Journal
SEMINARS IN PEDIATRIC SURGERY
Volume 26, Issue 5, Pages 322-327Publisher
ELSEVIER SCIENCE INC
DOI: 10.1053/j.sempedsurg.2017.09.008
Keywords
Hirschsprung disease; Fecal incontinence; Constipation; Soiling; Bowel function; Quality of life
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Hirschsprung disease is a developmental defect of the enteric nervous system characterized by lack of enteric neurons in the distal hindgut. There are numerous reports on short-term outcomes indicating that impaired bowel function is common. Recently, several controlled studies show that bowel function outcomes are affected beyond childhood, in adolescents and adults, compared with healthy control subjects. Constipation and fecal incontinence are common. The impaired bowel function appears to have a negative impact on quality of life, although, a majority of patients have adapted to their symptoms. On the other hand, Hirschsprung disease seems to have limited impact on education and occupation in adult life. The aim of this review was to summarize current knowledge of bowel function outcome beyond childhood in patients with Hirschsprung disease. (C) 2017 Elsevier Inc. All rights reserved.
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