Article
Obstetrics & Gynecology
R. Aughwane, N. Mufti, D. Flouri, K. Maksym, R. Spencer, M. Sokolska, G. Kendall, D. Atkinson, A. Bainbridge, J. Deprest, T. Vercauteren, S. Ourselin, A. L. David, A. Melbourne
Summary: The study found that MRI technique can reveal differences in feto-placental oxygen saturation between normal and early-onset fetal growth restriction (FGR) pregnancies, and this difference is associated with disease severity.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Teresa Tropea, Carina Nihlen, Eddie Weitzberg, Jon O. Lundberg, Mark Wareing, Susan L. Greenwood, Colin P. Sibley, Elizabeth C. Cottrell
Summary: Nitric oxide (NO) plays a crucial role in regulating fetoplacental vascular tone to ensure proper oxygen and nutrient delivery to the fetus. Reduced fetoplacental blood flow can lead to pregnancy complications and fetal growth restriction. The study found that nitrite-induced vasorelaxation is preserved in FGR, suggesting interventions targeting this pathway could improve blood flow in FGR pregnancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu'uhevaha J. Kaitu'u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Lisa Hui, Natalie J. Hannan
Summary: Elevated levels of OLAH in the placenta may be associated with placental dysfunction in pregnancies complicated by preterm preeclampsia and fetal growth restriction. Further research is required to understand the role of OLAH in the placenta, and whether these changes are a maternal adaptation or consequence of disease.
Article
Biochemistry & Molecular Biology
Fatima Merech, Vanesa Hauk, Daniel Paparini, Laura Fernandez, Zaira Naguila, Rosanna Ramhorst, James Waschek, Claudia Perez Leiros, Daiana Vota
Summary: The study reveals that deficiency of VIP in the placenta leads to reduced fetal weight in a normal maternal background, accompanied by increased glucose uptake and gene expression. However, in a maternal VIP-deficient environment, placental uptake and transplacental transport of glucose increase while fetal weights remain unaffected.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Acoustics
Yan Deng, Ying Jin, Ran Xu, Shi Zeng
Summary: Maternal oxygenation has been widely used in obstetrics, with studies showing various effects on fetal circulation during normal and complicated pregnancies. However, further large randomized controlled trials and longitudinal studies are necessary to determine its potential benefits and risks for fetal well-being in complicated pregnancies.
ULTRASCHALL IN DER MEDIZIN
(2021)
Article
Chemistry, Multidisciplinary
Dimitra Flouri, Jack R. T. Darby, Stacey L. Holman, Steven K. S. Cho, Catherine G. Dimasi, Sunthara R. Perumal, Sebastien Ourselin, Rosalind Aughwane, Nada Mufti, Christopher K. Macgowan, Mike Seed, Anna L. David, Andrew Melbourne, Janna L. Morrison
Summary: Magnetic resonance imaging (MRI) assessment of fetal blood oxygen saturation (SO2) is important for the clinical management of high-risk pregnancies. A novel MRI method is used to evaluate fetal growth and distinguish between normally grown and FGR fetuses in sheep and humans. A multi-compartment placental MRI model can detect placental SO2 and differentiate between different types of fetuses.
Article
Developmental Biology
Johannes K. Steinweg, Grace Tin Yan Hui, Maximilian Pietsch, Alison Ho, Milou P. M. van Poppel, David Lloyd, Kathleen Colford, John M. Simpson, Reza Razavi, Kuberan Pushparajah, Mary Rutherford, Jana Hutter
Summary: This study evaluated placental oxygenation using relaxometry in pregnancies with fetal CHD, finding significant differences in placental structure and function compared to normal pregnancies. Specific altered patterns in placental function assessed by T2* provide crucial complementary information to antenatal assessments in the presence of fetal CHD.
Article
Radiology, Nuclear Medicine & Medical Imaging
Junshen He, Zhao Chen, Chunlin Chen, Ping Liu
Summary: Functional MRI can assess the differences in oxygenation and perfusion status between pregnancies complicated by FGR and SGA. The results showed that oxygenation status was significantly lower in pregnancies complicated by FGR compared to pregnancies complicated by SGA. However, diffusion and perfusion parameters were similar between the two groups.
