Article
Clinical Neurology
Xiao Liu, Jingjing Huang, Yuan Jiang, Zhengyu Cao, Maoxiong Wu, Runlu Sun, Zhiteng Chen, Peng Yu, Jianyong Ma, Yangxin Chen, Yuling Zhang, Jingfeng Wang
Summary: This study investigated the inflammatory biomarker profiles of psychological treatment-naive individuals and found that levels of IL-6 and IL-8 were positively correlated with symptoms of depression, suggesting they may play a role in the pathogenesis of psychological disorders. However, these associations were not significant after multiple testing. Larger and longitudinal studies are needed to confirm these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Chemistry, Multidisciplinary
Asma B. Omer, Obaid Afzal, Abdulmalik S. A. Altamimi, Shaktipal Patil, Shareefa A. AlGhamdi, Amira M. Alghamdi, Sami I. Alzarea, Waleed Hassan Almalki, Imran Kazmi
Summary: Streptozotocin (STZ) impairs memory in rats through various mechanisms including cholinergic dysfunction, oxidative stress, hyperglycemia, and alterations in glucagon-like peptide (GLP). Barbaloin has been shown to have pharmacological effects but its effectiveness in improving STZ-induced memory dysfunction is not clear. In this study, barbaloin treatment significantly improved memory and cognitive functions, as measured by Y-maze and Morris water maze tests. The levels of oxidative stress markers, cholinergic dysfunction indicators, and inflammatory cytokines were also regulated by barbaloin treatment. These findings suggest that barbaloin has a protective impact against cognitive dysfunction caused by STZ.
Article
Chemistry, Multidisciplinary
Asma B. Omer, Obaid Afzal, Abdulmalik S. A. Altamimi, Shaktipal Patil, Shareefa A. AlGhamdi, Amira M. Alghamdi, Sami I. Alzarea, Waleed Hassan Almalki, Imran Kazmi
Summary: Streptozotocin (STZ) impairs memory in rats through various mechanisms, but it can be improved by cholinergic agonist, antioxidant, and antihyperglycemic treatment. Barbaloin, a compound with multiple pharmacological effects, was found to significantly improve cognitive dysfunction caused by STZ in rats. Barbaloin treatment decreased body weight and improved learning and memory capacities in behavioral tests. It also regulated oxidative stress markers and indicators of cholinergic dysfunction. The findings suggest that barbaloin has a protective impact against cognitive dysfunction caused by STZ.
Article
Nutrition & Dietetics
Patrycja Bielawiec, Ewa Harasim-Symbor, Klaudia Sztolsztener, Karolina Konstantynowicz-Nowicka, Adrian Chabowski
Summary: Excessive intake of fatty acids leads to oxidative stress and inflammation, while CBD has potential therapeutic properties by improving the n-6/n-3 PUFA ratio, preventing lipid peroxidation, and attenuating inflammatory response in skeletal muscles.
Article
Multidisciplinary Sciences
Teng Huang, Jia Song, Jia Gao, Jia Cheng, Hao Xie, Lu Zhang, Yu-Han Wang, Zhichao Gao, Yi Wang, Xiaohui Wang, Jinhan He, Shiwei Liu, Qilin Yu, Shu Zhang, Fei Xiong, Qing Zhou, Cong-Yi Wang
Summary: Aberrant amino acid metabolism, particularly the excessive plasma kynurenine (Kyn), is common in obesity. This study demonstrates that overexpressed indoleamine 2,3-dioxygenase 1 (IDO1) in adipocytes is the primary source of excessive Kyn, highlighting the central role of adipocytes in Kyn metabolism. Depletion of Ido1 in adipocytes eliminates Kyn accumulation, protecting mice against obesity.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Danny Luan, Benyamin Dadpey, Jessica Zaid, Pania E. Bridge-Comer, Julia H. DeLuca, Wenmin Xia, Joshua Castle, Shannon M. Reilly
Summary: The bidirectional interaction between adipocytes and adipose tissue immune cells is crucial for regulating adipose function, inflammation, and insulin responsiveness. Obesity reduces cAMP-driven IL-6 secretion from adipocytes, but restoring their catecholamine sensitivity can stimulate IL-6 secretion and activate macrophages to promote an anti-inflammatory gene expression pattern.
