Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 81, Issue -, Pages 2-12Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.07.032
Keywords
Cadherin; Cell-cell adhesion; Junctional adhesion molecule (JAM); Cell polarity; Planar cell polarity
Categories
Funding
- German Research Foundation [EB 160/4-2, EB 160/5-1, EXC-1003 FF-2016-01, MA 6726/1-1, EXC-1003 FF-2015-07]
- Medical Faculty of the University Munster [IZKF Eb2/020/14, Mat2/019/16]
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The ability of cells to polarize is an intrinsic property of almost all cells and is required for the devlopment of most multicellular organisms. To develop cell polarity, cells integrate various signals derived from intrinsic as well as extrinsic sources. In the recent years, cell-cell adhesion receptors have turned out as important regulators of cellular polarization. By interacting with conserved cell polarity proteins, they regulate the recruitment of polarity complexes to specific sites of cell-cell adhesion. By initiating intracellular signaling cascades at those sites, they trigger their specific subcellular activation. Not surprisingly, cell-cell adhesion receptors regulate diverse aspects of cell polarity, including apico-basal polarity in epithelial and endothelial cells, front-to-rear polarity in collectively migrating cells, and planar cell polarity during organ development. Here, we review the recent developments highlighting the central roles of cell-cell adhesion molecules in the development of cell polarity. (C) 2017 Elsevier Ltd. All rights reserved.
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