Article
Critical Care Medicine
Robert M. Rodriguez, Zian H. Tseng, Juan Carlos C. Montoy, Daniel Repplinger, Ellen Moffatt, Newton Addo, Ralph C. Wang
Summary: This study developed simple decision instruments to rapidly identify occult opioid overdose-associated out-of-hospital cardiac arrests, in order to guide the selective administration of the antidote naloxone in resuscitation efforts.
Article
Medicine, General & Internal
Tea Rosic, Gillian Kolla, Pamela Leece, Sophie Kitchen, Tara Gomes
Summary: Rates of opioid-related deaths are increasing among youths in Ontario, Canada while the use of opioid agonist treatment (OAT) is declining. Further investigation is needed to understand the reasons behind these trends and to optimize care for youths who use substances.
Article
Cardiac & Cardiovascular Systems
Arnar B. Ingason, Arnar Geirsson, Tomas Gudbjartsson, Jochen D. Muehlschlegel, Martin Sigurdsson
Summary: This nationwide cohort study examined the rate of new persistent opioid use after cardiac surgery by sternotomy and found it to be 4.6%. Risk factors for new persistent opioid use included chronic obstructive pulmonary disease, preoperative use of nonsteroidal anti-inflammatory drugs, gabapentinoids, and nitrates. Patients with new persistent opioid use did not have higher rates of readmission or all-cause mortality.
ANNALS OF THORACIC SURGERY
(2022)
Letter
Medicine, General & Internal
Senada S. Malik, Wilbert S. Aronow, Alexandros Briasoulis
Summary: Opioid abuse is a significant cause of cardiac arrest, and cardiac arrest related to opioid abuse is more likely to have severe complications compared to those without opioid abuse, despite similar in-hospital mortality.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ingrid A. Binswanger, Susan M. Shetterly, Stanley Xu, Komal J. Narwaney, David L. McClure, Deborah J. Rinehart, Anh P. Nguyen, Jason M. Glanz
Summary: This study evaluated the association between opioid dose trajectories observed in practice and patient outcomes, finding that decreasing opioid dose was associated with reduced risk of opioid use disorder and continued opioid therapy but increased risk of disenrollment compared with stable dosing.
Article
Substance Abuse
Katarina Jones, Dana Bernson, Katherine T. Fillo, Amy L. Bettano
Summary: This study aims to create a new framework for emergency medical service (EMS) opioid-related incidents (ORIs) to accurately describe the opioid epidemic in Massachusetts. By categorizing the data, the study reveals new trend details and strains on the EMS system. Over half of the ORIs were acute overdose, followed by intoxication, other ORIs, withdrawal, and dead on arrival. The study also found differences in naloxone administration between the categories. Overall, the findings improve dataset linkage and interstate rate comparisons.
Article
Pediatrics
Natalie J. Wilkins, Heather Clayton, Christopher M. Jones, Melissa Brown
Summary: The study found a significant association between youth prescription opioid misuse and suicidal behaviors, particularly with higher risks for suicidal ideation, planning, and attempts among current misusers. Comprehensive prevention approaches are needed to address these public health challenges among youth.
Article
Substance Abuse
Grant A. Victor, Katie Bailey, Brad Ray
Summary: A retrospective study in Indiana in 2017 on drug overdose deaths showed that increasing buprenorphine dispensation significantly reduces the likelihood of fatal overdoses.
SUBSTANCE USE & MISUSE
(2021)
Review
Neurosciences
Stevie C. Britch, Sharon L. Walsh
Summary: This narrative review provides a brief overview of naloxone, its history and pharmacology, as well as the evidence regarding naloxone efficacy against fentanyl and fentanyl analogs. Current advances in overdose treatments and technologies are highlighted.
PSYCHOPHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Jennifer R. Lyden, Stanley Xu, Komal J. Narwaney, Jason M. Glanz, Ingrid A. Binswanger
Summary: Individuals prescribed long-term opioid therapy (LTOT) are at increased risk of readmission and death after hospital discharge, and the risk of opioid overdose during the immediate post-discharge period is unknown. This study aimed to examine the association between time since hospital discharge and opioid overdose among individuals prescribed LTOT. The results showed that individuals prescribed LTOT appear to be at elevated risk for opioid overdose during the first 7 days after hospital discharge.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Letter
Medicine, General & Internal
Aryn Z. Phillips, Lori A. Post, Maryann Mason
Summary: This cross-sectional study examines the frequency of alcohol abuse in accidental deaths caused by opioid overdose in Illinois between 2017 and 2020.
Article
Oncology
Katie Fitzgerald Jones, Dmitry Khodyakov, Robert Arnold, Hailey Bulls, Emily Dao, Jennifer Kapo, Diane Meier, Judith Paice, Jane Liebschutz, Christine Ritchie, Jessica Merlin
Summary: This qualitative study aims to establish consensus among palliative care and addiction specialists on the appropriateness of various opioid management strategies in individuals with advanced cancer-related pain and opioid misuse or OUD. The findings provide urgently needed guidance for clinicians and highlight critical research and policy gaps.
