Article
Pharmacology & Pharmacy
Salah M. Seif, Mohamed A. Elnady, Hoda Rabea, Haitham Saeed, Mohamed E. A. Abdelrahim
Summary: This study evaluated the impact of different connections on aerosol delivery in invasive mechanical ventilation settings. The results showed that there was no significant difference between old and new Combihalers in delivering aerosol drugs with or without pMDI, while the pMDI T-piece adapter delivered significantly higher pMDI aerosol than Combihaler. The new Combihaler had a slightly higher pMDI dose compared to the old Combihaler, suggesting that its antistatic properties impact pMDI delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yoann Montigaud, Quentin Georges, Lara Leclerc, Anthony Clotagatide, Aurore Louf-Durier, Jeremie Pourchez, Nathalie Prevot, Sophie Perinel-Ragey
Summary: The success of aerosol therapy in mechanically ventilated patients relies on various factors, including the position of the nebulizer in the ventilator circuit and the humidification of inhaled gases. A preclinical study was conducted to evaluate the impact of gas humidification and nebulizer position on aerosol deposition and losses in the lungs during invasive mechanical ventilation. The study found that the optimal nebulizer position is proximal before the Y-piece adapter, resulting in a higher lung dose compared to positions next to the ventilator. Dry conditions are more likely to cause peripheral deposition of aerosols in the lungs. However, interrupting gas humidification efficiently and safely in clinical use is challenging.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Xinyu Li, Wei Tan, Hongwen Zhao, Wei Wang, Bing Dai, Haijia Hou
Summary: External jet nebulizers had a significant impact on triggering performance in both VC and PC modes, while the effects on control performance and tidal volume varied significantly.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Jian-Fu Zhou, Yi-Bing Zhang, Zhi-Wei Zhang
Summary: This study compared the efficacy of budesonide inhalation suspension administered via a vibrating mesh nebulizer versus a jet nebulizer in premature infants with bronchopulmonary dysplasia (BPD) undergoing high-frequency oscillatory ventilation (HFOV). The results showed that using a vibrating mesh nebulizer for budesonide inhalation suspension resulted in improved oxygenation index and reduced arterial partial pressure of carbon dioxide compared to a jet nebulizer, indicating superior therapeutic efficacy.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pharmacology & Pharmacy
Luciana Alcoforado, Dulciane Nunes Paiva, Arzu Ari, Jacqueline de Melo Barcelar, Simone Cristina Soares Brandao, James B. Fink, Armele Dornelas de Andrade
Summary: This study compared the pulmonary deposition of a jet nebulizer (JN) and a mesh nebulizer (MN) with and without a valved holding chamber (VHC) in a randomized cross-over trial. The results showed that using a VHC significantly increased pulmonary deposition for the JN, while the MN with VHC had the highest pulmonary deposition. However, the addition of a VHC did not substantially improve the efficiency of aerosol lung deposition for the JN alone.
Article
Pharmacology & Pharmacy
Safura Binti Mohd Mohari, Nattika Nimmano
Summary: This study investigates the aerodynamic properties of nebulized droplets from nebulizers for the delivery of salbutamol sulfate. The results show that the vibrating-mesh nebulizer performs better with higher FPF values for the aerosolized droplets.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Amal E. Rashad, Mohammad F. Mohammad, Myriam Eckes, Thierry Poree, Rania M. Sarhan, Yasmin M. Madney, Mohamed EA. Abdelrahim
Summary: Aerosol delivery efficiency was evaluated using newly developed spacers versus standard T-pieces in dual limb NIV circuit. Results showed that Combihaler + VMN delivered the highest TID, and Combihaler + pMDI and Minimhal + pMDI had significantly higher aerosol delivery compared to T-piece + pMDI.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shu-Yu Wu, Chun-Kai Hsu, Li-Yi Lim, Yi-Chyan Chen, Hsi-Hsien Chang, Stephen Shei-Dei Yang
Summary: We evaluated the effects of ketamine on mice using both inhalation and intraperitoneal injection models. Mice in the inhalation group showed similar behavioral and lower urinary tract changes as mice in the injection group. These changes included increased locomotor activity, detrusor overactivity, reduced bladder capacity, and mucosa damage. Ketamine inhalation successfully mimicked the effects of ketamine abuse in humans.
