Article
Immunology
Qianqian Liu, Yan Gao, Tao Yang, Zhe Zhou, Ke Lin, Wei Zhang, Ting Li, Yi Lu, Lingyun Shao, Wenhong Zhang
Summary: This study investigated the profile of neutrophil CD64 index in febrile patients and explored its diagnostic and prognostic value in infectious and non-infectious inflammatory diseases. The results showed that the CD64 index can be used to predict 28-day hospital mortality in sepsis patients and evaluate prognosis. Additionally, serial determinations of the CD64 index are helpful for predicting disease progression in patients with non-infectious inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Cesar de la Fuente-Nunez, Angela Cesaro, Robert E. W. Hancock
Summary: Despite advances in antibiotic discovery, millions of people still die from infections every year. Antibiotic failure is not solely due to antibiotic resistance, but also related to biofilm formation, sepsis, and the microbiome. To address the crisis of antibiotic failure, it is necessary to explore treatment strategies beyond antibiotics and develop new anti-infectives or host-directed therapies.
DRUG RESISTANCE UPDATES
(2023)
Review
Biotechnology & Applied Microbiology
Chung-Nga Ko, Shaohong Zang, Yingtang Zhou, Zhangfeng Zhong, Chao Yang
Summary: This article provides an up-to-date overview of the strategies and applications of nanocarrier-assisted innate immune modulation for the management of infections and their associated complications. It discusses the importance of innate immunity in defending against pathogens and the role of immunomodulators in treating infectious diseases. The use of nanocarriers as a promising tool to overcome challenges in immunomodulator therapy is also explored.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Emergency Medicine
Carmen C. Polito, Ingrid Bloom, Charity Dunn, Renee ' Moore, Jiandong Chen, Arthur H. Yancey II, Jonathan E. Sevransky
Summary: This study aims to evaluate whether the implementation of an EMS sepsis screening and prehospital alert protocol called PRESS is associated with improved sepsis recognition by EMS providers. The results show that the implementation of the PRESS protocol increased sepsis recognition rates by EMS providers and resulted in a decreased time to first antibiotic administration in the emergency department.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Infectious Diseases
Gamze Gursoy, Omrum Uzun, Gokhan Metan, Mehmet Yildirim, Melda Bahap, Salih Kutay Demirkan, Arzu Topeli, Seda Banu Akinci, Mehmet Akif Topcuoglu, Mustafa Berker, Gulsen Hazirolan, Murat Akova, Serhat Unal
Summary: Antibiotic resistance is a major public health concern, with a slower rate of introducing new molecules. This study evaluated the quality of care before and after active intervention and feedback in an ICU setting, and significant improvements were observed.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Neil Pearce, Giovenale Moirano, Milena Maule, Manolis Kogevinas, Xavier Rodo, Deborah A. Lawlor, Jan Vandenbroucke, Christina Vandenbroucke-Grauls, Fernando P. Polack, Adnan Custovic
Summary: The death rate of Covid-19 increases exponentially with age, with the main risk factors being underlying conditions, and the relationship between CFR and age is approximately linear in various countries. Compared to SARS, Covid-19 and SARS have different age patterns in terms of death.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Immunology
Stephanie Shulder, Pranita D. Tamma, Suiyini Fiawoo, Kathryn Dzintars, Daniel Escobar, Daniel J. Livorsi, Anurag N. Malani, Danica Palacio, Emily S. Spivak, Matty Zimmerman, Jacqueline T. Bork
Summary: A 24-site observational cohort study showed that infectious diseases consultation (IDC) reduced the risk of 30-day mortality by 40% in hospitalized patients with Gram-negative bacteremia (GN-BSI).
