Article
Pediatrics
Mikhail M. Kostik, Alexey S. Maletin, Veronika V. Petukhova, Alexander Yu. Mushkin
Summary: This study aimed to compare the clinical and laboratory features of nonbacterial osteomyelitis (NBO) and bacterial osteomyelitis (BO) in children, in order to define key discriminative criteria and create an NBO diagnostic score (NBODS). The results showed significant differences between NBO and BO in terms of onset age, fever, symptomatic arthritis, and bone involvement. The use of the NBODS allowed for effective differentiation between NBO and BO.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Sarah Diamond, Jesus G. Vallejo, J. Chase McNeil
Summary: This study investigated the microbiology, management, and orthopedic outcomes of osteoarticular infections in infants aged <= 1 year. The most common pathogen was Staphylococcus aureus, followed by group B Streptococcus. Transitioning to oral antibiotic therapy after <= 14 days of parenteral therapy was found to have similar orthopedic outcomes compared to prolonged parenteral therapy.
JOURNAL OF PEDIATRICS
(2022)
Article
Orthopedics
Dun Liu, Aierken Rehemutula, Yu Si, Hongyu Zhou, Jingyang Li, Zihao Chen, Li Li
Summary: Drug-loaded calcium sulfate is an effective method for the treatment of hematogenous osteomyelitis in children, reducing complications and recurrence.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Immunology
Elisabeth A. Hoyer, Marritta Joseph, Sheldon L. Kaplan, Jesus G. Vallejo, Jonathon Chase McNeil
Summary: This study aimed to examine clinical factors and guide empiric treatment for pediatric acute hematogenous osteomyelitis (AHO). The findings suggest that critically ill children with CRP >7 mg/dL, subperiosteal abscess, and history of soft tissue infection are more likely to have MRSA infection, and empiric vancomycin use could be considered. Further validation is needed.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Review
Infectious Diseases
Elyne M. M. Brunink, Lotje A. A. Hoogervorst, Koen Steentjes, Demien Broekhuis, Mark G. J. de Boer
Summary: This paper provides an overview of the clinical presentation, prognosis, and treatment of hematogenous osteomyelitis caused by Streptococcus intermedius in immunocompetent adults. Through a systematic literature review, four case reports were identified, and the most common symptoms were localized pain and fever. Treatment strategies varied, but antibiotics (penicillins) were administered in each case, and some patients underwent surgical debridement. Limited data is available, but based on the available evidence, the clinical presentation, prognosis, and treatment of hematogenous osteomyelitis caused by Streptococcus intermedius in immunocompetent adults were summarized.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Immunology
Tori Kinamon, Michael Dagher, Lawrence Park, Felicia Ruffin, Vance G. Fowler Jr, Stacey A. Maskarinec
Summary: Among patients with Staphylococcus aureus bacteremia (SAB), the risk of hematogenous vertebral osteomyelitis (HVOM) is associated with clinical factors rather than bacterial genotype. Despite being a rare complication, patients with HVOM have high mortality rates and healthcare resource requirements up to 1 year after diagnosis. Close clinical monitoring is necessary for this vulnerable population.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Blaise Cochard, Celine Habre, Nastassia Pralong-Guanziroli, Nathaly Gavira, Giorgio Di Laura Frattura, Giacomo Di Marco, Christina N. Steiger, Geraldo De Coulon, Romain Dayer, Dimitri Ceroni
Summary: This study aimed to explore the prevalence and epidemiology of pediatric Transphyseal Hematogenous Osteomyelitis (THO) and discuss its underlying pathophysiology. Retrospective analysis of 17 years of data revealed that 54 out of 210 patients (25.7%) with acute or subacute osteomyelitis were diagnosed with THO. The most common sites of THO were the distal tibia, proximal tibia, and distal fibula. The study also found that transphyseal lesions above 7% of the physeal cross-sectional area have a greater impact on subsequent growth.
