Article
Endocrinology & Metabolism
Xinyang Zhao, Xu Zhang, Shanshan Wu, Jichun Tan
Summary: The duration of ovarian stimulation has a significant impact on IVF outcomes. The length of the menstrual cycle can be used to predict ovarian response and the duration of ovarian stimulation. There is a correlation between the duration of ovarian stimulation and the number of oocytes, fertilization rate, and high-quality blastocyst formation rate.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Chunxia Yang, Naijun Dong, Feng Li, Yurong Ji, Yu Pan, Hong She
Summary: The study found that rFSH-alfa group had higher number of retrieved oocytes, transferable embryos, fresh embryo transfer rate, and multiple birth rate compared to the uFSH group. However, both groups had similar pregnancy rates and LBR per transfer cycle, with rFSH-alfa group achieving higher CLBR per started cycle. This suggests that rFSH-alfa might produce more transferrable blastocysts and higher overall success rates compared to uFSH.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Cell Biology
Luyi Chen, Wei Zhang, Ruiqi Huang, Xiaoping Miao, Jianying Li, Dongliang Yu, Yan Li, Wei Hsu, Mengsheng Qiu, Zunyi Zhang, Feixue Li
Summary: This study demonstrates the crucial role of Wls in female fertility and luteinization, with the deletion of Wls leading to impaired ovarian function and corpus luteum formation.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Jihyun Kim, Hoyoung Lee, Tae-Young Choi, Joong Il Kim, Byoung-Kab Kang, Myeong Soo Lee, Jong Kil Joo, Kyu Sup Lee, Sooseong You
Summary: The study showed that network-optimized acupuncture followed by IVF treatment significantly increased the number of retrieved mature oocytes in women with poor ovarian response, especially in those aged over 37 years and undergoing multiple controlled ovarian hyperstimulation cycles. The negative correlation between the number of retrieved mature oocytes and consecutive controlled ovarian hyperstimulation cycles was not observed in the acupuncture + IVF group, suggesting that acupuncture may be considered as a beneficial treatment option for women facing poor ovarian response and advanced maternal age or multiple IVF cycles.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Reproductive Biology
Jing Xu, Mary B. Zelinski
Summary: In vitro follicle development (IVFD) is a valuable model for understanding folliculogenesis, screening ovarian toxicity, and preserving fertility and species. This review discusses the culture systems used in IVFD across various species and the improvements made in follicle growth and oocyte maturation through optimization of culture conditions. The evaluation of oocyte quality following IVFD, including epigenetic and genetic profile, maturation, embryonic development, and pregnancy outcomes, is summarized. The review also highlights the limitations and knowledge gaps in IVFD for proper oocyte development. This information contributes to the goal of producing competent oocytes with genetic integrity for successful embryonic development and healthy offspring.
BIOLOGY OF REPRODUCTION
(2022)
Article
Environmental Sciences
Si-Cheng Zhao, Zhi-Ran Xu, Chang-Long Xu, Quan-Kuo He, Guang-Ming Yang, Yan-Ping Li, Yu-Shen Luo, Hai-Long Wang, Zhong-Quan Qi, Yu Liu
Summary: Exposure to nickel sulfate negatively affects ovarian homeostasis and oocyte quality, triggering ovarian fibrosis and inflammation, and causing structural and functional disorders of mitochondria.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Endocrinology & Metabolism
Hao Jin, Haiyan Yang, Jiujia Zheng, Jiechun Zhou, Rong Yu
Summary: This study aimed to evaluate the distribution data of oocyte retrieval rate (ORR) in women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and explore the risk factors for low ORR. The results showed that low estradiol levels/follicles (≥12 mm), progesterone levels, and the use of progestin-primed protocol were significant risk factors for low ORR.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Michael Fanton, Veronica Nutting, Funmi Solano, Paxton Maeder-York, Eduardo Hariton, Oleksii Barash, Louis Weckstein, Denny Sakkas, Alan B. Copperman, Kevin Loewke
Summary: This study developed an interpretable machine learning model to optimize the day of trigger in in vitro fertilization cycles. The model used linear regression with follicle counts and estradiol levels to predict early and late triggers, which were found to result in fewer mature oocytes, fertilized oocytes, and usable blastocysts.
