Article
Endocrinology & Metabolism
Yu Min, Xiaoman Liu, Daixing Hu, Hang Chen, Jialin Chen, Ke Xiang, Guobing Yin, Yuling Han, Yang Feng, Haojun Luo
Summary: Breast cancer patients with no lymph node metastasis but distant metastasis present specific clinicopathological characteristics that are associated with the risk of distant metastasis and prognosis, including factors such as age, tumor size, race, tumor location, grade, and histology. A novel nomogram for predicting 1-, 3-, and 5- year CSS in T1-3N0M1 patients has been established and validated, which could assist clinicians in better stratifying patients and implementing relatively aggressive management.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Federica Grillo, Manuela Albertelli, Pasqualino Malandrino, Andrea Dotto, Genoveffa Pizza, Giuseppe Cittadini, Annamaria Colao, Antongiulio Faggiano
Summary: Well-differentiated, low-grade neuroendocrine tumors (NETs) in the small bowel have a tendency to metastasize despite their slow growth. Extended regional mesenteric lymphadenectomy and the presence of mesenteric tumor deposits (MTDs) may be prognostic indicators for small bowel NETs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Otorhinolaryngology
Helene Stampe, Kathrine Kronberg Jakobsen, Jesper Filtenborg Tvedskov, Irene Wessel, Katalin Kiss, Jeppe Friborg, Amanda Oester Andersen, Christian Gronhoj, Christian von Buchwald, Anders Christensen
Summary: This study aims to investigate the thresholds for lymph node yield, lymph node density, and pN in patients with oral squamous cell carcinoma and their relation to survival outcomes. The results suggest that increased nodal yield, decreased LND, and decreasing number of pN are associated with significantly improved survival outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Liwei Jiang, Sungwook Jung, Jing Zhao, Vivek Kasinath, Takaharu Ichimura, John Joseph, Paolo Fiorina, Andrew S. Liss, Khalid Shah, Nasim Annabi, Nitin Joshi, Tomoya O. Akama, Jonathan S. Bromberg, Motohiro Kobayashi, Kenji Uchimura, Reza Abdi
Summary: The newly developed MHA112-Taxol drug delivery platform can simultaneously target tumors, TDLNs, and metastatic lesions, effectively reducing the size of primary tumors and the number of metastatic lesions.
Article
Computer Science, Information Systems
Lu Wang, Tian Song, Takafumi Katayama, Xiantao Jiang, Takashi Shimamoto, Jenq-Shiou Leu
Summary: An innovative deep regional metastases segmentation framework is proposed for patient-level classification of lymph node metastasis in breast cancer patients. The framework combines deep segmentation network and density-based spatial clustering algorithm to provide consistent and accurate metastasis diagnosis in histological lymph node section images.
Article
Medicine, General & Internal
Hong Pan, Hui Wang, Mengjia Qian, Xinrui Mao, Guojian Shi, Ge Ma, Muxin Yu, Hui Xie, Lijun Ling, Qiang Ding, Kai Zhang, Shui Wang, Wenbin Zhou
Summary: This cohort study examined the survival of breast cancer patients with distant lymph node metastases compared to ipsilateral supraclavicular lymph node metastases and other stage IV breast cancer. The results suggest that DLNM may be a regional disease with similar survival outcomes to N3c disease, indicating the need for reassessment of the role of lymph node metastases in breast cancer and consideration of aggressive locoregional therapies for DLNM patients.
Article
Medicine, General & Internal
Cinthia Minatel Riguetto, Icleia Siqueira Barreto, Frederico Fernandes Ribeiro Maia, Ligia Vera Montali da Assumpcao, Denise Engelbrecht Zantut-Wittmann
Summary: The study focused on examining the relationships of NLR, PLR, and MLR with clinicopathological characteristics of patients with differentiated thyroid cancer. PLR was higher in patients with distant metastasis, while MLR was associated with active disease. Cut-off values of NLR, PLR, and MLR were able to differentiate distant metastasis from lymph node metastasis with good sensitivity and accuracy.
