Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors
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Title
Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors
Authors
Keywords
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Journal
Science Translational Medicine
Volume 9, Issue 414, Pages eaam9078
Publisher
American Association for the Advancement of Science (AAAS)
Online
2017-11-02
DOI
10.1126/scitranslmed.aam9078
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Note: Only part of the references are listed.- DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH)
- (2017) Michael G. Kemp JOURNAL OF BIOLOGICAL CHEMISTRY
- AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells
- (2017) Ahrum Min et al. MOLECULAR CANCER THERAPEUTICS
- Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer
- (2017) Di Zhao et al. NATURE
- PGBD5 promotes site-specific oncogenic mutations in human tumors
- (2017) Anton G Henssen et al. NATURE GENETICS
- PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma
- (2017) V Colicchia et al. ONCOGENE
- CHK1 as a therapeutic target to bypass chemoresistance in AML
- (2016) Laure David et al. Science Signaling
- Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models ofMLL-rearranged AML
- (2016) Isabel Morgado-Palacin et al. Science Signaling
- Efficacy of ATR inhibitors as single agents in Ewing sarcoma
- (2016) Maria Nieto-Soler et al. Oncotarget
- CHK1 as a therapeutic target to bypass chemoresistance in AML
- (2016) Laure David et al. Science Signaling
- Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models ofMLL-rearranged AML
- (2016) Isabel Morgado-Palacin et al. Science Signaling
- ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells
- (2015) M. Kwok et al. BLOOD
- Molecular Pathways: Targeting ATR in Cancer Therapy
- (2015) L. M. Karnitz et al. CLINICAL CANCER RESEARCH
- Drugging ATR: progress in the development of specific inhibitors for the treatment of cancer
- (2015) Kevin M Foote et al. Future Medicinal Chemistry
- Synthetic lethality in chronic lymphocytic leukaemia with DNA damage response defects by targeting the ATR pathway
- (2015) Marwan Kwok et al. LANCET
- Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma
- (2015) Erika A. Newman et al. MOLECULAR CANCER RESEARCH
- Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors
- (2015) R. L. Flynn et al. SCIENCE
- PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1
- (2015) Chiara Giorgi et al. Oncotarget
- Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition
- (2015) Fiona K. Middleton et al. Oncotarget
- The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo
- (2015) Frank P. Vendetti et al. Oncotarget
- Machine-based method for multiplex in situ molecular characterization of tissues by immunofluorescence detection
- (2015) Dmitry Yarilin et al. Scientific Reports
- Genomic DNA transposition induced by human PGBD5
- (2015) Anton G Henssen et al. eLife
- A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments
- (2015) Kareem N. Mohni et al. PLoS One
- ATR Pathway Inhibition Is Synthetically Lethal in Cancer Cells with ERCC1 Deficiency
- (2014) K. N. Mohni et al. CANCER RESEARCH
- Cisplatin in cancer therapy: Molecular mechanisms of action
- (2014) Shaloam Dasari et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Platinum compounds in children with cancer
- (2013) Antonio Ruggiero et al. ANTI-CANCER DRUGS
- Rhabdoid Tumors: An Initial Clue to the Role of Chromatin Remodeling in Cancer
- (2013) Ryan S. Lee et al. BRAIN PATHOLOGY
- Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity
- (2013) Kevin M. Foote et al. JOURNAL OF MEDICINAL CHEMISTRY
- Current and Future Strategies for Relapsed Neuroblastoma
- (2013) Daniel A. Morgenstern et al. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
- ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage
- (2013) Armin M. Gamper et al. NUCLEIC ACIDS RESEARCH
- DNA Damage Sensing by the ATM and ATR Kinases
- (2013) A. Marechal et al. Cold Spring Harbor Perspectives in Biology
- An Animal Model of MYC-Driven Medulloblastoma
- (2012) Yanxin Pei et al. CANCER CELL
- HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment
- (2012) Till Milde et al. JOURNAL OF NEURO-ONCOLOGY
- Novel mutations target distinct subgroups of medulloblastoma
- (2012) Giles Robinson et al. NATURE
- Passenger deletions generate therapeutic vulnerabilities in cancer
- (2012) Florian L. Muller et al. NATURE
- Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia
- (2012) Alex Kentsis et al. NATURE MEDICINE
- Paracrine Signaling Through MYCN Enhances Tumor-Vascular Interactions in Neuroblastoma
- (2012) Y. H. Chanthery et al. Science Translational Medicine
- Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation
- (2012) E Fokas et al. Cell Death & Disease
- Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents
- (2011) Jean-Damien Charrier et al. JOURNAL OF MEDICINAL CHEMISTRY
- Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
- (2011) Philip M Reaper et al. Nature Chemical Biology
- Challenging issues in pediatric oncology
- (2011) Ching-Hon Pui et al. Nature Reviews Clinical Oncology
- A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
- (2011) Luis I Toledo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
- (2010) Michael R. Lieber Annual Review of Biochemistry
- A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability
- (2010) Brenda C. O'Connell et al. MOLECULAR CELL
- A minority of foci or pan-nuclear apoptotic staining of H2AX in the S phase after UV damage contain DNA double-strand breaks
- (2010) S. de Feraudy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
- (2009) Andrea Beucher et al. EMBO JOURNAL
- Dose-Intensified Compared With Standard Chemotherapy for Nonmetastatic Ewing Sarcoma Family of Tumors: A Children's Oncology Group Study
- (2009) Linda Granowetter et al. JOURNAL OF CLINICAL ONCOLOGY
- Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
- (2009) S. E. Golding et al. MOLECULAR CANCER THERAPEUTICS
- A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
- (2009) Matilde Murga et al. NATURE GENETICS
- Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers
- (2009) Peter C. Fong et al. NEW ENGLAND JOURNAL OF MEDICINE
- Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells
- (2008) J SCHULTE et al. DNA REPAIR
- AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
- (2008) S. D. Zabludoff et al. MOLECULAR CANCER THERAPEUTICS
- ATR: an essential regulator of genome integrity
- (2008) Karlene A. Cimprich et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Complementary functions of ATM and H2AX in development and suppression of genomic instability
- (2008) S. Zha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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