FERTILITY AND STERILITY
(2022)
Article
Reproductive Biology
Michal Andrzej Kosior, Riccardo Esposito, Natascia Cocchia, Federica Piscopo, Valentina Longobardi, Nunzio Antonio Cacciola, Giorgio Antonio Presicce, Giuseppe Campanile, Hilde Aardema, Bianca Gasparrini
Summary: The aim of this study was to evaluate the seasonal effect on the metabolomic profile of the ovarian follicle in Italian Mediterranean buffalo and identify potential strategies to improve oocyte competence during the non-breeding season. Analysis of follicular fluid, follicular cells, cumulus cells, and oocytes revealed seasonal differences in metabolite content, suggesting alterations in metabolic pathways during the non-breeding season. Pathway enrichment analysis identified metabolites linked to glutathione, energy generation, amino acid metabolism, and phospholipid biosynthesis. The identification of positive and negative competence markers in the follicular fluid provides a basis for optimizing the follicular environment and improving oocyte competence during the non-breeding season.
Article
Reproductive Biology
Tian Tian, Yu Li, Jiaxin Lv, Lixue Chen, Yuanyuan Wang, Rui Yang, Ping Liu, Rong Li, Jie Qiao
Summary: This study found that in women with DOR undergoing NC-IVF, even if a premature LH surge occurs and small follicles are retrieved, these follicles can still be used in subsequent treatment and provide a comparable chance of clinical pregnancy to normal-sized follicles.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chao-Chin Hsu, Isabel Hsu, Li-Hsuan Lee, Yuan-Shuo Hsueh, Chih-Ying Lin, Hui Hua Chang
Summary: The study investigated the efficacy of controlled ovulation stimulation (DuoStim) using intraovarian injection of recombinant human follicle-stimulating hormone (rhFSH) in women with diminished ovarian reserve (DOR). The results showed that DuoStim can significantly improve the number and quality of retrieved oocytes, while reducing the dosage of medication and the duration of treatment.
Article
Endocrinology & Metabolism
Guangxin Li, Jingkai Gu, Xiaomei Zhou, Ting Wu, Xian Li, Renwu Hua, Zhuo Hai, Yuan Xiao, Jiaping Su, Willian S. B. Yeung, Kui Liu, Chenxi Guo, Tianren Wang
Summary: Chemotherapy often leads to ovarian damage, but the role of mitochondria in this process is unknown. Using a mouse model, this study investigated mitochondrial homeostasis in oocytes and found that the oocyte-specific deletion of Clpp impaired both fertility and mitochondrial function. Furthermore, treatment with the chemotherapeutic drug CTX exacerbated the damage, leading to decreased oocyte competence and folliculogenesis. Overall, Clpp is essential for oocyte competence and its deficiency worsened cyclophosphamide induced ovarian damage.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Reproductive Biology
Xiangfei Wang, Lingjuan Wang, Wenpei Xiang
Summary: Ovarian aging is a natural and physiological process, characterized by the decline in quantity and quality of oocytes or follicles. This aging process poses challenges for women of advanced age who desire a healthy baby, as the finite follicle pool declines and oocyte quality decreases. Mechanisms of ovarian aging involve both extra-ovarian (hypothalamic-pituitary-ovarian axis) and intra-ovarian factors (telomere, mitochondria, oxidative stress, DNA damage, protein homeostasis, aneuploidy, apoptosis, and autophagy). Genetic characteristics of ovarian aging have been explored through Genome-wide association studies (GWAS) and next generation sequencing (NGS) studies of primary ovarian insufficiency (POI). Reliable anti-aging interventions for ovarian aging are desired as the understanding of mechanisms and genetics progresses.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Fabio De Rensis, Roberta Saleri, Irina Garcia-Ispierto, Rex Scaramuzzi, Fernando Lopez-Gatius
Summary: Environmentally induced hyperthermia, or heat stress (HS), has negative effects on reproductive physiology in mammals, particularly altering oocyte quality and follicular growth dynamics. Dairy cows, under metabolic stress from high milk production, serve as a good model for studying the impact of HS on ovarian function. Heat stress may impair ovulation, fertilization, and early embryo development, with evidence of long-lasting effects on oogenesis and final follicular maturation.