Article
Gastroenterology & Hepatology
Sorin Tiberiu Alexandrescu, Florin M. Selaru, Andrei S. Diaconescu, Cristian A. Zlate, Diana Blanita, Razvan T. Grigorie, Narcis O. Zarnescu, Vlad Herlea, Irinel Popescu
Summary: The study showed that in patients with resected synchronous colorectal liver metastases and less than 12 evaluated lymph nodes, a LNR value greater than 0.22 was independently associated with poor overall survival and disease-free survival. High LNR, bilobar SCLMs, and lack of adjuvant chemotherapy were identified as independent predictors of poor prognosis.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Urology & Nephrology
Berdine L. Heesterman, Henk G. van der Poel, Ivo G. Schoots, Niven Mehra, Katja K. H. Aben
Summary: This study evaluated the prognostic importance of concomitant non-regional lymph node and bone metastases in men with synchronous metastatic hormone-sensitive prostate cancer. It found that in low-volume disease, the presence of these metastases was a poor prognostic sign, while survival was worse for men with visceral metastases. This implies a need to reconsider the classification of metastatic burden.
Article
Surgery
Anders L. Ebbehoj, Henry G. Smith, Lars N. Jorgensen, Peter-Martin Krarup
Summary: This study investigated the impact of histopathological risk factors on lymph node metastasis in different types of pT1 colorectal cancer. The results showed that lymphovascular invasion and venous invasion were consistently associated with lymph node metastasis in all pT1 colorectal cancers, while tumor budding only had predictive value for pedunculated tumors.
Article
Gastroenterology & Hepatology
E. Agger, V. Akerlund, O. Ekberg, F. Jorgren, M. L. Lydrup, P. Buchwald
Summary: Lateral lymph node metastases in rectal cancer pose a clinical challenge. This study found that synchronous distant metastases were associated with MRI-positive LLN, but there were no significant differences in recurrence rates between patients with MRI-positive and MRI-negative LLN. Long-course chemoradiotherapy was a standard practice in cases of MRI-positive LLN.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Oncology
Guixin Wang, Shuhao Zhang, Meiling Wang, Lin Liu, Yaqian Liu, Lianjun Tang, He Bai, Haidong Zhao
Summary: This meta-analysis found that occult metastases in axillary lymph nodes are associated with poorer prognosis in patients with breast cancer, with lower five-year and ten-year disease-free survival and overall survival rates.
Article
Computer Science, Artificial Intelligence
Iam Palatnik de Sousa, Marley M. B. R. Vellasco, Eduardo Costa da Silva
Summary: This study presents a novel evolutionary approach for Explainable Artificial Intelligence, combining Local Interpretable Model Agnostic Explanations (LIME) with Multi-Objective Genetic Algorithms. The results show that this methodology can find high quality explanations and has the advantage of automated parameter fine tuning.
Article
Oncology
Neal Andruska, Lily Mahapatra, Randall J. Brenneman, Yi Huang, Randal C. Paniello, Sidharth V. Puram, Mena Mansour, Jason T. Rich, Brian C. Baumann, Wade L. Thorstad, Mackenzie D. Daly
Summary: Regional lymph node radiation therapy, including definitive nodal radiotherapy and adjuvant nodal radiotherapy, has been shown to improve regional recurrence-free survival, distant recurrence-free survival, disease-free survival, and disease-specific survival in patients with Merkel cell carcinoma. Adjuvant nodal radiotherapy is particularly beneficial for high-risk subgroups and its benefit increases with higher disease burden. These results support a more liberal use of nodal RT for MCC patients with node-positive disease.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Agata Kurczyk, Marta Gawin, Piotr Paul, Ewa Chmielik, Tomasz Rutkowski, Monika Pietrowska, Piotr Widlak
Summary: This study investigated the potential association between phenotypic intra-tumor heterogeneity (ITH), analyzed by mass spectrometry imaging (MSI), and the prognosis of head and neck cancer. The results showed that higher levels of ITH were associated with more favorable outcomes. The similarity of spectra within the tumor was higher in patients with progressive disease, while the diversity of clusters identified during image segmentation was higher in patients with no evidence of disease. Furthermore, molecular components correlated with long-term outcomes were found to be associated with proteins involved in immune functions.