Article
Multidisciplinary Sciences
Cristina Lalmolda, Pablo Florez, Carles Grimau, Roberto Larrosa, Marta Corral, Javier Sayas, Manel Lujan
Summary: The introduction of external gas in the NIV circuit can lead to asynchronies in both bench and patient studies, with autotriggering being the most common issue. Variations were observed based on the ventilator model and gas source used. Monitoring the patient at the initiation of treatment is recommended due to the variable impact of external gas on ventilator triggers.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Andrew Arnott, Robert Hart, Scott McQueen, Malcolm Watson, Malcolm Sim
Summary: This study aims to compare the viscosity of respiratory secretions after treatment with nebulised normal saline administered via vibrating mesh nebuliser or jet nebuliser. Sixty mechanically ventilated adult critical care patients with high secretion loads will be enrolled and randomised into three groups to receive different treatment modalities. The results will provide information for a definitive clinical study.
Article
Critical Care Medicine
Serpil Ocal, Serkan Ozen, Emirhan Nemutlu, Didem Kart, Cemil Can Eylem, Arzu Topeli
Summary: The presence of Acinetobacter baumannii biofilm did not affect the deposition of salbutamol on the endotracheal tube. There was no difference in surface deposition of salbutamol on component parts of the closed system between a single dose and a double dose delivered via a jet nebulizer.
Review
Respiratory System
Ronan MacLoughlin, Ignacio Martin-Loeches
Summary: This review discusses the use of aerosol therapy in mechanically ventilated patients, with a focus on jet nebulizers (JN) and vibrating mesh nebulizers (VMN). Despite VMN's superior performance, JN remains the more commonly used type. The selection of nebulizer type should consider the unique needs of the drug, disease, and patient, as well as safety considerations.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Review
Anesthesiology
Natalie Anderson, Sarah Clarke, Britta S. von Ungern-Sternberg
Summary: Bronchospasm is a common respiratory adverse event in pediatric anesthesia, commonly treated with inhaled salbutamol. It is important for clinicians to be familiar with various administration techniques and stay updated on best clinical practice in aerosolized drug delivery to efficiently treat and prevent life-threatening respiratory emergencies in pediatric patients. Innovation in orally inhaled drug products is crucial to address the unmet needs in delivering aerosolized medications during critical events like bronchospasm.
PEDIATRIC ANESTHESIA
(2022)
Article
Pharmacology & Pharmacy
Marc Mac Giolla Eain, Mary Joyce, Ronan MacLoughlin
Summary: COVID-19 can lead to serious respiratory complications that require invasive ventilatory support and aerosol therapy. It has been found that the choice of aerosol delivery device during therapy can impact the release of infectious bioaerosols from mechanically ventilated patients.
Article
Clinical Neurology
Susanne Spittel, Andre Maier, Dagmar Kettemann, Bertram Walter, Birgit Koch, Kerstin Krause, Jenny Norden, Christoph Muench, Thomas Meyer
Summary: The study found that although NIV represents the standard of care, its utilization rate was low, and TIV was mainly started without preceding NIV. The survival benefit observed in NIV patients was equal to that reported in controlled trials, but the prognosis with TIV varies greatly.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Immunology
Marwa O. Elgendy, Ahmed O. El-Gendy, Sarah Mahmoud, Tarek Yehia Mohammed, Mohamed E. A. Abdelrahim, Ahmed M. Sayed
Summary: This study aimed to investigate the safety and efficacy of vaccines among the Egyptian population. Common side effects after vaccination included pain, fatigue, dizziness, fever, and headache. Individuals with prior coronavirus infections developed better antibodies compared to those who were only vaccinated. Different vaccines had varying degrees of side effect severity and efficacy.
Article
Immunology
Marwa O. Elgendy, Ahmed O. El-Gendy, Abdulaziz Ibrahim Alzarea, Sarah Mahmoud, Saad S. Alqahtani, Alzhraa M. Fahmy, Hesham R. El-Seedi, Ahmed M. Sayed, Ahmed D. Alatawi, Mohamed E. A. Abdelrahim, Abdullah S. Alanazi
Summary: Vaccines are the solution to overcome SARS-CoV-2. This study aimed to determine the post-Sinopharm vaccine safety-profile and immunity through antibody titers. The study found that headache and fatigue were the most common symptoms post-vaccination, with most participants experiencing mild or no symptoms. Participants with past SARS-CoV-2 infection had higher antibody levels. The administration methods of these vaccines need to be reevaluated.
