Article
Biotechnology & Applied Microbiology
Parisa Badiee, Michelle F. Maritz, Pouya Dehghankelishadi, Nicole Dmochowska, Benjamin Thierry
Summary: This study introduces a nanoformulation of the IDO inhibitor navoximod within polymeric nanoparticles, prepared using a high-throughput microfluidic mixing device. The nanoformulation efficiently inhibits IDO and enhances the anti-cancer cytotoxicity of T-cells through synergy with PD-1 antibodies.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Orthopedics
Genxiang Rong, Tao Zhang, Yayun Xu, Zhenyu Zhang, Binjie Gui, Kongzu Hu, Jinling Zhang, Zhi Tang, Cailiang Shen
Summary: This study found that the levels of TDO2 in the synovium of patients with osteoarthritis were significantly higher, and were correlated with pro-inflammatory cytokines and severity of the disease.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Ciprian Rezus, Alexandra Maria Burlui, Elena Rezus
Summary: Cardiovascular diseases are a leading cause of high mortality in SLE patients, and traditional risk factors are insufficient in predicting their risk. Inflammation has been found to play a crucial role in the development of atherosclerosis in SLE, highlighting the need for new biomarkers to assess subclinical CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ivan K. Domingo, Asna Latif, Amit P. Bhavsar
Summary: Cisplatin, a widely used chemotherapeutic drug, is effective against various solid cancers but limited by its adverse drug reactions. The most common reactions include nephrotoxicity, peripheral neuropathy, and ototoxicity. Previous studies focused on oxidative stress as the cause of these toxicities, but recent evidence suggests that inflammation may be the main driving force. This review summarizes the common and distinct inflammation characteristics among different adverse reactions, as well as current treatments targeting pro-inflammatory signaling pathways to improve the use of cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Piotr Szpakowski, Dominika Ksiazek-Winiarek, Malgorzata Turniak-Kusy, Ilona Pacan, Andrzej Glabinski
Summary: Astrocytes, once considered passive brain cells, have been found to play a more active role in the central nervous system. This study aimed to evaluate the production of inflammatory chemokines and neurotrophic factors by primary human astrocytes after inflammatory or anti-inflammatory stimulation. The results showed that only astrocytes induced by inflammatory mediators produced certain chemokines, and pro-inflammatory conditions decreased the release of a neurotrophic factor while anti-inflammatory cytokines increased its production.
Article
Biochemistry & Molecular Biology
Rafael Cardoso Maciel Costa Silva, Luis Tan, Danielle Aparecida Rodrigues, Elisa Beatriz Prestes, Caroline Pereira Gomes, Andreza Moreira Gama, Pedro Lagerblad de Oliveira, Claudia Neto Paiva, Benedicte Manoury, Marcelo Torres Bozza
Summary: The study indicates that chloroquine may be used as a supportive therapy to control heme-induced deleterious inflammation in different hemolytic diseases by inhibiting inflammatory effects induced by heme.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jiebo Zhu, Min Joung Lee, Jong Hun An, Eungseok Oh, Woosuk Chung, Jun Young Heo
Summary: Microglial activation is correlated with the unfolded protein response (UPRmt) in mitochondria, which acts as a protective mechanism during neuroinflammation and may be a potential therapeutic target for reducing inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Gamze Guney Eskiler, Cemil Bilir
Summary: Indoximod showed therapeutic potential in TNBC cells, with pro-inflammatory cytokines affecting its effectiveness. Further studies are needed to elucidate the role of IDO-associated signaling pathways, molecular mechanisms of indoximod-induced apoptotic cell death, and the relationship between IDO inhibition and pro-inflammatory cytokine levels.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Dorina Lauritano, Filiberto Mastrangelo, Cristian D'Ovidio, Gianpaolo Ronconi, Alessandro Caraffa, Carla E. Gallenga, Ilias Frydas, Spyros K. Kritas, Matteo Trimarchi, Francesco Carinci, Pio Conti
Summary: Mast cells (MCs) are tissue cells derived from bone marrow stem cells and play a role in various diseases and disorders. They communicate with microglia in the brain through the production of mediators and can have pathological effects. MCs release preformed chemical mediators and cytokines, and can interact with neuropeptides, leading to inflammation in the central nervous system. This article explores the activation of MCs by neuropeptides and the therapeutic potential of anti-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Andrea Gerbino, Cinzia Forleo, Serena Milano, Francesca Piccapane, Giuseppe Procino, Martino Pepe, Mara Piccolo, Piero Guida, Nicoletta Resta, Stefano Favale, Maria Svelto, Monica Carmosino
