Journal
ENVIRONMENTAL POLLUTION
Volume 197, Issue -, Pages 181-186Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2014.12.010
Keywords
Amyotrophic lateral sclerosis; Hazardous air pollutants; NATA; Environmental exposures; Risk factors
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Funding
- University of Pittsburgh Center for ALS Research
- ALS Hope Foundation
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Background: Amyotrophic lateral sclerosis (ALS) is a serious and rapidly fatal neurodegenerative disorder with an annual incidence of 1-2.6/100,000 persons. Few known risk factors exist although gene environment interaction is suspected. We investigated the relationship between suspected neuro-toxicant hazardous air pollutants (HAPs) exposure and ALS. Methods: A case control study involving sporadic ALS cases (n = 51) and matched controls (n = 51) was conducted from 2008 to 2011. Geocoded residential addresses were linked to U.S. EPA NATA data (1999, 2002, and 2005) by census tract. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Results: Residential exposure to aromatic solvents significantly elevated the risk of ALS among cases compared to controls in 2002 (OR = 5.03, 95% Cl: 1.29, 19.53) and 1999 (OR = 4.27, 95% Cl: 1.09, 16.79) following adjustment for education, smoking, and other exposure groups. Metals, pesticides, and other HAPs were not associated with ALS. Conclusions: A potential relationship is suggested between residential ambient air aromatic solvent exposure and risk of ALS in this study. (C) 2014 Elsevier Ltd. All rights reserved.
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