Article
Critical Care Medicine
Michael Kreuter, Joyce S. Lee, Argyrios Tzouvelekis, Justin M. Oldham, Philip L. Molyneaux, Derek Weycker, Mark Atwood, Klaus-Uwe Kirchgaessler, Toby M. Maher
Summary: This study aimed to investigate the association between monocyte count and prognosis in patients with idiopathic pulmonary fibrosis (IPF). The results showed that elevated monocyte count was associated with increased risks of IPF progression, hospitalization, and mortality.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Respiratory System
Masato Kono, Yutaro Nakamura, Yasunori Enomoto, Hideki Yasui, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Yoshihiro Miki, Dai Hashimoto, Tomoyuki Fujisawa, Noriyuki Enomoto, Naoki Inui, Yusuke Kaida, Koshi Yokomura, Naoki Koshimizu, Mikio Toyoshima, Shiro Imokawa, Takashi Yamada, Toshihiro Shirai, Hiroshi Hayakawa, Hidenori Nakamura, Takafumi Suda
Summary: A retrospective study on the complication of pneumothorax in patients with idiopathic PPFE revealed a high incidence rate of pneumothorax, predominantly asymptomatic and small in size, with some cases presenting recurrent pneumothorax. Male patients with PPFE pathological diagnosis, prior history of pneumothorax, and corticosteroid use were more likely to develop pneumothorax, which led to significantly poorer survival outcomes.
Article
Critical Care Medicine
Claire M. Nolan, Oliver Polgar, Susie J. Schofield, Suhani Patel, Ruth E. Barker, Jessica A. Walsh, Karen A. Ingram, Peter M. George, Philip L. Molyneaux, Toby M. Maher, William D-C Man
Summary: This study found that patients with IPF have similar completion rates and magnitude of response to pulmonary rehabilitation compared with a matched group of patients with COPD. In IPF, noncompletion of and nonresponse to pulmonary rehabilitation were associated with increased all-cause mortality.
Article
Respiratory System
Hee-Young Yoon, Sun-Young Kim, Ok-Jin Kim, Jin Woo Song
Summary: This study aimed to identify the effect of individual exposure to nitrogen dioxide (NO2) and particulate matter (PM10) on disease progression in patients with idiopathic pulmonary fibrosis (IPF). The results showed that increased individual exposure to NO2 can increase the risk of disease progression in IPF patients.
Article
Immunology
Yupeng Li, Yaowu He, Shibin Chen, Qi Wang, Yi Yang, Danting Shen, Jing Ma, Zhe Wen, Shangwei Ning, Hong Chen
Summary: This study found that S100A12 might be an efficient disease severity and prognostic biomarker in patients with IPF. It is highly expressed in monocytes, but downregulated in lung tissue. Ten genes interacting with S100A12 and the co-expressed genes S100A8 and S100A9 are significantly associated with lung function, survival rates, and survival time in IPF patients. The prognostic predictive value of S100A12 is superior to S100A8 and S100A9 in IPF patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Respiratory System
Hong Yeul Lee, Jinwoo Lee, Chang-Hoon Lee, Kyungdo Han, Sun Mi Choi
Summary: IPF is associated with an increased risk for cancer incidence, especially lung cancer. Healthcare providers should be aware of this risk when treating patients with IPF.
Article
Respiratory System
Ryo Yamazaki, Osamu Nishiyama, Kyuya Gose, Sho Saeki, Hiroyuki Sano, Takashi Iwanaga, Yuji Tohda
Summary: The study found that pneumothorax in patients with IPF was difficult to treat successfully, had a relatively poor prognosis, and showed a high recurrence rate.