Meeting Abstract
Oncology
Ulka N. Vaishampayan, Shipra Gandhi, Seth David Rosen, Anna Spreafico, Debora S. Bruno, Quincy S. Chu, Aman Chauhan, Olivier Dumas, Hal W. Hirte, Jared E. Lopes, Heather Losey, Yan Wang, Lei Sun, Monali Bhardwaj Desai, Rita P. Dalal, Yangchun Du, Julie R. Graham, Jameel Muzaffar, Ira Seth Winer
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Pei Jye Voon, Eric X. Chen, Helen X. Chen, Albert C. Lockhart, Solmaz Sahebjam, Karen Kelly, Ulka N. Vaishampayan, Vivek Subbiah, Albiruni R. Razak, Daniel J. Renouf, Sebastien J. Hotte, Arti Singh, Philippe L. Bedard, Aaron R. Hansen, S. Percy Ivy, Lisa Wang, Lee-Anne Stayner, Lillian L. Siu, Anna Spreafico
Summary: This study evaluated the recommended dose, maximum tolerated dose, and pharmacokinetic profile of Trametinib in patients with advanced solid tumors and various degrees of hepatic dysfunction. The recommended dose for patients with mild hepatic dysfunction was 2 mg daily. However, due to difficulty in patient accrual, the recommended dose and maximum tolerated dose could not be determined for patients with moderate and severe hepatic dysfunction. Treatment-related adverse events were consistent with previous studies.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Thiago P. Muniz, Daniel V. Araujo, Kerry J. Savage, Tina Cheng, Moumita Saha, Xinni Song, Sabrina Gill, Jose G. Monzon, Debjani Grenier, Sofia Genta, Michael J. Allen, Diana P. Arteaga, Samuel D. Saibil, Marcus O. Butler, Anna Spreafico, David Hogg
Summary: This study describes the characteristics of ICI-induced IDDM in patients treated at five Canadian cancer centers, and observes that presentation with hyperglycemic crisis is common and that patients treated with combination immunotherapy regimens develop ICI-induced IDDM earlier than those treated with monotherapy. ICI-induced IDDM is irreversible but is associated with high tumor response rates and prolonged survival.
Review
Oncology
Houda Bahig, Shao Hui Huang, Brian O'Sullivan
Summary: This review summarizes the recent knowledge about oligometastasis in head and neck cancer, including its characteristics, investigational efforts, and evidence for local ablative therapy. It also discusses the challenges and opportunities in patient selection and the role of radiotherapy and immunotherapy combinations.
Article
Oncology
Funda Meric-Bernstam, Randy F. Sweis, Stefan Kasper, Omid Hamid, Shailender Bhatia, Reinhard Dummer, Agostina Stradella, Georgina Long, Anna Spreafico, Toshio Shimizu, Neeltje Steeghs, Jason J. Luke, Sarah M. McWhirter, Thomas Mueller, Nitya Nair, Nancy Lewis, Xinhui Chen, Andrew Bean, Lisa Kattenhorn, Marc Pelletier, Shahneen Sandhu
Summary: This study assessed the safety and tolerability of the combination of MIW815 and spartalizumab in patients with advanced solid tumors or lymphomas. The results showed that the combination therapy had immune activation but limited antitumor activity.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
John J. W. Lee, Vijay Kunaratnam, Christina J. H. Kim, Martha Pienkowski, Katrina Hueniken, Axel Sahovaler, Andrew C. L. Lam, Joel C. Davies, Catherine M. Brown, John R. De Almeida, Shao Hui Huang, John N. Waldron, Anna Spreafico, Rayjean J. Hung, Wei Xu, David P. Goldstein, Geoffrey Liu
Summary: Smoking cessation and long-term abstinence are associated with improved overall survival and HNSCC-specific survival in patients with HNSCC. Former smokers have a reduced risk of overall mortality compared with current smokers, especially those who quit smoking more than 10 years before diagnosis. Long-term abstinence is significantly associated with a decreased risk of HNSCC-specific death.