Summary: The study identified high levels of G-CSF and IL-6 in all patients with lmna mutations, as well as elevated levels of other interleukins and GM-CSF in patients with more aggressive clinical manifestations. Furthermore, increased expression of Hsp70 in serum exosomes was observed in patients with the more severe phenotype, suggesting potential diagnostic, prognostic, and therapeutic implications against Lamin A/C cardiomyopathies.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Natalia Lehman, Wioleta Kowalska, Michal Zarobkiewicz, Marek Mazurek, Karolina Mrozowska, Agnieszka Bojarska-Junak, Radoslaw Rola
Summary: Monocyte subpopulations in glioma patients' peripheral blood were analyzed based on CD14, CD16, and SLAN expression. The study found different profiles of monocytes with varying cytokine expression. The presence of these different profiles might hinder the effectiveness of immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Roberto Gramignoli, Aarati R. Ranade, Raman Venkataramanan, Stephen C. Strom
Summary: Pro-inflammatory cytokines can affect liver cell functions, particularly ammonia and drug metabolism, but do not necessarily indicate rejection or loss of cell graft.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Thiara Manuele Alves de Souza, Caroline Fernandes-Santos, Jessica Araujo da Paixao de Oliveira, Larissa Cristina Teixeira Tome, Victor Edgar Fiestas-Solorzano, Priscila Conrado Guerra Nunes, Gabriel Macedo Costa Guimaraes, Juan Camilo Sanchez-Arcila, Iury Amancio Paiva, Luis Jose de Souza, Paulo Vieira Damasco, Valber da Silva Frutuoso, Manoela Heringer, Luzia Maria De Oliveira-Pinto, Roberta Olmo Pinheiro, Flavia Barreto dos Santos, Elzinandes Leal de Azeredo
Summary: This study evaluated the activity of IDO-1 and the patterns of cytokines/chemokines in CHIKV patients. It was found that IDO-1 activity increased during the early acute phase of infection and decreased in the chronic phase. In the acute phase, concentrations of TNF-alpha, IL-6, IFN-gamma, CCL2/MCP-1, and CXCL10/IP-10 were increased. In the chronic phase, concentrations of CCL4/MIP-1 beta were increased, especially in patients with arthritis.
Article
Biochemistry & Molecular Biology
A. V. Weber, B. L. Firth, I. G. Cadonic, P. M. Craig
Summary: This study investigated the impact of Venlafaxine (VFX) on zebrafish, and found that environmentally relevant concentrations of VFX had no effect on the thermal tolerance of zebrafish, but could lead to a decrease in the function of heat shock mechanisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Narges Navaei-Alipour, Mohadeseh Mastali, Gordon A. Ferns, Maryam Saberi-Karimian, Majid Ghayour-Mobarhan
Summary: Honey contains flavonoids and phenolic acids that may have important implications for human health due to their antioxidant and anti-inflammatory properties. Studies have shown that honey can inhibit the expression of pro-inflammatory factors in conditions such as cancer and neuro-inflammatory disorders. However, more high-quality research is needed to firmly establish the clinical efficacy of honey and understand the specific mechanisms of its anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Neurosciences
Saima Zameer, Mahtab Alam, Salman Hussain, Divya Vohora, Javed Ali, Abul Kalam Najmi, Mohd Akhtar
BRAIN RESEARCH BULLETIN
(2020)
Review
Pharmacology & Pharmacy
Manoj Kumar, Ram Bajpai, Abdul Rahaman Shaik, Swati Srivastava, Divya Vohora
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Neurosciences
Preeti Vyas, Raj Kumar Tulsawani, Divya Vohora
Review
Clinical Neurology
Divya Vohora, Shreshta Jain, Manjari Tripathi, Heidrun Potschka
Article
Pharmacology & Pharmacy
Saima Zameer, Javed Ali, Divya Vohora, Abul Kalam Najmi, Mohd Akhtar
Summary: The study aimed to develop ALN-loaded chitosan nanoparticles for brain delivery via the intranasal route. The CS-ALN-NPs showed reduced peripheral side effects, direct release of ALN to the brain, and controlled release properties. The optimized NPs demonstrated a smaller particle size within the 200nm range and sustained drug release, making them a promising brain-targeted delivery system for Alzheimer's disease treatment.
