Article
Psychiatry
Or Burstein, Noam Simon, Yaarit Simchon-Tenenbaum, Moshe Rehavi, Motty Franko, Alon Shamir, Ravid Doron
Summary: Maternal stress can have negative effects on both mother and child, with the current COVID-19 pandemic exacerbating this situation. Animal models suggest that SSRIs may help alleviate anxiety, but further research is needed to understand their impact on offspring.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Psychiatry
Jianjun Wang, Fiammetta Cosci
Summary: This study systematically evaluated the symptoms and risks of neonatal SSRI withdrawal syndrome, and proposed relevant preventive measures.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2021)
Article
Obstetrics & Gynecology
Julie A. Vignato, S. Banu Gumusoglu, Heather A. Davis, Sabrina M. Scroggins, Wendy S. Hamilton, Debra S. Brandt, Gary L. Pierce, Boyd A. Knosp, Donna A. Santillan, Mark K. Santillan
Summary: Depression and preeclampsia are bi-directionally associated with each other, and SSRIs may attenuate the risk of preeclampsia. This study found that SSRIs use was associated with decreased risk of preeclampsia and reduced copeptin levels in early pregnancy, suggesting a potential therapeutic effect.
REPRODUCTIVE SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Elli Anna Kotsailidi, Catherine Gagnon, Lucy Johnson, Abdul Barmak Basir, Alexandra Tsigarida
Summary: This retrospective study evaluated the association between the use of selective serotonin reuptake inhibitors (SSRIs) and changes in peri-implant marginal bone levels. The results showed a significant correlation between SSRI use and marginal bone loss around dental implants.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Psychology, Clinical
Chittaranjan Andrade
Summary: The exposure to antidepressants during pregnancy, especially SSRIs, is associated with a slightly increased risk of postpartum hemorrhage. However, the findings should be interpreted with caution, and precautionary measures are still recommended.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Ethan A. Poweleit, Margaret A. Cinibulk, Sarah A. Novotny, Melissa Wagner-Schuman, Laura B. Ramsey, Jeffrey R. Strawn
Summary: Pregnancy can affect the pharmacokinetics of selective serotonin reuptake inhibitors (SSRIs), which are commonly used for treating depressive and anxiety disorders. The activity of cytochrome P450 (CYP) enzymes, which metabolize SSRIs, changes significantly during pregnancy, leading to pharmacokinetic variability that may impact the tolerability and efficacy of these medications. This perspective examines the impact of pharmacokinetic genes related to CYP activity on SSRI pharmacokinetics during pregnancy and discusses the implications for dosing and future research.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Jakob Christensen, Betina B. Trabjerg, Yuelian Sun, Julie Werenberg Dreier
Summary: This study examined the association between maternal antidepressant prescription during pregnancy and standardized test scores among Danish schoolchildren. Results showed that children born to mothers filling antidepressant prescriptions during pregnancy had significantly lower math test scores but no significant difference in language test scores compared to children whose mothers did not fill antidepressant prescriptions. The difference in math scores was small and of uncertain clinical importance, suggesting the need to balance the findings against the benefits of treating maternal depression during pregnancy.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Oncology
Naiqi Zhang, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: This population-based cohort study suggests that the use of SSRIs is associated with a reduced risk of CRC among individuals with a family history of CRC. The decreased risk of CRC showed a non-linear, dose-dependent pattern. Furthermore, the use of SSRIs was strongly associated with advanced-stage CRC rather than early-stage CRC.
Review
Neurosciences
Gideon Koren, Asher Ornoy
Summary: There is still uncertainty regarding the fetal safety or risk of selective serotonin reuptake inhibitors (SRIs) during pregnancy after multiple studies and meta-analyses. Bias in studies may lead to the belief that SRIs cause malformations in fetuses when there may be other factors at play. Pregnant women treated for depression and anxiety appear to differ from healthy women in ways that may impact pregnancy outcomes, highlighting the need to adjust for biases before deciding on treatment for depression and anxiety during pregnancy.
CURRENT NEUROPHARMACOLOGY
(2021)
Editorial Material
Pediatrics
Leonora Hendson, Vibhuti Shah, Sandra Trkulja
Summary: This position statement provides guidance for the monitoring, care, and follow-up of newborns exposed to SSRIs or SNRIs in utero. While there are risks involved, the common neonatal adaptation syndrome is generally mild and treatable with nonpharmacological measures. The low levels of these drugs in breast milk make them compatible with breastfeeding, and serious adverse effects from exposure to SSRIs or SNRIs in utero are low.
PAEDIATRICS & CHILD HEALTH
(2021)
Review
Chemistry, Analytical
Ilona Oledzka, Alina Plenis, Piotr Kowalski, Tomasz Baczek, Anna Roszkowska
Summary: The pharmacotherapy of depression relies on different types of antidepressants, with SSRIs being the most commonly used first-line treatment. There is a growing demand for fast and accurate methods to monitor SSRI levels during depression therapy. Recent efforts have focused on developing instrumental methods that enable lower detection limits, better quantitation, and separation of multiple analytes, resulting in more reliable and selective determination of SSRIs. However, the preparation of biological samples for analysis remains a bottleneck in most analytical procedures. This review discusses recent advancements in methods for preparing various conventional and non-conventional complex biological matrices for precise determination of SSRI levels, as well as the advantages, challenges, and potential applications of these developed methodologies in clinical studies.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Anesthesiology
Li Wang, Joshua Tobe, Emily Au, Cody Tran, Jane Jomy, Yvgeniy Oparin, Rachel J. Couban, James Paul
Summary: The systematic review and meta-analysis found that SSRIs and SNRIs as adjuncts for postoperative pain management significantly reduced postoperative pain, opioid consumption, and improved patient satisfaction without increasing adverse events compared with placebo. SSRIs tend to be less effective than SNRIs, but the effects of SSRIs remain inconclusive due to limited evidence.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Clinical Neurology
Shuzhe Zhou, Qinhong Ma, Yiwei Lou, Xiaozhen Lv, Hongjun Tian, Jing Wei, Kerang Zhang, Gang Zhu, Qiaoling Chen, Tianmei Si, Gang Wang, Xueyi Wang, Nan Zhang, Yu Huang, Qi Liu, Xin Yu
Summary: This study utilized machine learning models to explore baseline variables for predicting the 8-week treatment outcome of patients with MDD receiving SSRIs. Results showed that neurocognitive functions and anxiety symptoms were important predictors, with SVM achieving an accuracy of 74.49% and sensitivity and specificity of 0.899 and 0.422, respectively.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Avital Fischer, Hedy S. Rennert, Gad Rennert
Summary: The study found that the use of SSRIs before and after breast cancer diagnosis is associated with increased mortality in breast cancer patients. Research is needed to further understand the mechanisms behind this association.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Psychiatry
Fredrik Hieronymus, Alexander Lisinski, Elias Eriksson, Soren Dinesen Ostergaard
Summary: This study analyzed patient-level data to assess the relationship between antidepressant side effects and HDRS-17 ratings, finding that some HDRS-17 items are associated with common antidepressant side effects, potentially leading to an underestimation of antidepressant efficacy.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychiatry
Elin Thornblom, Malin Gingnell, Janet L. Cunningham, Mikael Landen, Robert Boden
Summary: This study aimed to explore the correlation between peak heart rate and prolactin increase after seizure, and found a positive correlation between the two. This finding may support the use of peak heart rate as an indicator for evaluating seizure propagation to the diencephalon.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Peter Andersson, Esmail Jamshidi, Carl-Johan Ekman, Kristina Tedroff, Jonnie Bjorkander, Magnus Sjogren, Johan Lundberg, Jussi Jokinen, Adrian Desai E. Bostrom
Summary: This study investigated the updated international guideline recommendations for AN inpatient care using higher-level ecological evidence. The results showed a negative correlation between the length of inpatient stays and the relapse rate within the same year, supporting the inclusion of a stabilization phase in inpatient ED treatment.
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Wei Hu, Yaorui Hu, Yao Pei, Rongrong Li, Fuyi Xu, Xiaodong Chi, Jia Mi, Jonas Bergquist, Lu Lu, Luping Zhang, Chunhua Yang
Summary: A study found that there were 46 differentially expressed proteins between cervical carcinoma (CC) and normal tissues, with Integrin beta 6, PPP1CB, TMPO, PTGES3, and DTX3L significantly upregulated in CC, while Desmin was significantly downregulated. Silencing DTX3L could suppress CC cell proliferation, migration, invasion, and tumorigenesis, and enhance cell apoptosis. Furthermore, DTX3L silencing inhibited the activity of the PI3K/AKT/mTOR signaling pathway. These findings suggest that DTX3L may regulate CC progression through the PI3K/AKT/mTOR signaling pathway and could serve as a potential biomarker and therapeutic target for CC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Beatriz Penalver Bernabe, Pauline M. Maki, Janet L. Cunningham, Tory Eisenlohr-Moul, Lisa Tussing-Humphreys, Ian M. Carroll, Samantha Meltzer-Brody, Jack A. Gilbert, Mary Kimmel
Summary: Higher stress during pregnancy is associated with negative outcomes and elevated inflammation. The gut microbiota and host immune responses provide insights into perceived stress during pregnancy. This study examined the associations between perceived stress, gut microbiota composition, and immune system activity in two cohorts of pregnant individuals. The results showed distinct taxonomical and immunological signatures related to perceived stress, suggesting the potential role of the gut microbiome and immune factors in modulating stress during pregnancy.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Cell Biology
Esmail Jamshidi, Adrian E. Desai Bostrom, Alexander Wilczek, Asa Nilsonne, Marie Asberg, Jussi Jokinen
Summary: This study found that brain-derived neurotrophic factor (BDNF) is associated with the pathogenesis of emotionally unstable personality disorder (EUPD) and suicidal behavior. Epigenetic alterations of BDNF were observed in severely impaired EUPD and suicidal patients. The findings contribute to a better understanding of the mechanisms underlying suicide and EUPD and may lead to the development of novel treatment methods.
