Article
Pharmacology & Pharmacy
Xiao-Feng Li, Sha Wu, Qi Yan, Yuan-Yuan Wu, He Chen, Su-Qin Yin, Xin Chen, Hua Wang, Jun Li
Summary: The study reveals that PTEN methylation promotes inflammation and activation in fibroblast-like synoviocytes (FLS) in the pathogenesis of rheumatoid arthritis (RA). Inhibiting methylation can reduce inflammation and alleviate joint swelling, potentially serving as an effective treatment strategy for RA.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Zewen Wu, Dan Ma, Helin Yang, Jinfang Gao, Gailian Zhang, Ke Xu, Liyun Zhang
Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Parisa Zafari, Mahdi Taghadosi, Fatemeh Faramarzi, Misagh Rajabinejad, Alireza Rafiei
Summary: This study demonstrates that DMF treatment can suppress the proliferation and promote apoptosis of RA synovial cells, and reduce the release of inflammatory factors. These findings suggest that DMF may be considered as a therapeutic approach in the treatment of RA.
Article
Immunology
Chuyu Shen, Yu Kuang, Shudi Xu, Ruiru Li, Jingnan Wang, Yaoyao Zou, Cuicui Wang, Siqi Xu, Liuqin Liang, Changsong Lin, Youjun Xiao, Hanshi Xu
Summary: Nitidine chloride (NC) inhibits the invasive and inflammatory actions of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) by targeting KCNH1 gene and inhibiting AKT phosphorylation, reducing the severity of arthritis in mice with RA. This discovery suggests that NC may be a novel therapeutic agent for RA, controlling FLS-mediated rheumatoid synovial inflammation and joint destruction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Kathrin Koedderitzsch, Ekaterina Zezina, Lingzi Li, Matthias Herrmann, Nadine Biesemann
Summary: The study revealed a direct role of TNF in the glycolytic reprogramming of FLS, confirming the potency of immunometabolism in RA. TNF stimulation was shown to enhance glycolysis, reduce GLUT1 and GAPDH levels, which may be linked to treatment response in patients.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Alexander Blagov, Andrey Grechko, Nikita G. Nikiforov, Alexander D. Zhuravlev, Nikolay K. Sadykhov, Alexander N. Orekhov
Summary: This article discusses the connection between metabolism and inflammation in rheumatoid arthritis, exploring the changes in metabolic processes and their immunomodulatory effects, as well as the metabolic features of synovial membrane cells during inflammation and potential targets for the therapy of rheumatoid arthritis.
Article
Immunology
Dorra Elhaj Mahmoud, Wajih Kaabachi, Nadia Sassi, Amel Mokhtar, Myriam Moalla, Lobna Ben Ammar, Samia Jemmali, Sonia Rekik, Lamjed Tarhouni, Maryam Kallel-Sellami, Elhem Cheour, Lilia Laadhar
Summary: RA td-FLS, fd-FLS, and fibrocytes from patients express similar levels of Wnt5a and its receptors/coreceptors. Wnt5a stimulates pro-inflammatory targets in RA td-FLS, especially IL1 beta, IL8, and IL6, and this inflammation is enhanced in the presence of SFRP5. Additionally, Wnt5a and SFRP5 inhibit the expression of TCF4 and the canonical coreceptor LRP5.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Robin Caire, Estelle Audoux, Guillaume Courbon, Eva Michaud, Claudie Petit, Elisa Dalix, Marwa Chafchafi, Mireille Thomas, Arnaud Vanden-Bossche, Laurent Navarro, Marie-Therese Linossier, Sylvie Peyroche, Alain Guignandon, Laurence Vico, Stephane Paul, Hubert Marotte
Summary: The study indicates that YAP/TAZ play crucial roles in arthritis, and their transcriptional inhibition may be relevant for treating inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yuan Liu, Peishi Rao, Hongyan Qian, Yesi Shi, Shiju Chen, Jingying Lan, Dan Mu, Rongjuan Chen, Xinwei Zhang, Chaoqiong Deng, Gang Liu, Guixiu Shi
Summary: Fibroblast-like synoviocytes (FLS) are the main cell component in inflamed joints of patients with rheumatoid arthritis (RA) and interact with infiltrating T cells. Under normal conditions, FLS have inhibitory effects on T cells, but in RA, FLS exhibit a proinflammatory phenotype. The signals that control FLS heterogeneity are still unclear.