Article
Endocrinology & Metabolism
Xinmei Huang, Yue Li, Xiaoxu Tong, Yueyue Wu, Rui Zhang, Li Sheng, Jiong Xu, Zhiyan Yu, Zaoping Chen, Tiange Sun, Fang Wang, Qian Yang, Zhangyan Li, Cuijun Gao, Ling Ma, Heyuan Ding, Shufei Zang, Ni Yang, Tie-Ning Zhang, Jun Liu
Summary: Increased circulating IL-32 throughout pregnancy is closely associated with placenta macrophage-derived IL-32 expression and GDM. First trimester IL-32 level in peripheral blood may serve to predict the development of GDM.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Lilian Correa Costa-Beber, Pauline Brendler Goettems-Fiorin, Jaine Borges dos Santos, Paula Tais Friske, Matias Nunes Frizzo, Thiago Gomes Heck, Mirna Stela Ludwig
Summary: Obesity and PM2.5 are important risk factors for cardiometabolic diseases. This study aimed to investigate the synergistic effects of ROFA and a high-fat diet (HFD) on female rats. The results showed that HFD combined with ROFA exposure worsened lipid metabolism, challenged systemic and cardiac antioxidant defense, and had a synergistic effect in inducing an immune-inflammatory condition. The findings suggest that ROFA exposure combined with a bad diet can exacerbate metabolic and cardiovascular diseases.
Review
Immunology
Yen-Ju Lin, Alexandra Goretzki, Stefan Schuelke
Summary: Allergic disorders have been on the rise in recent decades, prompting the emergence of a new research field called immune metabolism. It has been found that metabolic changes in T and B cells may play a role in the development and maintenance of allergies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Juan Chen, Yanghui Wei, Weiqin Yang, Qingnan Huang, Yong Chen, Kai Zeng, Jiawei Chen
Summary: Breast cancer is a leading cause of female mortality, and IL-6 plays a crucial role in its regulation. Recent studies have shown promising outcomes for breast cancer treatment through combination therapy of IL-6 inhibitory antibodies with other drugs.
FRONTIERS IN ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
Samuel T. Orange, Jack Leslie, Mark Ross, Derek A. Mann, Henning Wackerhage
Summary: IL-6 has both anticancer and procancer effects depending on the context, known as the 'exercise IL-6 enigma'. Exercise-induced IL-6 can protect against cancer by improving insulin sensitivity, stimulating the production of anti-inflammatory cytokines, mobilizing immune cells, and reducing DNA damage. However, IL-6 continuously produced in inflammatory sites drives tumorigenesis by promoting chronic inflammation. This review explores the roles of IL-6 in chronic inflammation, tumorigenesis, and exercise-associated cancer prevention and identifies the factors underlying the exercise IL-6 enigma.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Medicine, Research & Experimental
Luana Heimfarth, Marilia Matos Rezende, Erik Willyame Menezes Pereira, Fabiolla Rocha Santos Passos, Brenda Souza Monteiro, Tiffany Karoline Barroso Santos, Natalia Teles Lima, Isana Carla Leal Souza, Ricardo Luiz Cavalcanti de Albuquerque Junior, Pollyana de Souza Siqueira Lima, Adriano Antunes de Souza Araujo, Lucindo Jose Quintans Junior, Bonglee Kim, Henrique D. M. Coutinho, Jullyana de Souza Siqueira Quintans
Summary: Inflammatory arthritis is a common chronic inflammatory disease, and oral administration of BIS and β CD/BIS can significantly alleviate its symptoms, with the cyclodextrin inclusion complex also improving the pharmacological profile of the drug.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Reem S. Alruhaimi, Gomaa Mostafa-Hedeab, Maisa Siddiq Abduh, Albandari Bin-Ammar, Emad H. M. Hassanein, Emadeldin M. Kamel, Ayman M. Mahmoud
