POM-1 inhibits P2 receptors and exhibits anti-inflammatory effects in macrophages

Medicinal chemistry of adenosine, P2Y and P2X receptors

(2016) Kenneth A. Jacobson et al.   NEUROPHARMACOLOGY

Pharmacology and structure of P2Y receptors

(2016) Ivar von Kügelgen et al.   NEUROPHARMACOLOGY

Extracellular ATP mediates inflammatory responses in colitis via P2 × 7 receptor signaling

(2016) Ping Wan et al.   Scientific Reports

Purinergic signaling in the immune system

(2015) Francesco Di Virgilio et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Polyoxometalates—Potent and selective ecto-nucleotidase inhibitors

(2015) Sang-Yong Lee et al.   BIOCHEMICAL PHARMACOLOGY

Effective suppression of pro-inflammatory molecules by DHCA via IKK-NF-κB pathway,in vitroandin vivo

(2015) Junghun Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing

(2015) Balázs Csóka et al.   FASEB JOURNAL

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Inhibition of ecto-ATPase activities impairs HIV-1 infection of macrophages

(2015) Julieta Schachter et al.   IMMUNOBIOLOGY

Ecto-Nucleotidase Inhibitors: Recent Developments in Drug Discovery

(2015) Younis Baqi   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Physical basis of apparent pore dilation of ATP-activated P2X receptor channels

(2015) Mufeng Li et al.   NATURE NEUROSCIENCE

Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages

(2014) Hercules Antônio da Silva-Souza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

P2X7-induced zeiosis promotes osteogenic differentiation and mineralization of postmenopausal bone marrow-derived mesenchymal stem cells

(2014) José Bernardo Noronha-Matos et al.   FASEB JOURNAL

Antimicrobial Cathelicidin Peptide LL-37 Inhibits the LPS/ATP-Induced Pyroptosis of Macrophages by Dual Mechanism

(2014) Zhongshuang Hu et al.   PLoS One

Purinergic signalling and immune cells

(2014) Geoffrey Burnstock et al.   Purinergic Signalling

The role of p2x7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases

(2014) Robson Coutinho-Silva et al.   Biomedical Journal

Inhibition of hepatitis C virus infection by polyoxometalates

(2013) Yue Qi et al.   ANTIVIRAL RESEARCH

Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation

(2013) Ana Pinheiro et al.   Cell Communication and Signaling

Purinergic signalling: from discovery to current developments

(2013) Geoffrey Burnstock   EXPERIMENTAL PHYSIOLOGY

Autocrine Regulation of Macrophage Activation via Exocytosis of ATP and Activation of P2Y11 Receptor

(2013) Hayato Sakaki et al.   PLoS One

Perspective on the role of P2X-purinoceptor activation in human vas deferens contractility

(2012) Nnaemeka I. B. Amobi et al.   EXPERIMENTAL PHYSIOLOGY

Transient P2X 7 Receptor Activation Triggers Macrophage Death Independent of Toll-like Receptors 2 and 4, Caspase-1, and Pannexin-1 Proteins

(2012) Peter J. Hanley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Macrophage Activation Alters the Expression Profile of NTPDase and Ecto-5′-Nucleotidase

(2012) Rafael Fernandes Zanin et al.   PLoS One

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Biochemical properties of Candida parapsilosis ecto-5′-nucleotidase and the possible role of adenosine in macrophage interaction

(2011) Thais Russo-Abrahão et al.   FEMS MICROBIOLOGY LETTERS

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

(2011) Y. Qu et al.   JOURNAL OF IMMUNOLOGY

Inhibitory effects of decavanadate on several enzymes and Leishmania tarentolae In Vitro

(2011) Timothy L. Turner et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

NTPDase1 governs P2X7-dependent functions in murine macrophages

(2010) Sébastien A. Lévesque et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Polyoxometalates as effective inhibitors for sialyl- and sulfotransferases

(2009) Akira Seko et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

P2X7 Receptor Activates Multiple Selective Dye-Permeation Pathways in RAW 264.7 and Human Embryonic Kidney 293 Cells

(2009) S. Cankurtaran-Sayar et al.   MOLECULAR PHARMACOLOGY

The P2X7 receptor–pannexin connection to dye uptake and IL-1β release

(2009) Pablo Pelegrin et al.   Purinergic Signalling

ATP-induced P2X7-associated uptake of large molecules involves distinct mechanisms for cations and anions in macrophages

(2008) J. Schachter et al.   JOURNAL OF CELL SCIENCE

Facilitation of P2X7 Receptor Currents and Membrane Blebbing via Constitutive and Dynamic Calmodulin Binding

(2008) S. Roger et al.   JOURNAL OF NEUROSCIENCE

The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition

(2008) Mark J. Wall et al.   NEUROPHARMACOLOGY

ATP-induced apoptosis involves a Ca2+-independent phospholipase A2 and 5-lipoxygenase in macrophages

(2008) Helio Miranda Costa-Junior et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Synthesis and characterization of polyoxometalates loaded starch nanocomplex and its antitumoral activity

(2007) Fengying Zhai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY