4.8 Correction

Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance (vol 9, eaan3788, 2017)

Journal

SCIENCE TRANSLATIONAL MEDICINE
Volume 9, Issue 385, Pages -

Publisher

AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.aan3788

Keywords

-

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Review Oncology

Sentinel Lymph Node Biopsy for Extremity and Truncal Soft Tissue Sarcomas: A Systematic Review of the Literature

Emily Z. Keung, Kate J. Krause, Jessica Maxwell, Carol D. Morris, Aimee M. Crago, Matthew T. Houdek, John Kane, Valerae Lewis, Dario Callegaro, Benjamin Miller, Alexander J. Lazar, Rebecca Gladdy, Chandrajit P. Raut, Nicola Fabbri, Waddah Al-Refaie, Mark Fairweather, Sandra L. Wong, Christina L. Roland

Summary: Regional lymph node metastasis (RLNM) is uncommon in patients with soft tissue sarcoma (STS), although certain STS subtypes are more prone to RLNM. The impact of node-positive disease on patient survival is still controversial. There is ongoing debate about the benefits of sentinel lymph node biopsy (SLNB) in STS patients. Further multicenter prospective studies are needed to determine the true incidence and potential benefits of SLNB in patients with clinically occult RLNM.

ANNALS OF SURGICAL ONCOLOGY (2023)

Article Oncology

Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma

Andrew W. Hahn, Ashley Menk, Dayana B. Rivadeneira, Ryan C. Augustin, Mingchu Xu, Jun Li, Xiaogang Wu, Aditya K. Mishra, Tuba N. Gide, Camelia Quek, Yan Zang, Christine N. Spencer, Alexander M. Menzies, Carrie R. Daniel, Courtney W. Hudgens, Theodore Nowicki, Lauren E. Haydu, M. A. Wadud Khan, Vancheswaran Gopalakrishnan, Elizabeth M. Burton, Jared Malke, Julie M. Simon, Chantale Bernatchez, Nagireddy Putluri, Scott E. Woodman, Y. N. Vashisht Gopal, Renato Guerrieri, Grant M. Fischer, Jian Wang, Khalida M. Wani, John F. Thompson, Jeffrey E. Lee, Patrick Hwu, Nadim Ajami, Jeffrey E. Gershenwald, Georgina Long, Richard A. Scolyer, Michael T. Tetzlaff, Alexander J. Lazar, Dirk Schadendorf, Jennifer A. Wargo, John M. Kirkwood, Ralph J. DeBerardinis, Han Liang, Andrew Futreal, Jianhua Zhang, James S. Wilmott, Weiyi Peng, Michael A. Davies, Greg M. Delgoffe, Yana G. Najjar, Jennifer L. McQuade

Summary: This study investigated the association between body mass index (BMI) and tumor or microbiome characteristics in patients with metastatic melanoma. The findings suggest that the host metabolic phenotype influences melanoma metabolism and may explain the improved outcomes observed in overweight/obese patients treated with immune checkpoint inhibitors and targeted therapies.

CLINICAL CANCER RESEARCH (2023)

Article Oncology

Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness

Yize Li, Tung-Shing M. Lih, Saravana M. Dhanasekaran, Rahul Mannan, Lijun Chen, Marcin Cieslik, Yige Wu, Rita Jiu-Hsien Lu, David J. Clark, Iga Koodziejczak, Runyu Hong, Siqi Chen, Yanyan Zhao, Seema Chugh, Wagma Caravan, Nataly Naser Al Deen, Noshad Hosseini, Chelsea J. Newton, Karsten Krug, Yuanwei Xu, Kyung-Cho Cho, Yingwei Hu, Yuping Zhang, Chandan Kumar-Sinha, Weiping Ma, Anna Calinawan, Matthew A. Wyczalkowski, Michael C. Wendl, Yuefan Wang, Shenghao Guo, Cissy Zhang, Anne Le, Aniket Dagar, Alex Hopkins, Hanbyul Cho, Felipe da Veiga Leprevost, Xiaojun Jing, Guo Ci Teo, Wenke Liu, Melissa A. Reimers, Russell Pachynski, Alexander J. Lazar, Arul M. Chinnaiyan, Brian A. Van Tine, Bing Zhang, Karin D. Rodland, Gad Getz, D. R. Mani, Pei Wang, Feng Chen, Galen Hostetter, Mathangi Thiagarajan, W. Marston Linehan, David Fenyo, Scott D. Jewell, Gilbert S. Omenn, Rohit Mehra, Maciej Wiznerowicz, Ana I. Robles, Mehdi Mesri, Tara Hiltke, Eunkyung An, Henry Rodriguez, Daniel W. Chan, Christopher J. Ricketts, Alexey I. Nesvizhskii, Hui Zhang, Li Ding

Summary: By integrating histopathologic, proteogenomic, and metabolomic analyses, this study reveals the inter- and intratumoral heterogeneity of clear cell renal cell carcinomas (ccRCCs). It identifies high-risk disease subsets based on tumor grade, BAP1 mutation, genome instability, hypermethylation, and protein glycosylation signature. RNA sequencing provides insights into gene signatures and potential targeted therapies, while in vitro cell line studies validate the efficacy of inhibiting identified phosphoproteome targets.