Summary: This study found that Euphorbia peplus extract (EPE) has anti-diabetic effects in rats with type 2 diabetes, improving hyperglycemia, insulin resistance, dyslipidemia, inflammation, and oxidative stress, and increasing antioxidant capacity.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lihua Zhang, Zhongliang Li, Changcheng Xing, Ning Gao, Rui Xu
Summary: This study found that HHcy synergistically aggravated arterial damage in hypertensive rats through immune/inflammatory response, while folate demonstrated anti-inflammatory properties and reversed the NF-kappa B p65/Rela/IL-6 levels induced by HHcy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Lauren K. Vasilakos, Baiba Steinbrekera, Donna A. Santillan, Mark K. Santillan, Debra S. Brandt, Daniel Dagle, Robert D. Roghair
Summary: Diabetes during pregnancy and chorioamnionitis are associated with increased levels of maternal insulin, leptin, and IL-6. While both leptin and IL-6 play roles in inflammation, they have contrasting effects on neurodevelopment. In a study of cord blood samples from 104 term infants, it was found that maternal diabetes increased levels of leptin and insulin, while chorioamnionitis was associated with elevated IL-6 levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Halah Nori Asad, Hussein Kadhem Al-Hakeim, Shatha Rouf Moustafa, Michael Maes
Summary: This study aimed to investigate the associations between severity of fatigue and physio-somatic symptoms and glomerular filtration rate, inflammatory biomarkers, and Wnt/β-catenin pathway in ESRD patients. The results showed that ESRD patients exhibit high levels of fatigue and physio-somatic symptoms, which are associated with dialysis-induced changes in inflammatory pathways, the Wnt/β-catenin pathway, and copper levels.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Correction
Clinical Neurology
Andressa K. Matsumoto, Michael Maes, Thitiporn Supasitthumrong, Annabel Maes, Ana P. Michelin, Laura De Oliveira Semeao, Joao V. De Lima Pedrao, Estefania G. Moreira, Buranee Kanchanatawan, Decio S. Barbosa
Article
Clinical Neurology
Marco Solmi, Trevor Thompson, Andres Estrade, Agorastos Agorastos, Joaquim Radua, Samuele Cortese, Elena Dragioti, Friedrich Leisch, Davy Vancampfort, Lau Caspar Thygesen, Harald Aschauer, Monika Schloegelhofer, Elena Aschauer, Andres Schneeberger, Christian G. Huber, Gregor Hasler, Philippe Conus, Kim Q. Do Cuenod, Roland von Kaenel, Gonzalo Arrondo, Paolo Fusar-Poli, Philip Gorwood, Pierre-Michel Llorca, Marie-Odile Krebs, Elisabetta Scanferla, Taishiro Kishimoto, Golam Rabbani, Karolina Skonieczna-Zydecka, Paolo Brambilla, Angela Favaro, Akihiro Takamiya, Leonardo Zoccante, Marco Colizzi, Julie Bourgin, Karol Kaminski, Maryam Moghadasin, Soraya Seedat, Evan Matthews, John Wells, Emilia Vassilopoulou, Ary Gadelha, Kuan-Pin Su, Jun Soo Kwon, Minah Kim, Tae Young Lee, Oleg Papsuev, Denisa Mankova, Andrea Boscutti, Cristiano Gerunda, Diego Saccon, Elena Righi, Francesco Monaco, Giovanni Croatto, Guido Cereda, Jacopo Demurtas, Natascia Brondino, Nicola Veronese, Paolo Enrico, Pierluigi Politi, Valentina Ciappolino, Andrea Pfennig, Andreas Bechdolf, Andreas Meyer-Lindenberg, Kai G. Kahl, Katharina Domschke, Michael Bauer, Nikolaos Koutsouleris, Sibylle Winter, Stefan Borgwardt, Istvan Bitter, Judit Balazs, Pal