Article
Immunology
Ji Young Kim, Patrick Stevens, Manjula Karpurapu, Hyunwook Lee, Joshua A. A. Englert, Pearlly Yan, Tae Jin Lee, Navjot Pabla, Maciej Pietrzak, Gye Young Park, John W. W. Christman, Sangwoon Chung
Summary: By utilizing a mouse model and studying clinical patients, we discovered the important role of ETs in asthma, with miR-155 inhibition showing therapeutic benefits in severe asthma. Targeting dsDNA release may be a potential therapeutic target for mitigating neutrophilic asthma phenotype.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ziling Zhong, Xueying Huang, Shaojie Zhang, Shaochuan Zheng, Xiqiao Cheng, Rongrong Li, Di Wu, Liping Mo, Shenhong Qu
Summary: Recent studies have shown that the Notch signalling pathway induces the production of Th2-related immune factors, but the exact mechanism through which Notch signalling exacerbates allergic rhinitis (AR) remains unknown. In this study, serum, nasal mucosa, and spleen samples were isolated to investigate the roles of Notch in AR. The results demonstrated that blocking the Notch pathway may alleviate miR-155-mediated inflammation via the regulation of immune homeostasis in AR.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Genetics & Heredity
Andrea Latin, Cinzia Ciccacci, Giada De Benedittis, Lucia Novelli, Fulvia Ceccarelli, Fabrizio Conti, Giuseppe Novelli, Carlo Perricone, Paola Borgiani
Summary: The study evaluated the genetic and expression variability of three miRNAs potentially involved in systemic lupus erythematosus (SLE), and identified down-expression of miR-142 and miR-499a in patients, with a trend for down-expression of miR-155. The lower expression of miR-142 was associated with a specific polymorphism variant allele, and predictive analyses identified MDM2 as a target gene common to the three miRNAs. These findings suggest that the three miRNAs and MDM2 may play a role in SLE.
Article
Immunology
Rachel E. Crossland, Jean Norden, Sakhila Ghimire, Mateja Kralj Juric, Kim F. Pearce, Clare Lendrem, Matthew Collin, Eva Mischak-Weissinger, Ernst Holler, Hildegard T. Greinix, Anne M. Dickinson
Summary: The study found that miR-155 and miR-146a were upregulated in gastrointestinal and skin tissue samples of aGvHD patients, and their expression levels in serum and urine samples were also associated with the risk of developing aGvHD. These results support the potential of miR-155 and miR-146a as biomarkers for aGvHD, but further investigation is needed to understand their role in generalized inflammation and specific pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yi-Hsuan Su, Jin-Yuarn Lin
Summary: Researchers found that inhalation of menthone can alleviate allergic inflammation in asthmatic mice, improving related symptoms. This study provides new insights into the treatment of allergic asthma using menthone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wenxin Wang, Jie Geng, Xiaohan Wu, Jianguang Zhang, Chenna Zheng, Huachun Rao, Tianyu Li, Yong Diao, Huiyong Yang
Summary: The molecular mechanisms underlying inflammation remain unclear. This study designed a nucleic acid nanoflowers (NFs) complex to directly activate inflammatory genes and investigate the molecular mechanism of inflammation. The findings suggest that miR-155 and its target genes act as a molecular switch role in the development of inflammation.
MOLECULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Aisha Alamri
Summary: Asthma is a chronic inflammatory disease with a rising global incidence. Factors such as strict hygiene compliance and early exposure to antibiotics are linked to changes in the biological environment within the airways, leading to allergies like asthma. Further research is needed to understand the impact of microbial diversity on asthma pathogenesis.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Immunology
Jiayi Dong, Lindsey M. Warner, Ling-Li Lin, Mei-Chi Chen, Ryan M. O'Connell, Li-Fan Lu
Summary: miR-155 plays a crucial role in promoting tT reg cell differentiation by promoting mTEC maturation in the thymus. RANKL stimulation induces miR-155 expression to target molecules within the TGF beta signaling pathway, safeguarding thymic medulla integrity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Cell Biology
Dong Wang, Xiaohui Wang, Yujia Song, Mahan Si, Yuqi Sun, Xiaohui Liu, Shuxiang Cui, Xianjun Qu, Xinfeng Yu
Summary: This study found a significant positive correlation between CXCR7 expression and CAF activation markers in colonic tissues and transgenic mice. RNA sequencing revealed an increase in miR-146a-5p and miR-155-5p levels in CXCR7-overexpressing CRC cells and their exosomes. Furthermore, these CRC cell-derived miRNAs could be uptaken by CAFs via exosomes and promote their activation, leading to enhanced invasive capacity of CRC cells and pro-metastatic switch. The activation of CAFs by miR-146a-5p and miR-155-5p also facilitated tumor formation and lung metastasis of CRC in vivo. Therefore, these findings provide new insights into CXCR7-mediated CRC metastasis and suggest potential biomarkers and therapeutic targets for inhibiting CRC metastasis.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Yuechao Dong, Florian Alonso, Tiya Jahjah, Isabelle Fremaux, Christophe F. Grosset, Elisabeth Genot
Summary: Angiogenesis involves interactions between vascular endothelial growth factor and Notch signaling pathways. This study reveals the regulatory role of miR-155 in angiogenesis. miR-155 is found to be involved in podosome formation, proteolytic machinery activation, and cell migration. Overexpression of miR-155 weakens Notch signaling, leading to defective angiogenesis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Valeria Domenica Zingale, Agnese Gugliandolo, Emanuela Mazzon
Summary: miRNAs, small non-coding RNA molecules, play a crucial role in the development of neurological diseases by regulating gene expression. Imbalance in miRNAs expression pattern may lead to the occurrence of neurological disorders. Modulation of miRNAs expression could be utilized as a therapeutic strategy in treating pathological neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Jie Wen, Yiru Wu, Yufei Tian, Janwei Han, Qiuyuan Wang, Yang Liu, Chaolai Man
Summary: This study investigated the expression, potential function, and mechanism of miR-155 in the immune responses of 12-day-old chickens to three vaccines. The results showed differential expression levels of serum circulating miR-155 during the immune responses, with some common key time points and associated tissues. Bioinformatics analysis suggested key target genes of miR-155 that possibly play a role in immune function regulation through specific signaling pathways.