Article
Medicine, General & Internal
Hannia Diaz Ayllon, Oscar L. Hernandez, Talwinder Nagi, Carlos M. Cespedes
Summary: Ovarian hyperstimulation syndrome (OHSS) is a complication of fertility treatments that involve pharmacological ovarian stimulation. It is characterized by increased vascular permeability, leading to fluid shift from blood vessels to other compartments. Severe complications of OHSS include ascites, pleural effusions, and shock. This case report describes a patient who developed OHSS after transvaginal oocyte retrieval, resulting in severe ascites, pleural effusion, and hypotension necessitating urgent intervention.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Corinne Iampietro, Alessia Brossa, Stefano Canosa, Stefania Tritta, Glenn E. Croston, Torsten Michael Reinheimer, Filippo Bonelli, Andrea Roberto Carosso, Gianluca Gennarelli, Stefano Cosma, Chiara Benedetto, Alberto Revelli, Benedetta Bussolati
Summary: Quinagolide inhibits the invasive properties of endometrial mesenchymal stromal cells (E-MSCs) in endometriosis, but has no effect on their proliferation and limits their endothelial differentiation. These effects are mediated through activation of a specific dopamine receptor and are independent of VEGFR2 inhibition. The effects are more prominent in ectopic E-MSCs. These findings increase the rationale for the use of quinagolide in endometriosis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Stefano Canosa, Lodovico Parmegiani, Lorena Charrier, Gianluca Gennarelli, Cristina Garello, Francesca Granella, Francesca Evangelista, Giuseppe Monelli, Daniela Guidetti, Alberto Revelli, Marco Filicori, Francesca Bongioanni
Summary: This study found no significant differences in the clinical effectiveness of different combinations of warming kits for vitrified human blastocysts, supporting the efficacy of a single warming protocol.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Medicine, General & Internal
Andrea Roberto Carosso, Rik van Eekelen, Alberto Revelli, Stefano Canosa, Noemi Mercaldo, Chiara Benedetto, Gianluca Gennarelli
Summary: None of FORT, FOI and OSI are independent predictors of live birth in women of advanced reproductive age. These three metrics are not more informative than the 'component' characteristics that are used to calculate them.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Stefano Canosa, Katia Mareschi, Elena Marini, Andrea Roberto Carosso, Sara Castiglia, Deborah Rustichelli, Ivana Ferrero, Gianluca Gennarelli, Benedetta Bussolati, Alberto Nocifora, Valentina Asnaghi, Massimiliano Bergallo, Ciro Isidoro, Chiara Benedetto, Alberto Revelli, Franca Fagioli
Summary: The study compared two different endometrial sampling methods and validated a novel xeno-free method for culturing human E-MSCs. Results showed that VABRA endometrial sampling could be an alternative to surgical curettage, providing efficient isolation and culture of E-MSCs in Good Manufacturing Practice compliance conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Sara Cesarano, Paul Pirtea, Achraf Benammar, Dominique De Ziegler, Marine Poulain, Alberto Revelli, Chiara Benedetto, Alexandre Vallee, Jean Marc Ayoubi
Summary: This study aimed to evaluate the performance of ovarian response indexes in predicting cumulative assisted reproductive technology (ART) outcomes in women aged 39 and above. The study found that the Ovarian Sensitivity Index (OSI) performed the best in predicting cumulative live birth rate (cLBR) and implantation rate, while the Follicle Oocyte Index (FOI) and Follicular Output Rate (FORT) were also associated with embryo culture success and the number of MII oocytes collected.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Alessandro Rolfo, Stefano Cosma, Anna Maria Nuzzo, Chiara Salio, Laura Moretti, Marco Sassoe-Pognetto, Andrea Roberto Carosso, Fulvio Borella, Juan Carlos Cutrin, Chiara Benedetto
Summary: This study observed oxidative stress and mitochondrial pathological changes in the placenta of pregnant women with SARS-CoV-2 infection during the third trimester, but the pregnant women maintained a good physiological state. This suggests that the placenta has a certain inhibitory effect on oxidative stress during SARS-CoV-2 infection.
Article
Nutrition & Dietetics
Alessandra Manca, Stefano Cosma, Alice Palermiti, Martina Costanzo, Miriam Antonucci, Elisa Delia De Vivo, Alice Ianniello, Fulvio Borella, Andrea Roberto Carosso, Silvia Corcione, Francesco Giuseppe De Rosa, Chiara Benedetto, Antonio D'Avolio, Jessica Cusato
Summary: This is the first study demonstrating the role of vitamin D in affecting the clinical characteristics of pregnant women during the COVID-19 era. Vitamin D-related polymorphisms can affect vitamin D levels in both SARS-CoV-2 positive and negative patients. Vitamin D levels were lower in preterm births among SARS-CoV-2 positive patients.