Czobor, Zsolt Unoka, Dimitris Mavridis, Konstantinos Tsamakis, Vasilios P. Bozikas, Chavit Tunvirachaisakul, Michael Maes, Teerayuth Rungnirundorn, Thitiporn Supasitthumrong, Ariful Haque, Andre R. Brunoni, Carlos Gustavo Costardi, Felipe Barreto Schuch, Guilherme Polanczyk, Jhoanne Merlyn Luiz, Lais Fonseca, Luana V. Aparicio, Samira S. Valvassori, Merete Nordentoft, Per Vendsborg, Sofie Have Hoffmann, Jihed Sehli, Norman Sartorius, Sabina Heuss, Daniel Guinart, Jane Hamilton, John Kane, Jose Rubio, Michael Sand, Ai Koyanagi, Aleix Solanes, Alvaro Andreu-Bernabeu, Antonia San Jose Caceres, Celso Arango, Covadonga M. Diaz-Caneja, Diego Hidalgo-Mazzei, Eduard Vieta, Javier Gonzalez-Penas, Lydia Fortea, Mara Parellada, Miquel A. Fullana, Norma Verdolini, Eva Andrlikova, Karolina Janku, Mark John Millan, Mihaela Honciuc, Anna Moniuszko-Malinowska, Igor Loniewski, Jerzy Samochowiec, Lukasz Kiszkiel, Maria Marlicz, Pawel Sowa, Wojciech Marlicz, Georgina Spies, Brendon Stubbs, Joseph Firth, Sarah Sullivan, Asli Enez Darcin, Hatice Aksu, Nesrin Dilbaz, Onur Noyan, Momoko Kitazawa, Shunya Kurokawa, Yuki Tazawa, Alejandro Anselmi, Cecilia Cracco, Ana Ines Machado, Natalia Estrade, Diego De Leo, Jackie Curtis, Michael Berk, Philip Ward, Scott Teasdale, Simon Rosenbaum, Wolfgang Marx, Adrian Vasile Horodnic, Liviu Oprea, Ovidiu Alexinschi, Petru Ifteni, Serban Turliuc, Tudor Ciuhodaru, Alexandra Bolos, Valentin Matei, Dorien H. Nieman, Iris Sommer, Jim van Os, Therese van Amelsvoort, Ching-Fang Sun, Ta-wei Guu, Can Jiao, Jieting Zhang, Jialin Fan, Liye Zou, Xin Yu, Xinli Chi, Philippe de Timary, Ruud van Winkel, Bernardo Ng, Edilberto Pena, Ramon Arellano, Raquel Roman, Thelma Sanchez, Larisa Movina, Pedro Morgado, Sofia Brissos, Oleg Aizberg, Anna Mosina, Damir Krinitski, James Mugisha, Dena Sadeghi-Bahmani, Farshad Sheybani, Masoud Sadeghi, Samira Hadi, Serge Brand, Antonia Errazuriz, Nicolas Crossley, Dragana Ignjatovic Ristic, Carlos Lopez-Jaramillo, Dimitris Efthymiou, Praveenlal Kuttichira, Roy Abraham Kallivayalil, Afzal Javed, Muhammad Iqbal Afridi, Bawo James, Omonefe Joy Seb-Akahomen, Jess Fiedorowicz, Andre F. Carvalho, Jeff Daskalakis, Lakshmi N. Yatham, Lin Yang, Tarek Okasha, Aicha Dahdouh, Bjoern Gerdle, Jari Tiihonen, Jae Il Shin, Jinhee Lee, Ahmed Mhalla, Lotfi Gaha, Takoua Brahim, Kuanysh Altynbekov, Nikolay Negay, Saltanat Nurmagambetova, Yasser Abu Jamei, Mark Weiser, Christoph U. Correll
Summary: The COH-FIT survey is a valid instrument to measure global mental health during the COVID-19 pandemic. The study confirmed the validity of COH-FIT items and the internal reliability of the co-primary outcome, the P-score. The survey has been translated into 30 languages and measures various mental health symptoms and factors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Letter
Clinical Neurology
Abbas F. Almulla, Hussein Kadhem Al-Hakeim, Michael Maes
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Review
Virology
Aristo Vojdani, Elroy Vojdani, Evan Saidara, Michael Maes
Summary: Long-haul COVID, also known as long COVID, is a novel syndrome that occurs in a significant percentage of individuals a few months after being infected with SARS-CoV-2. It is characterized by persistent, recurring, or new symptoms that affect various tissues and organs. There are similarities between long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), with infections, immune dysregulation, and inflammation playing a role in both conditions.
