Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 81, Issue -, Pages 13-20Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.10.018
Keywords
Polarity complexes; Cell polarity; Cell migration; Cytoskeleton
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Funding
- labex INFORM [ANR-11-LABX-0054]
- ANR grant Ghearact [14-CE13-0013]
- CNRS
- Aix-Marseille University
- La Ligue Nationale contre le Cancer
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Epithelial cell organization relies on a set of proteins that interact in an intricate way and which are called polarity complexes. These complexes are involved in the determination of the apico-basal axis and in the positioning and stability of the cell-cell junctions called adherens junctions at the apico-lateral border in invertebrates. Among the polarity complexes, two are present at the apical side of epithelial cells. These are the Par complex including aPKC, PAR3 and PAR6 and the Crumbs complex including, CRUMBS, PALS1 and PATJ/MUPP1. These two complexes interact directly and in addition to their already well described functions, they play a role in other cellular processes such as ciliogenesis and polarized cell migration. In this review, we will focus on these aspects that involve the apical Crumbs polarity complex and its relation with the cortical actin cytoskeleton which might provide a more comprehensive hypothesis to explain the many facets of Crumbs cell and tissue properties. (C) 2017 Elsevier Ltd. All rights reserved .
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