Article
Multidisciplinary Sciences
Yi-Hsuan Lin, Hsiao-Ting Chang, Yen-Han Tseng, Harn-Shen Chen, Shu-Chiung Chiang, Tzeng-Ji Chen, Shinn-Jang Hwang
Summary: This study aimed to investigate the situation of metabolically healthy overweight and obesity (MHOO) individuals in Asia and the factors associated with maintaining their metabolic health. The results showed that older age, longer follow-up time, higher BMI, and increased waist circumference were detrimental factors for metabolic health. However, sociodemographic factors and lifestyle factors did not have significant relationships with metabolic health among MHOO individuals.
Article
Endocrinology & Metabolism
Xiu Huang, Guifang Li, Bei Xu, Junyi Zhang, Xingchun Wang, Xiaoyun Cheng, Muthukumaran Jayachandran, Yueye Huang, Shen Qu
Summary: The study examined the predictive value of baseline serum triglyceride (TG) levels for metabolic improvements after laparoscopic sleeve gastrectomy (LSG). Patients with baseline TG levels under 1.7 mmol/L had greater weight loss at six months follow-up, indicating that baseline TG levels may have predictive value for weight loss in the short-term. The study suggests a potential association between TG levels and weight loss outcomes post-LSG.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Nandini Nair, Eric Vittinghoff, Mark J. Pletcher, Elizabeth C. Oelsner, Norrina B. Allen, Chiadi E. Ndumele, Nancy A. West, Elsa S. Strotmeyer, Kenneth J. Mukamal, David S. Siscovick, Mary L. Biggs, Blandine Laferrere, Andrew E. Moran, Yiyi Zhang
Summary: The study examined the relationship between overweight and obesity in young adulthood and incident diabetes later in life, finding that elevated BMI and waist circumference during young adulthood were independently associated with later-life incident diabetes. Insulin resistance was identified as a key mediator in this association, with other factors such as high-density lipoproteins and triglycerides playing a smaller role.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Idalia Cura-Esquivel, Marlene Marisol Perales-Quintana, Liliana Torres-Gonzalez, Katia Guzman-Avilan, Linda Munoz-Espinosa, Paula Cordero-Perez
Summary: This study describes the metabolic, inflammatory and adipokine differences in overweight/obese children with and without metabolic syndrome (MetS). Results showed that children with MetS had higher levels of C-reactive protein, while children with normal body weight had lower levels of PAI-1 and leptin. The findings suggest that the triglyceride/high-density lipoprotein cholesterol ratio, obtainable from routine lab tests, can help identify MetS.
Article
Clinical Neurology
Keun You Kim, Junghee Ha, Jun-Young Lee, Eosu Kim
Summary: Using nationwide cohort data, this study explored the relationship between loss in body mass index (BMI) or waist circumference (WC) and risk of dementia, and found that BMI loss increased the risk of all-cause dementia and Alzheimer's disease in participants without obesity, but not in participants with obesity. WC loss was only associated with decreased Alzheimer's disease risk in participants with obesity.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Gabriela Cardenas-Fuentes, Camille Lassale, Miguel Angel Martinez-Gonzalez, Maria Grau, Jordi Salas-Salvado, Dolores Corella, Lluis Serra-Majem, Julia Warnberg, Jadwiga Konieczna, Ramon Estruch, Xavier Pinto, J. Alfredo Martinez, Clotilde Vazquez, Josep Vidal, Josep A. Tur, Andres Diaz-Lopez, Hana Lancova, Montserrat Fito, Helmut Schroder
Summary: In older adults at high cardiovascular risk, increasing levels of physical activity and adherence to a Mediterranean diet were associated with a lower inflammatory score, which was partly mediated by a reduction in body fat.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Jamee Guerra Valencia, Willy Ramos, Liliana Cruz-Ausejo, Jenny Raquel Torres-Malca, Joan A. Loayza-Castro, Gianella Zulema Zenas-Trujillo, Norka Rocio Guillen Ponce, Fiorella E. Zuzunaga-Montoya, Mario J. Valladares-Garrido, Victor Juan Vera-Ponce, Jhony A. De La Cruz-Vargas
Summary: The study analyzed the association between fruit intake and body mass index (BMI) and waist circumference (WC) in a representative sample of Peruvians. Fruit intake per serving was found to be negatively related to general body adiposity and central fat distribution. However, the consumption of fruit in the form of juices was positively associated with a significant increase in BMI and WC.