Letter
Biochemistry & Molecular Biology
Abbas F. Almulla, Michael Maes
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Xia Qiu, Yin Wu, Ying Sun, Brooke Levis, Jizhou Tian, Jill T. Boruff, Pim Cuijpers, John P. A. Ioannidis, Sarah Markham, Roy C. Ziegelstein, Simone N. Vigod, Andrea Benedetti, Brett Thombs, Chen He, Ankur Krishnan, Parash Mani Bhandari, Dipika Neupane, Zelalem Negeri, Mahrukh Imran, Danielle B. Rice, Marleine Azar, Matthew J. Chiovitti, Simon A. Gilbody, Lorie B. Kloda, Scott D. Patten, Nicholas Mitchell, Ruben Alvarado, Jacqueline Barnes, Cheryl Tatano Beck, Carola Bindt, Humberto Correa, Tiago Castro e Couto, Genesis Chorwe-Sungani, Valsamma Eapen, Nicolas Favez, Ethel Felice, Gracia Fellmeth, Michelle Fernandes, Sally Field, Barbara Figueiredo, Jane R. W. Fisher, Eric P. Green, Simone Honikman, Louise M. Howard, Pirjo A. Kettunen, Jane Kohlhoff, Zoltan Kozinszky, Angeliki A. Leonardou, Michael Maes, Pablo Martinez, Sandra Nakic Rados, Daisuke Nishi, Susan J. Pawlby, Tamsen J. Rochat, Heather J. Rowe, Deborah J. Sharp, Alkistis Skalkidou, Johanne Smith-Nielsen, Alan Stein, Kuan-Pin Su, Inger Sundstroem-Poromaa, Meri Tadinac, S. Darius Tandon, Iva Tendais, Annamaria D. Toereki, Thach Tran, Kylee Trevillion, Katherine S. Turner, Mette Vaever, Thandi M. van Heyningen, Johann Vega-Dienstmaier, Karen A. Wynter, Kimberly Yonkers
Summary: Item 10 of the EPDS assesses self-harm thoughts but may also elicit concerns about accidental self-harm. The EPDS-9, which omits item 10, is sometimes used in research due to concerns about its implications. A meta-analysis of individual participant data showed that EPDS-9 performs similarly to the full EPDS in detecting major depression among pregnant and postpartum women.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Hussein Kadhem Al-Hakeim, Anwar Khairi Abed, Shatha Rouf Moustafa, Abbas F. Almulla, Michael Maes
Summary: In this study, we found that severe Long COVID patients had low serum tryptophan, low oxygen saturation, high insulin resistance, high C-reactive protein, and high ratings on all symptom domains. Inflammatory responses, decreased tryptophan, and increased kynurenine may contribute to the physio-affective phenome of Long COVID.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Psychiatry
Ketsupar Jirakran, Asara Vasupanrajit, Chavit Tunvirachaisakul, Michael Maes
Summary: This study aimed to determine whether neuroticism is a feature of the acute state of major depressive disorder (MDD), including suicidal behaviors, and whether adverse childhood experiences are associated with neuroticism in MDD. The results showed that neuroticism was significantly higher in MDD patients compared to healthy controls, and it explained a large portion of the variance in the depression phenome. Neglect and abuse in childhood accounted for a significant portion of the variance in the latent vector representing MDD phenome, with neuroticism partially mediating the effects of neglect and completely mediating the effects of abuse.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Rosa Savino, Alessandro Medoro, Sawan Ali, Giovanni Scapagnini, Michael Maes, Sergio Davinelli