Article
Medicine, General & Internal
Yu-Jung Jenny Wei, Cheng Chen, Ting-Yuan David Cheng, Siegfried O. Schmidt, Roger B. Fillingim, Almut G. Winterstein
Summary: This study examines the association between incident injury after prescription opioid initiation and the subsequent risk of opioid-related adverse events (ORAEs) among older adults. The findings indicate that injury after starting opioid therapy is associated with an increased risk of ORAEs, especially among patients with injury in the month before starting medication.
Article
Medicine, General & Internal
Michael L. L. Barnett, Ellen Meara, Terri Lewinson, Brianna Hardy, Deanna Chyn, Moraa Onsando, Haiden A. A. Huskamp, Ateev Mehrotra, Nancy E. E. Morden
Summary: An analysis of Medicare claims data from 2016-2019 revealed that white patients were more likely to receive medications for opioid use disorder (OUD) compared to black and Hispanic patients. Despite an increase in opioid overdose-related mortality among black individuals, racial and ethnic disparities in the use of OUD medications remained consistent and substantial over time.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Psychiatry
Bradley Watts, Daniel J. Gottlieb, Natalie B. Riblet, Jiang Gui, Brian Shiner
Summary: Medication treatment for opioid use disorder (MOUD) has been shown to significantly reduce the risk of suicide mortality as well as external causes of mortality and all-cause mortality.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Review
Emergency Medicine
Muhammad Haisum Maqsood, Kumar Ashish, Alexander G. Truesdell, Matthew Belford, David X. Zhao, S. Tanveer Rab, Saraschandra Vallabhajosyula
Summary: This study compared the impact of additional anticoagulation or thrombolytic therapy in patients with cardiac arrest without ST-segment-elevation on electrocardiography and not receiving percutaneous coronary intervention. The study included three studies (two randomized controlled studies and one observational study), which showed that the use of anticoagulation or thrombolytic therapy was associated with a higher risk of bleeding, with no improvements in time to return of spontaneous circulation or in-hospital mortality.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sri Harsha Patlolla, Alexander G. G. Truesdell, Mir B. B. Basir, Syed T. T. Rab, Mandeep Singh, Peter Matthew Belford, David X. X. Zhao, Saraschandra Vallabhajosyula
Summary: This study examined the impact of new trainees on clinical outcomes at teaching hospitals in the United States, specifically in patients with acute myocardial infarction (AMI). The findings showed that AMI patients admitted in July had lower in-hospital mortality, and this effect was not associated with the presence of new trainees in teaching hospitals.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Akshay Machanahalli Balakrishna, Mahmoud Ismayl, Anirudh Palicherla, Ahmed Aboeata, Andrew M. Goldsweig, David X. Zhao, Saraschandra Vallabhajosyula
Summary: This meta-analysis investigated the impact of previous coronary artery bypass graft (CABG) on the outcomes of transcatheter aortic valve replacement (TAVR). The results showed that among patients undergoing TAVR, a history of prior CABG was not associated with an increased risk of periprocedural complications (except for acute myocardial infarction) or short-term mortality.
CORONARY ARTERY DISEASE
(2023)
Article
Critical Care Medicine
Anusha G. Bhat, Dhiran Verghese, Sri Harsha Patlolla, Alexander G. Truesdell, Wayne B. Batchelor, Timothy Henry, Robert J. Cubeddu, Matthew Budoff, Quang Bui, Peter Matthew Belford, David X. Zhao, Saraschandra Vallabhajosyula
Summary: This study investigated the relationship between different management strategies for ST-segment-elevation myocardial infarction (STEMI) and in-hospital cardiac arrest (IHCA). The results showed that early percutaneous coronary intervention (PCI) and delayed PCI were associated with lower incidence and mortality of IHCA compared to medical management, but also resulted in more multiorgan damage and cardiogenic shock.
Review
Critical Care Medicine
Mridul Bansal, Aryan Mehta, Akshay Machanahalli Balakrishna, Arvind Kalyan Sundaram, Ardaas Kanwar, Mandeep Singh, Saraschandra Vallabhajosyula
Summary: Sepsis is a significant public health challenge, with high morbidity and mortality. It affects the cardiovascular system, including the reversible dysfunction of one or both ventricles. There is limited research on the impact of right ventricle dysfunction and its biomarkers in sepsis.