BMC PULMONARY MEDICINE
(2021)
Article
Biochemical Research Methods
Kun Lin, Ting Wang, Qingqin Tang, Tingsang Chen, Meishan Lin, Jieyu Jin, Jun Cao, Sheng Zhang, Yanru Xing, Longwei Qiao, Yuting Liang
Summary: In this study, the role of inflammation-related proteins in predicting asthma severity and outcome was investigated. IL18R1 and related genes were found to play an important role in asthma and IPF, and IL18R1-related molecules may serve as biomarkers for monitoring asthma severity and as prognostic markers for IPF.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Changqing Yang, Guixin Wang, Wenyu Zhan, Yubao Wang, Jing Feng
Summary: This study identified IPF subtypes based on metabolism-related pathways and explored potential drugs for each subtype. Two subtypes with significant prognosis differences were discovered, with subtype C1 having a poor prognosis, low metabolic levels, and a unique immune signature. Finally, subtype-specific drugs for potential IPF treatment were identified.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Xinyu Li, Haozheng Cai, Yufeng Cai, Quyan Zhang, Yinghe Ding, Quan Zhuang
Summary: This study developed a hypoxia-immune-related prediction model for the prognosis of IPF, identifying high hypoxia and high immune status as risk factors for poor prognosis in IPF patients. Specific immune cells were found to play key roles in the hypoxia-immune-related microenvironment, and a prediction model based on one protective and nine risk genes was established. The model showed significant applicability in peripheral whole blood, peripheral blood mononuclear cell, and lung tissue of IPF patients in independent validation cohorts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Respiratory System
Toby M. Maher, Elisabeth Bendstrup, Louis Dron, Jonathan Langley, Gerald Smith, Javaria Mona Khalid, Haridarshan Patel, Michael Kreuter
Summary: IPF is a progressive lung disease with varying reported incidence and prevalence globally. Based on analyzed countries, estimated adjusted incidence and prevalence of IPF range from 0.09-1.30 and 0.33-4.51 per 10,000 persons, respectively. Future epidemiologic studies of IPF should account for age, sex, smoking status, and case definition specificity for consistency.
RESPIRATORY RESEARCH
(2021)
Article
Critical Care Medicine
Yosafe Wakwaya, Deepa Ramdurai, Jeffrey J. Swigris
Summary: Chronic cough in patients with IPF may involve multiple mechanisms, including comorbid conditions and IPF itself. Diagnostic and management approaches need to be multi-faceted, but may lack robust data support.
Article
Medicine, General & Internal
Ali-Reza Mohammadi-Nejad, Richard J. Allen, Luke M. Kraven, Olivia C. Leavy, R. Gisli Jenkins, Louise V. Wain, Dorothee P. Auer, Stamatios N. Sotiropoulos, DEMISTIFI Consortium
Summary: This study explored the association between genetic risk of idiopathic pulmonary fibrosis (IPF) and brain structure. The results revealed strong associations between IPF risk loci and cortical morphological features, as well as white matter microstructure. The DEPTOR variant may mediate the association between IPF risk and white matter microstructure.
Article
Respiratory System
Yilin Zhang, Yihong Gan, Hong Zhang
Summary: The study found a causal relationship between dietary intake and IPF, with oily fish and dried fruit intake associated with a decreased risk of IPF, and beef intake suggesting an increased risk of IPF.