Article
Immunology
Ziye Wang, Zhen Zhao, Zhichang Li, Liling Xu, Hongchao Li, Huaqun Zhu, Gong Cheng, Ranran Yao, Wenwen Pei, Ruyu Liang, Renge Liang, Hua Ye, Shan Jiang, Haitao Niu, Xiaolin Sun, Yin Su
Summary: This study reveals the correlation between Tyro3 Protein Tyrosine Kinase (Tyro3TK) expression and the progression of rheumatoid arthritis (RA). Blocking Tyro3TK can reduce the secretion of inflammatory cytokines and matrix metalloproteinases, limit migration and invasiveness of RA fibroblast-like synoviocytes (FLS), and attenuate the differentiation of pathogenic helper T cell subsets mediated by FLS. Additionally, in vivo studies show that Tyro3TK-deficient mice have reduced joint pathology, tempered synovial inflammation, and restored immune cell equilibrium.
CLINICAL IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Weihong Xu, Lu Ye, Huaxiang Wu
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with increasing incidence globally. The study revealed that miR-4423-3p is downregulated in RA patients and targets MMP13 to inhibit cell proliferation, migration, and invasion while promoting apoptosis in HFLS-RA cells.
Article
Oncology
Jian Chen, Xian Lin, Juan He, Dandan Liu, Lianhua He, Miaomiao Zhang, Huijie Luan, Yiping Hu, Cheng Tao, Qingwen Wang
Summary: The study found that ATT has potential therapeutic effects on RA by suppressing proliferation, migration, and invasion of RA-FLSs, as well as inducing apoptosis. ATT achieves therapeutic potential for RA by modulating the METTL3/ICAM2/PI3K/AKT/p300 feedback loop.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Yanhua Zuo, Huaheng Xu, Yanxia Li, Zongfang Zhang, Ran Tao, Manxiang Wang
Summary: Synovial samples from RA patients and normal controls were used to isolate FLSs. Increased expression of circ_0007707 was observed in synovial samples from RA patients and FLS-RA cells. Circ_0007707 silencing inhibited cell proliferation, induced cell apoptosis, and decreased cell inflammatory response in FLS-RA cells. Mechanistically, circ_0007707 mediated cell apoptosis and inflammatory response in FLS-RA cells through the miR-27b-3p/PDE3B axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Xinpeng Zhou, Duoli Xie, Jie Huang, Aiping Lu, Rongsheng Wang, Yehua Jin, Runrun Zhang, Cen Chang, Lingxia Xu, Linshuai Xu, Junyu Fan, Chao Liang, Dongyi He
Summary: The study found that LLDT-8 inhibited the proliferation, invasion, and cytokine production of RA FLS by regulating the WAKMAR2/miR-4478/E2F1/p53 axis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yu Tai, Bei Huang, Pai-pai Guo, Zhen Wang, Zheng-wei Zhou, Man-man Wang, Han-fei Sun, Yong Hu, Sheng-lin Xu, Ling-ling Zhang, Qing-tong Wang, Wei Wei
Summary: Our study demonstrates the impact of TNF-alpha on cAMP homeostasis and the interaction between TNF-alpha and EP4 signaling, revealing the potential role of TRAF2 and GRK2 in the treatment of inflammatory diseases. The findings provide valuable insights into a novel form of cross-talk between cytokine receptors and G protein-coupled receptors, suggesting TRAF2-GRK2 interaction as a potential new drug target.
ACTA PHARMACOLOGICA SINICA
(2022)
Editorial Material
Rheumatology
Qiang Xu, Chang-Song Lin, Cong-Qiu Chu
Article
Pharmacology & Pharmacy
Yan-Zhuan Xiao, Zhi-Zhong Ye, Yuan-Tong Liang, Xin-Peng Chen, Yu-Hsun Wang, Qiang Xu, James Cheng-Chung Wei
Summary: This study using data from the National Health Insurance Research database in Taiwan found that Chinese herbal medicine therapy does not significantly increase the risk of chronic kidney disease in gout patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiao-Bao Liu, Lu-Shi Tang, Jing-Wen Chen, Chang-Song Lin, Qiu-Hong Liu, Qiang Xu
Summary: This case study demonstrates that tofacitinib can alleviate ocular inflammation and improve eyesight in patients with uveitis, while reducing glucocorticoid consumption and normalizing blood sugar levels. The use of JAK inhibitors could be a potential treatment option for noninfectious uveitis, especially in patients who do not respond to conventional anti-TNF-alpha inhibitors like adalimumab.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Jing-Wen Chen, Guo-Shu Deng, Wen-Shuang Zhang, Ming-Ying Zhang, Tong Guan, Qiang Xu