Review
Biochemistry & Molecular Biology
Pavlina Spiliopoulou, Olga Vornicova, Sofia Genta, Anna Spreafico
Summary: Recent advances in treating cutaneous melanoma have significantly improved patient survival rates by refining disease staging, accurately classifying patient risk, and introducing cancer immunotherapy. Immunotherapy, particularly in the form of immune checkpoint inhibition, has played a crucial role in managing both early and late-stage melanoma and has extended its benefits to other types of skin cancers as well. This review summarizes the current role of immunotherapy in melanoma and non-melanoma skin cancers, highlights important immunotherapy-related molecular biomarkers, and discusses future research directions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Sofia Genta, Katherine Lajkosz, Noelle R. Yee, Pavlina Spiliopoulou, Alya Heirali, Aaron R. Hansen, Lillian L. Siu, Sam Saibil, Lee-Anne Stayner, Maryia Yanekina, Maxwell B. Sauder, Sareh Keshavarzi, Abdulazeez Salawu, Olga Vornicova, Marcus O. Butler, Philippe L. Bedard, Albiruni R. Abdul Razak, Robert Rottapel, Andrzej Chruscinski, Bryan Coburn, Anna Spreafico
Summary: This study used custom autoantigen microarrays to analyze autoantibodies related to immune-related adverse events in patients receiving immune checkpoint inhibitors. The results support the potential role of autoantibodies in the occurrence and development of immune-related adverse events.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Alberto Hernando-Calvo, Eoghan Malone, Daphne Day, Amy Prawira, Ilan Weinreb, S. Y. Cindy Yang, Horace Wong, Angela Rodriguez, Sarah Jennings, Anneli Eliason, Lisa Wang, Anna Spreafico, Lillian L. Siu, Aaron R. Hansen
Summary: This study aimed to evaluate the activity of selinexor in patients with recurrent or metastatic salivary gland tumors. The results showed limited anti-tumor activity of selinexor, although some tumor reduction was observed.
Article
Oncology
Maysa Vilbert, Erica C. Koch, April A. N. Rose, Rob C. Laister, Diana Gray, Valentin Sotov, Susanne Penny, Anna Spreafico, Devanand M. Pinto, Marcus O. Butler, Samuel D. Saibil
Summary: Cutaneous melanoma (CM) patients respond better to immune checkpoint inhibitors (ICI) than mucosal and uveal melanoma patients (MM/UM). Aiming to explore these differences and understand the distinct response to ICI, we evaluated the serum metabolome of advanced CM, MM, and UM patients. Our study revealed a distinct metabolomic profile between the most resistant melanoma subtypes, UM and MM, compared to CM. Alterations within the kynurenine pathway, polyamine metabolism, and sphingolipid metabolic pathway may contribute to the poor response to ICI.
Review
Oncology
Danny Lavigne, Sweet Ping Ng, Brian O'Sullivan, Phuc Felix Nguyen-Tan, Edith Filion, Laurent Letourneau-Guillon, Clifton D. Fuller, Houda Bahig
Summary: Magnetic resonance-guided radiation therapy (MRgRT) is a method that uses magnetic resonance imaging (MRI) information to guide radiation treatment planning in patients with head and neck cancer. It has several potential advantages, including enhanced evaluation, adaptive adjustment, hypofractionation, and multiparametric response assessment.
Meeting Abstract
Oncology
Kirsty Taylor, Jinfeng Zou, Marcos Aurelio Fonseca Magalhaes Filho, Karen Howarth, Giovanni Marsico, Samantha Terrell, Gregory Jones, Charlene Knape, Tim Forshew, Marc Oliva, Anna Spreafico, Aaron Richard Hansen, Simon McDade, Victoria M. Coyle, Mark Lawler, Elena Elimova, Scott Victor Bratman, Lillian L. Siu
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Ulka N. Vaishampayan, Piotr Tomczak, Jameel Muzaffar, Ira Seth Winer, Seth David Rosen, Christopher J. Hoimes, Aman Chauhan, Anna Spreafico, Karl D. Lewis, Debora S. Bruno, Olivier Dumas, David F. McDermott, James Fredric Strauss, Quincy S. Chu, Lucy Gilbert, Arvind Chaudhry, Julie R. Graham, Valentina Boni, Marc S. Ernstoff, Vamsidhar Velcheti
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Helena Jacoba Janse Van Rensburg, Zhihui Amy Liu, Albiruni Ryan Abdul Razak, Anna Spreafico, Philippe L. Bedard, Aaron Richard Hansen, Stephanie Lheureux, Marcus O. Butler, Lillian L. Siu
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Amita Patnaik, Justin A. Call, Anna Spreafico, Lisle Nabell, Mingjin Yan, Andres Forero-Torres, Maura L. Gillison
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)