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Pharmacology & Pharmacy
Nicolas Severino, Soledad Urzua, Mauricio Ibacache, Claudio Paulos, Luis Cortinez, Alberto Toso, Liliana Leguizamon, Rocio Inojosa, Andrea Maccioni, Sebastian Meza, Andres Garcia, Marcelo Ramirez, Catalina Von Mentlen, Javiera Ceballos, Noemi Paredes
Summary: This study aimed to characterize the pharmacokinetic parameters of intravenous amikacin in newborns and assess the impact of sepsis on amikacin exposure. Data from 329 drug assay samples obtained from 116 newborn patients showed that weight, postmenstrual age (PMA), and renal function were key factors influencing amikacin pharmacokinetics in newborns. Additionally, it was found that pathophysiological states such as sepsis and shock had opposite effects on amikacin clearance and should be considered in dose adjustments.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pediatrics
Godwin Oligbu, Leila Ahmed, Laura Ferraras-Antolin, Shamez Ladhani
Summary: The overall and infection-related neonatal mortality rates decreased from 2003-2005 to 2013-2015. Infections were responsible for 13.1% of neonatal deaths, with bacterial pathogens being the most common. Further preventive measures, such as antenatal GBS vaccines, may be needed to reduce infection-related deaths in neonates.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2021)
Review
Medicine, General & Internal
Victoria Birlutiu, Loredana Camelia Boicean
Summary: This article provides an overview of the correlations between variations of leptin levels and infectious diseases and sepsis. The results suggest potential therapeutic roles of leptin analogs in states of leptin deficiency and the need for further investigation into therapeutic strategies for hyperleptinemia. Further studies are needed to demonstrate the specificity and sensitivity of leptin in the early diagnosis of sepsis and its role in managing this life-threatening condition.
Article
Medicine, General & Internal
Fai Lam, Chien-Chang Liao, Ta-Liang Chen, Yu-Min Huang, Yuarn-Jang Lee, Hung-Yi Chiou
Summary: Based on Taiwan's National Health Insurance Research Data, recent influenza infection increases the risk of postoperative complications, especially when it occurs within 7 days prior to surgery.
FRONTIERS IN MEDICINE
(2023)
Article
Health Care Sciences & Services
Stacey L. Rowe, Karin Leder, Lalitha Sundaresan, Dennis Wollersheim, Jock Lawrie, Nicola Stephens, Benjamin C. Cowie, Terry M. Nolan, Allen C. Cheng
Summary: By analyzing the mortality data of communicable diseases reported in Victoria, Australia, it was found that the case fatality rate of these diseases is often underestimated, and people notified with communicable diseases have a higher all-cause mortality rate up to one year following illness onset compared to the general population. This may be related to underlying comorbidities or behaviors in these individuals.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Health Care Sciences & Services
Oyelola A. Adegboye, Emma S. McBryde, Damon P. Eisen
Summary: Based on the study, male sex, Indigenous status, age and comorbidity are associated with an increased risk of mortality in patients with infectious diseases.
Editorial Material
Geriatrics & Gerontology
Rodrigo Nunez-Cortes, Ruben Lopez-Bueno, Rodrigo Torres-Castro, Camilo Soto-Carmona, Maritza Ortega-Palavecinos, Sofia Perez-Alenda, Lilian Solis-Navarro, Oscar Diaz-Cambronero, Francisco M. Martinez-Arnau, Joaquin Calatayud
Summary: The aim of this prospective study was to examine the risk factors most associated with mortality one year after diagnosis of COVID-19. The study found that age was the most important risk factor, and disabilities, institutionalization, and socioeconomic status were also significantly associated with mortality.
Letter
Immunology
Shu-Chen Kuo, Hsiao-Hui Tsou, Hsiao-Yu Wu, Ya-Ting Hsu, Fang-Jing Lee, Shu-Man Shih, Chao A. Hsiung, Wei J. Chen
Summary: Adherence to non-pharmaceutical interventions in Taiwan during the 2020 coronavirus pandemic led to lower nonpolio enterovirus activity compared to 2014-2019. The study suggests that 90% of nonpolio enterovirus activity during 2014-2019 could have been prevented by adopting the same measures enforced in 2020.
EMERGING INFECTIOUS DISEASES
(2021)