Transition metal–catalyzed alkyl-alkyl bond formation: Another dimension in cross-coupling chemistry

Total Synthesis of (−)-Daphenylline

(2016) Ryosuke Yamada et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of axially chiral biaryl compounds by asymmetric catalytic reactions with transition metals

(2016) Pauline Loxq et al.   COORDINATION CHEMISTRY REVIEWS

Metallaphotoredox-catalysed sp3–sp3 cross-coupling of carboxylic acids with alkyl halides

(2016) Craig P. Johnston et al.   NATURE

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents

(2016) T. Qin et al.   SCIENCE

Highly Efficient, Convergent, and Enantioselective Synthesis of Phthioceranic Acid

(2015) Shiqing Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Suzuki Cross-Couplings of Unactivated 1-Fluoro-1-haloalkanes: Synthesis of Chiral β-, γ-, δ-, and ε-Fluoroalkanes

(2015) Xiaojian Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Cross-Coupling Reaction of Allyl Boron Ester with 1°/2°/3°-Halogenated Alkanes

(2015) Guang-Zu Wang et al.   ORGANIC LETTERS

Copper-Catalyzed Reductive Cross-Coupling of Nonactivated Alkyl Tosylates and Mesylates with Alkyl and Aryl Bromides

(2014) Jing-Hui Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of the Anti-inflammatory and Pro-resolving Lipid Mediator MaR1n−3 DPAUtilizing an sp3-sp3Negishi Cross-Coupling Reaction

(2014) Jørn Eivind Tungen et al.   CHEMISTRY-A EUROPEAN JOURNAL

sp3-sp3 Coupling reactions in the synthesis of natural products and biologically active molecules

(2014) Egor Geist et al.   NATURAL PRODUCT REPORTS

Enantioconvergent Cross-Couplings of Racemic Alkylmetal Reagents with Unactivated Secondary Alkyl Electrophiles: Catalytic Asymmetric Negishi α-Alkylations of N-Boc-pyrrolidine

(2013) Christopher J. Cordier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-Catalyzed Alkyl-Alkyl Suzuki-Miyaura Coupling

(2012) Takuji Hatakeyama et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Cross-Couplings of Secondary Alkyl Electrophiles with Secondary Alkylmetal Nucleophiles: Negishi Reactions of Racemic Benzylic Bromides with Achiral Alkylzinc Reagents

(2012) Jörg T. Binder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New Directing Groups for Metal-Catalyzed Asymmetric Carbon–Carbon Bond-Forming Processes: Stereoconvergent Alkyl–Alkyl Suzuki Cross-Couplings of Unactivated Electrophiles

(2012) Ashraf Wilsily et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Escape from Flatland 2: complexity and promiscuity

(2012) Frank Lovering   MedChemComm

Copper-Catalyzed Cross-Coupling Reaction of Organoboron Compounds with Primary Alkyl Halides and Pseudohalides

(2011) Chu-Ting Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reactivity of mixed organozinc and mixed organocopper reagents: 5-A kinetic insight to compare the transfer ability of the same group in copper catalyzed alkylation of mixed and homozincates

(2011) Ender Erdik et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Stereoconvergent Amine-Directed Alkyl–Alkyl Suzuki Reactions of Unactivated Secondary Alkyl Chlorides

(2011) Zhe Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The final frontier

(2011) Ben W. Glasspoole et al.   Nature Chemistry

Nickel-Catalyzed Reductive Cross-Coupling of Unactivated Alkyl Halides

(2011) Xiaolong Yu et al.   ORGANIC LETTERS

Asymmetric Alkyl−Alkyl Cross-Couplings of Unactivated Secondary Alkyl Electrophiles: Stereoconvergent Suzuki Reactions of Racemic Acylated Halohydrins

(2010) Nathan A. Owston et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Allylation of Alkyl Halides with Allylic Grignard Reagents

(2009) Masahiro Sai et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric Cross-Coupling of Non-Activated Secondary Alkyl Halides

(2008) Frank Glorius   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Alkyl−Alkyl Suzuki Cross-Couplings of Unactivated Homobenzylic Halides

(2008) Bunnai Saito et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Concise and Modular Synthesis of Pyranicin

(2008) Nolan D. Griggs et al.   ORGANIC LETTERS

Silver-Catalyzed Benzylation and Allylation Reactions of Tertiary and Secondary Alkyl Halides with Grignard Reagents

(2008) Hidenori Someya et al.   ORGANIC LETTERS