Article
Medicine, General & Internal
Wawaimuli Arozal, Edwina Rogayah Monayo, Agian Jeffilano Barinda, Dian Pribadi Perkasa, Vivian Soetikno, Nafrialdi Nafrialdi, Melva Louisa
Summary: The study revealed that AgNPs exhibit superior cardioprotective effects against Iso-induced MI compared to AgNO3, by reducing oxidative stress, enhancing antioxidant enzyme activity, modulating mitochondrial biogenesis genes, and decreasing NF-κB expression in cardiac tissue.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Einav Stern, Naama Shterzer, Erez Mills
Summary: In this study, the researchers found that 5-oxoproline (5OP) can be specifically sensed by Salmonella enterica serovar Typhimurium and regulate cellular aggregation. This response is mediated through an independent signaling pathway compared to the regulation of gene expression. Furthermore, 5OP or its derivatives may have the potential to be developed into useful biofilm inhibitors.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Ying Han, Chuanfeng Li, Puzhao Zhang, Xiaoqi Yang, Jianxin Min, Qinghua Wu, Yongyan Xie, Dezhong Jin, Zengtao Wang, Feng Shao, Hexiu Quan
Summary: The compound 5(S)-5-carboxystrictosidine (5-CS) found in a traditional Chinese medicine has been shown to protect the heart from ischemia/reperfusion (I/R) injury by activating antioxidant enzymes and suppressing apoptosis through opening mitochondrial K-ATP channels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Microbiology
Qiulian Zhou, Jiali Deng, Xue Pan, Danni Meng, Yujiao Zhu, Yuzheng Bai, Chao Shi, Yi Duan, Tianhui Wang, Xinli Li, Joost P. G. Sluijter, Junjie Xiao
Summary: Exercise training improves cardiac dysfunction post-myocardial infarction (MI) and modulates gut microbiota. Pre-depletion of gut microbiota abolishes the protective effects of exercise training in MI mice. Mice receiving microbiota transplants from exercised MI mice have better cardiac function. The metabolites 3-Hydroxyphenylacetic acid (3-HPA) and 4-Hydroxybenzoic acid (4-HBA) protect cardiac dysfunction and reduce apoptosis through NRF2 pathway.
Article
Endocrinology & Metabolism
S. Li, Z. Guo, Z-Y Zhang
Summary: The NLRP3 inhibitor MCC950 effectively reduces the release of LDH and other cellular inflammatory factors, improving cardiac function and slowing down cardiomyocyte apoptosis, possibly through inhibition of the NLRP3/Caspase-1/IL-1 beta pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Pharmacology & Pharmacy
Pengqiang Ma, Menghui Zhao, Yue Li, Guanqian Zhang, Yuxia Ma, Youlan Shi, Peihui Su, Rongxia Chen, Zhen-gang Tang, Yan Zhang, Bing Liu, Qiong Zhang, Xiang Liu, Feifeng Li
Summary: This study demonstrates that uric acid can ameliorate oxidative stress caused by myocardial ischemia by activating the Nrf2 pathway and inducing downstream antioxidant factors. This finding contributes to the understanding of the protective effects of uric acid in heart disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Reinis Vilskersts, Dana Kigitovica, Stanislava Korzh, Melita Videja, Karlis Vilks, Helena Cirule, Andris Skride, Marina Makrecka-Kuka, Edgars Liepinsh, Maija Dambrova
Summary: This study found that improved mitochondrial bioenergetics by cardiometabolic drug meldonium can attenuate the development of right ventricular (RV) and left ventricular (LV) dysfunction. The results indicate that meldonium treatment restores mitochondrial function in cardiac fibers, preventing the systolic dysfunction in ventricular dysfunction models resembling cardiovascular complications in COVID-19 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Xiaopan Chen, Chuan Yun, Hailong Zheng, Xu Chen, Qianfei Han, Hua Pan, Yang Wang, Jianghua Zhong
Summary: The study demonstrates that S14G-humanin (HNG) has protective effects against streptozotocin-induced cardiac dysfunction by attenuating myocardial hypertrophy and improving heart function. HNG treatment also reduces levels of various myocardial injury indicators and suppresses the activation of the p38/nuclear factor kappa-B (NF-kappa B) signaling pathway, highlighting its potential therapeutic role in diabetic cardiomyopathy.