Article
Respiratory System
Yasmin M. Madney, Hadeer S. Harb, Thierry Poree, Myriam Eckes, Marina E. Boules, Mohamed E. A. Abdelrahim
Summary: This study evaluated the effect of a preliminary bronchodilator dose on aerosol delivery in noninvasively ventilated COPD patients. The results showed that using a preliminary bronchodilator dose significantly increased the effective lung dose of the nebulized drug with both vibrating mesh nebulizers and jet nebulizers. However, adding a preliminary bronchodilator dose increased the 24-hour cumulative urinary amount of the drug, indicating higher systemic delivery and potential for increased systemic side effects.
EXPERIMENTAL LUNG RESEARCH
(2022)
Article
Nutrition & Dietetics
Hasnaa Osama, Ehdaa O. Hamed, Muhammed A. Mahmoud, Mohamed E. A. Abdelrahim
Summary: This study aimed to evaluate the efficacy of hesperidin and diosmin individually and in combination in improving metabolic syndrome and diabetic neuropathy among patients with T2DM. The results showed that both hesperidin and diosmin were effective in reducing blood glucose, triglycerides, and low density lipoprotein levels. However, the combination of both was more effective in improving metabolic components and reducing neuropathy symptoms.
JOURNAL OF DIETARY SUPPLEMENTS
(2023)
Article
Dermatology
Mohamed S. Imam, Randa M. Abdel-Sattar, Amr S. Alamri, Abdullah M. Alqurashi, Ahmed M. Amer Alnefaie, Mohamed E. A. Abdelrahim
Summary: Negative pressure wound drainage after thyroid tumor surgery is more effective than spontaneous wound drainage in terms of drainage output, drain placement time, infection rate, wound healing rate, and occurrence of wound seroma.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Chemistry, Medicinal
Heba F. F. Salem, Marwa Mohamed Abd El-Maboud, Amira S. A. Said, Mohamed Nabil Salem, Dina Sabry, Nadia Hussain, Omnia A. M. Abd El-Ghafar, Raghda R. S. Hussein
Summary: Nanomedicine is an important approach for targeting RA medication. The combination of methotrexate with gold nanoparticles can overcome the restrictions of methotrexate and improve its anti-arthritic effects.
Article
Immunology
Hager Salah, Israa Sinan, Omar Alsamani, Lamyaa Samir Abdelghani, May Hassan ElLithy, Nazar Bukamal, Huda Jawad, Raghda R. S. Hussein, Marwa O. Elgendy, Al Shaimaa Ibrahim Rabie, Doaa Mahmoud Khalil, Amira S. A. Said, Mohammad M. AlAhmad, Azza Khodary
Summary: A survey conducted in the Kingdom of Bahrain and Egypt revealed that some healthcare workers expressed concerns and opposition to taking booster doses and regarding COVID-19 vaccines as annual vaccines. Furthermore, healthcare workers' beliefs on vaccine effectiveness, suspension or contact with patients, and infection after vaccination were found to be significant factors associated with their willingness to take booster vaccines.
Article
Health Care Sciences & Services
Al Shaimaa Ibrahim Rabie, Hager Salah, Amira S. A. Said, Ahmed Hassan Shaaban, Lamya Mohamed Abdou, Doaa Mahmoud Khalil, Zelal Kharaba, Hala Afifi, Mahmoud R. Sofy, Eman M. I. Youssef, Eman S. M. Bayoumy, Raghda R. S. Hussein
Summary: There are currently no therapeutic medications for severe COVID-19 infection. Tocilizumab, an immunomodulatory treatment, was hypothesized to reduce inflammation in the respiratory system and prevent the need for ventilators. However, a randomized controlled trial found that tocilizumab was ineffective in preventing intubation or death in hospitalized patients with severe illness and COVID-19.