Review
Pediatrics
Andrzej Krzysztofiak, Elena Chiappini, Elisabetta Venturini, Livia Gargiullo, Marco Roversi, Carlotta Montagnani, Elena Bozzola, Sara Chiurchiu, Davide Vecchio, Elio Castagnola, Paolo Toma, Gian Maria Rossolini, Renato Maria Toniolo, Susanna Esposito, Marco Cirillo, Fabio Cardinale, Andrea Novelli, Giovanni Beltrami, Claudia Tagliabue, Silvio Boero, Daniele Deriu, Sonia Bianchini, Annalisa Grandin, Samantha Bosis, Martina Ciarcia, Daniele Ciofi, Chiara Tersigni, Barbara Bortone, Giulia Trippella, Giangiacomo Nicolini, Andrea Lo Vecchio, Antonietta Giannattasio, Paola Musso, Elena Serrano, Paola Marchisio, Daniele Dona, Silvia Garazzino, Luca Pierantoni, Teresa Mazzone, Paola Bernaschi, Alessandra Ferrari, Guido Castelli Gattinara, Luisa Galli, Alberto Villani
Summary: Acute hematogenous osteomyelitis is a bone infection that primarily affects young males and is often caused by bacterial infection. Diagnosis relies on inflammatory biomarkers and imaging, while treatment lacks national guidelines and depends heavily on clinician experience.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Review
Pediatrics
Karen M. Alexander, Tal Laor, M. Alejandra Bedoya
Summary: Pediatric musculoskeletal infection is a challenging diagnosis, and tailored MRI protocols based on patient age are necessary for accurate localization and identification of complications.
PEDIATRIC RADIOLOGY
(2023)
Article
Infectious Diseases
Adriana Sarmiento Clemente, J. Chase McNeil, Kristina G. Hulten, Jesus G. Vallejo, Michael E. Scheurer, Sheldon L. Kaplan
Summary: In this retrospective study of children with acute hematogenous osteomyelitis, the A-SCORE and C-SCORE were found to be useful in predicting acute and chronic complications, respectively. These scores can aid in guiding acute management and long-term follow-up decisions.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2023)
Article
Immunology
Maria J. Sanchez, Karisma Patel, Eduardo A. Lindsay, Naureen G. Tareen, Chanhee Jo, Lawson A. Copley, Paul K. Sue
Summary: This study aimed to investigate the optimal treatment strategy for children with acute hematogenous osteomyelitis (AHO) and Staphylococcus aureus bacteremia (SAB). The results showed that early transition to oral antimicrobial therapy was safe in children with mild or moderate AHO despite the presence of SAB.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Francois Chalard, Anne-Laure Hermann, Monique Elmaleh-Berges, Hubert Ducou le Pointe
Summary: A wide range of disorders involving the parotid glands can occur during infancy and childhood. Inflammatory/infectious diseases are the most common, followed by congenital lesions and tumors. Benign tumors are more common than malignant tumors. Imaging characteristics play a crucial role in the diagnosis and treatment of these conditions.
INSIGHTS INTO IMAGING
(2022)
Article
Pediatrics
Paola Musso, Sara Parigi, Grazia Bossi, Gian Luigi Marseglia, Luisa Galli, Elena Chiappini
Summary: Acute hematogenous osteomyelitis (AHOM) is rare in pediatric population. Most cases involve Staphylococcus aureus, with MRI being the gold standard for diagnosis. Treatment duration varies based on the type of osteomyelitis, with overall high recovery rates.
Article
Orthopedics
Cheng-he Qin, Rui Tao, Ji-wei Luo, Liang Hong, Lei Xu, Jia Fang, Chun-hao Zhou
Summary: Hematogenous osteomyelitis in infancy is unique in its severity and rapid progression, with the transition from acute to chronic form occurring within just 7 days. The presented case of chronic hematogenous osteomyelitis in a 2-month-old girl is the youngest reported case to date.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Immunology
Philip M. Roper, Kara R. Eichelberger, Linda Cox, Luke O'Connor, Christine Shao, Caleb A. Ford, Stephanie A. Fritz, James E. Cassat, Deborah J. Veis
Summary: This study investigated the pathogenesis of hematogenous osteomyelitis (HOM) in pediatric patients by inoculating mice with various strains of Staphylococcus aureus. The results showed differences in disease manifestation among the different strains, laying the groundwork for future studies on strain-dependent differences in musculoskeletal infection in children.
INFECTION AND IMMUNITY
(2021)