Review
Endocrinology & Metabolism
Caroline S. S. Johnson, Paul E. Micevych, Paul G. G. Mermelstein
Summary: Recent studies have shown that traditional estrogen receptors, alpha and beta, can also act at the cell surface in addition to their nuclear functions. Signaling from these membrane-bound estrogen receptors can rapidly affect cellular excitability and ultimately impact gene expression. The interaction between these membrane receptors and metabotropic glutamate receptors (mGluRs) plays a key role in various female functions such as reproduction and motivation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Giuseppina Basini, Simona Bussolati, Veronica Torcianti, Francesca Grasselli
Summary: PFOA is restricted in several countries due to its persistence, bioaccumulation, and critical effects on health. This research aims to explore its effects on swine ovarian granulosa cells, as well as its impact on antioxidant enzymes. The study found that PFOA inhibited cell proliferation, disrupted steroidogenesis, and stimulated antioxidant enzyme activity.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Entomology
Yu Zhang, Wenhui Xiong, Shan Yang, Hui Ai, Zhiwen Zou, Bin Xia
Summary: This study showed that long-term exposure to cadmium adversely affected the development, reproduction, and physiology of Aleuroglyphus ovatus. A. ovatus proved to be a sensitive organism for studying the toxicity of long-term heavy metal exposure on offspring. The findings also provided a basis for future evaluation of cadmium pressure on genetic evolution.
Article
Pharmacology & Pharmacy
Maha Abdelhamid Fathy, Amira Ebrahim Alsemeh, Marwa A. A. Habib, Hanim M. M. Abdel-nour, Doaa M. M. Hendawy, Asmaa Monir Eltaweel, Adel Abdelkhalek, Mona M. M. Ahmed, Maha K. K. Desouky, Jinlian Hua, Liana Mihaela Fericean, Ioan Banatean-Dunea, Ahmed Hamed Arisha, Tarek Khamis
Summary: Glucagon-like peptide-1 (GLP-1) released by intestinal cells stimulates glucose-dependent insulin release. Liraglutide, a GLP-1 receptor agonist, has been found to improve reproductive dysfunction in diabetic male rats.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Vinicius Elias de Moura Oliveira, Julie Bakker
Summary: Traditionally, the neurobiology of aggression has mainly focused on studying males, considering females to be less aggressive except during lactation. However, recent studies have shown that non-lactating females can exhibit exaggerated and pathological aggression similar to males. This review provides an overview of recent findings on the neuroendocrine mechanisms regulating female aggression, with special attention given to novel rodent models that display heightened aggression in non-lactating females. Among the neuromodulatory systems influencing female aggression, the role of sex steroids, sex-steroid-sensitive neuronal populations, oxytocin, and vasopressin is highlighted.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Myles H. Alderman, Hugh S. Taylor
Summary: The development of the female reproductive tract is influenced by estrogen and environmental factors. Exposure to xenoestrogens during critical periods can affect uterine morphology and increase the risk of disease later in life. Recent research suggests that these effects are related to epigenetic regulation of gene expression.
Article
Biochemistry & Molecular Biology
Giacomo Lazzarino, Romina Pallisco, Gabriele Bilotta, Ilaria Listorti, Renata Mangione, Miriam Wissam Saab, Giuseppe Caruso, Angela Maria Amorini, Maria Violetta Brundo, Giuseppe Lazzarino, Barbara Tavazzi, Pasquale Bilotta
Summary: The study analyzed metabolites in follicular fluid and identified 27 low molecular weight compounds with significantly different values in infertile females compared to control subjects. These compounds were used to calculate a Biomarker Score that effectively discriminated between control and infertile groups, indicating their potential as infertility biomarkers. Additionally, the Biomarker Score values correlated with various outcome measures of assisted reproduction techniques, suggesting a strong influence of follicular fluid metabolism on IVF success and embryonic development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Forestry
Dan Sun, Xilin Zhao, Jun Ai, Zhenxing Wang, Guangli Shi, Yumeng Liu, Xiang Li, Chengcheng Zhao
Summary: This study aimed to determine a suitable growing medium and appropriate root hormone type, concentration, and treatment time for the cutting propagation of Schisandra chinensis. The optimal treatment resulted in a rooting rate of 60% with 225 ppm ABT and 75 ppm NAA for 2.5 h. The vermiculite/perlite = 1:1 (urea+potassium) substrate promoted adventitious root formation, reaching 79%. The timing of enzyme activity and hormone concentration was affected by the treatments. High endogenous IAA concentration promoted early adventitious root formation, while lower endogenous IAA and GA(3) concentrations promoted root elongation and growth in the later stages. Low ABA and ZR concentrations facilitated adventitious root formation and elongation. Developing an efficient cutting propagation system would enable mass propagation of S. chinensis seedlings.
Article
Endocrinology & Metabolism
Kenji Saito, Jacob E. Dickey, Samuel R. Rodeghiero, Brandon A. Toth, Matthew J. Kelly, Yue Deng, Uday Singh, Guorui Deng, Jingwei Jiang, Huxing Cui
Summary: This study identifies a tissue-specific enriched long ER alpha isoform and demonstrates its preferential role in female reproductive function.