EUROPEAN RADIOLOGY
(2023)
Article
Acoustics
T. Van Mieghem, L. Lewi, F. Slaghekke, E. Lopriore, Y. Yinon, L. Raio, D. Baud, P. Dekoninck, N. Melamed, E. Huszti, L. Sun, S. Shinar
Summary: This study aimed to identify predictors of fetal death in monochorionic diamniotic twin pregnancies complicated by Type-III selective fetal growth restriction (sFGR). The results showed that earlier diagnosis, oligohydramnios in the smaller twin, deterioration in umbilical artery Doppler flow, and larger fetal weight discordance were associated with an increased risk of fetal death. The CART model identified three risk groups. These findings are of importance for improving pregnancy outcomes in this high-risk population.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Developmental Biology
M. Aertsen, A. Melbourne, I. Couck, E. King, S. Ourselin, F. De Keyzer, S. Dymarkowski, J. Deprest, L. Lewi
Summary: This study investigates diffusion and relaxation differences in uncomplicated MCDA pregnancies and MCDA pregnancies complicated by TTTS and sFGR in mid-pregnancy. The results show significant differences in several MRI parameters between the placenta of uncomplicated MCDA pregnancies and those complicated by sFGR and TTTS.
Article
Developmental Biology
Anat Shmueli, Liat Mor, Ophir Blickstein, Rinat Sela, Eran Weiner, Noa Gonen, Letizia Schreiber, Michal Levy
Summary: Late fetal growth restriction (FGR) is associated with mild growth restriction and normal or mild abnormal doppler flows. Abnormal cerebroplacental ratio (CPR) in late FGR is reflected in placental vascular malperfusion lesions, resulting in adverse maternal and neonatal outcomes.
Article
Acoustics
Xinlin Chen, Xia Wei, Sheng Zhao, Hui Huang, Weiyun Wang, Junyu Qiu, Xiao Chen, Chen Cheng, Zhiyun Tian, Jack Rychik
Summary: The study observed the microvascular architecture in the placental bed and explored the feasibility and clinical utility of MV-Flow imaging during normal pregnancy and fetal growth restriction. Results showed that MV-Flow technology can display and quantify placental microvascular architecture and provide new information on pregnancy-related conditions. The study suggests that MV-Flow is a potentially powerful tool to explore placental microvascular perfusion.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Developmental Biology
Michal Levy, Michal Kovo, Ohad Feldstein, Ann Dekalo, Letizia Schreiber, Omer Levanon, Jacob Bar, Eran Weiner
Summary: Pregnancies complicated by FGR with concomitant HC were associated with higher rates of adverse neonatal outcomes, including lower Apgar scores, increased neonatal death, and higher rates of composite adverse and severe adverse neonatal outcomes.
Review
Obstetrics & Gynecology
Ilaria Fantasia, Sofia Bussolaro, Tamara Stampalija, Daniel L. Rolnik
Summary: Placental insufficiency can lead to various complications in pregnancy, and melatonin may play an important role in this condition, but more research is needed to confirm this. Current studies have found that the circadian pattern of melatonin secretion may be altered in pregnancies complicated by placental insufficiency, and melatonin treatment may be beneficial in prolonging gestation and improving outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Elizabeth Sherwin, Russell Deter, Noor Joudi, Paula Trepman, Wesley Lee, Yasser Y. El-Sayed, Anna Girsen, Imee Datoc, Susan R. Hintz, Yair J. Blumenfeld
Summary: Prenatal ultrasound can overestimate suspected fetal growth restriction in gastroschisis cases due to altered sonographic measurements. Individualized Growth Assessment (IGA) effectively distinguishes normal and pathological fetal growth in these cases, revealing different growth patterns. IGA showed high agreement with conventional methods in identifying pathological growth in different fetal growth patterns.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Alice Dempsey, Clare Mumby, Giovanna Bernatavicius, Stephen A. Roberts, Jenny E. Myers
Summary: This study aimed to evaluate the feasibility and clinical outcomes of metformin treatment in women with mild fasting hyperglycemia during pregnancy. The results showed that most women were satisfied with metformin treatment and it helped to lower blood glucose levels. However, the recruitment rate in the study was low, suggesting that future research may need to consider alternative approaches.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Developmental Biology
Teresa M. MacDonald, Stephen Tong, Jenny Myers, Ping Cannon, Tuong-Vi Nguyen, Emerson Keenan, Elizabeth Murray, Alesia Harper, Natasha Pritchard, Natalie J. Hannan, Kirsten M. Dane, Anna L. Middleton, Valerie P. Kyritsis, Susan P. Walker, Tu'uhevaha J. Kaitu'u-Lino
Summary: The study found that circulating TFPI levels significantly increase prior to preeclampsia at 36 weeks, and are markedly elevated in preterm preeclampsia. TFPI may be beneficial for a multi-marker blood test to predict preeclampsia.