Article
Biochemistry & Molecular Biology
Sofia Persson, Kumari A. Ubhayasekera, Jonas Bergquist, Sahruh Turkmen, Inger Sundstroem Poromaa, Evangelia Elenis
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women, and hyperandrogenism can cause psychological morbidity and impaired quality of life. This study aimed to investigate whether hyperandrogenism persists into midlife and its impact on quality of life.
Article
Psychiatry
Adrian E. Desai Bostrom, Esmail Jamshidi, Diana-Maria Manu, Lara Kular, Helgi B. Schioth, Marie Asberg, Jussi Jokinen
Summary: This study finds that the CYP2D6-coupled epigenetic markers are hypomethylated in females and hypermethylated in male suicide completers, indicating a potential role for CYP2D6 in severe suicidality or suicide deaths.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Adrian E. Desai Bostroem, Peter Andersson, Mathias Rask-Andersen, Hakan Jarbin, Johan Lundberg, Jussi Jokinen
Summary: Advanced psychiatric treatments are uncertain in preventing suicide among adolescents. A study in Sweden shows a negative correlation between adolescent excess suicide mortality and the usage of clozapine, ECT, and lithium among adolescents, especially males. The results suggest that early recognition and medication treatment may benefit suicide prevention in male adolescents with severe mental illness.
NATURE COMMUNICATIONS
(2023)
Article
Food Science & Technology
Julio Cesar Espana Amortegui, Heidi Pekar, Mark Dennis Chico Retrato, Malin Persson, Bengt Karlson, Jonas Bergquist, Aida Zuberovic-Muratovic
Summary: A LC-MS/MS method was developed for the simultaneous identification and quantification of cyanotoxins in edible bivalves. The method successfully detected and resolved two previously detected cyanotoxin congeners separately. The method showed limitations for certain cyanotoxins but overall was specific and robust for the parameters investigated. The method was applied to analyze mussel and oyster samples collected along the Swedish coast, and the results can contribute to future regulatory monitoring for cyanotoxins to ensure seafood safety.
Article
Psychiatry
Peter Andersson, Jussi Jokinen, Hakan Jarbin, Johan Lundberg, Adrian E. Desai Bostroem
Summary: This study aimed to assess the association between the diagnosis frequency of bipolar disorder and suicide mortality rates in adolescents. The results showed that female adolescents were diagnosed with bipolar disorder more frequently than male adolescents. Moreover, the study found a negative correlation between the diagnosis rates of bipolar disorder and suicide rates in male adolescents, while no such association was observed in female adolescents.
Letter
Psychiatry
Peter Andersson, Hakan Jarbin, Adrian Emmanuel Desai Bostrom
Article
Psychiatry
Adrian Desai E. Bostrom, Peter Andersson, Esmail Jamshidi, Alexander Wilczek, Asa Nilsonne, Mathias Rask-Andersen, Marie asberg, Jussi Jokinen
Summary: Emotional unstable personality disorder (EUPD) is associated with increased natural-cause mortality, comorbid medical conditions, poor health habits, and stress-related epigenomic alterations. Using the GrimAge algorithm, this study found that women with EUPD and a history of recent suicide attempts exhibited accelerated epigenetic aging compared to healthy controls. These findings emphasize the importance of addressing medical health conditions in the treatment of EUPD.
TRANSLATIONAL PSYCHIATRY
(2023)
Letter
Cardiac & Cardiovascular Systems
Adrian E. Desai Bostrom, Johan Lundberg
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Infectious Diseases
Anja Naas, Peng Li, Clas Ahlm, Elisabeth Aurelius, Josef D. Jarhult, Silvia Schliamser, Marie Studahl, Wenzhong Xiao, Jonas Bergquist, Gabriel Westman
Summary: This study investigated the temporal changes of the CSF proteome in patients with herpes simplex encephalitis (HSE) and its association with factors such as anti-NMDAR serostatus, corticosteroid treatment, brain MRI, and neurocognitive performance. The results showed that the composition and activation pathways of CSF proteins vary at different stages of the disease. Additionally, it was found that several proteins were less abundant in patients with anti-NMDAR seropositivity compared to seronegativity.
INFECTIOUS DISEASES
(2023)
Article
Chemistry, Analytical
Mark Dennis Chico Retrato, Siyuan Qiu, Anna Lundquist, Aida Zuberovic Muratovic, Farshid Mashayekhy Rad, S. J. Kumari A. Ubhayasekera, Jonas Bergquist
Summary: This study describes a simple and robust method for the identification and quantification of 22 fatty acids in TPN components using gas chromatography-mass spectrometry. The method was evaluated according to the guidelines from FDA, EMA, and ICH, and demonstrated good methodological performance. The developed method has potential applications for quality assurance and control of TPN products.
ANALYTICAL METHODS
(2023)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)