New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability

Clostridium difficile infection

(2016) Wiep Klaas Smits et al.   Nature Reviews Disease Primers

Bacteriophage Combinations Significantly Reduce Clostridium difficile GrowthIn Vitroand ProliferationIn Vivo

(2015) Janet Y. Nale et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The gut microbiota and host health: a new clinical frontier

(2015) Julian R Marchesi et al.   GUT

Cyclic diGMP Regulates Production of Sortase Substrates ofClostridium difficileand Their Surface Exposure through ZmpI Protease-mediated Cleavage

(2015) Johann Peltier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clostridium difficilesurface proteins are anchored to the cell wall using CWB2 motifs that recognise the anionic polymer PSII

(2015) Stephanie E. Willing et al.   MOLECULAR MICROBIOLOGY

Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states

(2015) Peng Ge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Burden of Clostridium difficile Infection in the United States

(2015) Fernanda C. Lessa et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-Throughput Analysis of Gene Essentiality and Sporulation in Clostridium difficile

(2015) Marcin Dembek et al.   mBio

A Modified R-Type Bacteriocin Specifically Targeting Clostridium difficile Prevents Colonization of Mice without Affecting Gut Microbiota Diversity

(2015) Dana Gebhart et al.   mBio

Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states

(2015) Peng Ge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of Temperate Phages Infecting Clostridium difficile Isolates of Human and Animal Origins

(2014) Ognjen Sekulovic et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Clostridium difficile Extracytoplasmic Function   Factor  V Regulates Lysozyme Resistance and Is Necessary for Pathogenesis in the Hamster Model of Infection

(2014) T. D. Ho et al.   INFECTION AND IMMUNITY

Identification and Characterization of a Gene Cluster Required for Proper Rod Shape, Cell Division, and Pathogenesis in Clostridium difficile

(2014) E. M. Ransom et al.   JOURNAL OF BACTERIOLOGY

Identification and Characterization of Glycoproteins on the Spore Surface of Clostridium difficile

(2014) P. C. R. Strong et al.   JOURNAL OF BACTERIOLOGY

Targeting virulence: can we make evolution-proof drugs?

(2014) Richard C. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Biogenesis and functions of bacterial S-layers

(2014) Robert P. Fagan et al.   NATURE REVIEWS MICROBIOLOGY

Clostridium difficile spore biology: sporulation, germination, and spore structural proteins

(2014) Daniel Paredes-Sabja et al.   TRENDS IN MICROBIOLOGY

Genetic Evidence for the Involvement of the S-Layer Protein Gene sap and the Sporulation Genes spo0A, spo0B, and spo0F in Phage AP50c Infection of Bacillus anthracis

(2013) R. D. Plaut et al.   JOURNAL OF BACTERIOLOGY

The Clostridium difficile Exosporium Cysteine (CdeC)-Rich Protein Is Required for Exosporium Morphogenesis and Coat Assembly

(2013) J. Barra-Carrasco et al.   JOURNAL OF BACTERIOLOGY

Revenge of the phages: defeating bacterial defences

(2013) Julie E. Samson et al.   NATURE REVIEWS MICROBIOLOGY

Surface-Layer Protein A (SlpA) Is a Major Contributor to Host-Cell Adherence of Clostridium difficile

(2013) Michelle M. Merrigan et al.   PLoS One

TheClostridium difficile spo0AGene Is a Persistence and Transmission Factor

(2012) Laura J. Deakin et al.   INFECTION AND IMMUNITY

Novel High-Molecular-Weight, R-Type Bacteriocins of Clostridium difficile

(2012) D. Gebhart et al.   JOURNAL OF BACTERIOLOGY

Recombinational Switching of the Clostridium difficile S-Layer and a Novel Glycosylation Gene Cluster Revealed by Large-Scale Whole-Genome Sequencing

(2012) Kate E. Dingle et al.   JOURNAL OF INFECTIOUS DISEASES

Genome Sequence of E. coli O104:H4 Leads to Rapid Development of a Targeted Antimicrobial Agent against This Emerging Pathogen

(2012) Dean Scholl et al.   PLoS One

An Escherichia coli O157-Specific Engineered Pyocin Prevents and Ameliorates Infection by E. coli O157:H7 in an Animal Model of Diarrheal Disease

(2011) Jennifer M. Ritchie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clostridium difficileHas Two Parallel and Essential Sec Secretion Systems

(2011) Robert P. Fagan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Infection of hamsters with the UK Clostridium difficile ribotype 027 outbreak strain R20291

(2011) A. M. Buckley et al.   JOURNAL OF MEDICAL MICROBIOLOGY

A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins

(2011) Anthony Ryan et al.   PLoS Pathogens

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

An Engineered R-Type Pyocin Is a Highly Specific and Sensitive Bactericidal Agent for the Food-Borne Pathogen Escherichia coli O157:H7

(2009) D. Scholl et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural insights into the molecular organization of the S-layer fromClostridium difficile

(2009) Robert P. Fagan et al.   MOLECULAR MICROBIOLOGY

Retargeting R-Type Pyocins To Generate Novel Bactericidal Protein Complexes

(2008) S. R. Williams et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Capsule polysaccharide is a bacterial decoy for antimicrobial peptides

(2008) E. Llobet et al.   MICROBIOLOGY-SGM