Article
Cardiac & Cardiovascular Systems
Stephanie A. Worton, Harry A. T. Pritchard, Susan L. Greenwood, Mariam Alakrawi, Alexander E. P. Heazell, Mark Wareing, Adam Greenstein, Jenny E. Myers
Summary: Kynurenine promotes relaxation of human resistance arteries in both normotensive and hypertensive pregnant women by activating BKCa channels, indicating its potential as a new treatment for hypertension in pregnancy.
CIRCULATION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Helen R. Murphy, Carla Howgate, Jackie O'Keefe, Jenny Myers, Margery Morgan, Matthew A. Coleman, Matthew Jolly, Jonathan Valabhji, Eleanor M. Scott, Peter Knighton, Bob Young, Nick Lewis-Barned
Summary: The study aimed to compare modifiable risk factors associated with adverse pregnancy outcomes in women with type 1 and type 2 diabetes, and found that maternal glycaemia and BMI are key modifiable risk factors. There were no substantial differences in outcomes between maternity clinics.
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ciara N. Murphy, Susan P. Walker, Teresa M. MacDonald, Emerson Keenan, Natalie J. Hannan, Mary E. Wlodek, Jenny Myers, Jessica F. Briffa, Tania Romano, Alexandra Roddy Mitchell, Carole-Anne Whigham, Ping Cannon, Tuong-Vi Nguyen, Manju Kandel, Natasha Pritchard, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: SPINT2 is identified as a potential biomarker for placental dysfunction, associated with preterm preeclampsia and intrauterine growth restriction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Holly Hope, Matthias Pierce, Edward D. Johnstone, Jenny Myers, Kathryn M. Abel
Summary: The study aims to examine the sexual and reproductive health risks associated with mental illness among women. The findings indicate that women with mental illness are more likely to experience recurrent miscarriage, termination, gynaecological diseases, sexually transmitted infections, reproductive cancers, and less likely to attend for cervical screening, highlighting significant health inequalities for this population.
ARCHIVES OF WOMENS MENTAL HEALTH
(2022)
Article
Medicine, General & Internal
Chiamaka Esther Amaefule, Zoe Drymoussi, Francisco Jose Gonzalez Carreras, Maria Del Carmen Pardo Llorente, Doris Lanz, Julie Dodds, Lorna Sweeney, Elena Pizzo, Amy Thomas, James Heighway, Jahnavi Daru, Soha Sobhy, Lucilla Poston, Asma Khalil, Jenny Myers, Angela Harden, Graham Hitman, Khalid Saeed Khan, Javier Zamora, Teresa Perez, Mohammed S. B. Huda, Shakila Thangaratinam
Summary: This study aimed to assess the feasibility and acceptability of a randomized trial on the effects of myo-inositol in preventing gestational diabetes in high-risk pregnant women. The study found a potential reduction in insulin resistance during pregnancy with myo-inositol, but intervention in a non-powder form is needed to improve adherence.
Article
Obstetrics & Gynecology
Laura A. Magee, Mark A. Brown, David R. Hall, Sanjay Gupte, Annemarie Hennessy, S. Ananth Karumanchi, Louise C. Kenny, Fergus McCarthy, Jenny Myers, Liona C. Poon, Sarosh Rana, Shigeru Saito, Anne Cathrine Staff, Eleni Tsigas, Peter von Dadelszen
Summary: Uniform departmental management protocols should be maintained for managing hypertensive pregnant women, and regular audits of maternal and fetal outcomes should be conducted. The cause and optimal clinical management of pre-eclampsia and hypertensive disorders of pregnancy remain uncertain, therefore, it is recommended that every hypertensive pregnant woman be given the opportunity to participate in research, clinical trials, and follow-up studies.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Obstetrics & Gynecology
Laura Ormesher, Suzanne Higson, Matthew Luckie, Stephen A. Roberts, Heather Glossop, Andrew Trafford, Elizabeth Cottrell, Edward D. Johnstone, Jenny E. Myers
Summary: This study found that postnatal cardiovascular morbidity persists in women with preterm pre-eclampsia six months after childbirth, particularly in the form of diastolic dysfunction and increased total vascular resistance. Earlier gestation at delivery and lower birthweight are associated with worse cardiovascular function at six months postpartum.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Medicine, Research & Experimental
Alice Hurrell, Jenie Sparkes, Kate Duhig, Paul T. Seed, Jenny Myers, Cheryl Battersby, Katherine Clark, Marcus Green, Rachael M. Hunter, Andrew H. Shennan, Lucy C. Chappell, Louise Webster
Summary: The PARROT-2 trial is a multi-centre randomised controlled trial investigating the impact of repeat PIGF-based testing on women with suspected pre-eclampsia between 22-35 weeks of gestation. The primary objective of the trial is to determine whether repeat PIGF-based testing reduces severe adverse outcomes for both mother and baby. The clinical and cost-effectiveness of repeat PIGF-based testing has not yet been evaluated.
