4.7 Article

Organobromine compound profiling in human adipose: Assessment of sources of bromophenol

Journal

ENVIRONMENTAL POLLUTION
Volume 204, Issue -, Pages 81-89

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2015.04.015

Keywords

BRPs; Organobromine compounds; GC-NCI-MS; Adipose tissue; Co-exposure; Anthropogenic compounds

Funding

  1. National Natural Science Foundation of China [41330637, 21177003]
  2. Undergraduate Student Research Training Program
  3. 111 Project in Peking University [B14001]
  4. program of High Level Foreign Experts - State Administration of Foreign Experts Affairs [GDW20123200120]
  5. P.R. China
  6. Einstein Professor Program of the Chinese Academy of Sciences
  7. Canada Research Chair program
  8. Visiting Distinguished Professorship in the Department of Biology and Chemistry
  9. State Key Laboratory in Marine Pollution, City University of Hong Kong

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Bromophenols (BRPs) have been widely detected in human tissues, however, relative proportions from natural products and/or anthropogenic flame retardants are not clear. 21 polybrominated diphenyl ethers (PBDEs), 15 MeO/OH-PBDEs, and 10 BRPs were simultaneously quantified in adipose collected from people from New York City, USA. An in vitro assay utilizing human liver microsomes was performed for detected predominant organobromine. High concentrations of 2,4,6-triBRP and PBDEs were observed, and extremely low concentrations of naturally occurring MeO/OH-PBDEs were detected. Similar biotransformatioin rates of BRPs and MeO/OH-PBDEs indicated that the relative high concentration of 2,4,6-triBRP in humans was not of natural origin. Significant correlation observed between concentrations of 2,4,6-triBRP and BDE-209 suggested that the two chemicals may share a common source. Both 2,4,6-triBRP and BDE-209 were detected in commercial ABS resins, suggesting that plastic products made from ABS resins could be potential sources of co-exposure of the two compounds for humans. (C) 2015 Elsevier Ltd. All rights reserved.

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