CANCER CELL (2023)

Article Oncology

Sequential Targeting of Retinoblastoma and DNA Synthesis Pathways Is a Therapeutic Strategy for Sarcomas That Can Be Monitored in Real Time

Tuyen Duong Thanh Nguyen, Yan Wang, Tuyen N. Bui, Rossana Lazcano, Davis R. Ingram, Min Yi, Varshini Vakulabharanam, Linjie Luo, Marc A. Pina, Cansu Karakas, Mi Li, Nicole M. Kettner, Neeta Somaiah, Peter J. Hougton, Osama Mawlawi, Alexander J. Lazar, Kelly K. Hunt, Khandan Keyomarsi

Summary: Treatment strategies with CDK4/6 inhibitors followed by DNA-damaging agents showed synergistic killing of Rb-positive sarcomas and can be noninvasively monitored using functional imaging and serum biomarkers. This approach provides a potential avenue for novel targeted therapies in sarcomas with intact Rb signaling.

CANCER RESEARCH (2023)

Article Oncology

Changes in outcomes and factors associated with survival in melanoma patients with brain metastases

Merve Hasanov, Denai R. Milton, Alicia Bea Davies, Elizabeth Sirmans, Chantal Saberian, Eliza L. Posada, Sylvia Opusunju, Jeffrey E. Gershenwald, Carlos A. Torres-Cabala, Elizabeth M. Burton, Rivka R. Colen, Jason T. Huse, Isabella C. Glitza Oliva, Caroline Chung, Mary Frances McAleer, Susan L. McGovern, Debra N. Yeboa, Betty Y. S. Kim, Sujit S. Prabhu, Ian E. McCutcheon, Jeffrey S. Weinberg, Frederick F. Lang, Hussein A. Tawbi, Jing Li, Lauren E. Haydu, Michael A. Davies, Sherise D. Ferguson

Summary: This study evaluates changes in clinical features and overall survival (OS) for patients with melanoma brain metastasis (MBM). The treatment options for MBM have significantly changed in the last decade, leading to improved OS. Factors associated with survival in MBM patients include patient age, primary tumor Breslow thickness, prior immunotherapy, leptomeningeal disease, symptomatic MBMs, and whole brain radiation therapy in the current era.

NEURO-ONCOLOGY (2023)

Editorial Material Oncology

Mitotic rate in primary cutaneous melanoma: Cell division matters

Jeffrey E. Gershenwald

Summary: The prognostic significance of primary cutaneous melanoma tumor mitotic rate (TMR) has been of interest in the clinical field worldwide for many years. Is there a way to utilize the findings from Patuzzo et al. and other studies to enhance the classification and staging of melanoma, as well as develop clinical tools that incorporate TMR for improved risk and prognostic assessment?

CANCER (2023)

Article Oncology

Melanoma metastatic to the adrenal gland: An update on the role of adrenalectomy in multidisciplinary management

Elliot A. Asare, Sarah B. Fisher, Yi-Ju Chiang, Lauren E. Haydu, Sameer H. Patel, Emily Z. Keung, Anthony Lucci, Jennifer Wargo, Jeffrey E. Gershenwald, Merrick I. Ross, Jeffrey. E. Lee

Summary: Adrenectomy in patients with metastatic melanoma is associated with prolonged survival, especially when done selectively. Factors such as immune checkpoint blockade therapy and selection for surgery were found to be strongly associated with improved survival after adrenal metastasis diagnosis.

JOURNAL OF SURGICAL ONCOLOGY (2023)

Correction Multidisciplinary Sciences

Neoadjuvant relatlimab and nivolumab in resectable melanoma (vol 611, pg 155, 2022)

Rodabe N. Amaria, Michael Postow, Elizabeth M. Burton, Michael T. Tetzlaff, Merrick I. Ross, Carlos Torres-Cabala, Isabella C. Glitza, Fei Duan, Denai R. Milton, Klaus Busam, Lauren Simpson, Jennifer L. McQuade, Michael K. Wong, Jeffrey E. Gershenwald, Jeffrey E. Lee, Ryan P. Goepfert, Emily Z. Keung, Sarah B. Fisher, Allison Betof-Warner, Alexander N. Shoushtari, Margaret Callahan, Daniel Coit, Edmund K. Bartlett, Danielle Bello, Parisa Momtaz, Courtney Nicholas, Aidi Gu, Xuejun Zhang, Brinda Rao Korivi, Madhavi Patnana, Sapna P. Patel, Adi Diab, Anthony Lucci, Victor G. Prieto, Michael A. Davies, James P. Allison, Padmanee Sharma, Jennifer A. Wargo, Charlotte Ariyan, Hussein A. Tawbi

