Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation

Phase II Study of a Radiotherapy Total Dose Increase in Hypoxic Lesions Identified by 18 F-Misonidazole PET/CT in Patients with Non–Small Cell Lung Carcinoma (RTEP5 Study)

(2017) Pierre Vera et al.   JOURNAL OF NUCLEAR MEDICINE

Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair

(2016) Shigeaki Sunada et al.   CANCER SCIENCE

M3814, a DNA-dependent Protein Kinase Inhibitor (DNA-PKi), Potentiates the Effect of Ionizing Radiation (IR) in Xenotransplanted Tumors in Nude Mice

(2016) L. Damstrup et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Adaptation of the microdosimetric kinetic model to hypoxia

(2016) C Bopp et al.   PHYSICS IN MEDICINE AND BIOLOGY

Comparative analysis of transcriptomics based hypoxia signatures in head- and neck squamous cell carcinoma

(2016) Bouchra Tawk et al.   RADIOTHERAPY AND ONCOLOGY

Next generation multi-scale biophysical characterization of high precision cancer particle radiotherapy using clinical proton, helium-, carbon- and oxygen ion beams

(2016) Ivana Dokic et al.   Oncotarget

Phase Space Generation for Proton and Carbon Ion Beams for External Users’ Applications at the Heidelberg Ion Therapy Center

(2016) Thomas Tessonnier et al.   Frontiers in Oncology

Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model

(2015) Brita S. Sørensen et al.   ACTA ONCOLOGICA

Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment

(2015) Susan E. Scanlon et al.   DNA REPAIR

Phosphatidylinositol 3-kinase/Akt signaling as a key mediator of tumor cell responsiveness to radiation

(2015) Mahmoud Toulany et al.   SEMINARS IN CANCER BIOLOGY

Kill-painting of hypoxic tumours in charged particle therapy

(2015) Walter Tinganelli et al.   Scientific Reports

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

Cisplatin-mediated radiosensitization of non-small cell lung cancer cells is stimulated by ATM inhibition

(2014) Mahmoud Toulany et al.   RADIOTHERAPY AND ONCOLOGY

DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin

(2013) Wojciech M. Ciszewski et al.   BREAST CANCER RESEARCH AND TREATMENT

Radiobiological description of the LET dependence of the cell survival of oxic and anoxic cells irradiated by carbon ions

(2013) L. Antonovic et al.   JOURNAL OF RADIATION RESEARCH

Influence of acute hypoxia and radiation quality on cell survival

(2013) W. Tinganelli et al.   JOURNAL OF RADIATION RESEARCH

Preclinical Evaluation of a Novel ATM Inhibitor, KU59403, In Vitro and In Vivo in p53 Functional and Dysfunctional Models of Human Cancer

(2013) M. A. Batey et al.   MOLECULAR CANCER THERAPEUTICS

Including oxygen enhancement ratio in ion beam treatment planning: model implementation and experimental verification

(2013) E Scifoni et al.   PHYSICS IN MEDICINE AND BIOLOGY

Modelling of the oxygen enhancement ratio for ion beam radiation therapy

(2011) Tatiana Wenzl et al.   PHYSICS IN MEDICINE AND BIOLOGY

Impaired DNA damage response — An Achilles' heel sensitizing cancer to chemotherapy and radiotherapy

(2009) Zbigniew Darzynkiewicz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY