Hypocretin receptor 1 blockade produces bimodal modulation of cocaine-associated mesolimbic dopamine signaling

Reinforcing Doses of Intravenous Cocaine Produce Only Modest Dopamine Uptake Inhibition

(2016) Zachary D. Brodnik et al.   ACS Chemical Neuroscience

Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine

(2016) Jessica K. Shaw et al.   ADDICTION BIOLOGY

Nucleus accumbens core dopamine signaling tracks the need-based motivational value of food-paired cues

(2016) Tara J. Aitken et al.   JOURNAL OF NEUROCHEMISTRY

Phasic Dopamine Transmission Reflects Initiation Vigor and Exerted Effort in an Action- and Region-Specific Manner

(2016) D. Ko et al.   JOURNAL OF NEUROSCIENCE

Physiological state gates acquisition and expression of mesolimbic reward prediction signals

(2016) Jackson J. Cone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane

(2016) Ben D. Richardson et al.   Nature Communications

Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

(2016) Li-Wei Tung et al.   Nature Communications

Effect of 1-Substitution on Tetrahydroisoquinolines as Selective Antagonists for the Orexin-1 Receptor

(2015) David A. Perrey et al.   ACS Chemical Neuroscience

Hypocretin receptor 1 blockade preferentially reduces high effort responding for cocaine without promoting sleep

(2015) Zachary D. Brodnik et al.   BEHAVIOURAL BRAIN RESEARCH

The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor

(2015) David A. Perrey et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Orexin-1 receptor signaling increases motivation for cocaine-associated cues

(2015) Brandon S. Bentzley et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Distribution of the orexin-1 receptor (OX1R) in the mouse forebrain and rostral brainstem: A characterisation of OX1R-eGFP mice

(2015) Sarah Sulaiman Ch’ng et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Action initiation shapes mesolimbic dopamine encoding of future rewards

(2015) Emilie C J Syed et al.   NATURE NEUROSCIENCE

Dopamine Prediction Errors in Reward Learning and Addiction: From Theory to Neural Circuitry

(2015) Ronald Keiflin et al.   NEURON

Dopamine uptake dynamics are preserved under isoflurane anesthesia

(2015) Zachary D. Brodnik et al.   NEUROSCIENCE LETTERS

Hypocretin/Orexin Regulation of Dopamine Signaling and Cocaine Self-Administration Is Mediated Predominantly by Hypocretin Receptor 1

(2014) Courtney D. Prince et al.   ACS Chemical Neuroscience

Regional Variation in Phasic Dopamine Release during Alcohol and Sucrose Self-Administration in Rats

(2014) Tatiana A. Shnitko et al.   ACS Chemical Neuroscience

Motivational activation: a unifying hypothesis of orexin/hypocretin function

(2014) Stephen V Mahler et al.   NATURE NEUROSCIENCE

Dynamics of rapid dopamine release in the nucleus accumbens during goal-directed behaviors for cocaine versus natural rewards

(2014) Courtney M. Cameron et al.   NEUROPHARMACOLOGY

Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area

(2014) J. W. Muschamp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Illicit dopamine transients: Reconciling actions of abused drugs

(2014) Dan P. Covey et al.   TRENDS IN NEUROSCIENCES

Selective orexin receptor antagonists

(2013) Terry P. Lebold et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substituted Tetrahydroisoquinolines as Selective Antagonists for the Orexin 1 Receptor

(2013) David A. Perrey et al.   JOURNAL OF MEDICINAL CHEMISTRY

On the motivational properties of reward cues: Individual differences

(2013) Terry E. Robinson et al.   NEUROPHARMACOLOGY

Individual variation in resisting temptation: Implications for addiction

(2013) Benjamin T. Saunders et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Factors modulating neural reactivity to drug cues in addiction: A survey of human neuroimaging studies

(2013) Agnes J. Jasinska et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Seeing the Unseen

(2013) Subhojit Roy   NEUROSCIENTIST

Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: Possible confounding effects on in vivo and in vitro studies

(2012) Charles J. McElhinny et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phosphorylation of Dopamine Transporter Serine 7 Modulates Cocaine Analog Binding

(2012) Amy E. Moritz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local hypocretin-1 modulates terminal dopamine concentration in the nucleus accumbens shell

(2012) Robin Patyal et al.   Frontiers in Behavioral Neuroscience

Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms

(2012) Erin S. Calipari et al.   Frontiers in Behavioral Neuroscience

Demon Voltammetry and Analysis software: Analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures

(2011) Jordan T. Yorgason et al.   JOURNAL OF NEUROSCIENCE METHODS

Mesolimbic Dopamine Transients in Motivated Behaviors: Focus on Maternal Behavior

(2011) Donita L. Robinson et al.   Frontiers in Psychiatry

Orexin/Hypocretin Modulates Response of Ventral Tegmental Dopamine Neurons to Prefrontal Activation: Diurnal Influences

(2010) D. E. Moorman et al.   JOURNAL OF NEUROSCIENCE

Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration

(2010) Rodrigo A. España et al.   PSYCHOPHARMACOLOGY

Hypocretin/orexin in arousal and stress

(2009) Craig W. Berridge et al.   BRAIN RESEARCH

Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats

(2009) Brandon J. Aragona et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking

(2009) Rachel J. Smith et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system

(2009) Rodrigo A. España et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters

(2009) Ying-Jian Liang et al.   JOURNAL OF NEUROCHEMISTRY

Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

(2009) S. L. Borgland et al.   JOURNAL OF NEUROSCIENCE

Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals

(2009) Jeremy J Clark et al.   NATURE METHODS

Orexin/hypocretin is necessary for context-driven cocaine-seeking

(2009) Rachel J. Smith et al.   NEUROPHARMACOLOGY

Multivariate concentration determination using principal component regression with residual analysis

(2009) Richard B. Keithley et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Preferential Enhancement of Dopamine Transmission within the Nucleus Accumbens Shell by Cocaine Is Attributable to a Direct Increase in Phasic Dopamine Release Events

(2008) B. J. Aragona et al.   JOURNAL OF NEUROSCIENCE

Role of lateral hypothalamic orexin neurons in reward processing and addiction

(2008) Gary Aston-Jones et al.   NEUROPHARMACOLOGY