Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 72, Issue -, Pages 133-141Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.07.026
Keywords
Pore-forming toxins; Cnidaria; Actinoporins; Aerolysin-like proteins; MACPF/CDC toxins; Cry-like toxins
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Funding
- Slovenian Research Agency [P1-0391]
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The ancient phylum of Cnidaria contains many aquatic species with peculiar lifestyle. In order to survive, these organisms have evolved attack and defense mechanisms that are enabled by specialized cells and highly developed venoms. Pore-forming toxins are an important part of their venomous arsenal. Along some other types, the most representative are examples of four protein families that are commonly found in other kingdoms of life: actinoporins, Cry-like proteins, aerolysin-like toxins and MACPF/CDC toxins. Some of the homologues of pore-forming toxins may serve other functions, such as in food digestion, development and response against pathogenic organisms. Due to their interesting physicochemical properties, the cnidarian pore-forming toxins may also serve as tools in medical research and nanobiotechnological applications. (C) 2017 Elsevier Ltd. All rights reserved.
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