Journal
RNA BIOLOGY
Volume 15, Issue 4-5, Pages 480-491Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2017.1356980
Keywords
Lipid aminoacylation; antimicrobial resistance; cationic antimicrobial peptides; tRNA
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Funding
- National Institute of General Medical Sciences Grant [R15-109404]
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tRNA-dependent addition of amino acids to lipids on the outer surface of the bacterial membrane results in decreased effectiveness of antimicrobials such as cationic antimicrobial peptides (CAMPs) that target the membrane, and increased virulence of several pathogenic species. After a brief introduction to CAMPs and the various bacterial resistance mechanisms used to counteract these compounds, this review focuses on recent advances in tRNA-dependent pathways for lipid modification in bacteria. Phenotypes associated with amino acid lipid modifications and regulation of their expression will also be discussed.
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