NATURE (2023)

Article Oncology

Microparticle-Delivered Cxcl9 Prolongs Braf Inhibitor Efficacy in Melanoma

Gabriele Romano, Francesca Paradiso, Peng Li, Pooja Shukla, Lindsay N. Barger, Olivia El Naggar, John P. Miller, Roger J. Liang, Timothy L. Helms, Alexander J. Lazar, Jennifer A. Wargo, Francesca Taraballi, James C. Costello, Lawrence N. Kwong

Summary: Patients with BRAF-mutant melanoma respond well to combined BRAF and MEK inhibition, but relapse is common within 2 years. Minimal residual disease (MRD), which consists of drug-tolerant tumor cells in a dormant state, is a major cause of drug resistance. By studying a mouse model, researchers found that sustaining chemokine signaling can impair MRD maintenance by increasing the recruitment of effector T cells.

CANCER IMMUNOLOGY RESEARCH (2023)

Review Oncology

Targeting the Molecular and Immunologic Features of Leiomyosarcoma

Brandon M. Cope, Raymond S. Traweek, Rossana Lazcano, Emily Z. Keung, Alexander J. Lazar, Christina L. Roland, Elise F. Nassif

Summary: Immunotherapy has greatly improved cancer care, but leiomyosarcoma is not responsive to early immune-based therapies. This review discusses the results of immunotherapy trials in leiomyosarcoma and highlights the differences between soft-tissue and uterine leiomyosarcomas. It also explores the molecular subgroups of leiomyosarcomas and their impact on response to immune checkpoint blockade, proposing future directions for improving immunotherapy in leiomyosarcoma patients. Leiomyosarcoma is a rare and aggressive tumor with low tumor mutational burden, frequent alterations in certain genes, and a highly infiltrated immune microenvironment. This review provides insights for the development of biomarker-based immune therapies.

CANCERS (2023)

Article Dermatology

Telomerase reverse transcriptase immunohistochemical expression is sensitive but not specific for TERT gene amplification in acral melanoma

Woo Cheal Cho, Wen Li, Jun Gu, Wei-Lien Wang, Jing Ning, Steven Sfamenos, Pavandeep Gill, Priyadharsini Nagarajan, Jonathan L. Curry, Alexander J. Lazar, Victor G. Prieto, Carlos A. Torres-Cabala, Phyu P. Aung

Summary: The clinical utility of TERT IHC to predict TGA status in AMs appears to be limited given its low specificity and positive predictive value.

JOURNAL OF CUTANEOUS PATHOLOGY (2023)

Meeting Abstract Oncology

The epigenetic impact and therapeutic opportunity of AR-directed therapy for desmoplastic small round cell tumor

Danh D. Truong, Salah-Eddine Lamhamedi-Cherradi, Mayinuer Maitituoheti, Hannah C. Beird, Chia-Chin Wu, Sandhya Krishnan, Davis Ingram, P. Andrew Futreal, Mark Titus, Alexander Lazar, Kunal Rai, A. Robert MacLeod, Najat C. Daw, Andrea Hayes, Joseph Ludwig

CANCER RESEARCH (2023)

Meeting Abstract Medicine, Research & Experimental

TRPS1 Expression is a Marker for Malignancy in Peripheral Nerve Sheath Tumors

Rossana Lazcano, Davis Ingram, Alexander Lazar, Wei-Lien (Billy) Wang, Jeffrey Cloutier

LABORATORY INVESTIGATION (2023)

Meeting Abstract Medicine, Research & Experimental

Improved Pathological Response in Undifferentiated Pleomorphic Sarcoma (UPS) Treated by Concurrent Immunotherapy and Radiation Therapy (RT) Compared with Radiation Therapy Alone

Rossana Lazcano, Raymond Traweek, Davis Ingram, Khalida Wani, B. Ashleigh Guadagnolo, Ahsan Farooqi, Christina Roland, Emily Keung, Andrew Bishop, Wei-Lien (Billy) Wang, Elise Nassif, Alexander Lazar

LABORATORY INVESTIGATION (2023)

Meeting Abstract Medicine, Research & Experimental

GPNMB Can Be a Useful Ancillary Tool to Identify Perivascular Epithelioid Cell Tumor (PEComa)

Sintawat Wangsiricharoen, Davis Ingram, Alexander Lazar, Wei-Lien (Billy) Wang

LABORATORY INVESTIGATION (2023)

No Data Available