Article
Health Care Sciences & Services
Noppawit Aiumtrakul, Charat Thongprayoon, Supawadee Suppadungsuk, Pajaree Krisanapan, Jing Miao, Fawad Qureshi, Wisit Cheungpasitporn
Summary: This study individually assessed the citation accuracy of AI tools (ChatGPT, Bing Chat, and Bard AI) in the field of Nephrology. The results showed inconsistent citation accuracy among these tools, highlighting the need for cautious and rigorous vetting of AI-sourced references in medicine due to the strict requirements for research integrity.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Charat Thongprayoon, Jing Miao, Caroline C. Jadlowiec, Shennen A. Mao, Michael A. Mao, Napat Leeaphorn, Wisit Kaewput, Pattharawin Pattharanitima, Supawit Tangpanithandee, Pajaree Krisanapan, Pitchaphon Nissaisorakarn, Matthew Cooper, Wisit Cheungpasitporn
Summary: Using unsupervised machine learning, the study identified three clinically distinct clusters of recipients in diabetic deceased donor kidney transplants with differing outcomes. The findings highlight opportunities to improve utilization of high KDPI kidneys from diabetic donors for recipients with survival-limiting comorbidities, as observed in Cluster 1.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Health Care Sciences & Services
Oscar A. Garcia Valencia, Supawadee Suppadungsuk, Charat Thongprayoon, Jing Miao, Supawit Tangpanithandee, Iasmina M. Craici, Wisit Cheungpasitporn
Summary: This critical review examines the ethical implications of integrating chatbots into nephrology and proposes policies and potential solutions. The review highlights the importance of establishing robust guidelines for data collection and sharing, ensuring privacy and data security. It also emphasizes the need for transparent data usage and informed consent. The review suggests regular algorithm reviews and diversity strategies to address potential biases. It further emphasizes the importance of clarity, user-friendly interfaces, and explicit consent procedures. Striking a balance between automation and human intervention and considering cultural sensitivity and multilingual support during chatbot training are also mentioned. The development of comprehensive ethical frameworks encompassing data handling, security, bias mitigation, informed consent, and collaboration is crucial for ethical chatbot utilization in nephrology.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Charat Thongprayoon, Supawit Tangpanithandee, Caroline C. Jadlowiec, Shennen A. Mao, Michael A. Mao, Pradeep Vaitla, Prakrati C. Acharya, Napat Leeaphorn, Wisit Kaewput, Pattharawin Pattharanitima, Supawadee Suppadungsuk, Pajaree Krisanapan, Pitchaphon Nissaisorakarn, Matthew Cooper, Iasmina M. Craici, Wisit Cheungpasitporn
Summary: An unsupervised machine learning approach was used to cluster kidney transplant recipients with prolonged dialysis duration and identify three clinically distinct types. Despite dialysis duration exceeding 10 years, most recipients had good post-transplant outcomes, including those with moderate sensitization.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Health Care Sciences & Services
Oscar A. Garcia Valencia, Charat Thongprayoon, Caroline C. Jadlowiec, Shennen A. Mao, Jing Miao, Wisit Cheungpasitporn
Summary: This article explores the potential integration of chatbots in kidney transplant care to enhance patient outcomes and decision making. Chatbots can provide healthcare professionals with real-time access to medical literature, personalized information, and post-transplant care guidance. However, further studies are needed to validate their effectiveness and safety, and to evaluate the factors influencing their impact and generalizability.
Article
Medicine, General & Internal
Aryan Mehta, Mridul Bansal, Yashashwi Pokharel, Saraschandra Vallabhajosyula
Summary: A 65-year-old male presented with symptoms of chest pain, tachycardia, tachypnea, and diminished breath sounds. Lab investigations showed elevated levels of leukocyte count, erythrocyte sedimentation rate, and B-type natriuretic peptide. Imaging revealed pericardial effusion without tamponade, and the patient was initially treated for acute idiopathic pericarditis. However, subsequent developments of pleural effusions and ascites led to the diagnosis of constrictive pericarditis. The patient underwent pericardiectomy and had a successful recovery.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mridul Bansal, Aryan Mehta, Saraschandra Vallabhajosyula
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Anusha Bhat, Mandeep Singh, Sri Harsha Patlolla, Saraschandra Vallabhajosyula
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Anoop Titus, Vidit Majmundar, Nirav Patel, Janaki M. Omkumar, Rohan Mathews Koshy, Mannil Sooraj, Aishwarya Titus, Akil Adrian Sherif, Anu Mariam Saji, Pramukh Arun Kumar, Mahati Dasari, Sabeeda Kadavath, Saraschandra Vallabhajosyula, Sourbha S. Dani
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Kruti D. Gandhi, Errol C. Moras, Shailesh Niroula, Persio D. Lopez, Devika Aggarwal, Kirtipal Bhatia, Yoni Balboul, Joseph Daibes, Ashish Correa, Abel Casso Dominguez, Edo Y. Birati, David A. Baran, Gregory Serrao, Kiran Mahmood, Saraschandra Vallabhajosyula, Arieh Fox
Summary: In patients requiring circulatory support with VA-ECMO, the use of Impella or IABP resulted in comparable short-term mortality. However, Impella use was associated with an increased risk of major bleeding and hemolysis.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