BMC PULMONARY MEDICINE
(2023)
Article
Medicine, General & Internal
Toru Arai, Takayuki Takimoto, Naoko Takeuchi, Shojiro Minomo, Tomoko Kagawa, Yoshikazu Inoue
Summary: This study aimed to investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in patients with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). The results showed that the NLR on day 1 was a significant predictor of 90-day survival. Additionally, monitoring NLR on day 4 and day 8, as well as evaluating oxygenation deterioration, may be helpful in managing AE-IPF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Masato Karayama, Naoki Inui, Yusuke Inoue, Katsuhiro Yoshimura, Kazutaka Mori, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Kazuhiro Asada, Tomohiro Uto, Masato Fujii, Takashi Matsui, Shun Matsuura, Dai Hashimoto, Mikio Toyoshima, Hideki Kusagaya, Hiroyuki Matsuda, Nao Inami, Yusuke Kaida, Mitsuru Niwa, Yasuhiro Ito, Takafumi Suda
Summary: Increased serum cholesterol and long-chain fatty acid levels were associated with prolonged survival in non-small cell lung cancer patients treated with nivolumab, suggesting that serum lipid levels may be predictive of the efficacy of immune checkpoint inhibitor therapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Respiratory System
Noriyuki Enomoto, Sakae Homma, Naohiko Inase, Yasuhiro Kondoh, Takeshi Saraya, Hajime Takizawa, Yoshikazu Inoue, Hiroshi Ishii, Yoshio Taguchi, Shinyu Izumi, Yasuhiko Yamano, Yoshinori Tanino, Yasuhiko Nishioka, Mikio Toyoshima, Koshi Yokomura, Shiro Imokawa, Naoki Koshimizu, Takehisa Sano, Taisuke Akamatsu, Hiroshi Mukae, Motoyasu Kato, Naoki Hamada, Hirofumi Chiba, Shinobu Akagawa, Shigeo Muro, Hironori Uruga, Hiroyuki Matsuda, Yusuke Kaida, Miho Kanai, Kazutaka Mori, Masafumi Masuda, Hironao Hozumi, Tomoyuki Fujisawa, Yutaro Nakamura, Noriyoshi Ogawa, Takafumi Suda
Summary: This nationwide multicentre study prospectively evaluated 376 patients with IIP, finding that 18.6% of them met the IPAF criteria. Patients with IPAF were more likely to develop systemic autoimmune diseases, had fewer acute exacerbations of IIP, and showed better survival outcomes. Cluster analysis identified a subgroup with more autoimmune features, predominantly female, and with a better prognosis.
Article
Cell Biology
Yuzo Suzuki, Yuya Aono, Norimichi Akiyama, Yasuoki Horiike, Hyogo Naoi, Ryo Horiguchi, Kiyoshi Shibata, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Takafumi Suda
Summary: Obesity is a common comorbidity in patients with asthma and obese asthma patients present the most refractory phenotype among patients with severe asthma. This study found that autophagy contributes to the exacerbation of eosinophilic inflammation in obese asthma, and modulation of autophagy may be a therapeutic target in obesity-associated asthma.
Article
Medicine, General & Internal
Yasutaka Mochizuka, Masato Kono, Mineo Katsumata, Ryutaro Hirama, Masayuki Watanuki, Yuiko Oshima, Kenichiro Takeda, Akari Tsutsumi, Hideki Miwa, Yoshihiro Miki, Dai Hashimoto, Noriyuki Enomoto, Yutaro Nakamura, Takafumi Suda, Hidenori Nakamura
Summary: This article reports a case of silicosis-associated sarcoid-like granulomatous lung disease, rather than sarcoidosis, in a patient with long-term exposure to silica. The patient's pulmonary manifestations improved after discontinuation of silica exposure and combination therapy.
Article
Oncology
Masato Karayama, Yusuke Inoue, Katsuhiro Yoshimura, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda
Summary: The nutritional status may affect the efficacy of nivolumab in NSCLC patients. A post hoc analysis of 158 NSCLC patients receiving nivolumab showed that low Geriatric Nutritional Risk Index (GNRI) was associated with shorter progression-free survival and overall survival. GNRI can predict the efficacy of immune checkpoint inhibitor therapy.
JOURNAL OF IMMUNOTHERAPY
(2022)
Article
Respiratory System
Toshiya Hiramatsu, Moeko Murano, Shogo Nakai, Yurina Murakami, Koji Nishimoto, Sayomi Matsushima, Masanori Harada, Tomohiro Uto, Jun Sato, Shiro Imokawa, Takafumi Suda
Summary: Anti-MDA5 and anti-ARS antibodies are important myositis-specific autoantibodies with distinct clinical features. This case report highlights the need for careful follow-up and different intensities of treatment for patients with co-existing anti-MDA5 and anti-ARS antibodies in CADM-ILD.
RESPIRATORY MEDICINE CASE REPORTS
(2022)
Article
Respiratory System
Hyogo Naoi, Yuzo Suzuki, Kazutaka Mori, Yuya Aono, Masato Kono, Hirotsugu Hasegawa, Koshi Yokomura, Yusuke Inoue, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Hidenori Nakamura, Takafumi Suda
Summary: Antifibrotic therapy may reduce the risk of lung cancer development in patients with idiopathic pulmonary fibrosis (IPF) and potentially prolong their survival.