Article
Health Care Sciences & Services
Hager Salah, A. L. Shaimaa Ibrahim Rabie, Amira S. A. Said, Mohammad M. AlAhmad, Ahmed Hassan Shaaban, Doaa Mahmoud Khalil, Raghda R. S. Hussein, Azza Khodary
Summary: Patients with chronic conditions may experience anxiety, depression, and stress during COVID-19, which can change their pattern of seeking medical care. In this study, 52.5% of patients with chronic diseases were depressed, 57.9% were anxious, and 35.6% were stressed during the pandemic. The research findings showed that patients with moderate to severe depression, anxiety, or stress were significantly more likely to have no follow-up for their chronic conditions.
Article
Health Care Sciences & Services
Marwa O. Elgendy, Ahmed O. El-Gendy, Sara O. Elgendy, Lamiaa N. Abdelaty, Mohamed E. A. Abdelrahim, Mona A. Abdelrahman
Summary: A cross-sectional study was conducted to evaluate the knowledge level and experience of healthcare teams in using face masks to protect themselves from COVID-19. The study found that the healthcare team had satisfactory knowledge about face mask use techniques, but there were still unsatisfactory practices. Providing them with knowledge and experience is critical to increase their awareness and prevent the infection from spreading.
Article
Dermatology
Mohamed S. Imam, Amjad Abdullah S. Alotaibi, Norah Obaid M. Alotaibi, Nujud Saud Alosaimi, Shroog Ghazi M. Alotaibi, Mohamed E. A. Abdelrahim
Summary: This meta-analysis aimed to evaluate the efficiency of platelet-rich plasma (PRP) in the management of burn wounds. The results showed that PRP significantly reduced healing time, increased healing rate, and improved healed and graft take area percent in patients with burn wounds compared to standard therapy. However, there were no significant differences in graft take ratio or infection rate between PRP and standard therapy.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Mohamed S. Imam, Randa M. Abdel-Sattar, Faisal Alqarni, Saad Yousef S. Aljumayi, Ibrahim Altukhais, Abdullah Saad Altukhays, Mohamed E. A. Abdelrahim
Summary: This meta-analysis evaluated the relationship between nasal colonization of methicillin-resistant Staphylococcus aureus (MRSA) and surgical site infection (SSI) after spine surgery (SS). The results showed that MRSA-positive individuals had a significantly higher SSI rate, while methicillin-susceptible Staphylococcus aureus and Staphylococcus aureus had no significant effect on SSI in SS patients.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Mohamed S. Imam, Ahmed Khalid Almutairi, Abdullah Mutrik Alhajri, Mishary Mosleh Alharby, Mohammed H. Alanazi, Ahmad G. Alotaibi, Mohamed E. A. Abdelrahim
Summary: This meta-analysis aimed to assess the effect of hyperbaric oxygen treatment on diabetic foot ulcers. The results showed that hyperbaric oxygen treatment had significantly higher rates of healed ulcers, adverse events, and ulcer area reduction, as well as lower mortality, compared to standard treatment. However, there was no significant difference in amputation and healing time between the two treatments. It is important to note that the selected studies had small sample sizes and limited comparisons.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Chemistry, Medicinal
Doaa G. El-Hosari, Wesam M. Hussein, Marwa O. Elgendy, Sara O. Elgendy, Ahmed R. N. Ibrahim, Alzhraa M. Fahmy, Afnan Hassan, Fatma Alzahraa Mokhtar, Modather F. Hussein, Mohamed E. A. Abdelrahim, Eman G. Haggag
Summary: This study aimed to assess the effectiveness of a domestic herbal mixture, galangal-cinnamon extract, in inhibiting SARS-CoV-2. The extract showed significant antiviral effects against Low Pathogenic HCoV-229E, with rutin identified as the most active compound. Quantum-chemical calculations and docking techniques were used to determine the molecular properties and potential inhibitors.
Article
Dermatology
Mohamed S. Imam, Randa M. Abdel-Sattar, Ghadah Rashed Alotaibi, Khalid Sinhat Alotaibi, Nasser Mutiq Almuthaybiri, Shahad Abdullah Alshahrani, Mohammed Abdulaziz Alghamdi, Mohamed E. A. Abdelrahim
Summary: A meta-analysis study found that total gastrectomy (TG) carries a higher risk of wound infections, peritoneal abscess, anastomotic leakage, and overall postoperative problems compared to distal gastrectomy (DG) in gastric cancer patients.
INTERNATIONAL WOUND JOURNAL
(2023)