Review
Obstetrics & Gynecology
Danilo Cimadomo, Laura Rienzi, Alessandro Conforti, Eric Forman, Stefano Canosa, Federica Innocenti, Maurizio Poli, Jenna Hynes, Laura Gemmell, Alberto Vaiarelli, Carlo Alviggi, Filippo Maria Ubaldi, Antonio Capalbo
Summary: The normal chromosomal constitution determined by PGT-A is the strongest predictor for embryo implantation, but its positive predictive value is limited. The causes of reproductive failure in euploid blastocysts, known as "the black box of implantation," are not well understood.
HUMAN REPRODUCTION UPDATE
(2023)
Review
Nutrition & Dietetics
Rossella Attini, Maria Elena Laudani, Elisabetta Versino, Alessio Massaro, Arianna Pagano, Francesca Petey, Alberto Revelli, Bianca Masturzo
Summary: Based on research findings, being pregnant does not increase the risk of COVID-19 infection, but it may lead to more severe complications for both the mother and the fetus. This study found that obesity is associated with a higher risk of severe infection, maternal death, and hospital admission for pregnant women with COVID-19. The level of micronutrients, especially Vitamin D, appears to be lower in COVID-19-positive pregnant women.
Article
Medicine, General & Internal
Alice Ronco, Sofia Roero, Silvana Arduino, Arianna Arese, Isabella Ferrando, Gabriella Scaltrito, Viola Casula, Teresa Fea, Mattia Mazza, Carlotta Bossotti, Roberto Zizzo, Alberto Revelli
Summary: This study analyzed the specific effects of gestational diabetes mellitus (GDM) on twin pregnancy outcomes. The results showed that compared to GDM singleton pregnancies, GDM twins had higher rates of preeclampsia, cesarean section, and neonatal hypoglycemia. Compared to twin pregnancies without GDM, women with GDM twins were older, had higher BMI, had a higher incidence of large-for-gestational-age (LGA) newborns, and a lower incidence of low APGAR scores. Overall, GDM does not worsen outcomes of twin pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Andrea Roberto Carosso, Nicole Brunod, Claudia Filippini, Alberto Revelli, Bernadette Evangelisti, Stefano Cosma, Fulvio Borella, Stefano Canosa, Chiara Benedetto, Gianluca Gennarelli
Summary: This study compared reproductive and obstetric outcomes of frozen embryo transfer using different endometrial preparation strategies. The results showed no significant differences in reproductive outcomes between natural/modified cycle and artificial cycle groups. However, pregnancies achieved after artificial endometrial preparation were associated with increased risks of pregnancy-induced hypertension and abnormal placental insertion.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Chiara Germano, Ilenia Mappa, Antonella Cromi, Enrico Busato, Maddalena Incerti, Andrea Lojacono, Giuseppe Rizzo, Rossella Attini, Lodovico Patrizi, Alberto Revelli, Bianca Masturzo
Summary: This retrospective cohort study evaluated the use of a cervical ripening balloon (CRB) in women with a previous cesarean section and unfavorable Bishop score. The results showed that CRB induction of labor was safe and effective, with a vaginal birth rate of 57.3% and minimal side effects.
Review
Health Care Sciences & Services
Stefano Canosa, Alberto Revelli, Gianluca Gennarelli, Gennaro Cormio, Vera Loizzi, Francesca Arezzo, Easter Anna Petracca, Andrea Roberto Carosso, Danilo Cimadomo, Laura Rienzi, Alberto Vaiarelli, Filippo Maria Ubaldi, Erica Silvestris
Summary: Recent advances in anticancer treatment have greatly improved the survival rate of young females, but one third of cancer survivors still face the risk of ovarian insufficiency and infertility. Several procedures have been developed to preserve fertility, including ovarian surgical transposition, gonadotropin-releasing hormone agonists (GnRH-a) treatment, and oocyte and/or ovarian cortical tissue cryopreservation. Innovative techniques, such as the construction of an artificial ovary and the use of stem cells for neo-folliculogenesis and oocyte development, are under investigation. These techniques offer potential strategies for oncofertility programs and provide hope for young female cancer survivors.
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