Article
Multidisciplinary Sciences
Laura Ormesher, Sarah Vause, Suzanne Higson, Anna Roberts, Bernard Clarke, Stephanie Curtis, Victoria Ordonez, Faiza Ansari, Thomas R. Everett, Claire Hordern, Lucy Mackillop, Victoria Stern, Tessa Bonnett, Alice Reid, Suzanne Wallace, Ebruba Oyekan, Hannah Douglas, Matthew Cauldwell, Maya Reddy, Kirsten Palmer, Maggie Simpson, Janet Brennand, Laura Minns, Leisa Freeman, Sarah Murray, Nirmala Mary, James Castleman, Katie R. Morris, Elizabeth Haslett, Christopher Cassidy, Edward D. Johnstone, Jenny E. Myers
Summary: This multicentre retrospective cohort study aimed to determine the prevalence of pre-eclampsia in women with pre-existing cardiac dysfunction and explore the relationship between pregnancy outcome and pre-pregnancy cardiac phenotype. The study found that there was a modest increase in preterm pre-eclampsia and significant increase in fetal growth restriction in women with pre-existing cardiac dysfunction. The study also found that there was no correlation between cardiac function and pregnancy outcome, but the use of antenatal ss blockers was associated with lower birthweight.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
James M. Roberts, Tekoa L. King, John R. Barton, Stacy Beck, Ira M. Bernstein, Tiffani E. Buck, Michele A. Forgues-Lackie, Francesca L. Facco, Alison D. Gernand, Cornelia R. Graves, Arundhati Jeyabalan, Alisse Hauspurg, Tracy A. Manuck, Jenny E. Myers, Trashaun M. Powell, Elizabeth F. Sutton, Elizabeth Tinker, Eleni Tsigas, Leslie Myatt
Summary: Preeclampsia is a pregnancy disorder that affects a large number of pregnant individuals worldwide. Low-dose aspirin has been found to modestly reduce the occurrence of preeclampsia, but its long-term effects on infants are not well-studied. Expert groups have identified clinical factors and tests that can help assess the risk of preeclampsia and recommend preventive therapy. Additional care and interventions can improve outcomes for individuals at risk. A collaborative care plan has been developed to reduce the risk of preeclampsia and its associated morbidities.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Lucy Hammer, Alexander E. P. Heazell, Andrew Povey, Jenny E. Myers, John M. D. Thompson, Edward D. Johnstone
Summary: This study found that levels of ambient air pollution during pregnancy in the UK, which were all below recommended thresholds, are not associated with an increased risk of stillbirth. However, periconceptual exposure to NO2 may be associated with an increased risk, but further research is needed to investigate this association.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Peripheral Vascular Disease
Thomas Willmott, Laura Ormesher, Andrew J. Mcbain, Gavin J. Humphreys, Jenny E. Myers, Gurdeep Singh, Jon O. Lundberg, Eddie Weitzberg, Carina Nihlen, Elizabeth C. Cottrell
Summary: This study aimed to investigate the role of oral microbiota profiles and oral nitrate-reducing capacity in explaining individual differences in blood pressure (BP) lowering following dietary nitrate supplementation. The results showed that women with hypertension had lower salivary nitrite concentrations and reduced abundance of nitrate-reducing bacteria compared to normotensive women. Oral nitrate reductase (NaR) activity did not differ significantly between pregnant and nonpregnant women, but it tended to be lower in hypertensive women. Oral NaR activity was associated with both baseline diastolic BP and changes in diastolic BP after acute nitrate intake.
Article
Medicine, General & Internal
Jameela Sheikh, John Allotey, Tania Kew, Borja M. Fernandez-Felix, Javier Zamora, Asma Khalil, Shakila Thangaratinam
Summary: Globally, babies born to Black women in underserved groups consistently have poorer perinatal outcomes than those born to White women, despite variations in risks for other ethnic groups. The effects of race and ethnicity on adverse perinatal outcomes do not vary across regions.