Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 60, Issue 10, Pages 1081-1086Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-017-9164-1
Keywords
DNA break repair; transcription; RNA
Categories
Funding
- NIH [GM076388, CA197779, GM118833]
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Repair of DNA double-strand breaks (DSBs) via the homologous recombination (HR) pathway is a highly regulated process. A number of proteins that participate in HR are intricately modulated by the cell cycle and chromatin environments of DSBs. Recent studies have revealed a clear impact of transcription on HR in transcribed regions of the genome. Several models have been put forth to explain how the process of transcription and/or its RNA products may influence HR. Here we discuss the results and models from these studies, presenting an emerging view of transcription-coupled DSB repair.
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