Article
Respiratory System
Mineo Katsumata, Tomoyuki Fujisawa, Yosuke Kamiya, Yuko Tanaka, Chiaki Kamiya, Yusuke Inoue, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Masato Maekawa, Mitsutoshi Setou, Hiroshi Watanabe, Koji Ikegami, Takafumi Suda
Summary: Long-acting muscarinic antagonists (LAMAs) have a direct enhancing effect on airway ciliary functions and may improve impaired mucociliary clearance in asthma and COPD.
BMC PULMONARY MEDICINE
(2022)
Article
Respiratory System
Chinatsu Nakane, Koji Nishimoto, Ei Kishimoto, Kosuke Suzuki, Emiko Nakagawa, Moeko Morikawa, Yurina Murakami, Yoichiro Aoshima, Sayomi Matsushima, Masanori Harada, Tomohiro Uto, Shiro Imokawa
Summary: This is a case report on severe immune thrombocytopenia caused by rifampicin. A 74-year-old male patient developed severe thrombocytopenia after first exposure to rifampicin. The platelet count recovered after discontinuation of the drug, indicating that rifampicin can induce acute and severe thrombocytopenia.
RESPIRATORY MEDICINE CASE REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Noriyuki Enomoto
Summary: This review discusses the life-threatening rapidly progressive interstitial lung diseases and provides an overview of the clinical characteristics, diagnostic methods, and treatment strategies for each disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Respiratory System
Yuko Tanaka, Yuzo Suzuki, Hirotsugu Hasegawa, Koshi Yokomura, Atsuki Fukada, Yusuke Inoue, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Takafumi Suda
Summary: This study developed a method for assessing pulmonary physiology using standardized 3D-CT-derived lung volumes, and validated its predictive value for mortality in patients with IPF and IPF acute exacerbation.
RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Takafumi Koyauchi, Yuzo Suzuki, Kazuki Sato, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Koshi Yokomura, Shiro Imokawa, Hidenori Nakamura, Tatsuya Morita, Takafumi Suda
Summary: This multicenter study investigated the impact of end-of-life respiratory modalities on quality of dying and death (QODD) and symptom relief among patients dying with interstitial lung disease (ILD). The results showed that high-flow nasal cannula (HFNC) was associated with higher QODD and symptom relief ratings from bereaved families, suggesting it may improve outcomes for patients dying in a hospital setting with end-stage ILD.
RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Yasutaka Mochizuka, Tomoyuki Fujisawa, Yusuke Inoue, Hironao Hozumi, Yuzo Suzuki, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda
Summary: We report a case of eosinophilic pneumonia induced by trimethoprim-sulfamethoxazole (TMP-SMX) in a 27-year-old woman. Radiological examination showed bilateral nonsegmental airspace consolidation resembling cryptogenic organizing pneumonia. Eosinophil infiltration was observed in lung specimens and there was marked eosinophilia in the peripheral blood and bronchoalveolar lavage fluid. Discontinuation of TMP-SMX improved eosinophilia and radiological abnormality, confirming the association between TMP-SMX use and onset of eosinophilic pneumonia. TMP-SMX induced eosinophilic pneumonia is rare, but clinicians should be aware of the possibility during TMP-SMX administration.
RESPIRATORY MEDICINE CASE REPORTS
(2022)
Article
Respiratory System
Hironao Hozumi, Masato Kono, Hirotsugu Hasegawa, Shinpei Kato, Yusuke Inoue, Yuzo Suzuki, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Koshi Yokomura, Hidenori Nakamura, Takafumi Suda
Summary: This study found that post-AE mortality was high in patients with AE-RA-ILD, similar to AE-IPF patients. The study also created a predictive model for AE-RA-ILD mortality, which can aid in the management of these patients.
RESPIRATORY RESEARCH
(2022)