RESEARCH IN VETERINARY SCIENCE
(2022)
Review
Oncology
Katerina Kalkusova, Pavla Taborska, Dmitry Stakheev, Daniel Smrz
Summary: MiR-155 is a significant regulator of immune responses against tumors, particularly in different immune cell populations, and it can impact the process of cancer immunoediting. Its role in cellular communication is also important. MiR-155 targeting is increasingly used in cancer immunotherapy.
Article
Engineering, Environmental
Wei-Hsin Chen, Che-Ming Chang, Justus Kavita Mutuku, Su Shiung Lam, Wen-Jhy Lee
Summary: By predicting the deposition fractions of aerosols in healthy and asthmatic human airways using numerical methods, this study reveals that the curved and sinuous folds in asthmatic airways lead to the formation of complex secondary flows and higher deposition fractions, compared to healthy airways. This information is crucial for understanding the effects of aerosol particle sizes on asthma treatment and for preventing exacerbation of chronic ailments like asthma and epidemics like COVID-19.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Oncology
Reham Hammad, Mona A. Eldosoky, Asmaa A. Elmadbouly, Reda Badr Aglan, Sherihan G. Abdelhamid, Samy Zaky, Elham Ali, Fatma El-Zahraa Abd El Hakam, Alshaimaa M. Mosaad, Neamat A. Abdelmageed, Fatma M. Kotb, Hend G. Kotb, Ahmed A. Hady, Omaima I. Abo-Elkheir, Sandy Kujumdshiev, Ulrich Sack, Claude Lambert, Nadia M. Hamdy
Summary: The authors aim to investigate the altered monocytes subsets distribution in liver cirrhosis (LC) and subsequent hepatocellular carcinoma (HCC) in association with the expression level of plasma Homo sapiens (has)-miR-21-5p and hsa-miR-155-5p. This is a step towards non-protein coding (nc) RNA precision medicine based on the immune perturbation manifested as altered monocytes distribution, on top of LC and HCC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Bright Nwaru, Linda Ekerljung, Madeleine Radinger, Anders Bjerg, Roxana Mincheva, Carina Malmhall, Malin Axelsson, Goran Wennergren, Jan Lotvall, Bo Lundback
Letter
Immunology
Carina Malmhall, Julie Weidner, Madeleine Radinger
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Letter
Allergy
Henry McSorley, Kristina Johansson
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Emma Boberg, Kristina Johansson, Carina Malmhall, Julie Weidner, Madeleine Radinger
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Immunology
Emma Boberg, Kristina Johansson, Carina Malmhall, Jenny Calven, Julie Weidner, Madeleine Radinger
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Luke R. Bonser, Kyung Duk Koh, Kristina Johansson, Semil P. Choksi, Dan Cheng, Leqian Liu, Dingyuan Sun, Lorna T. Zlock, Walter L. Eckalbar, Walter E. Finkbeiner, David J. Erle
Summary: Researchers have developed a new method to characterize and isolate different subsets of airway epithelial cells in human bronchial epithelial-cell cultures, which will help to further understand airway epithelial biology.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jenny Calven, Elisabeth Ax, Madeleine Radinger
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Patricia Ramos-Ramirez, Carina Malmhall, Kristina Johansson, Mikael Adner, Jan Lotvall, Apostolos Bossios
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, Research & Experimental
Sana Siddiqui, Kristina Johansson, Alex Joo, Luke R. Bonser, Kyung Duk Koh, Olivier Le Tonqueze, Samaneh Bolourchi, Rodriel A. Bautista, Lorna Zlock, Theodore L. Roth, Alexander Marson, Nirav R. Bhakta, K. Mark Ansel, Walter E. Finkbeiner, David J. Erle, Prescott G. Woodruff
Summary: The study identifies miR-141 as a key regulator of pathological airway mucus production induced by IL-13, with disruption leading to decreased goblet cell frequency and reduced mucus secretion. This miRNA may offer a novel therapeutic target for airway diseases.
