Journal
REVIEWS IN THE NEUROSCIENCES
Volume 28, Issue 2, Pages 155-159Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/revneuro-2016-0060
Keywords
ABCA1; ABCA5; ABCA7; ABCB1; ABCG2; cholesterol metabolism
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Funding
- Focus on Research and Development Plan of Science & Technology Department of Hunan Province of China [2015SF2029-2]
- New Xiangya Talent Project of the Third Xiangya Hospital of Central South University [20150305]
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The ATP-binding cassette (ABC) transporter superfamily is a large family of proteins that transport specific molecules across membranes. These proteins are associated with both cholesterol metabolism and Alzheimer's disease (AD). Cholesterol homeostasis has a key role in AD, and ABC transporters are important mediators of lipid transportation. Emerging evidence suggests that decreased expression and hypofunction of ABC transporters are crucial to the occurrence and development of AD. In the present article, we review the current knowledge regarding ABC transporters and speculate on their role in the pathogenesis of AD.
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