Journal
RUSSIAN CHEMICAL BULLETIN
Volume 66, Issue 1, Pages 129-135Publisher
SPRINGER
DOI: 10.1007/s11172-017-1710-2
Keywords
glycyrrhizic acid; glycyrrhizin; arabinogalactan; beta-cyclodextrin; K562 cells; membrane permeability; drug delivery
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Funding
- Russian Foundation for Basic Research [15-04-02538, 15-29-05792]
- Federal Agency of Scientific Organizations of Russia [0324-2015-0004]
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Glycyrrhizic acid, arabinogalactan, and beta-cyclodextrin are capable of forming complexes with various drug compounds significantly enhancing their solubility and bioavailability. To elucidate the mechanism of action of oligo- and polysaccharides, the exchange time of transporting formate ions through the membrane of myeloblastic leukemia cells (K562) was measured by NMR spectroscopy with the addition of paramagnetic ions. It was found that glycyrrhizic acid and arabinogalactan substantially increased the membrane permeability.
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