinally connected NW junctions in the ZnO gas sensor platform enhances gas response, sensitivity, and lower limit of detection compared to sensors consisting of only laterally connected NWs. Additionally, the complete sensor structures can be cost-effectively fabricated using batch fabrication processes.
Review
Chemistry, Multidisciplinary
Rahul Sharma, Deepti Sharma, Linda D. Hazlett, Nikhlesh K. Singh
Summary: Nanoscience and nanotechnology have revolutionized environmental sciences, particularly in the field of ocular tissue engineering and regenerative ophthalmology. The use of innovative nanomaterials offers promising prospects for improving eye health, but there are challenges and future directions that should be considered for further development in this area.
Article
Biochemistry & Molecular Biology
Suresh Govatati, Prahalathan Pichavaram, Arul M. Mani, Raj Kumar, Deepti Sharma, Ari Dienel, Sunita Meena, Michelle A. Puchowicz, Edwards A. Park, Gadiparthi N. Rao
Summary: The study revealed the significant role of 12/15-LOX in high-fat diet-induced weight gain by influencing lipid synthesis and transport, leading to white adipose tissue expansion and increased weight. Modulation of 12/15-LOX metabolism could serve as a potential therapeutic target for weight gain and obesity.
Meeting Abstract
Biochemistry & Molecular Biology
Deepti Sharma, Shivantika Bisen, Geetika Kaur, Nikhlesh K. Singh
Meeting Abstract
Biochemistry & Molecular Biology
Geetika Kaur, Shivantika Bisen, Deepti Sharma, Nikhlesh K. Singh
Article
Biology
Deepti Sharma, Shivantika Bisen, Geetika Kaur, Eric C. Van Buren, Gadiparthi N. Rao, Nikhlesh K. Singh
Summary: This study discovered that genetic deletion or siRNA-mediated downregulation of IL-33 can reduce pathological neovascularization in a mouse model of oxygen-induced retinopathy without affecting normal retinal repair. It was also found that IL-33 induces angiogenesis through the NFkappaB-Jagged1-Notch1 signaling pathway. Additionally, IL-33 interacts with BRCA1-associated protein 1 (BAP1) and Numb to enhance the de-ubiquitination and stabilization of Notch1 intracellular domain.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Analytical
Wootaek Cho, Taejung Kim, Heungjoo Shin
Summary: In this study, an ultralow-power thermal conductivity detector (TCD) was developed using cost-effective technology. The TCD showed high sensitivity and ultrafast response/recovery by optimizing the nanoheater's aspect ratio and employing a suspended architecture. The sensor exhibited a linear gas response and reduced power consumption through pulse-width modulation.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Taejung Kim, Wootaek Cho, Beomsang Kim, Junyeong Yeom, Yeong Min Kwon, Jeong Min Baik, Jae Joon Kim, Heungjoo Shin
Summary: There is an increasing demand for power-efficient micro and nanodevices, and electrothermal nanowire-based heaters have emerged as promising solutions. This article demonstrates a method for producing a 1D nanoheater without complex fabrication processes, and showcases its application in a portable gas sensor system. The developed nanoheater offers superior performance in terms of low power consumption and reliable gas detection.
Article
Cell Biology
Deepti Sharma, Geetika Kaur, Shivantika Bisen, Anamika Sharma, Ahmed S. Ibrahim, Nikhlesh K. Singh
Summary: Angiogenesis, neovascularization, and vascular remodeling are dynamic processes controlled by endothelial cell-cell adhesion within blood vessel walls. The role of cadherins and catenins in maintaining the integrity and function of the inner blood-retinal barrier (iBRB) is not fully understood. This study investigates the significance of IL-33 in retinal endothelial barrier disruption, abnormal angiogenesis, and increased vascular permeability. Results show that IL-33 induces endothelial-barrier disruption and phosphorylation of alpha-catenin in retinal endothelial cells, which is regulated by PKC mu/PRKD1-p38 MAPK signaling. Genetic deletion of IL-33 reduces vascular leakage and signaling in the hypoxic retina. Overall, IL-33-induced PKC mu/PRKD1-p38 MAPK-alpha-catenin signaling plays a significant role in endothelial permeability and iBRB integrity.
Meeting Abstract
Ophthalmology
Geetika Kaur, Shivantika Bisen, Deepti Sharma, Nikhlesh K. Singh
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Electrochemistry
Shalik Ram Joshi, Beomsang Kim, Shin-Kwan Kim, Gun-Ho Kim, Wonho Song, Kibog Park, Heungjoo Shin
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2020)
Article
Chemistry, Physical
Rahul Purbia, Yeong Min Kwon, Hong-Dae Kim, Yun Sik Lee, Heungjoo Shin, Jeong Min Baik
JOURNAL OF MATERIALS CHEMISTRY A
(2020)