Article
Environmental Sciences
Omayma Missawi, Ikram Ben Jeddou, Massimo Venditti, Nesrine Zitouni, Mohamed Amin Zaouali, Hassen Ben Abdennebi, Imed Messaoudi, Russel J. Reiter, Sergio Minucci, Mohamed Banni
Summary: This study investigated the impact of melatonin on ischemia-reperfusion injury induced by environmental microplastics. The results showed that melatonin can alleviate liver damage caused by microplastics and reduce cellular dysfunction.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Medicine, General & Internal
Weijia Wang, Xiuyun Tian, Liang Yan, Xiaoya Guan, Bin Dong, Min Zhao, Daoning Liu, Jianhui Wu, Chunyi Hao
Summary: By analyzing the metabolites in PDAC tissues and normal pancreatic tissues, this study identified 51 tissue metabolites and 26 serum metabolites that were altered in PDAC. The γ-glutamyl cycle was found to be the most significantly changed metabolic pathway, and 5-oxoproline was identified as the biomarker of PDAC with the most significantly decreased levels.
ANNALS OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Weizhuo Liu, Xiaoyu Guo, Lei Jin, Ting Hong, Qianyun Zhang, Fan Su, Yi Shen, Saiqi Li, Bin He
Summary: LCN-2 plays a significant role in sepsis-induced cardiomyopathy (SIC) and may serve as an early diagnostic and predictive indicator of SIC. LCN-2 is likely involved in the process of septic myocardial injury by mediating lipid accumulation and affecting mitochondrial function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Environmental Sciences
Volkan Gelen, Emin Sengul, Serkan Yildirim, Esra Senturk, Samet Tekin, Abdulsamed Kukurt
Summary: Hesperidin and curcumin have been shown to have protective effects against 5-FU-induced kidney damage by improving oxidative stress, apoptosis, and renal dysfunction. Therefore, hesperidin and curcumin may be promising agents for combating 5-FU-induced nephrotoxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yasuhiro Kaku, Koji Chiba, Katsuya Sato, Atsushi Onishi, Takaki Ishida, Keisuke Okada, Masato Fujisawa
Summary: The study found that tadalafil (a commonly used medication) has a protective effect against the testicular toxicity caused by CDDP (an anticancer drug) in mice, improving adverse effects such as testicular atrophy and decreased sperm concentration. The results suggest that the antioxidant effect of tadalafil may contribute to its protective effect, and ROCK2 and oxidative stress may be involved in the antioxidant effects of tadalafil.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Fitri Fareez Ramli, Adli Ali, Nurul 'Izzah Ibrahim
Summary: Tocotrienols have shown significant benefits in cerebral and myocardial I/R injury, improving structural, functional, and biochemical parameters while reducing oxidative stress, inflammation, and apoptosis. Differences in animal models, disease inductions, tocotrienol forms, and bias risks were limitations in the analysis, but tocotrienols have the potential to serve as a supplement for reducing the impact of reperfusion injury.
APPLIED SCIENCES-BASEL
(2021)
Article
Emergency Medicine
Yong He, Guoxing Wang, Chuang Li, Yuxing Wang, Qian Zhang
Summary: In a porcine model of cardiac arrest and resuscitation, sildenafil was found to attenuate myocardial injury and improve survival rate by regulating the expressions of miRNA-155 and miR-145. This study suggests the potential cardioprotective role of sildenafil in post-resuscitation myocardial dysfunction.
SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Bauge, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloise Woitrain, Niels J. Kloosterhuis, Eleonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberle, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean-Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikael Croyal, Bart van de Sluis, Sven Francque, Francois Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas
Summary: Non-alcoholic fatty liver disease (NAFLD) affects nearly 25% of the global population and is associated with cardiovascular disease (CVD). A study found that apolipoprotein F (APOF) expression was negatively correlated with hepatic steatosis and plasma triglyceride (TG) levels in NAFLD patients. Further experiments showed that overexpression of APOF increased very low density lipoprotein (VLDL)-TG secretion and hepatic lipoprotein remnant clearance, leading to a reduction in plasma TG levels. These findings highlight the important role of APOF in plasma and hepatic lipoprotein metabolism.
