Journal
ENVIRONMENTAL RESEARCH
Volume 136, Issue -, Pages 352-362Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2014.10.010
Keywords
Airborne particulate matter; Lebanon; Physicochemical characterization; BEAS-2B cells; Genotoxicity; Epigenotoxicity; Lung cancer
Funding
- Lebanese National Council for Scientific Research [02-07-10]
- Agence Universitaire de la Francophonie (PCSI) [6317PS011]
- Unite de Chimie Environnementale et Interactions sur le Vivant [EA 4492]
- Institut de Recherche en EN-vironnement Industriel
- Communaute Urbaine de Dunkerque
- Region Nord-Pas-de-Calais
- Ministere de l'Enseignement Superieur et de la Recherche
- CNRS and European Regional Development Fund
- Doctoral School of Sciences and Technologies of the Lebanese University
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Assessment of air pollution by particulate matter (PM) is strongly required in Lebanon in the absence of an air quality law including updated air quality standards. Using two different PM2.5-03 samples collected at an urban and a rural site, we examined genotoxic/epigenotoxic effects of PM exposure within a human bronchial epithelial cell line (BEAS-2B). Inorganic and organic contents evidence the major contribution of traffic and generating sets in the PM2.5-0.3 composition. Urban PM2.5-0.3 sample increased the phosphorylation of H2AX, the telomerase activity and the miR-21 up-regulation in BEAS-2B cells in a dose-dependent manner. Furthermore, urban PM2.5-0.3 induced a significant increase in CYP1A1, CYP1B1 and AhRR genes expression. The variable concentrations of transition metals and organic compounds detected in the collected PM2.5-0.3 samples might be the active agents leading to a cumulative DNA damage, critical for carcinogenesis. (C) 2014 Elsevier Inc. All rights reserved.
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