Article
Marine & Freshwater Biology
Leila Basti, Jyoji Go, Sho Okano, Keita Higuchi, Satoshi Nagai, Kiyohito Nagai
Summary: The harmful algae Heterocapsa circularisquama, Chattonella marina, Hetrosigma akashiwo, Karenia mikimotoi, K. papilionacea, Margalefidinium (Cochlodinium) polykrikoides have differential effects on early life stages of Japanese pearl oyster and activate detoxification enzymes in feeding larvae.
Article
Biochemistry & Molecular Biology
Miriam Gonzalez-Gomez, Ricardo Reyes, Ma del Carmen Damas-Hernandez, Xiomara Plasencia-Cruz, Ibrahim Gonzalez-Marrero, Rafael Alonso, Aixa R. Bello
Summary: The study found that prolonged exposure to the environmental estrogenic substance bisphenol-A (BPA) can negatively affect the reproductive axis, resulting in accelerated sexual maturation and a shorter fertile life in offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Marija Kundakovic, Devin Rocks
Summary: This review addresses the increased risk of depression and anxiety disorders in women, focusing on the role of fluctuating sex hormones in brain plasticity and vulnerability. The molecular mechanism driven by sex hormones, namely chromatin organizational changes, is also discussed. Future directions in experimental and clinical studies are highlighted to facilitate innovative approaches in treating depression and anxiety disorders in women.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Fisheries
Shouquan Hou, Jiayao Li, Jin Huang, Yongxu Cheng
Summary: The current study evaluates the interactive effects of different phospholipids and cholesterol levels on the immune response and intestinal microbiota of juvenile female red swamp crayfish. The results suggest that optimal levels of phospholipids and cholesterol can improve the abundance and composition of intestinal microbiota, as well as influence immune response and antioxidant capacity.
AQUACULTURE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Pulak R. Manna, Shengping Yang, P. Hemachandra Reddy
Summary: In this study, the dysregulation of epigenetic enzymes in breast cancer patients was identified using TCGA data, and their correlation with tumor development was found. Furthermore, abnormal expression of genes related to cholesterol metabolism was also observed in breast cancer. These findings provide new targets for the treatment of breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Ana C. R. Lopes, Bruno Zavan, Yuri J. C. Correa, Tania M. Vieira, Liza J. Severs, Luiz M. Oliveira, Roseli Soncini
Summary: The coexistence of obesity and ovariectomy in female mice has a significant impact on the respiratory system, airway resistance, collagen I deposition, and airway estrogen beta-receptors. In obese female mice, bronchoconstriction after methacholine challenge was attenuated in sham-operated mice compared to those who underwent ovariectomy.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Toxicology
Saba Shahin, Somanshu Banerjee, Surya Pal Singh, Chandra Mohini Chaturvedi
TOXICOLOGICAL SCIENCES
(2015)
Article
Toxicology
Saba Shahin, Somanshu Banerjee, Vivek Swarup, Surya Pal Singh, Chandra Mohini Chaturvedi
TOXICOLOGICAL SCIENCES
(2018)
Article
Environmental Sciences
Saba Shahin, Surya Pal Singh, Chandra Mohini Chaturvedi
ENVIRONMENTAL TOXICOLOGY
(2018)
Article
Geriatrics & Gerontology
Somanshu Banerjee, Saba Shahin, Chandra Mohini Chaturvedi
EXPERIMENTAL GERONTOLOGY
(2018)
Article
Cell Biology
Saba Shahin, Surya P. Singh, Chandra M. Chaturvedi
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Article
Genetics & Heredity
Samuel Morabito, Emily Miyoshi, Neethu Michael, Saba Shahin, Alessandra Cadete Martini, Elizabeth Head, Justine Silva, Kelsey Leavy, Mari Perez-Rosendahl, Vivek Swarup
Summary: An integrative analysis of single-nucleus assay for transposase-accessible chromatin with sequencing and RNA sequencing in normal and Alzheimer's disease brain tissue reveals cell-type-specific cis-regulatory elements and candidate target genes. The study highlights the dynamic gene-regulatory landscape of the brain, identifying disease-related regulatory modules and transcription factors in specific cell types, demonstrating the utility of a multi-omic single-nucleus approach.
Article
Pharmacology & Pharmacy
Saba Shahin, Hui Xu, Bin Lu, Augustus Mercado, Melissa K. Jones, Benjamin Bakondi, Shaomei Wang
Summary: Retinitis pigmentosa (RP) is a group of inherited retinal degenerative disorders. Gene therapy has been effective in treating autosomal recessive RP, but limited options are available for autosomal dominant RP. In vivo gene editing may be a therapeutic option, and this study shows the successful rescue of vision in rats with autosomal dominant RP through AAV delivery of a CRISPR/Cas9 construct.
Article
Multidisciplinary Sciences
Saba Shahin, Bin Lu, Yueqin Zhou, Hui Xu, Jason Chetsawang, Robert H. Baloh, Shaomei Wang
Summary: Charcot-Marie-Tooth disease type 2A (CMT2A) is the most common inherited peripheral axonal neuropathy with over 100 dominant mutations, including the R94Q mutation in the MFN2 gene. CMT2A is characterized by progressive motor and sensory loss, color vision defects, and progressive loss of visual acuity. Using a transgenic mouse model with the R94Q mutation, researchers found extensive vision loss and retinal degeneration, which were rescued by augmenting MFN1 and restoring mitochondrial homeostasis.
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)