Article
Nutrition & Dietetics
Wan-Yu Lin
Summary: Regular physical exercise, particularly jogging and yoga, is highly effective in reducing obesity indices such as body mass index, body fat percentage, waist circumference, hip circumference, and waist-hip ratio. Jogging engages multiple body parts, while yoga targets the muscles around the hips and pelvis.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Nana Wang, Yuying Li, Chuanji Guo
Summary: This study demonstrates that waist-corrected body mass index (wBMI), combining BMI and waist circumference measurements, is superior in predicting obesity and diabetes mellitus (DM). The study found a significant association between wBMI and the incidence of DM, with wBMI being a more reliable predictor compared to waist circumference, BMI, and waist-to-height ratio.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiao-cong Liu, Yu Huang, Kenneth Lo, Yu-qing Huang, Ji-yan Chen, Ying-qing Feng
Summary: The study found that the Waist-BMI Ratio can independently predict overall and cardiovascular mortality risk in a dose-response relationship, with ROC curve analysis showing it to be a better discriminator of mortality compared to BMI, WC, and waist-to-height ratio.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Mee-Ri Lee, Sung Min Jung
Summary: This study investigated the effects of folic acid on obesity and high-sensitivity CRP levels. The results showed a significant inverse association between folic acid levels and obesity and inflammatory biomarkers, especially in the middle-aged group.
Article
Oncology
Mi Na Kim, Kyungdo Han, Juhwan Yoo, Yeonjung Ha, Young Eun Chon, Ju Ho Lee, Seong Gyu Hwang
Summary: This study investigated the impact of short-term changes in general and central fatness on the risk of hepatocellular carcinoma (HCC). The results showed that both incident and persistent general and central fatness were associated with an increased risk of HCC. This emphasizes the importance of preventing and reversing body fatness to reduce the incidence of HCC.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
David A. Holdsworth, Rebecca Chamley, Rob Barker-Davies, Oliver O'Sullivan, Peter Ladlow, James L. Mitchell, Dominic Dewson, Daniel Mills, Samantha L. J. May, Mark Cranley, Cheng Xie, Edward Sellon, Joseph Mulae, Jon Naylor, Betty Raman, Nick P. Talbot, Oliver J. Rider, Alexander N. Bennett, Edward D. Nicol
Summary: Post-COVID illness can lead to significant physical and neurocognitive deficits, impacting patients' daily lives and work performance. This study conducted a comprehensive assessment on a group of recovered patients and found a high burden of symptoms persisting 6 months after recovery, with a failure to regain pre-infection health status.
Article
Pediatrics
Hsun-Chin Chao, Hsin-Yeh Lin
Summary: In overweight and obese children, waist circumference, BMI, and abdominal subcutaneous fat thickness are positively correlated with the severity of NAFLD. Particularly, waist circumference has the highest predictive accuracy, especially in subjects aged 6-12 years and 13-17 years.