Review
Cardiac & Cardiovascular Systems
Sanne de Wit, Claire Glen, Rudolf A. de Boer, Ninian N. Lang
Summary: Heart failure and cancer have a bidirectional relationship, with patients with heart failure at increased risk for developing cancer and cancer presence leading to impaired cardiac function. Additionally, targeted anti-cancer therapies may also cause cardiac toxicity due to overlap between their targets and pathways required for normal cardiac function.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Canxia Shi, Joseph Pierre Aboumsallem, Navin Suthahar, Aniek O. de Graaf, Joop H. Jansen, Isabelle A. van Zeventer, Valentina Bracun, Sanne de Wit, Elles M. Screever, Pieter F. van den Berg, Wouter C. Meijers, Ron T. Gansevoort, Stephan J. L. Bakker, Pim van der Harst, Herman H. W. Sillje, Gerwin Huls, Rudolf A. de Boer
Summary: This study aimed to analyze the association between clonal hematopoiesis of indeterminate potential (CHIP) and incident heart failure (HF) in a European population cohort. Results showed that CHIP mutations were correlated with age, smoking, hypertension, and cardiovascular biomarkers, but the frequency of CHIP was similar between individuals with incident HF and control participants. However, among people younger than 65 years, CHIP mutations were more frequently detected in the case cohort and significantly associated with new-onset HF.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Finnian R. Mc Causland, Brian L. Claggett, Muthiah Vaduganathan, Akshay S. Desai, Pardeep Jhund, Rudolf A. de Boer, Kieran Docherty, James Fang, Adrian F. Hernandez, Silvio E. Inzucchi, Mikhail N. Kosiborod, Carolyn S. P. Lam, Felipe Martinez, Jose F. Kerr Saraiva, Martina M. McGrath, Sanjiv J. Shah, Subodh Verma, Anna Maria Langkilde, Magnus Petersson, John J. McMurray, Scott D. Solomon
Summary: Dapagliflozin has no effect on baseline kidney function in patients with heart failure and a mildly reduced or preserved ejection fraction. Dapagliflozin does not significantly reduce the frequency of kidney composite outcomes, but can slow the decline in eGFR.
Article
Cardiac & Cardiovascular Systems
Xiaowen Wang, Muthiah Vaduganathan, Brian L. Claggett, Sheila M. Hegde, Maria Pabon, Ian J. Kulac, Orly Vardeny, Eileen O'Meara, Shelley Zieroth, Tzvetana Katova, Martina M. McGrath, Anne-Catherine Pouleur, Pardeep S. Jhund, Akshay S. Desai, Silvio E. Inzucchi, Mikhail N. Kosiborod, Rudolf A. de Boer, Lars Kober, Marc S. Sabatine, Felipe A. Martinez, Piotr Ponikowski, Sanjiv J. Shah, Adrian F. Hernandez, Anna Maria Langkilde, John J. McMurray, Scott D. Solomon, Carolyn S. P. Lam
Summary: This study analyzed the efficacy and safety of sodium-glucose cotransporter-2 inhibitors in the treatment of heart failure, and assessed the impact of sex on their effectiveness and safety. The study found that, after adjusting for baseline differences, women had fewer cardiovascular and all-cause deaths, as well as lower rates of HF hospitalizations and total events, compared to men. There were no sex-related differences in adverse events or drug discontinuation. Therefore, sex does not modify the treatment effect of sodium-glucose cotransporter-2 inhibitors.
Editorial Material
Cardiac & Cardiovascular Systems
Rudolf A. de Boer, Johann Bauersachs
EUROPEAN HEART JOURNAL
(2023)
Article
Physiology
Nicolaas J. Bekker, Alienke van Pijkeren, Justina C. Wolters, Alejandro Sanchez Brotons, Victor Guryev, Roy R. Woldhuis, Rainer Bischoff, Wynand Alkema, Peter Horvatovich, Johannes L. L. van Nijnatten, Maarten van den Berge, Wim Timens, Corry-Anke Brandsma
Summary: This study compared COPD and non-COPD fibroblasts using proteomic and transcriptomic analysis, and identified 40 differentially expressed proteins, including previously described COPD proteins and new COPD research targets. Lack of overlap and correlation between gene and protein data supports the use of unbiased proteomics analysis.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Chemistry, Analytical
Baubek Spanov, Oladapo Olaleye, Tomes Mesurado, Natalia Govorukhina, Alois Jungbauer, Nico C. van de Merbel, Nico Lingg, Rainer Bischoff
Summary: The study found that Pertuzumab undergoes changes in charge heterogeneity, primarily due to deamidation in the Fc domain and N-terminal pyroglutamate formation in the heavy chain. Peptide mapping analysis also showed that clinical samples had 2-3% deamidation in the heavy chain CDR2, 20-25% deamidation in the Fc domain, and 10-15% N-terminal pyroglutamate formation in the heavy chain.
ANALYTICAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Niels T. B. Scholte, Muhammed T. Gurgoze, Dilan Aydin, Dominic A. M. J. Theuns, Olivier C. Manintveld, Eelko Ronner, Eric Boersma, Rudolf A. de Boer, Robert M. A. van der Boon, Jasper J. Brugts
Summary: A comprehensive meta-analysis suggests that home telemonitoring systems (hTMS) can significantly reduce all-cause mortality and heart failure-related hospitalizations in heart failure patients.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Carolin Pozder, Elles M. Screever, A. Rogier van der Velde, Herman H. Sillje, Janne Suwijn, Saskia de Rond, Marcus E. Kleber, Graciela Delgado, Jan Jacob Schuringa, Wiek H. van Gilst, Wouter C. Meijers, Winfried Maerz, Rudolf A. de Boer
Summary: Previous studies have found a link between ABO blood group and cardiovascular events and outcomes. In this study, the authors investigated the role of galectin-3 in different blood groups. They found that galectin-3 had a higher binding capacity for red blood cells (RBCs) and von Willebrand factor (VWF) in non-O blood groups compared to blood group O. Additionally, non-O blood groups had lower plasma levels of galectin-3. The prognostic value of galectin-3 for all-cause mortality showed a non-significant trend towards higher mortality in non-O blood groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Elles M. M. Screever, Laura I. E. Yousif, Javid J. J. Moslehi, Joe-Elie Salem, Adriaan A. A. Voors, Herman H. W. Sillje, Rudolf A. A. de Boer, Wouter C. C. Meijers
Summary: This study investigates the role of immune checkpoint ligands in heart failure. The findings suggest that immune checkpoint ligands are involved in the pathophysiology of heart failure and are associated with disease severity and prognosis.
Article
Cardiac & Cardiovascular Systems
Ankeet S. Bhatt, Daniel Lindholm, Ann Nilsson, Natalia Zaozerska, Brian L. Claggett, Muthiah Vaduganathan, Mikhail N. Kosiborod, Carolyn S. P. Lam, Adrian F. Hernandez, Felipe A. Martinez, Silvio E. Inzucchi, Sanjiv J. Shah, Rudolf A. de Boer, Akshay Desai, Pardeep S. Jhund, Anna Maria Langkilde, Magnus Petersson, John J. V. McMurray, Scott D. Solomon
Summary: The COVID-19 pandemic has had significant impacts on clinical research, including randomized clinical trials. This study specifically focuses on the operational impact and mitigation measures of the DELIVER trial, which is one of the largest and most globally diverse cardiovascular clinical trials. The findings may have important implications for future clinical trials contingency planning.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Coenraad Withaar, Laura M. G. Meems, Edgar E. Nollet, Marloes Schouten, Marie A. Schroeder, Lotte B. Knudsen, Kristoffer Niss, Christian T. Madsen, Annabelle Hoegl, Gianluca Mazzoni, Jolanda van der Velden, Carolyn S. P. Lam, Herman H. W. Sillje, Rudolf A. de Boer
Summary: Semaglutide, a glucagon-like peptide-1 receptor agonist, can improve cardiometabolic profile, cardiac structure, and function in obesity-related heart failure with preserved ejection fraction (HFpEF) by improving left ventricular cytoskeleton and endothelial function, and restoring protective immune responses in visceral adipose tissue. It induces a wide array of favorable cardiometabolic effects beyond weight loss.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Mark Jansen, Maike Schuldt, Beau O. van Driel, Amand F. Schmidt, Imke Christiaans, Saskia N. van der Crabben, Yvonne M. Hoedemaekers, Dennis Dooijes, Jan D. H. Jongbloed, Ludolf G. Boven, Ronald H. Lekanne Deprez, Arthur A. M. Wilde, Judith J. M. Jans, Jolanda van der Velden, Rudolf A. de Boer, J. Peter van Tintelen, Folkert W. Asselbergs, Annette F. Baas
Summary: This exploratory case-control study identified metabolites associated with severe phenotypes in carriers of MYBPC3 founder variants. The identified metabolites are involved in multiple metabolic pathways, including acylcarnitine, histidine, lysine, purine and steroid hormone metabolism, and proteolysis. Further studies are needed to explore the role of these biomarkers in the pathogenesis of HCM and their potential contribution to risk stratification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Toru Kondo, P. S. Jhund, M. Vaduganathan, A. F. Hernandez, C. S. P. Lam, S. E. Inzucchi, F. A. Martinez, R. A. De Boer, M. N. Kosiborod, A. S. Desai, L. Kober, P. Ponikowski, M. S. Sabatine, S. D. Solomon, J. J. V. Mcmurray
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