JOURNAL OF DRUG TARGETING
(2021)
Article
Neurosciences
Sumaira Khan, Mallika Khurana, Preeti Vyas, Divya Vohora
Summary: Melatonin and its analogues are considered to have antiseizure effects, but further research is needed to investigate their mechanisms of action and potential implications in the treatment of epilepsy. Evaluating melatonergic signaling pathways and mechanisms may lead to significant advancements in the field of epileptology in the future.
REVIEWS IN THE NEUROSCIENCES
(2021)
Review
Pharmacology & Pharmacy
Nikita Nirwan, Nikita, Yasmin Sultana, Divya Vohora
Summary: Liposomes-based bone-targeted delivery of therapeutics shows promise for treating osteoporosis effectively. However, despite extensive in vitro and in vivo research on liposomes, significant progress in their clinical translation has not been achieved. Successful translation from bench to bedside requires interdisciplinary collaboration between preclinical and clinical experts at different stages of liposomes development.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Review
Endocrinology & Metabolism
Divya Goel, Divya Vohora
Summary: LXR is a nuclear receptor that regulates lipid metabolism and inflammatory response, and also plays a role in bone remodeling. Through different molecular pathways, LXR modulates skeletal homeostasis.
Article
Toxicology
Saima Zameer, Salman Hussain, Divya Vohora, Abul Kalam Najmi, Javed Ali, Mohd Akhtar
Summary: The study demonstrates that alendronate can improve cognitive and neurological disturbances caused by age-related disorders, including neuroinflammation, oxidative stress, and neuronal damage. Experimental findings show that alendronate can effectively reverse these changes.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Review
Endocrinology & Metabolism
Abdul Rahaman Shahik, Prabhjeet Singh, Chandini Shaik, Sunil Kohli, Divya Vohora, Serge Livio Ferrari
Summary: Diabetes and osteoporosis pose significant burdens on quality of life and healthcare costs. Recent research has focused on the impact of diabetes on bone metabolism, as well as the effects of metformin on bone health in individuals with type 2 diabetes. While studies have shown beneficial effects of metformin on bone microarchitecture, bone mineral density, and fracture risk, there are limitations in animal and clinical studies that warrant further investigation.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Clinical Neurology
Shreshta Jain, Heidrun Potschka, P. Prarthana Chandra, Manjari Tripathi, Divya Vohora
Summary: When it comes to potential therapeutic options for COVID-19 management and potential drug-drug interactions between antiseizure drugs and COVID-19 candidate drugs, further research and experimental results support are needed.
Article
Multidisciplinary Sciences
Shreshta Jain, Reena Rai, Divya Singh, Divya Vohora
Summary: Octanoic acid, a medium-chained saturated fatty acid found in ketogenic dietary supplements, has been shown to have significant negative effects on bone health, indicating the need for further investigation and validation.
SCIENTIFIC REPORTS
(2021)
Article
Toxicology
Hisaa Nassir Abdulla Lotah, Anoop Kumar Agarwal, Razia Khanam
Summary: This study shows that hair and nail samples can be used as markers for assessing occupational exposure to heavy metals, with cadmium and nickel concentrations increasing in hair with longer exposure time and work experience.
TOXICOLOGICAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Razia Khanam
Summary: Diabetic patients are at high risk for severe symptoms of COVID-19, with some studies suggesting that COVID-19 can also induce diabetes. The renin-angiotensin-aldosterone system (RAAS) plays an important role in the bidirectional association between COVID-19 and diabetes.
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES
(2021)
Meeting Abstract
Pharmacology & Pharmacy
Preeti Vyas, Rajkumar Tulsawani, Divya Vohora
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