FRONTIERS IN PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Solange Parra-Soto, Fanny Petermann-Rocha, Jirapitcha Boonpor, Stuart R. Gray, Jill P. Pell, Carlos Celis-Morales, Frederick K. Ho
Summary: The combination of overweight and central obesity is associated with a higher risk of abdominal cancer, and some associations are sex-specific.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Nutrition & Dietetics
Moien A. B. Khan, Preetha Menon, Romona Govender, Amal Mb Abu Samra, Kholoud K. Allaham, Javaid Nauman, Linda Ostlundh, Halla Mustafa, Jane E. M. Smith, Juma M. AlKaabi
Summary: This systematic review evaluates the impact of pandemic confinement on body weight and finds that weight gain and weight loss were observed during the pandemic. Weight gain was more common among individuals who were already overweight or obese, while weight loss was observed in individuals with previous low weight. Factors such as changes in diet, physical activity, and sleep patterns were associated with these changes in body weight. Individuals with reduced income, particularly those with lower educational attainment, faced greater challenges in maintaining a stable weight.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Medicine, Research & Experimental
Abderrahim Nemmar, Suhail Al-Salam, Sumaya Beegam, Nur Elena Zaaba, Ozaz Elzaki, Javed Yasin, Badreldin H. Ali
Summary: Waterpipe tobacco smoking is harmful to the cardiovascular system, but smoking cessation can alleviate the associated toxicity. Waterpipe smoking causes hypertension, prothrombotic events, oxidative stress, inflammation, DNA damage, and apoptosis in the heart, while quitting smoking can reduce these negative effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Nutrition & Dietetics
Fatme Al Anouti, Luai A. Ahmed, Azmat Riaz, William B. Grant, Nadir Shah, Raghib Ali, Juma Alkaabi, Syed M. Shah
Summary: Vitamin D deficiency is prevalent among female migrants in the UAE, especially among Arabs and South Asians. Low physical activity, residing in the UAE for more than 5 years, and obesity are independently associated with vitamin D deficiency. Health professionals should be aware of this situation in this vulnerable population and provide intervention strategies focusing on sun exposure, physical activity, and supplementation.
Article
Biochemistry & Molecular Biology
Suhail Al-Salam, Karthishwaran Kandhan, Manjusha Sudhadevi, Javed Yasin, Saeed Tariq
Summary: Doxorubicin is a commonly used drug for cancer treatment, but its usage is limited due to serious side effects, including cardiotoxicity. This study found that Gal-3, a protein, is upregulated in conditions such as heart failure. The findings suggest that Gal-3 can affect the redox pathways and regulate cell survival and death in acute Doxorubicin-induced cardiotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Raya Almazrouei, Charu Sharma, Bachar Afandi, Khaled M. Aldahmani, Elhadi H. Aburawi, Salem A. Beshyah, Gehad ElGhazali, Zain Al Yafei, Rami H. Al-Rifai, Juma Alkaabi
Summary: This study aimed to characterize Emiratis patients with Type 1 diabetes (T1D) and compare the outcomes of continuous subcutaneous insulin infusion (CSII) versus multiple daily insulin injections (MDI) users. The results showed that CSII usage was associated with better glycemic control compared to MDI. However, there was no significant difference in diabetic ketoacidosis (DKA) and severe hypoglycemia between the two groups. The study concludes that overall glycemic control among Emiratis with T1D is unsatisfactory and calls for more rigorous patient counseling and education.
Article
Environmental Sciences
Nirmin F. Juber, Abdishakur Abdulle, Abdulla AlJunaibi, Abdulla AlNaeemi, Amar Ahmad, Andrea Leinberger-Jabari, Ayesha S. Al Dhaheri, Eiman AlZaabi, Fatima Mezhal, Fatma Al-Maskari, Fatme AlAnouti, Habiba Alsafar, Juma Alkaabi, Laila Abdel Wareth, Mai Aljaber, Marina Kazim, Michael Weitzman, Mohammad Al-Houqani, Mohammed Hag Ali, Naima Oumeziane, Omar El-Shahawy, Scott Sherman, Sharifa AlBlooshi, Syed M. Shah, Tom Loney, Wael Almahmeed, Youssef Idaghdour, Raghib Ali
Summary: Limited studies have focused on maternal early-life risk factors and the later development of gestational diabetes mellitus (GDM). This study aimed to estimate GDM prevalence and examine the associations between maternal birthweight and parental history of diabetes with later GDM. The findings suggest that low birthweight and parental history of diabetes are significantly associated with later GDM.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biology
Abdelouahab Bellou, Nacira Sennoun, Elhadi H. Aburawi, Richard L. Jayaraj, Seth L. Alper, Ibrahim Abdallah Alfaki, Javed Yasin, Subramanian Sekar, Mohamed Shafiuallah, Suhail Al-Salam, Abderrahim Nemmar, Elsadig Kazzam, Paul Michel Mertes, Suleiman Al-Hammadi
Summary: The mechanism of anaphylactic shock and potential treatments were investigated using experiments on ovalbumin rats. The potassium channel blocker 4-aminopyridine (4-AP) was found to be effective in restoring blood pressure and improving survival rates, especially when used in combination with other drugs.