Summary: While autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome, studies have shown that oxidative stress and inflammation are common factors in ASD. Flavonoids, plant-derived compounds with antioxidant, anti-inflammatory, and neuroprotective effects, have been investigated for their potential impact on ASD. A review of preclinical and clinical studies found that flavonoids may improve oxidative stress parameters, reduce inflammation, and ameliorate core symptoms of ASD. However, more randomized placebo-controlled trials are needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
George Anderson, Abbas F. Almulla, Russel J. Reiter, Michael Maes
Summary: There is increasing evidence that autoimmune processes play an important role in various medical conditions, including cancers, neurodegenerative diseases, and psychiatric disorders. These conditions are associated with alterations in mitochondrial function across cells. The mitochondrial melatonergic pathway is present in all body cells and has important implications for driving autoimmune processes.
Article
Cell Biology
Michael Maes, Asara Vasupanrajit, Ketsupar Jirakran, Pavit Klomkliew, Prangwalai Chanchaem, Chavit Tunvirachaisakul, Sunchai Payungporn
Summary: Maes et al. (2008) found that major depressive disorder (MDD) is associated with abnormalities in the microbiota-gut-brain axis, characterized by elevated IgM/IgA levels to lipopolysaccharides (LPS) from Gram-negative bacteria. In a study of Thai patients with MDD, fecal samples were analyzed using 16S rDNA sequencing. The results showed a specific profile of gut dysbiosis in MDD, with increased pathobionts and depleted beneficial microbiota, suggesting a potential biomarker of MDD.
Article
Developmental Biology
Fernanda Mithie Ogo, Glaucia Eloisa Munhoz Lion Siervo, Ana Maria Praxedes, Henrique Rodrigues Vieira, Suellen Ribeiro da Silva Scarton, Ana Tereza Guimaraes Bitencourt, Arielle Cristina Arena, Andrea Name Colado Simao, Marina Trevizan Guerra, Paulo Cesar de Freitas Mathias, Glaura Scantamburlo Alves Fernandes
Summary: This study aimed to evaluate the impact of maternal exposure to continuous light during pregnancy on the adult reproductive system in female offspring. The results showed that continuous light exposure during the intrauterine period resulted in reduced LH levels and increased progesterone levels, uterine injuries, increased number of endometrial glands, and reduced antioxidant enzyme activity in the uterus of female offspring.
BIRTH DEFECTS RESEARCH
(2023)
Article
Psychiatry
Hussein Kadhem Al-Hakeim, Haneen Tahseen Al-Rubaye, Abdulsahib S. Jubran, Abbas F. Almulla, Shatha Rouf Moustafa, Michael Maes
Summary: This study examined the association between long COVID and increased insulin resistance, as well as its connection with neuroimmune and oxidative processes. The results showed that long COVID patients had increased insulin resistance, which was associated with depressive symptoms.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Michael Maes, Paul Thisayakorn, Yanin Thipakorn, Saran Tantavisut, Sunee Sirivichayakul, Aristo Vojdani
Summary: This study found that elevated IgA levels against neuronal self-antigens, AQP4, and HSP60 are risk factors for delirium. The breakdown of immune tolerance, activation of the immune-inflammatory response system, and injuries in neuronal and glial cells are involved in the pathophysiology of delirium.
EUROPEAN GERIATRIC MEDICINE
(2023)