Article
Biochemistry & Molecular Biology
Cecilia Lasser, Yasunari Kishino, Kyong-su Park, Ganesh Vilas Shelke, Nasibeh Karimi, Shintaro Suzuki, Lilit Hovhannisyan, Madeleine Radinger, Jan Lotvall
Summary: Studying the proteomes of tissue-derived extracellular vesicles can help identify disease biomarkers and understand cell-to-cell communication. This study isolated EVs from mouse lungs and found changes in their proteomes during allergen-induced airway inflammation, with proteins mainly associated with immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Kristina Johansson, Prescott G. Woodruff, Karl Mark Ansel
Summary: The airway epithelium is crucial for protection from inhaled pathogens and particles, but inflammatory diseases are often associated with failure of epithelial functions, leading to immune activation and tissue damage. MicroRNAs play a key role in cellular responses and disease prevention, with significant changes in epithelial miRNA expression in respiratory diseases.
IMMUNOLOGICAL REVIEWS
(2021)
Review
Allergy
Guo-Qiang Zhang, Saliha Selin Ozuygur Ermis, Madeleine Radinger, Apostolos Bossios, Hannu Kankaanranta, Bright Nwaru
Summary: There is a gender-related disparity in asthma, with males more affected in childhood and females more affected in adulthood. Adult-onset asthma, especially non-atopic cases, is more severe and has a poorer prognosis in women. Sociocultural, environmental, and biological factors, including sex hormones, have been implicated in explaining this disparity. However, the evidence regarding the role of sex hormones in asthma pathogenesis and clinical outcomes remains inconclusive.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Respiratory System
Elga Bandeira, Su Chul Jang, Cecilia Lasser, Kristina Johansson, Madeleine Radinger, Kyong-Su Park
Summary: This study aimed to investigate the effects of mesenchymal stem cell-derived vesicles on allergic airway inflammation. The findings showed that vesicles obtained from bone marrow stem cells can effectively attenuate inflammation in an asthma model. Nanovesicles derived from these cells demonstrated superior therapeutic effects. Therefore, stem cell-derived nanovesicles may be a promising therapeutic candidate for allergic diseases such as asthma.
RESPIRATORY RESEARCH
(2023)
Article
Respiratory System
Elisabeth Ax, Zala Jevnikar, Aleksander Cvjetkovic, Carina Malmhall, Henric Olsson, Madeleine Radinger, Cecilia Lasser
RESPIRATORY RESEARCH
(2020)
Article
Immunology
Hilal Uensal, Canan Caka, Hacer Neslihan Bildik, Saliha Esenboga, Alphan Kupesiz, Baris Kuskonmaz, Duygu Uckan Cetinkaya, Mirjam van Der Burg, Ilhan Tezcan, Deniz Cagdas
Summary: The study investigated the demographic, clinical, laboratory, follow-up, and treatment characteristics of 21 patients with Major Histocompatibility Complex Class II (MHC-II) deficiency. It was found that patients with Bare Lymphocyte Syndrome (BLS) exhibited clinical findings similar to severe combined immunodeficiency (SCID), and the flow cytometric MHC-II expression study played a crucial role in the diagnosis, differential diagnosis, early hematopoietic stem cell transplantation (HSCT), and post-HSCT follow-up.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Axel Rosell, Cecilia Karlstrom, Joakim S. Dahlin, Daryl Boey, Monika Klimkowska, Kajsa Ax, Charlotte Thalin, Johanna Ungerstedt
Summary: There is no evidence of global increase in neutrophil extracellular trap release in patients with systemic mastocytosis.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Charles W. Armitage, Connor P. O'Meara, Emily R. Bryan, Avinash Kollipara, Logan K. Trim, Danica Hickey, Alison J. Carey, Wilhelmina M. Huston, Gavin Donnelly, Anusch Yazdani, Richard S. Blumberg, Kenneth W. Beagley
Summary: This study demonstrates that IgG seroconversion during male infection can amplify female immunopathology and infertility. IgG transcytosis through the FcRn receptor allows Chlamydia to cross the epithelial barrier and be phagocytosed by antigen-presenting cells. This leads to increased pro-inflammatory signaling and T cell proliferation, resulting in more severe pathology and infertility in female mice.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
Article
Immunology
Fatma Gonca Kocanci, Azize Yasemin Goksu Erol, Fatma Yildiz, Hamiyet Eciroglu
Summary: Calcineurin inhibitors, such as pimecrolimus, have been found to have preventive effects against neuroinflammation and apoptotic pathways, which are underlying mechanisms in neurodegenerative diseases. This study demonstrated that pimecrolimus exerts neuroprotective effects by inhibiting inflammation and oxidative stress, making it a potential treatment option for neurodegenerative diseases.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2024)