Summary: This study reported the first successful case of a 60-year-old HIV-positive woman with difficult-to-treat RA who was treated with ADA therapy. It was found that adalimumab is a safe option for patients with RA-HIV and may slow down the progression of HIV infection. Furthermore, HAART therapy has the potential to reduce joint pain and fatigue in patients with difficult-to-treat RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wei Feng, Xiao-Qin Zhong, Xue-Xia Zheng, Qing-Ping Liu, Min-Ying Liu, Xiao-Bao Liu, Chang-Song Lin, Qiang Xu
Summary: Quercetin, widely found in Chinese herbal plants, has been used to treat gout arthritis in China for thousands of years. This study used network pharmacology and experiments to uncover the mechanisms of quercetin in treating gout arthritis. It was found that quercetin mainly influenced the interleukin-17, tumor necrosis factor, mitogen-activated protein kinase, and phosphoinositide 3-kinase-Akt signaling pathways in the treatment of gout arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Editorial Material
Rheumatology
Qiang Xu, Zhi-Shan Huang, Qing-Ping Liu, James Cheng-Chung Wei
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2022)
Article
Immunology
Shu-Lin Chen, Hui-Juan Zheng, Li-Yu Zhang, Qiang Xu, Chang-Song Lin
Summary: This study reports a case of systemic lupus erythematosus complicated with Jaccoud arthropathy without bone erosion. The patient's joint symptoms improved after treatment, suggesting that the use of tofacitinib, methotrexate, celecoxib, and prednisone may be an effective regimen for the treatment of Jaccoud arthropathy.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Editorial Material
Rheumatology
Qiang Xu, Chang-Song Lin
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Plant Sciences
Nan Li, Zhixin Chen, Wei Feng, Zhaohui Gong, Changsong Lin, Jiaxu Chen, Congqiu Chu, Qiang Xu
Summary: This study explores the molecular mechanisms underlying the therapeutic effects of triptolide in rheumatoid arthritis (RA) and identifies the miRNA pathway responsible for these effects. It reveals that triptolide regulates the growth and secretory functions of chondrocytes via inhibiting miR-221 secretion by fibroblast-like synovial cells, providing a potential target for future RA treatments.
Article
Cell Biology
Nan Li, Shulin Chen, Weiqing Deng, Zhaohui Gong, Yu Guo, Shan Zeng, Qiang Xu
Summary: This study explored the potential mechanisms by which kaempferol regulates gouty arthritis (GA) through network pharmacology and experimental validation. The results showed that kaempferol exerts therapeutic effects on GA by regulating the IL-17, AGE-RAGE, p53, TNF, and FoxO signaling pathways. Experimental validation supported the clinical use of kaempferol for GA treatment.
Article
Multidisciplinary Sciences
Jing-Wen Chen, Qiang Xu, Pei-Dan Yang, Jing-Yang Huang, James Cheng-Chung Wei
Summary: This retrospective cohort study aimed to analyze the association between thalassemia and gout arthritis. The results indicated that thalassemia did not significantly increase the risk of gout arthritis.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Wei Feng, Xiao-Qin Zhong, Xue-Xia Zheng, Qing-Ping Liu, Min-Ying Liu, Xiao-Bao Liu, Chang-Song Lin, Qiang Xu
Summary: This study investigated the influence of Duanteng Yimu decoction (DTYMT) on miR-221 in rheumatoid arthritis (RA) individuals. The results showed that DTYMT effectively inhibited RA fibroblast-like synoviocyte (FLS) proliferation and reduced the expression level of miR-221. This suggests that DTYMT treats RA by reducing miR-221 expression.
JOURNAL OF IMMUNOLOGY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Wei Feng, Xin Wan, Shirong Fan, Cui-Zhen Liu, Xue-Xia Zheng, Qing-Ping Liu, Min-Ying Liu, Xiao-Bao Liu, Chang-Song Lin, Li-juan Zhang, De -tang Li, Qiang Xu
Summary: This study investigated the anti-RA effects of DTYMT and its potential mechanisms using network pharmacology and mouse models, and found that DTYMT may treat RA by regulating the Treg/Th17 cell balance.
Article
Immunology
Shu-Lin Chen, Qiang Xu, Chang-Song Lin
Summary: A study found that the therapeutic drugs for rheumatoid arthritis (RA) are associated with thyroid function, with methotrexate being linked to decreased levels of total thyroxine (TT4) and glucocorticoids being linked to decreased levels of total triiodothyronine (TT3).
INFLAMMOPHARMACOLOGY
(2023)
Article
Urology & Nephrology
Kai-Jun Zhu, Guo-Shu Deng, Li-Yu Zhang, Ye-Chun Yang, Qiang Xu, Ming-Ying Zhang
Summary: This study found that NLR might be an important potential factor for evaluating renal impairment during flares in GA.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)