Article
Nutrition & Dietetics
Nur Elena Zaaba, Suhail Al-Salam, Sumaya Beegam, Ozaz Elzaki, Javed Yasin, Abderrahim Nemmar
Summary: Catalpol, an active compound in traditional Chinese medicine Rehmannia glutinosa, has shown significant protective effects against adenine-induced chronic kidney disease (CKD) in mice. It reduces inflammation, oxidative stress, and fibrosis in the kidneys, and improves renal function. This study suggests that catalpol may be a potential nephroprotective agent for CKD.
Article
Nutrition & Dietetics
Fayez T. Hammad, Suhail Al-Salam, Rahaf Ahmad, Javed Yasin, Awwab F. Hammad, Jasmine Abdul Rasheed, Loay Lubbad
Summary: It has been found that nerolidol has a protective effect on renal ischemia-reperfusion injury, improving renal function and reducing tissue damage.
Article
Biochemistry & Molecular Biology
Fayez T. Hammad, Loay Lubbad, Suhail Al-Salam, Javed Yasin, Mohamed Fizur Nagoor Meeran, Shreesh Ojha, Waheed F. Hammad
Summary: Both ureteral obstruction and hypertension have significant impacts on kidney functions. Reversible ureteral obstruction in hypertensive rats showed exaggerated alterations in renal functions and other parameters of renal injury compared to normotensive rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Salah Gariballa, Ghada S. M. Al-Bluwi, Javed Yasin
Summary: The prevalence of obesity and type 2 diabetes is increasing in Gulf countries. This study aimed to measure the effects of increased fruit and vegetable consumption on weight, waist circumference, oxidative damage, and inflammation markers.
Article
Endocrinology & Metabolism
Javed Yasin, Charu Sharma, Muhammad Jawad Hashim, Sania Al Hamed, Juma AlKaabi, Elhadi H. Aburawi
Summary: This study aimed to investigate the obesity pattern in children in the UAE and determine clinical correlations with biomarkers. The results showed a strong association between body fat composition, lipid profile, and inflammatory and endothelial dysfunction biomarkers in obese children. Immediate measures should be taken to reduce the risk of obesity and associated diseases.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Biochemistry & Molecular Biology
Salah Gariballa, Ghada S. M. Al-Bluwi, Javed Yasin
Summary: This study investigated the effects of physical activity on obesity and metabolic risk factors in a sample of 965 Emirati subjects. It found that increased physical activity was associated with decreased risk of obesity, as well as lower oxidative damage and inflammatory responses.
Article
Biochemistry & Molecular Biology
Salah Gariballa, Ghada S. M. Al-Bluwi, Javed Yasin
Summary: A study on 277 healthy individuals in the United Arab Emirates found an association between vitamin D receptor gene polymorphisms and vitamin D levels. However, this association became non-significant after adjusting for clinical parameters that influence vitamin D levels. Additionally, no association was found between obesity and related pathologies and the vitamin D receptor gene polymorphisms.
Article
Oncology
Juma Alkaabi, Charu Sharma, Javed Yasin, Bachar Afandi, Salem A. Beshyah, Raya Almazrouei, Ahmed Alkaabi, Sania Al Hamad, Luai A. Ahmed, Rami Beiram, Elhadi H. Aburawi
Summary: This study revealed a strong association between elevated lipid profile and inflammatory and ED markers with T1DM, which could lead to cardiovascular events in the UAE population.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
